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1. 发明申请

WO2011017147A1 LABEL-INDEPENDENT OPTICAL READER SYSTEM AND METHODS WITH OPTICAL SCANNING 审中-公开
标题翻译：标签相关光学读取器系统和光学扫描方法
公开(公告)号：WO2011017147A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/043486
申请日：2010-07-28
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett A , WEBB, Michael B
发明人： GOLLIER, Jacques , PIECH, Garrett A , WEBB, Michael B
IPC分类号： G01N21/77
CPC分类号： G01N21/7743 , G02B26/0833 , G02B26/101
摘要： Optical reader systems and methods for label-independent reading of resonant waveguide (RWG) biosensors operably supported by a microplate as defined herein. The system includes a light source, a spectrometer unit, a beam-forming optical system and a scanning optical system that includes a scanning mirror device, a mirror device driver operably coupled to the scanning mirror device, and an F-theta lens arranged between the microplate and the beam-forming optical system. Some systems use multiple optical beams to scan multiple biosensors at once without having to move the microplate. Asynchronous scanning of multiple beams allows for reducing the number of spectrometer units needed.
摘要翻译：光学读取器系统和用于标签无关读取谐振波导（RWG）生物传感器的方法，其可操作地由如本文定义的微孔板支撑。该系统包括光源，光谱仪单元，波束形成光学系统和扫描光学系统，其包括扫描镜装置，可操作地耦合到扫描反射镜装置的镜装置驱动器和布置在扫描镜装置之间的F-theta透镜微板和波束形成光学系统。一些系统使用多个光束一次扫描多个生物传感器，而不必移动微孔板。多个波束的异步扫描允许减少所需的光谱仪单元的数量。

2. 发明申请

WO2010075017A2 MULTI-VARIABLE CONTROL METHODS FOR OPTICAL PACKAGES 审中-公开
标题翻译：用于光学包装的多变量控制方法
公开(公告)号：WO2010075017A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/067818
申请日：2009-12-14
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett A , PIKULA, Dragan , RICKETTS, Daniel O
发明人： GOLLIER, Jacques , PIECH, Garrett A , PIKULA, Dragan , RICKETTS, Daniel O
IPC分类号： H01S5/0683 , H01S5/0687 , H01S5/022
CPC分类号： H01S5/0683 , G02F1/35 , G02F1/3775 , H01S5/0092 , H01S5/06256 , H01S5/0687
摘要： According to one embodiment of the present invention, an optical package comprises one or more semiconductor lasers coupled to a wavelength conversion device with adaptive optics. The optical package also comprises a package controller programmed to operate the semiconductor laser and the adaptive optics based on modulated feedback control signals supplied to the wavelength selective section of the semiconductor laser and the adaptive optics. The wavelength control signal supplied to the wavelength selective section of the semiconductor laser may be adjusted based on the modulated wavelength feedback control signal such that the response parameter of the wavelength conversion device is optimized. Similarly, the position control signals supplied to the adaptive optics may be adjusted based on the modulated feedback position control signals such that the response parameter of the wavelength conversion device is optimized.
摘要翻译：根据本发明的一个实施例，光学封装包括耦合到具有自适应光学器件的波长转换器件的一个或多个半导体激光器。光学封装还包括编程为基于提供给半导体激光器和自适应光学器件的波长选择部分的调制反馈控制信号来操作半导体激光器和自适应光学器件的封装控制器。提供给半导体激光器的波长选择部分的波长控制信号可以基于调制的波长反馈控制信号进行调整，使得波长转换器件的响应参数被优化。类似地，可以基于调制的反馈位置控制信号来调整提供给自适应光学器件的位置控制信号，使得波长转换装置的响应参数被优化。

