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1. 发明申请

WO2008057132A2 OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION 审中-公开
标题翻译： LID生物传感器共振检测的优化方法
公开(公告)号：WO2008057132A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/004626
申请日：2007-02-20
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett, A. , WEBB, Michael, Brian , WU, Qi
发明人： GOLLIER, Jacques , PIECH, Garrett, A. , WEBB, Michael, Brian , WU, Qi
IPC分类号： G01J3/28 , G01N21/27
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译：这里描述了一种光学询问系统，其可以询问独立于标签的检测（LID）生物传感器并监测生物传感器顶部的生物事件，而不会遭受有问题的寄生反射和/或有问题的像素化效应。在一个实施例中，光学询问系统能够询问生物传感器并且使用低通滤波算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在生物传感器。在另一实施例中，光学询问系统能够询问生物传感器并且使用过采样/平滑算法来减少由成问题的像素效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件发生在生物传感器上。

2. 发明申请

WO2008106013A1 SWEPT WAVELENGTH IMAGING OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 审中-公开
标题翻译： SWEPT波长成像光学系统及其使用方法
公开(公告)号：WO2008106013A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/001917
申请日：2008-02-13
申请人： CORNING INCORPORATED , GOLLIER, Jacques , WU, Qi
发明人： GOLLIER, Jacques , WU, Qi
IPC分类号： G01N21/39
CPC分类号： G01N21/7703 , G01D5/34 , G01N21/253
摘要： A swept wavelength imaging optical interrogation system (100) and a method for using the same to interrogate one or more biosensors (102) are described herein. The swept wavelength imaging optical interrogation system (100) is built upon a swept wavelength optical interrogation technology where a 2-D label free image is extracted from a series of high speed spectral images of the biosensor (s) (102) without the need of performing mechanical scanning.
摘要翻译：扫描波长成像光询问系统（100）及其使用方法来询问一个或多个生物传感器（102）。扫描波长成像光询问系统（100）基于扫描波长光询问技术，其中从生物传感器（102）的一系列高速光谱图像中提取2-D无标签图像，而不需要进行机械扫描。

3. 发明申请

WO2011102981A1 HIGH RESOLUTION LABEL FREE IMAGING 审中-公开
标题翻译：高分辨率标签免费成像
公开(公告)号：WO2011102981A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/023855
申请日：2011-02-07
申请人： CORNING INCORPORATED , WU, Qi
发明人： WU, Qi
IPC分类号： G01N21/77 , G01N21/55
CPC分类号： G01N21/7743 , G01N21/553
摘要： An apparatus having an optical reader system and method for label-independent detection having improved spatial resolution of the reader, as defined herein. The system includes an optical configuration for interrogating a sensor on a microplate at an incident angle (θ 1 ) of greater than 45°, and recording the image received from the contacted sensor with the image recorder, the image recorder being oriented with respect to the reflected beam at a reflected angle (θ 2 ) of greater than about 5°, as further defined herein.
摘要翻译：具有如本文所定义的具有改进的读取器的空间分辨率的用于标签独立检测的光学读取器系统和方法的装置。该系统包括用于以大于45°的入射角（θ1）在微板上询问传感器的光学配置，并且将从接触传感器接收的图像与图像记录器进行记录，图像记录器相对于反射光束的反射角（λ2）大于约5°，如本文进一步定义。

4. 发明申请

WO2013039738A1 APPARATUS FOR TEMPERATURE CONTROLLED LABEL FREE ASSAYS 审中-公开
标题翻译：用于温度控制的标签自由测试装置
公开(公告)号：WO2013039738A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/053618
申请日：2012-09-04
申请人： CORNING INCORPORATED , CARBERRY, Joel Patrick , WU, Qi
发明人： CARBERRY, Joel Patrick , WU, Qi
IPC分类号： G01N21/25
CPC分类号： G01N21/253 , G01N21/0332 , G01N2201/0233
摘要： An apparatus for label-free assay, including: a housing; a circulator; a reader module; and a sensor module comprising a microplate holder, the holder receives and holds at least one microplate article having at least one sensor, the sensor module being spatially separated from the reader module by a cavity, the cavity provides a conduit for ambient temperature gas flow from the circulator to between the sensor module and the reader module within the housing, as defined and disclosed herein. Methods for interrogating a sensor in a microplate using the apparatus, as defined and disclosed herein.
摘要翻译：一种用于无标记测定的装置，包括：壳体; 循环器阅读器模块; 以及传感器模块，其包括微孔板保持器，所述保持器容纳并保持具有至少一个传感器的至少一个微板制品，所述传感器模块通过空腔与所述读取器模块空间分离，所述空腔提供用于环境温度气体流的导管循环器到传感器模块和壳体内的读取器模块之间，如本文所定义和公开的。使用本文定义和公开的装置在微板中询问传感器的方法。

