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1. 发明申请

WO2012089225A1 COMBINATION OF VACCINATION AND INHIBITION OF MHC CLASS I RESTRICTED ANTIGEN PRESENTATION 审中-公开
标题翻译： MHC类限制性抗原呈递的组合和抑制
公开(公告)号：WO2012089225A1
公开(公告)日：2012-07-05
申请号：PCT/EP2010/007969
申请日：2010-12-29
申请人： CUREVAC GMBH , LORENZ, Christina , FOTIN-MLECZEK, Mariola , KALLEN, Karl-Josef
发明人： LORENZ, Christina , FOTIN-MLECZEK, Mariola , KALLEN, Karl-Josef
IPC分类号： A61K39/00 , A61P35/00 , A61P31/12
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/55516
摘要： The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumour cells and infected cells having lost the capability of MHC class I restricted antigen presentation.
摘要翻译：本发明涉及疫苗/抑制剂组合，其包含作为至少一种抗原的疫苗和作为主要组织相容性复合物（MHC）I类限制性抗原呈递的至少一种抑制剂的抑制剂。本发明还涉及使用本发明的疫苗/抑制剂组合接种哺乳动物的方法。本发明还提供了包含本发明的疫苗/抑制剂组合的部分试剂盒，优选在试剂盒的不同部分，例如，用于先前，并发或后续管理不同部件。另外，本发明涉及包含本发明的疫苗/抑制剂组合的药物组合物，以进一步改善针对肿瘤细胞的免疫应答和已失去MHC I类限制性抗原呈递能力的感染细胞。

2. 发明申请

WO2012089338A1 COMBINATION OF VACCINATION AND INHIBITION OF MHC CLASS RESTRICTED ANTIGEN PRESENTATION 审中-公开
标题翻译：疫苗接种和抑制MHC类限制性抗原呈递的组合
公开(公告)号：WO2012089338A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/006585
申请日：2011-12-27
申请人： CUREVAC GMBH , LORENZ, Christina , FOTIN-MLECZEK, Mariola , KALLEN, Karl-Josef
发明人： LORENZ, Christina , FOTIN-MLECZEK, Mariola , KALLEN, Karl-Josef
IPC分类号： A61K39/00 , A61P35/00 , A61P31/12
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/55516
摘要： The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumour cells and infected cells having lost the capability of MHC class I restricted antigen presentation.
摘要翻译：本发明涉及疫苗/抑制剂组合，其包含作为至少一种抗原的疫苗和作为主要组织相容性复合物（MHC）I类限制性抗原呈递的至少一种抑制剂的抑制剂。本发明还涉及使用本发明的疫苗/抑制剂组合接种哺乳动物的方法。本发明还提供了包含本发明的疫苗/抑制剂组合的部分试剂盒，优选在试剂盒的不同部分，例如，用于先前，并发或后续管理不同部件。另外，本发明涉及包含本发明的疫苗/抑制剂组合的药物组合物，以进一步改善针对肿瘤细胞的免疫应答和已失去MHC I类限制性抗原呈递能力的感染细胞。

3. 发明申请

WO2013113501A1 PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPIDE ANTIGEN 审中-公开
标题翻译：包含聚合物载体复合物和至少一种蛋白质或抗原抗原的药物组合物
公开(公告)号：WO2013113501A1
公开(公告)日：2013-08-08
申请号：PCT/EP2013/000291
申请日：2013-01-31
申请人： CUREVAC GMBH , BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
发明人： BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
IPC分类号： A61K47/48 , A61K39/39 , A61P35/00 , A61P37/00 , A61P31/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/29 , A61K39/35 , A61K47/64 , A61K47/645 , A61K47/646 , A61K48/0041 , A61K2039/5252 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , A61K2039/6093 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , C12N2730/10134 , C12N2730/10171 , C12N2760/16134 , C12N2760/16171 , C12N2760/20134 , C12N2760/20171 , Y02A50/416
摘要： The present invention is directed to a pharmaceutical composition including (e.g. for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease; an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits, as well as the use of the pharmaceutical composition or the kit as a vaccine, particularly in the treatment of infectious diseases, allergies, autoimmune diseases and tumour or cancer diseases.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫化物交联的阳离子组分形成的聚合物载体; 以及作为货物至少一种核酸分子和至少一种选自与感染性疾病相关的病原体的抗原的抗原; 与过敏或过敏性疾病相关的抗原; 与自身免疫性疾病相关的抗原; 或与癌症或肿瘤疾病相关的抗原，或在每种情况下都是所述抗原的片段，变体和/或衍生物。药物组合物允许有效诱导针对所述抗原的适应性免疫应答。本发明还提供试剂盒，以及药物组合物或试剂盒作为疫苗的用途，特别是用于治疗感染性疾病，过敏反应，自身免疫性疾病和肿瘤或癌症疾病。