3. 发明申请

WO2009058219A1 WAVELENGTH CONVERSION DEVICES AND FABRICATION METHODS FOR SAME 审中-公开
标题翻译：波长转换器件及其制造方法
公开(公告)号：WO2009058219A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012068
申请日：2008-10-23
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett A
发明人： GOLLIER, Jacques , PIECH, Garrett A
IPC分类号： G02F1/355 , G02F1/377
CPC分类号： G02F1/3558 , G02F1/3775 , G02F2201/307 , H01S5/0064
摘要： Particular embodiments of the present invention relate generally to a method of fabricating a wavelength conversion device. According to the method, the wavelength conversion device is fabricated by providing a nonlinear optical material and poling the nonlinear optical material to form a plurality of periodically inverted poling domains arranged at an anti-back reflective periodicity Λ. The geometry and the anti-back reflective periodicity Λ of the poled nonlinear material are selected such that the difference between a phase matching wavelength λ Φ of the poled nonlinear optical material and a Bragg wavelength λ BRAGG of the poled nonlinear optical material is greater than 1nm.
摘要翻译：本发明的具体实施方案一般涉及制造波长转换装置的方法。根据该方法，通过提供非线性光学材料并极化非线性光学材料以形成以反背反射周期α布置的多个周期性反转极化畴来制造波长转换器件。几何和反背反射周期？选择极化非线性材料的极化非线性光学材料的相位匹配波长λF与极化非线性光学材料的布拉格波长λBRAGG之间的差大于1nm。

4. 发明申请

WO2006088799A1 SINGLE MODE (SM) FIBER OPTICAL READER SYSTEM AND METHOD FOR INTERROGATING RESONANT WAVEGUIDE-GRATING SENSOR(S) 审中-公开
标题翻译：单模（SM）光纤读取器系统和谐波波导光栅传感器的混合方法（S）
公开(公告)号：WO2006088799A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005046
申请日：2006-02-13
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett A
发明人： GOLLIER, Jacques , PIECH, Garrett A
IPC分类号： G01N21/47 , G01N21/77
CPC分类号： G01N21/7743
摘要： An optical reader system is described herein which has a single mode (SM) optical fiber launch/receive system that uses one or more SM optical fibers to interrogate a biosensor and does not use multimode (MM) optical fibers to interrogate the biosensor. The use of the SM optical fiber launch/receive system effectively reduces angular sensitivity, reduces unwanted system reflections, improves overall angular tolerance, and improves resonant peak reflectivity and resonant peak width. Two specific embodiments of the SM optical fiber launch/receive system are described herein which include: (1) a dual fiber collimator launch/receive system; and (2) a single fiber launch/receive system that interrogates the biosensor at a normal incidence.
摘要翻译：本文描述了一种光学读取器系统，其具有使用一个或多个SM光纤询问生物传感器并且不使用多模（MM）光纤来询问生物传感器的单模（SM）光纤发射/接收系统。使用SM光纤发射/接收系统有效地降低了角度灵敏度，减少了不必要的系统反射，提高了整体角度公差，并且提高了谐振峰值反射率和谐振峰值宽度。本文描述了SM光纤发射/接收系统的两个具体实施例，其包括：（1）双光纤准直器发射/接收系统; 和（2）以正常入射方式询问生物传感器的单纤维发射/接收系统。

5. 发明申请

WO2010123988A1 RAPID ALIGNMENT METHODS FOR OPTICAL PACKAGES 审中-公开
标题翻译：用于光学包的快速对准方法
公开(公告)号：WO2010123988A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031893
申请日：2010-04-21
申请人： CORNING INCORPORATED , BLANDING, Douglass L , GOLLIER, Jacques , PIECH, Garrett A
发明人： BLANDING, Douglass L , GOLLIER, Jacques , PIECH, Garrett A
IPC分类号： H01S3/10
CPC分类号： G02F1/377 , G02F2001/3503 , G02F2001/3546 , H01S5/0014 , H01S5/0092 , H01S5/06821 , H01S5/0683
摘要： A method for aligning an optical package including a semiconductor laser operable to emit an output beam having a first wavelength, a wavelength conversion device operable to convert the output beam to a second wavelength and adaptive optics configured to optically couple the output beam into a waveguide portion of an input facet of the wavelength conversion device includes measuring a power of light having a first wavelength emitted by or scattered from the wavelength conversion device as the output beam is scanned over the input facet of the wavelength conversion device along a first scanning axis. A power of light emitted from the wavelength conversion device is then measured as the output beam is scanned over the input facet along a second scanning axis. A position of the second scanning axis relative to an edge of the wavelength conversion device is based on the measured power of light having the first wavelength.
摘要翻译：一种用于对准包括可操作以发射具有第一波长的输出光束的半导体激光器的光学封装的方法，可操作以将输出光束转换为第二波长的波长转换装置，以及配置为将输出光束光耦合到波导部分中的自适应光学器件所述波长转换装置的输入面包括：测量当所述波长转换装置沿着第一扫描轴扫描所述输出光束时从所述波长转换装置发射或散射的具有第一波长的光的功率。然后当输出光束沿着第二扫描轴在输入刻面上扫描时，测量从波长转换装置发射的光的功率。第二扫描轴相对于波长转换装置的边缘的位置是基于测量的具有第一波长的光的功率。

