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1. 发明申请

WO1988007199A1 AUTOMATED ANALYZER AND METHOD FOR SCREENING CELLS OR FORMED BODIES FOR ENUMERATION OF POPULATIONS EXPRESSING SELECTED CHARACTERISTICS 审中-公开
标题翻译：自动分析仪和筛选细胞或形成体系的方法，用于表达选择特征的人群
公开(公告)号：WO1988007199A1
公开(公告)日：1988-09-22
申请号：PCT/US1988000960
申请日：1988-03-11
申请人： COULTER ELECTRONICS, INC.
发明人： COULTER ELECTRONICS, INC. , KORTRIGHT, Kenneth, H. , COULTER, Wallace, H. , RODRIGUEZ, Carlos , RUSSELL, Thomas , PAUL, Ronald
IPC分类号： G01N33/53
CPC分类号： G01N33/56972 , G01N15/12 , G01N15/14 , G01N33/5094 , G01N33/5302 , G01N33/54326 , G01N35/0098 , G01N2015/1037 , G01N2015/1062 , G01N2015/1081
摘要： A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected white blood cell population and/or subset thereof of a whole blood sample (60) or portion thereof. A volume of a biological medium containing the white blood cells is prepared and at least one reactant (66, 74, 144, 132) specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed for a short period of time. The opacity and/or volume parameter of the cells can be modified and the mixture is then counted and analyzed in one or more steps to obtain the desired white blood cell population analysis. The biological sample can be a whole blood sample and the reactant can include or be a lyse (66) or a monoclonal antibody bound to microspheres (132, 144), which will bind to specific ones of the cells or a combination of lyse and microspheres with antibody bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed for retrieving and analyzing the remaining blood cell population.
摘要翻译：一种用于自动并快速地检索，计数和/或分析全血样品（60）或其部分的至少一个所选择的白细胞群体和/或其子集的方法和装置。制备一定体积的含有白细胞的生物培养基，至少将一些选定的生物细胞特异性或优先选择的至少一种反应物（66,74,144,132）引入其中并在短时间内快速混合。可以修改细胞的不透明度和/或体积参数，然后在一个或多个步骤中对混合物进行计数和分析以获得所需的白细胞群体分析。生物样品可以是全血样品，反应物可以包括裂解物（66）或与微球结合的单克隆抗体（132,144），其将结合特定的细胞或裂解和微球的组合与抗体结合。微球可以是磁性的，并且结合的细胞可被磁性去除，用于检索和分析剩余的血细胞群体。

2. 发明申请

WO1988006918A1 METHOD AND APPARATUS FOR RAPID MIXING OF SMALL VOLUMES FOR ENHANCING BIOLOGICAL REACTIONS 审中-公开
标题翻译：用于增强生物反应的小容量快速混合的方法和装置
公开(公告)号：WO1988006918A1
公开(公告)日：1988-09-22
申请号：PCT/US1988000969
申请日：1988-03-11
申请人： COULTER ELECTRONICS, INC.
发明人： COULTER ELECTRONICS, INC. , COULTER, Wallace, H. , HOLLINGER, John, David , RUSSELL, Thomas , RODRIGUEZ, Carlos , PAUL, Ronald , KORTRIGHT, Kenneth, H.
IPC分类号： B01L03/00
CPC分类号： G01N33/5005 , G01N33/56966 , G01N33/56972
摘要： A method and apparatus (10, 24, 46, 76, 90, 102) for accelerating at least one definitive biological reaction including increasing the accuracy of determinations made therefrom. The reaction involves selected viable biological cells which are prepared in a small sample volume and rapidly mixed with microspheres having antibody specific at least to specific ones of the cells bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed to analyze the remaining blood cell populations. The microspheres can be introduced sequentially or simultaneously.
摘要翻译：一种用于加速至少一种确定性生物反应的方法和装置（10,24,46,76,90,102），包括增加由其制备的测定精度。该反应涉及选择的活体生物细胞，它们以小的样品体积制备，并且与具有抗体特异性至少与结合于其上的特定细胞的微球快速混合。微球可以是磁性的，并且结合的细胞可以被磁性去除以分析剩余的血细胞群体。微球可以顺序或同时引入。

3. 发明申请

WO1990007259A2 METHOD AND APPARATUS FOR SCREENING CELLS OR FORMED BODIES WITH POPULATIONS EXPRESSING SELECTED CHARACTERISTICS 审中-公开
标题翻译：用于筛选表达选定特征的人群的细胞或形成体的方法和装置
公开(公告)号：WO1990007259A2
公开(公告)日：1990-07-12
申请号：PCT/US1989005548
申请日：1989-12-13
申请人： COULTER ELECTRONICS, INC.
发明人： COULTER ELECTRONICS, INC. , KORTRIGHT, Kenneth, H. , COULTER, Wallace, H. , RODRIGUEZ, Carlos , RUSSELL, Thomas , PAUL, Ronald
IPC分类号： G01N33/53 , A61K49/00 , C12N5/02 , G01N15/00 , G01N15/10 , G01N15/12 , G01N33/543 , G01N33/553 , G01N33/569 , G01N33/577
CPC分类号： G01N15/12 , G01N33/56972 , G01N2015/008 , G01N2015/1062 , G01N2015/1081
摘要： A method and apparatus (320, 340, 360) for automatically and rapidly retrieving, counting and/or analyzing at least one selected population of cells or formed bodies, such as a white blood cell population and at least one subset thereof of a whole blood sample (322, 342) or portion thereof. A volume of a biological medium containing the white blood cells is prepared and at least one reactant (326, 346) specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed (384) for a short period of time. The opacity and/or volume parameter of the cells can be modified and the mixture is then counted and analyzed (332, 352, 416, 422) in one or more steps to obtain the desired white blood cell population and subset analysis. The biological sample can be a whole blood sample and the reactant can include or be a lyse or a monoclonal antibody bound to microspheres, which will bind to specific ones of the cells or a combination of lyse and microspheres with antibody bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed for retrieving and analyzing the remaining blood cell population.
摘要翻译：一种用于自动和快速地检索，计数和/或分析至少一个选定的细胞群体或成体体（例如白细胞群体及其全血的至少一个子集）的方法和装置（320,340,360）样品（322,342）或其部分。制备一定体积的含有白细胞的生物培养基，并将至少一种至少特定或优先选择的一些选择的生物细胞的反应物（326,346）引入其中并在短时间内快速混合（384）。可以修改细胞的不透明度和/或体积参数，然后在一个或多个步骤中对混合物进行计数和分析（332,352,416,422）以获得所需的白细胞群体和子集分析。生物样品可以是全血样品，并且反应物可以包括结合微球的裂解液或单克隆抗体，其将与特异性细胞结合，或与结合抗体的溶血和微球体的组合。微球可以是磁性的，并且结合的细胞可被磁性去除，用于检索和分析剩余的血细胞群体。

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