4. 发明申请

WO2012113413A1 VACCINE COMPOSITION COMPRISING COMPLEXED IMMUNOSTIMULATORY NUCLEIC ACIDS AND ANTIGENS PACKAGED WITH DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES 审中-公开
标题翻译：包含复合免疫细胞核酸的疫苗组合物和用分离的聚乙二醇/肽结合物包装的抗体
公开(公告)号：WO2012113413A1
公开(公告)日：2012-08-30
申请号：PCT/EP2011/000827
申请日：2011-02-21
申请人： CUREVAC GMBH , BAUMHOF, Patrick , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
发明人： BAUMHOF, Patrick , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
IPC分类号： A61K47/48
CPC分类号： A61K39/39 , A61K39/0011 , A61K47/48092 , A61K47/481 , A61K47/48215 , A61K47/48323 , A61K47/549 , A61K47/55 , A61K47/60 , A61K47/6455 , A61K2039/53 , A61K2039/55561 , A61K2039/57 , A61K2039/575
摘要： The present invention is directed to a composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) an antigen, preferably a protein or peptide antigen and/or a nucleic acid sequence encoding said antigen; and c) a carrier molecule for combined packaging the adjuvant component and the antigen. The present invention is also directed to the first medical use of such a composition or vaccine composition and to the second medical use of such a composition or vaccine composition or components thereof for the treatment of diseases, such as infectious or cancer or tumour diseases as defined herein. The present invention furthermore discloses kits comprising such a composition or vaccine composition.
摘要翻译：本发明涉及一种组合物或疫苗组合物，其包含a）包含与由络合剂络合的至少一种免疫刺激核酸序列或由其组成的佐剂组分; b）抗原，优选蛋白质或肽抗原和/或编码所述抗原的核酸序列; 和c）用于将佐剂组分和抗原组合包装的载体分子。本发明还涉及这种组合物或疫苗组合物的第一医疗用途以及这种组合物或疫苗组合物或其组分的第二医疗用途，用于治疗疾病如感染性或癌症或定义的肿瘤疾病于此。本发明还公开了包含这种组合物或疫苗组合物的试剂盒。

5. 发明申请

WO2013113326A1 PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPTIDE ANTIGEN 审中-公开
标题翻译：包含聚合物载体复合物和至少一种蛋白质或肽抗原的药物组合物
公开(公告)号：WO2013113326A1
公开(公告)日：2013-08-08
申请号：PCT/EP2012/000420
申请日：2012-01-31
申请人： CUREVAC GMBH , BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
发明人： BAUMHOF, Patrick , KRAMPS, Thomas , VOSS, Söhnke , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
IPC分类号： A61K47/48 , A61K39/39 , A61P35/00 , A61P37/00 , A61P31/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/29 , A61K39/35 , A61K47/64 , A61K47/645 , A61K47/646 , A61K48/0041 , A61K2039/5252 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , A61K2039/6093 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , C12N2730/10134 , C12N2730/10171 , C12N2760/16134 , C12N2760/16171 , C12N2760/20134 , C12N2760/20171 , Y02A50/416
摘要： The present invention is directed to a pharmaceutical composition including (eg for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease;_an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits, as well as the use of the pharmaceutical composition or the kit as a vaccine, particularly in the treatment of infectious diseases, allergies, autoimmune diseases and tumour or cancer diseases.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫化物交联的阳离子组分形成的聚合物载体; 以及至少一种核酸分子和至少一种选自与感染性疾病相关的病原体的抗原的抗原; - 与过敏或过敏性疾病相关的抗原; 与自身免疫性疾病相关的抗原; 或与癌症或肿瘤疾病相关的抗原，或在每种情况下都是所述抗原的片段，变体和/或衍生物。药物组合物允许有效诱导针对所述抗原的适应性免疫应答。本发明还提供试剂盒，以及药物组合物或试剂盒作为疫苗的用途，特别是用于治疗感染性疾病，过敏反应，自身免疫性疾病和肿瘤或癌症疾病。