6. 发明申请

WO2006088879A1 OPTICAL READER SYSTEM AND METHOD THAT USES NON-COHERENT ILLUMINATION AND ANGULAR FILTERING TO INTERROGATE A LABEL INDEPENEDENT BIOSENSOR 审中-公开
标题翻译：光学读取器系统和方法，使用非相干照明和角度滤波来标记标签生物传感器
公开(公告)号：WO2006088879A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005191
申请日：2006-02-13
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett A
发明人： GOLLIER, Jacques , PIECH, Garrett A
IPC分类号： G01N21/47
CPC分类号： G01N21/7743
摘要： An optical reader system and method are described herein that directs a non-coherent light towards a biosensor, collects the non-coherent light which is reflected (or transmitted) from (or through) the biosensor, and then angularly filters the collected non-coherent light to obtain a narrow spectral response which can be analyzed to determine if a biological substance is located on the biosensor or if a biomolecular event took place on the biosensor.
摘要翻译：这里描述了一种光学读取器系统和方法，其将非相干光引向生物传感器，收集从（或通过）生物传感器反射（或传输）的非相干光，然后对所收集的非相干光以获得可以被分析以确定生物物质是位于生物传感器上还是在生物传感器上发生生物分子事件的窄光谱响应。

7. 发明申请

WO2005033680A1 DIFFERENTIAL SURFACE PLASMON SENSOR USING OPPOSITE LIGHT PROPAGATION IN GRATING-COUPLED WAVEGUIDE 审中-公开
标题翻译：差分表面等离子体传感器在光栅耦合波导中使用对称光传播
公开(公告)号：WO2005033680A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/032022
申请日：2004-09-29
申请人： CORNING INCORPORATED , MOZDY, Eric J , GOLLIER, Jacques , PIECH, Garrett A
发明人： MOZDY, Eric J , GOLLIER, Jacques , PIECH, Garrett A
IPC分类号： G01N21/55
CPC分类号： G01N21/7743 , Y10S436/805
摘要： A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical agents, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations. Also described is an optical interrogation system incorporating the method.
摘要翻译：提供了从具有给定的波长或角度的光束产生的在光栅耦合波导（GCW）传感器内使用双重共振效应的方法。该方法可用于生物和化学试剂的标签无关检测，以增加的灵敏度询问感测区域内的生物结合事件或化学反应，并且对环境扰动的敏感性降低。还描述了结合该方法的光学询问系统。

8. 发明申请

WO2010127060A1 FOLDED LASERS SYSTEM 审中-公开
标题翻译：折叠激光系统
公开(公告)号：WO2010127060A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/032882
申请日：2010-04-29
申请人： CORNING INCORPORATED , ALMORIC, Etienne , GOLLIER, Jacques , HUGHES, Lawrence C. Jr. , PIECH, Garrett A
发明人： ALMORIC, Etienne , GOLLIER, Jacques , HUGHES, Lawrence C. Jr. , PIECH, Garrett A
IPC分类号： H01S3/081
CPC分类号： H01S5/02252 , G02F1/3775 , H01S5/0035 , H01S5/005 , H01S5/0092 , H01S5/0427 , H01S5/1085
摘要： A folded laser system having an optical axis, the laser system comprising: (I) a coherent light source; (II) a reflector; (III) a lens component situated between the light source and the reflector; and (IV) a non-linear optical crystal, wherein the light source and the non-linear optical crystal are separated by a distance d>50µm. The lens component is positioned to provide a collimated beam when intercepting light from the light source, such that the collimated beam is at an angle Θ' to the optical axis, the reflector is situated to intercept the collimated beam and to reflect the collimated beam to the non-linear optical crystal through the lens; and the lens component is structured to provide an image on the non-linear optical crystal.
摘要翻译：一种具有光轴的折叠激光系统，所述激光系统包括：（I）相干光源; （II）反射器; （III）位于光源和反射器之间的透镜部件; 和（IV）非线性光学晶体，其中光源和非线性光学晶体分开距离d>50μm。透镜部件被定位成当截取来自光源的光时提供准直光束，使得准直光束与光轴成角度T'，反射器被定位成拦截准直光束并将准直光束反射到非线性光学晶体通过透镜; 并且透镜部件被构造成在非线性光学晶体上提供图像。

