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1. 发明申请

WO03040325A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO03040325A2
公开(公告)日：2003-05-15
申请号：PCT/US0235464
申请日：2002-11-05
申请人： CURAGEN CORP , AGEE MICHELE L , ALSOBROOK JOHN P II , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CHANT JOHN S , CHAUDHURI AMITABHA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
发明人： AGEE MICHELE L , ALSOBROOK JOHN P II , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CHANT JOHN S , CHAUDHURI AMITABHA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/00 , C12N
CPC分类号： C12N9/00 , A61K38/00 , A61K48/00 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

2. 发明申请

WO2004048512A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2004048512A2
公开(公告)日：2004-06-10
申请号：PCT/US0238371
申请日：2002-12-03
申请人： CURAGEN CORP , AGEE MICHELE L , ALSOBROOK JOHN P II , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CATTERTON ELINA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
发明人： AGEE MICHELE L , ALSOBROOK JOHN P II , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CATTERTON ELINA , DIPIPPO VINCENT A , EDINGER SHLOMIT R , EISEN ANDREW
IPC分类号： A61K38/00 , A61K38/17 , A61K48/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P21/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07K1/00 , C07K14/00 , C07K14/47 , C07K16/18 , C07K16/40 , C07K17/00 , C12N1/21 , C12N5/02 , C12N5/08 , C12N9/00 , C12N9/48 , C12N15/12 , C12N15/16 , C12N15/18 , C12N15/19 , C12N15/53 , C12N15/54 , C12N15/57 , C12N15/63 , C12P21/02 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/53 , C12N
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C12N9/00 , C12N9/48
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

3. 发明申请

WO03004687A8 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白质和编码相同的核酸
公开(公告)号：WO03004687A8
公开(公告)日：2003-05-08
申请号：PCT/US0221361
申请日：2002-07-03
申请人： CURAGEN CORP , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , CATTERTON ELINA
发明人： ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , CATTERTON ELINA
IPC分类号： C07K14/47 , C12Q
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。本发明还公开了与疾病相关的治疗性小分子。本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

4. 发明申请

WO2006020326A9 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE PROTEIN ACTIVITY 审中-公开
标题翻译：鉴定蛋白质活性调节化合物的方法
公开(公告)号：WO2006020326A9
公开(公告)日：2010-01-28
申请号：PCT/US2005025762
申请日：2005-07-20
申请人： CURAGEN CORP , BERGHS CONSTANCE , CATTERTON ELINA , CHAUDHURI AMITABHA , ELLERMAN KAREN E , ORT TATIANA A
发明人： BERGHS CONSTANCE , CATTERTON ELINA , CHAUDHURI AMITABHA , ELLERMAN KAREN E , ORT TATIANA A
IPC分类号： A61K38/03 , A61K38/00 , A61K38/28 , C07K14/00 , C07K14/62 , C07K16/00
CPC分类号： G01N33/6893 , G01N2500/04 , G01N2800/042 , G01N2800/044

5. 发明申请

WO2004056961A2 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE PROTEIN ACTIVITY 审中-公开
标题翻译：鉴定蛋白质活性调节化合物的方法
公开(公告)号：WO2004056961A2
公开(公告)日：2004-07-08
申请号：PCT/US0334114
申请日：2003-10-27
申请人： CURAGEN CORP , BERGHS CONSTANCE , CATTERTON ELINA , ELLERMAN KAREN , ORT TATIANA , RIEGER DANIEL , CHAUDHURI AMITABHA
发明人： BERGHS CONSTANCE , CATTERTON ELINA , ELLERMAN KAREN , ORT TATIANA , RIEGER DANIEL , CHAUDHURI AMITABHA
IPC分类号： C07K14/47 , C12N
CPC分类号： C07K14/47
摘要： Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obesity, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
摘要翻译：鉴定调节靶多肽活性的化合物的方法，其中测试化合物与靶多肽和靶多肽的底物组合，并且确定测试化合物是否调节靶多肽的活性。测试化合物可以是用于治疗肥胖症，糖尿病，胰岛素抵抗和增强胰岛素分泌的小分子药物。还公开了靶多肽及其相应的核酸及其变体。

6. 发明申请

WO2004015076A3 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2004015076A3
公开(公告)日：2005-07-28
申请号：PCT/US0324788
申请日：2003-08-07
申请人： CURAGEN CORP
发明人： ANDERSON DAVID W , BERGHS CONSTANCE , CATTERTON ELINA , EDINGER SHLOMIT R , GORMAN LINDA , GUO XIAOJIA , HERRMANN JOHN L , KEKUDA RAMESH , LI LI , RIEGER DANIEL K , ZHONG MEI
IPC分类号： C12N20060101 , C12Q1/68
CPC分类号： C12N1/00 , C12Q1/68
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

7. 发明申请

WO2004013347A8 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE PROTEIN ACTIVITY 审中-公开
标题翻译：鉴定调节蛋白质活性的化合物的方法
公开(公告)号：WO2004013347A8
公开(公告)日：2005-06-02
申请号：PCT/US0324504
申请日：2003-08-06
申请人： CURAGEN CORP
发明人： BERGHS CONSTANCE , ELLERMAN KAREN , GUO XIAOJIA , LI LI , ORT TATIANA , RIEGER DANIEL K , VERNET CORINE A M , ZHONG MEI
IPC分类号： C07K14/47 , C12N9/00 , C12Q20060101 , C12Q1/68
CPC分类号： C07K14/47 , C12N9/00
摘要： Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obestiy, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
摘要翻译：鉴定调节靶多肽活性的化合物的方法，其中将测试化合物与靶多肽和靶多肽的底物组合，并且确定测试化合物是否调节靶多肽的活性。测试化合物可以是用于治疗obestiy，糖尿病，胰岛素抵抗和增强胰岛素分泌的小分子药物。还公开了靶多肽及其相应的核酸及其变体。

8. 发明申请

WO2004013347A3 METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE PROTEIN ACTIVITY 审中-公开
标题翻译：鉴定蛋白质活性调节化合物的方法
公开(公告)号：WO2004013347A3
公开(公告)日：2005-04-14
申请号：PCT/US0324504
申请日：2003-08-06
申请人： CURAGEN CORP
发明人： BERGHS CONSTANCE , ELLERMAN KAREN , GUO XIAOJIA , LI LI , ORT TATIANA , RIEGER DANIEL K , VERNET CORINE A M , ZHONG MEI
IPC分类号： C07K14/47 , C12N9/00 , C12Q20060101 , C12Q1/68
CPC分类号： C07K14/47 , C12N9/00
摘要： Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obestiy, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
摘要翻译：鉴定调节靶多肽活性的化合物的方法，其中测试化合物与靶多肽和靶多肽的底物组合，并且确定测试化合物是否调节靶多肽的活性。测试化合物可以是用于治疗obestiy，糖尿病，胰岛素抵抗和增强胰岛素分泌的小分子药物。还公开了靶多肽及其相应的核酸及其变体。

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