5. 发明申请

WO2009045319A2 LASER SCORING WITH FLAT PROFILE BEAM 审中-公开
标题翻译：具有平面轮廓的激光测距
公开(公告)号：WO2009045319A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/011138
申请日：2008-09-25
申请人： CORNING INCORPORATED , ABRAMOV, Anatoli A , LUO, Weiwei , WU, Qi , XU, Wei , ZHOU, Naiyue
发明人： ABRAMOV, Anatoli A , LUO, Weiwei , WU, Qi , XU, Wei , ZHOU, Naiyue
IPC分类号： B29C35/08
CPC分类号： C03B33/093 , C03B33/0222 , C03B33/091
摘要： Disclosed are systems and methods for scoring glass sheets. A laser beam can be generated having a substantially uniform peak energy density along at least a portion of its length. The laser beam is moved across the glass sheet to create a score line. Further, the glass sheet can be separated along the score line. In some aspects, the laser beam is bimodal and comprises approximately 60-70% TEM00 mode and approximately 30-40% TEM01* mode.
摘要翻译：公开了用于评分玻璃板的系统和方法。可以产生沿其长度的至少一部分具有基本均匀的峰值能量密度的激光束。激光束移动穿过玻璃板以创建刻痕线。此外，玻璃板可以沿着刻痕线分离。在一些方面，激光束是双峰的并且包括大约60-70％的TEM00模式和大约30-40％的TEM01 *模式。

6. 发明申请

WO2012148724A1 COMPACT LABEL FREE IMAGING SYSTEM 审中-公开
标题翻译：紧凑的标签免费成像系统
公开(公告)号：WO2012148724A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/033860
申请日：2012-04-17
申请人： CORNING INCORPORATED , WU, Qi
发明人： WU, Qi
IPC分类号： G02B13/22 , G01N21/65 , G01N21/55
CPC分类号： G02B13/22 , G01N21/253 , G01N21/553 , G01N21/658 , G01N21/7743
摘要： A compact microplate imaging system, including: a tunable light source; a lens ensemble to collimate the light source onto the microplate and to transmit light that is reflected from the microplate; a beam splitter to divert a portion of the reflected light; an imaging lens to collect diverted light and to produce an optical image of the at least one sensor of the microplate; and an image sensor for receiving the optical image of the at least one sensor of the microplate. A method for interrogating a sensor using the compact microplate imaging system, as further defined herein, is also disclosed.
摘要翻译：一种紧凑型微板成像系统，包括：可调光源; 透镜组合，用于将光源准直到微板上并透射从微板反射的光; 分束器，用于转移一部分反射光; 成像透镜，用于收集转向的光并产生所述微板的所述至少一个传感器的光学图像; 以及用于接收微板的至少一个传感器的光学图像的图像传感器。还公开了如本文进一步定义的使用紧凑型微板成像系统询问传感器的方法。

7. 发明申请

WO2009151527A3 SCORING OF NON-FLAT MATERIALS 审中-公开
公开(公告)号：WO2009151527A3
公开(公告)日：2009-12-17
申请号：PCT/US2009/002988
申请日：2009-05-14
申请人： CORNING INCORPORATED , ABRAMOV, Anatoli A , UKRAINCZYK, Ljerka , WU, Qi , ZHOU, Naiyue
发明人： ABRAMOV, Anatoli A , UKRAINCZYK, Ljerka , WU, Qi , ZHOU, Naiyue
IPC分类号： C03B33/09 , C03B33/033 , B23K26/06
摘要： Disclosed are systems for scoring non-flat materials including non-flat glass sheets (1000). In one embodiment, a laser scoring system is described. The laser scoring system includes a laser (102) and an optical head (106). The optical head is configured to receive output from the laser and focus the output into an elongated laser beam having a beam waist and an extended focal depth (116) of greater than +/- 5 mm relative to the center of the beam waist with a power density sufficient for scoring a material having at least a portion within the extended focal depth. In one aspect the system can include a beam expander (104). The beam expander receives the output from the laser, expands the output from the laser to an expanded laser beam, and transmits the expanded laser beam to the optical head.

8. 发明申请

WO2009017637A1 OPTICAL INTERROGATION SYSTEM AND METHOD FOR USING SAME 审中-公开
标题翻译：光学互连系统及其使用方法
公开(公告)号：WO2009017637A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/008943
申请日：2008-07-23
申请人： CORNING INCORPORATED , MODAVIS, Robert, A. , WU, Qi
发明人： MODAVIS, Robert, A. , WU, Qi
IPC分类号： G01N21/31 , G01N21/47
CPC分类号： G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.
摘要翻译：本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

9. 发明申请

WO2009045524A3 SYSTEM AND METHOD FOR DUAL-DETECTION OF A CELLULAR RESPONSE 审中-公开
公开(公告)号：WO2009045524A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/011485
申请日：2008-10-03
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M. , LAHIRI, Joydeep , MUDALIAR, Deepti J. , WU, Qi
发明人： FANG, Ye , FERRIE, Ann M. , LAHIRI, Joydeep , MUDALIAR, Deepti J. , WU, Qi
IPC分类号： G01N21/77 , G01N21/64
摘要： A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.

10. 发明申请

WO2009045465A1 SINGLE-CELL LABEL-FREE ASSAY 审中-公开
标题翻译：单细胞无标签测定
公开(公告)号：WO2009045465A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011404
申请日：2008-10-02
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , WU, Qi
发明人： FANG, Ye , FERRIE, Ann, M. , WU, Qi
IPC分类号： G01N21/55 , G01N33/50
CPC分类号： G01N33/5008 , G01N21/211 , G01N21/553 , G01N21/554 , G01N33/54373
摘要： The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein.
摘要翻译：本公开提供了一种系统和方法，用于利用具有如本文所定义的单个细胞的分辨率水平固定在生物传感器上的细胞的生物传感器成像系统来表征对刺激的单个活细胞响应。

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