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1. 发明申请

WO2009045465A1 SINGLE-CELL LABEL-FREE ASSAY 审中-公开
标题翻译：单细胞无标签测定
公开(公告)号：WO2009045465A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011404
申请日：2008-10-02
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , WU, Qi
发明人： FANG, Ye , FERRIE, Ann, M. , WU, Qi
IPC分类号： G01N21/55 , G01N33/50
CPC分类号： G01N33/5008 , G01N21/211 , G01N21/553 , G01N21/554 , G01N33/54373
摘要： The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein.
摘要翻译：本公开提供了一种系统和方法，用于利用具有如本文所定义的单个细胞的分辨率水平固定在生物传感器上的细胞的生物传感器成像系统来表征对刺激的单个活细胞响应。

2. 发明申请

WO2005115622A1 POROUS SUBSTRATE PLATES AND THE USE THEREOF 审中-公开
标题翻译：多孔基板及其使用
公开(公告)号：WO2005115622A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/012040
申请日：2005-04-12
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
发明人： FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized a as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

3. 发明申请

WO2011081971A2 EGFR/VEGFR DUAL MODULATORS AND METHODS OF USING 审中-公开
标题翻译： EGFR / VEGFR双重调节剂及其使用方法
公开(公告)号：WO2011081971A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060663
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/381 , A61P35/00
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

4. 发明申请

WO2006071696A2 POROUS SUBSTRATES AND ARRAYS COMPRISING THE SAME 审中-公开
标题翻译：多孔基材和包含该材料的阵列
公开(公告)号：WO2006071696A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/046450
申请日：2005-12-21
申请人： CORNING INCORPORATED , TEPESCH, Patrick, D. , WIGHT, John, F. Jr., , YUEN, Po, Ki , MOZDY, Eric, J. , COONAN, Everett, W. , FANG, Ye , FERRIE, Ann, M. , FU, Xiadong , HONG, Yulong , LESLIE, Thomas, M. , LI, Xinghua , MONAHAN, Beth, C. , MUELLER, Dirk , TANNER, Cameron, W.
发明人： TEPESCH, Patrick, D. , WIGHT, John, F. Jr., , YUEN, Po, Ki , MOZDY, Eric, J. , COONAN, Everett, W. , FANG, Ye , FERRIE, Ann, M. , FU, Xiadong , HONG, Yulong , LESLIE, Thomas, M. , LI, Xinghua , MONAHAN, Beth, C. , MUELLER, Dirk , TANNER, Cameron, W.
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00423 , B01J2219/00639 , B01J2219/00644 , B01J2219/00722 , B01L2300/0819
摘要： The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
摘要翻译：本发明涉及包含用于连接核酸，多肽，膜或其他生物或有机材料的多孔底物的阵列。在许多实施方案中，本发明的阵列具有流通构型，使得洗涤缓冲液或样品可以从阵列的至少两侧接近多孔基材。本发明的特征还在于包含UV-可兼容的多孔基材的阵列，包含溶胶 - 凝胶中的三维膜的阵列以及包含使用低温熔融工艺制备的基于二氧化硅的多孔基材的阵列。

5. 发明申请

WO2011081968A1 PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译： PI3K调节剂，RHO激酶调节剂及其鉴定和使用方法
公开(公告)号：WO2011081968A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060648
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
发明人： FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
IPC分类号： G01N33/543 , C12Q1/48
CPC分类号： G01N33/5041 , G01N33/54373 , G01N2333/91215
摘要： Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.
摘要翻译：公开了使用无标记细胞测定来表征PI3K抑制剂和Rho激酶抑制剂的方法。还公开了表征细胞是否具有失去PI3K途径的方法。

6. 发明申请

WO2010060022A2 METHODS OF CREATING AN INDEX 审中-公开
标题翻译：创建索引的方法
公开(公告)号：WO2010060022A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/065490
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , LAHIRI, Joydeep , TRAN, Elizabeth
发明人： FANG, Ye , FERRIE, Ann, M. , LAHIRI, Joydeep , TRAN, Elizabeth
IPC分类号： G06F19/00
CPC分类号： G06F19/709 , G01N33/5041 , G01N33/54373 , G06F19/12
摘要： Drug discovery is a complex undertaking facing many challenges, not the least of which is a high attrition rate as many promising candidates prove ineffective or toxic in the clinic owing to a poor understanding of the diseases, and thus the biological systems, they target. Therefore, it is broadly agreed that to increase the productivity of drug discovery one needs a far deeper understanding of the molecular mechanisms of diseases, taking into account the full biological context of the drug target and moving beyond individual genes and proteins. The present methods rely on the use of label-free cellular assays, particularly the DMR index, to systematically display the mode of actions, the toxicity, and the target(s) and pathway(s) of any molecules.
摘要翻译：毒品发现是一项面临许多挑战的复杂工作，其中最重要的是高消耗率，因为许多有前途的候选人在诊所中证明是无效或有毒的，因为对疾病的认识不足，从而导致其生物系统的目标。因此，普遍同意，为了提高药物发现的生产力，需要更深入地了解疾病的分子机制，同时考虑到药物靶标的完整生物学背景，超越个别基因和蛋白质。本方法依赖于使用无标记细胞测定法，特别是DMR指数来系统显示任何分子的作用模式，毒性以及靶标和途径。

7. 发明申请

WO2006108183A2 LABEL FREE BIOSENSORS AND CELLS 审中-公开
标题翻译：标签免费生物传感器和细胞
公开(公告)号：WO2006108183A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/013539
申请日：2006-04-05
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H , LAHIRI, Joydeep , YUEN, Po Ki
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H , LAHIRI, Joydeep , YUEN, Po Ki
IPC分类号： C12Q1/02
CPC分类号： G01N33/5008 , G01N33/54373 , G01N33/554
摘要： Disclosed are compositions and methods for using label free optical biosensors for performing cell assays. In certain embodiments the assays can be performed in highthough put methods and can be multiplexed.
摘要翻译：公开了使用无标签光学生物传感器进行细胞测定的组合物和方法。在某些实施方案中，所述测定可以以放置方式进行并且可以被复用。

8. 发明申请

WO2006107506A2 SYSTEM AND METHOD FOR PERFORMING G PROTEIN COUPLED RECEPTOR (GPCR) CELL ASSAYS USING WAVEGUIDE-GRATING SENSORS 审中-公开
标题翻译：使用波导光栅传感器进行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：WO2006107506A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/008582
申请日：2006-03-10
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
发明人： FANG, Ye , FERRIE, Ann, M. , FONTAINE, Norman, H. , YUEN, Po Ki , LAHIRI, Joydeep
IPC分类号： G01N33/543 , G01N21/77 , G01N33/68
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器来实时监测活细胞内激动剂诱导的GPCR信号传导事件的系统和方法。具体而言，本发明包括使用光学LID生物传感器基于由激动剂诱导的GPCR激活引起的质量重新分布来筛选针对活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自引用光学LID生物传感器以消除对周围温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在另一个扩展的实施方案中，本发明公开了用于在单一介质溶液内的多种类型的细胞中筛选单一类型的细胞中的多种GPCR或多种GPCR的不同方式。在另一个扩展的实施方案中，本发明公开了确认化合物针对活细胞内特定GPCR的生理学或药理学作用的不同方法。

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