6. 发明申请

WO2012113513A1 VACCINE COMPOSITION COMPRISING COMPLEXED IMMUNOSTIMULATORY NUCLEIC ACIDS AND ANTIGENS PACKAGED WITH DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES 审中-公开
标题翻译：包含复合免疫刺激核酸和包含二硫键连接的聚乙二醇/肽偶联物的抗原的疫苗组合物
公开(公告)号：WO2012113513A1
公开(公告)日：2012-08-30
申请号：PCT/EP2012/000614
申请日：2012-02-10
申请人： CUREVAC GMBH , BAUMHOF, Patrick , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
发明人： BAUMHOF, Patrick , KALLEN, Karl-Josef , FOTIN-MLECZEK, Mariola
IPC分类号： A61K47/48
CPC分类号： A61K39/39 , A61K39/0011 , A61K47/48092 , A61K47/481 , A61K47/48215 , A61K47/48323 , A61K47/549 , A61K47/55 , A61K47/60 , A61K47/6455 , A61K2039/53 , A61K2039/55561 , A61K2039/57 , A61K2039/575
摘要： The present invention is directed to a composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) an antigen, preferably a protein or peptide antigen and/or a nucleic acid sequence encoding said antigen; and c) a carrier molecule for combined packaging the adjuvant component and the antigen. The present invention is also directed to the first medical use of such a composition or vaccine composition and to the second medical use of such a composition or vaccine composition or components thereof for the treatment of diseases, such as infectious or cancer or tumour diseases as defined herein. The present invention furthermore discloses kits comprising such a composition or vaccine composition.
摘要翻译：本发明涉及一种组合物或疫苗组合物，其包含a）佐剂成分，其包含至少一种免疫刺激核酸序列或与之配合，所述免疫刺激核酸序列与络合剂复合; b）抗原，优选蛋白质或肽抗原和/或编码所述抗原的核酸序列; 和c）用于组合包装佐剂组分和抗原的载体分子。本发明还涉及这种组合物或疫苗组合物的第一种医学用途，以及这种组合物或疫苗组合物或其组分的第二种医学用途，用于治疗如定义的感染或癌症或肿瘤疾病于此。本发明还公开了包含这种组合物或疫苗组合物的试剂盒。

7. 发明申请

WO2012116715A1 VACCINATION IN NEWBORNS AND INFANTS 审中-公开
标题翻译：新生儿和婴幼儿接种疫苗
公开(公告)号：WO2012116715A1
公开(公告)日：2012-09-07
申请号：PCT/EP2011/001047
申请日：2011-03-02
申请人： CUREVAC GMBH , KALLEN, Karl-Josef , KRAMPS, Thomas , SCHNEE, Margit , PETSCH, Benjamin , STITZ, Lothar
发明人： KALLEN, Karl-Josef , KRAMPS, Thomas , SCHNEE, Margit , PETSCH, Benjamin , STITZ, Lothar
IPC分类号： A61K39/00 , A61K9/00
CPC分类号： A61K39/155 , A61K39/00 , A61K39/12 , A61K39/145 , A61K45/06 , A61K47/59 , A61K47/6455 , A61K47/6921 , A61K2039/53 , A61K2039/54 , A61K2039/55 , A61K2039/55583 , A61K2039/572 , A61K2039/575 , A61K2039/6031 , A61K2039/622 , C12N2760/16134 , C12N2760/18534 , C12N2760/18571 , Y02A50/412
摘要： The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
摘要翻译：本发明涉及包含编码至少一种抗原的至少一种mRNA的疫苗，用于治疗新生儿和/或婴儿中的疾病，优选不超过2年，优选不超过1年的年龄，更优选不超过9个月甚至6个月，其中所述治疗包括接种新生儿或婴儿并在所述新生儿或婴儿中引发免疫应答。本发明还涉及包含这种疫苗和/或其组分的试剂盒和试剂盒，以及应用这种疫苗或试剂盒的方法。

