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1. 发明申请

WO2004000997A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO2004000997A3
公开(公告)日：2007-08-16
申请号：PCT/US0317512
申请日：2003-06-04
申请人： CURAGEN CORP , ANDERSON DAVID W , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , EDINGER SHLOMIT R , EISEN ANDREW , ELLERMAN KAREN , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , GUSEV VLADIMIR Y , JI WEIZHEN , LI LI , MACDOUGALL JOHN R , MALYANKAR URIEL M , MILLET ISABELLE , ORT TATIANA , PADIGARU MURALIDHARA , PRAYAGA SUDHIRDAS K , PATTURAJAN MEERA , PENA CAROL E A , PEYMAN JOHN A , RIEGER DANIEL K , ROTHENBERG MARK E , SCIORE PAUL , SHENOY SURESH G , SMITHSON GLENNDA , SPYTEK KIMBERLY A , STONE DAVID J , TAUPIER RAYMOND J JR , TCHERNEV VELIZAR T , VERNET CORINE A M , VOSS EDWARD Z , ZERHUSEN BRYAN D , ZHONG MEI
发明人： ANDERSON DAVID W , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , EDINGER SHLOMIT R , EISEN ANDREW , ELLERMAN KAREN , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , GUSEV VLADIMIR Y , JI WEIZHEN , LI LI , MACDOUGALL JOHN R , MALYANKAR URIEL M , MILLET ISABELLE , ORT TATIANA , PADIGARU MURALIDHARA , PRAYAGA SUDHIRDAS K , PATTURAJAN MEERA , PENA CAROL E A , PEYMAN JOHN A , RIEGER DANIEL K , ROTHENBERG MARK E , SCIORE PAUL , SHENOY SURESH G , SMITHSON GLENNDA , SPYTEK KIMBERLY A , STONE DAVID J , TAUPIER RAYMOND J JR , TCHERNEV VELIZAR T , VERNET CORINE A M , VOSS EDWARD Z , ZERHUSEN BRYAN D , ZHONG MEI
IPC分类号： A61K38/17 , A61K39/395 , C07H21/02 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C12N20060101 , C12N1/00 , C12N5/10 , C12N15/12 , C12N15/63 , C12P21/02 , C12P21/06 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/00 , G01N33/53
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

2. 发明申请

WO2004048512A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2004048512A2
公开(公告)日：2004-06-10
申请号：PCT/US0238371
申请日：2002-12-03
申请人： CURAGEN CORP , AGEE MICHELE L , ALSOBROOK JOHN P II , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CATTERTON ELINA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
发明人： AGEE MICHELE L , ALSOBROOK JOHN P II , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CATTERTON ELINA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
IPC分类号： A61K38/00 , A61K38/17 , A61K48/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P21/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07K1/00 , C07K14/00 , C07K14/47 , C07K16/18 , C07K16/40 , C07K17/00 , C12N1/21 , C12N5/02 , C12N5/08 , C12N9/00 , C12N9/48 , C12N15/12 , C12N15/16 , C12N15/18 , C12N15/19 , C12N15/53 , C12N15/54 , C12N15/57 , C12N15/63 , C12P21/02 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/53 , C12N
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C12N9/00 , C12N9/48
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

3. 发明申请

WO03040325A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO03040325A2
公开(公告)日：2003-05-15
申请号：PCT/US0235464
申请日：2002-11-05
申请人： CURAGEN CORP , AGEE MICHELE L , ALSOBROOK JOHN P II , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CHANT JOHN S , CHAUDHURI AMITABHA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
发明人： AGEE MICHELE L , ALSOBROOK JOHN P II , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CHANT JOHN S , CHAUDHURI AMITABHA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/00 , C12N
CPC分类号： C12N9/00 , A61K38/00 , A61K48/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

4. 发明申请

WO0125436A2 ENDOZEPINE-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：内肽类多肽和编码其的多核苷酸
公开(公告)号：WO0125436A2
公开(公告)日：2001-04-12
申请号：PCT/US0041077
申请日：2000-10-05
申请人： CURAGEN CORP , PRAYAGA SUDHIRDAS K , SHIMKETS RICHARD A , MAJUMDER KUMUD , EISEN ANDREW , VERNET CORINE , SPADERNA STEVEN K
发明人： PRAYAGA SUDHIRDAS K , SHIMKETS RICHARD A , MAJUMDER KUMUD , EISEN ANDREW , VERNET CORINE , SPADERNA STEVEN K
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/566 , A61K38/17 , G01N33/50
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are human nucleic acid sequences which encode endozepine-like polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human endozepine-like nucleic acid and protein.
摘要翻译：本文公开了编码多西他平样多肽的人核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明进一步公开了用于诊断，治疗和预防涉及该新型人类地塞津样核酸和蛋白质的病症的治疗，诊断和研究方法。

5. 发明申请

WO0107627A9 DROSOPHILA RECOMBINATION-ASSOCIATED PROTEIN AND METHODS FOR USE 审中-公开
标题翻译： DROSOPHILA重组相关蛋白及其使用方法
公开(公告)号：WO0107627A9
公开(公告)日：2002-09-06
申请号：PCT/US0019901
申请日：2000-07-21
申请人： EINSTEIN COLL MED , EISEN ANDREW
发明人： EISEN ANDREW
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K48/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/90 , C12N15/52 , C12N15/10
CPC分类号： C12N9/00 , A01K2217/05
摘要： The invention encompasses Drosophila Recombination Associated Protein (DRAP) isolated from D. melanogaster and a nucleic acid sequence encoding DRAP. The Drosophila Recombination Associated Protein, its homologues from other organisms or active peptides derived therefrom, as well as DNA encoding such protein are useful for homology-dependent pairing of three DNA strands. The combination of strand-transfer and topoisomerase activities associated with DRAP permits directed pairing and cleavage at defined site(s) within DNA. This in turn makes possible the isolation and/or removal of a defined segment of DNA. DRAP is also useful in cloning, genomic cloning and gene mapping, in promoting gene disruptions or "knockout" mutations, in carrying out targeted mutagenesis of specific genes and in generating transgenic animals. The invention further encompasses a method for experimental and therapeutic application of DRAP driven knockouts or other modifications of genes responsible for genetic diseases as well as the use of DRAP driven genetic manipulation of genes in gene therapy.
摘要翻译：本发明包括从黑腹果蝇分离的果蝇重组相关蛋白（DRAP）和编码DRAP的核酸序列。果蝇重组相关蛋白，其来自其他生物的同源物或由其衍生的活性肽，以及编码这种蛋白质的DNA可用于三个DNA链的同源性依赖性配对。与DRAP相关的链转移和拓扑异构酶活性的组合允许在DNA内的限定位点定向配对和切割。这反过来使得能够分离和/或去除限定的DNA片段。 DRAP还可用于克隆，基因组克隆和基因作图，促进基因破坏或“敲除”突变，进行特异性基因的靶向诱变和产生转基因动物。本发明进一步包括用于实验和治疗应用DRAP驱动敲除或负责遗传疾病的基因的其他修饰以及在基因治疗中使用DRAP驱动的基因遗传操作的方法。

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