9. 发明申请

WO2008033311A1 OPTICAL INTERROGATION SYSTEM AND MICROPLATE POSITION CORRECTION METHOD 审中-公开
标题翻译：光学系统与微波位置校正方法
公开(公告)号：WO2008033311A1
公开(公告)日：2008-03-20
申请号：PCT/US2007/019680
申请日：2007-09-11
申请人： CORNING INCORPORATED , DAILEY, Michael, J, Jr. , PIECH, Garrett A , SHEDD, Gordon M , WEBB, Michael B , ZAMBRANO, Elvis A
发明人： DAILEY, Michael, J, Jr. , PIECH, Garrett A , SHEDD, Gordon M , WEBB, Michael B , ZAMBRANO, Elvis A
IPC分类号： G01N21/25 , G01N21/64
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/0636 , G01N35/028
摘要： An optical interrogation system and method are described herein that are capable of detecting and correcting a positional misalignment of a label independent detection (LID) microplate so that the LID microplate can be properly interrogated after being removed from and then re-inserted back into a microplate holder/XY translation stage.
摘要翻译：本文描述了能够检测和校正标签无关检测（LID）微孔板的位置不对准的光学询问系统和方法，使得LID微孔板在被移除之后被重新插入微孔板之后被适当询问持有人/ XY翻译阶段。

10. 发明申请

WO2007019039A1 METHOD FOR INCREASING A READ-OUT SPEED OF A CCD-DETECTOR 审中-公开
标题翻译：增加CCD检测器读出速度的方法
公开(公告)号：WO2007019039A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/028745
申请日：2006-07-25
申请人： CORNING INCORPORATED , PIECH, Garrett A , WEBB, Michael B
发明人： PIECH, Garrett A , WEBB, Michael B
IPC分类号： G01J3/28 , G01N21/77
CPC分类号： G01N21/7743 , G01J3/2803
摘要： A typical use of linear or two dimensional spectrometers is to expose the detector area (102) , and then shift the photo-electric charges out of the device in a serial fashion. If the illuminating signal (118) is spatially narrow relative to the size of the array, this will drive down the percent of the detector that is utilized, as only a relatively small number of pixels are used to detect the beam. The present invention proposes a method which capitalizes on this spatial under-utilization, and alters the clocking scheme to maximize the read-out speed of the pixels containing signal information. This type of clocking scheme raises the optical power saturation level of the spectrometer. Such an improvement in optical power handling is beneficial for spectrometer based detection of resonant waveguide grating biochemical binding, since in such systems the performance is frequently limited by spectrometer saturation.
摘要翻译：线性或二维光谱仪的典型用途是暴露检测器区域（102），然后将光电荷以串联方式移出设备。如果照明信号（118）相对于阵列的尺寸在空间上窄，则这将驱动所使用的检测器的百分比，因为仅使用相对较少数量的像素来检测光束。本发明提出了一种利用该空间利用不足的方法，并且改变了时钟方案以使包含信号信息的像素的读出速度最大化。这种类型的时钟方案提高了光谱仪的光功率饱和水平。光功率处理的这种改进对于谐振波导光栅生化结合的基于光谱仪的检测是有利的，因为在这样的系统中，性能常常受到光谱仪饱和度的限制。

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