8. 发明申请

WO2012013326A1 COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION 审中-公开
标题翻译：用转移和免疫接种的交联中和组分的核酸复合物
公开(公告)号：WO2012013326A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/003719
申请日：2011-07-25
申请人： CUREVAC GMBH , BAUMHOF, Patrick , VOSS, Söhnke , KRAMPS, Thomas , KALLEN, Karl-Josef
发明人： BAUMHOF, Patrick , VOSS, Söhnke , KRAMPS, Thomas , KALLEN, Karl-Josef
IPC分类号： C12N15/87 , A61K48/00 , A61K47/34 , A61K47/48
CPC分类号： A61K48/0041 , A61K39/00 , A61K39/385 , A61K39/39 , A61K47/645 , A61K2039/51 , A61K2039/55516 , A61K2039/55561 , C12N15/87 , Y02A50/412 , Y02A50/472
摘要： The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably non-toxic and non-immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an (innate and/or adaptive) immune response, preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides, pharmaceutical compositions, particularly vaccines and adjuvants, comprising the inventive polymeric carrier cargo complex and optionally an antigen, as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell, a tissue or an organism, for (gene-)therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition, adjuvant or vaccine in one or more parts of the kit.
摘要翻译：本发明涉及一种聚合物载体货物复合物，其包含至少一种核酸（分子）和作为（优选无毒的和非免疫原性的）聚合物载体的二硫键交联的阳离子组分。本发明的聚合物载体货物复合物允许在体内和体外有效地将核酸转染到细胞中和/或诱导（先天和/或自适应）免疫应答，优选依赖于作为货物运输的核酸。本发明还提供药物组合物，特别是疫苗和佐剂，其包含本发明的聚合物载体货物复合物和任选的抗原，以及使用本发明的本发明的聚合物载体货物复合物和任选的抗原用于转染细胞，组织或用于本文公开的（基因 - ）治疗目的的生物体，和/或作为免疫刺激剂或佐剂，例如，用于引发用于治疗或预防上述疾病的免疫应答。最后，本发明涉及在试剂盒的一个或多个部分中含有本发明的聚合物载体货物复合物和/或本发明的药物组合物，佐剂或疫苗的试剂盒。

9. 发明申请

WO2013143698A1 ARTIFICIAL NUCLEIC ACID MOLECULES 审中-公开
标题翻译：人工核酸分子
公开(公告)号：WO2013143698A1
公开(公告)日：2013-10-03
申请号：PCT/EP2013/000936
申请日：2013-03-27
申请人： CUREVAC GMBH , THESS, Andreas , KALLEN, Karl-Josef
发明人： THESS, Andreas , KALLEN, Karl-Josef
IPC分类号： C12N15/67 , C12N15/85
CPC分类号： C12N15/85 , A61K48/00 , C12N15/67 , C12N15/88 , C12N2830/50
摘要： The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3'UTR element comprising a nucleic acid sequence which is derived from the 3'UTR of an albumin gene or from a variant of the 3'UTR of an albumin gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3'UTR element comprising a nucleic acid sequence which is derived from the 3'UTR of an albumin gene or from a variant of the 3'UTR of an albumin gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3'UTR element.
摘要翻译：本发明涉及包含至少一个开放阅读框和至少一个3'UTR元件的人源核酸分子，其包含衍生自白蛋白基因的3'UTR或3'UTR的变体的核酸序列的白蛋白基因。本发明还涉及这种人工核酸分子在基因治疗和/或基因疫苗接种中的用途。此外，本发明涉及包含衍生自白蛋白基因的3'UTR或白蛋白基因的3'UTR的变体的核酸序列的3'UTR元件用于稳定化和/或从包含这种3'UTR元件的核酸序列延长蛋白质表达。

10. 发明申请

WO2012116811A1 VACCINATION IN ELDERLY PATIENTS 审中-公开
标题翻译：老年患者接种疫苗
公开(公告)号：WO2012116811A1
公开(公告)日：2012-09-07
申请号：PCT/EP2012/000878
申请日：2012-02-29
申请人： CUREVAC GMBH , KALLEN, Karl-Josef , KRAMPS, Thomas , SCHNEE, Margit , PETSCH, Benjamin , STITZ, Lothar
发明人： KALLEN, Karl-Josef , KRAMPS, Thomas , SCHNEE, Margit , PETSCH, Benjamin , STITZ, Lothar
IPC分类号： A61K39/00 , A61K9/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/54 , A61K2039/55 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/572 , A61K2039/585 , A61K2039/6031 , A61K2039/622 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/412 , Y02A50/491
摘要： The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in an elderly patient preferably exhibiting an age of at least 50 years, more preferably of at least 55 years, 60 years, 65 years, 70 years, or older, wherein the treatment comprises vaccination of the patient and eliciting an immune response in said patient. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
摘要翻译：本发明涉及包含编码至少一种抗原的至少一种mRNA的疫苗，其用于治疗老年患者的疾病，优选年龄至少为50岁，更优选为至少55岁，60岁，65岁年龄，70岁或以上，其中所述治疗包括接种患者并在所述患者中引发免疫应答。本发明还涉及包含这种疫苗和/或其组分的试剂盒和试剂盒，以及应用这种疫苗或试剂盒的方法。

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