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    • 3. 发明申请
    • FLUID CONNECTORS FOR MICROREACTOR MODULES
    • 流体连接器用于微型模块
    • WO2011136915A1
    • 2011-11-03
    • PCT/US2011/032001
    • 2011-04-12
    • CORNING INCORPORATEDBRUNELLO, PierreDELAUTRE, PaulGREMETZ, Sylvain, Maxime, F.LOBET, Olivier
    • BRUNELLO, PierreDELAUTRE, PaulGREMETZ, Sylvain, Maxime, F.LOBET, Olivier
    • B01J19/00B01L3/00F16L19/02
    • B01J19/0093B01J2219/0081B01L3/502715B01L3/563B01L3/569B01L2200/027
    • An end-face sealing fluidic connector [20] for fluidic connection and/or interconnection of glass, glass-ceramic and/or ceramic fluidic modules [12] in a microreactor [10] and includes a connector body [22] having a circular first end face [26]with a recess [28] for retaining one or more O-rings [30]. The connector body [22] has a first end section [32] having a circular cylindrical outer surface [34] having a diameter [36] in the range of from 3 to 25 mm extending along the connector body [22] from the first end face [26]. The outer surface [34] of the first end section [32] is having a circumferential recess [38] dividing the first end section [32] into a proximal portion [40] adjacent the first end face [26] and a distal portion [42] separated from the proximal portion [40] by the circumferential recess [38]. A retaining ring [48] is seated in the circumferential recess and a circular cylindrical circumferential reinforcing and/or protecting ring [50] surrounds the proximal portion [40] of the first end section [32], the ring [50] being comprised of a high-compression-strength polymer. A circular cylindrical sleeve [58] surrounds the first end section [32] and the reinforcing and/or protecting ring [50], the sleeve [58] including a circumferentially extending inside bearing surface for engaging the retaining ring [48] on the distal side thereof. The circular cylindrical sleeve [58] further comprises an external thread [66] on a proximal outer surface [68] thereof and a gripping surface [70] on a distal outer surface [72] thereof.
    • 用于在微反应器[10]中的玻璃,玻璃 - 陶瓷和/或陶瓷流体模块[12]的流体连接和/或互连的端面密封流体连接器[20],并且包括连接器本体[22] 端面[26]具有用于保持一个或多个O形环[30]的凹部[28]。 连接器主体[22]具有第一端部部分32,其具有从第一端部沿着连接器主体[22]延伸的直径[36]在3至25mm范围内的圆柱形外表面[34] 脸[26]。 第一端部部分[32]的外表面[34]具有将第一端部部分[32]分成邻近第一端面[26]的近端部分[40]的周向凹部[38] 42]通过周向凹部[38]与近侧部分[40]分离。 保持环[48]位于周向凹槽中,并且环形圆周周向增强和/或保护环围绕第一端部[32]的近端部分[40],环[50]包括 高压缩强度聚合物。 环形圆柱形套筒围绕第一端部部分[32]和加强和/或保护环[50],套筒(58)包括周向延伸的内部支承表面,用于将保持环[48]接合在远端 侧。 圆柱形套筒[58]还包括在其近端外表面[68]上的外螺纹[66]和位于其远侧外表面[72]上的抓握表面[70]。
    • 6. 发明申请
    • MODULAR MOUNTING AND CONNECTION OR INTERCONNECTION SYSTEM FOR MICROFLUIDIC DEVICES
    • 用于微流量器件的模块化安装和连接或互连系统
    • WO2007131925A1
    • 2007-11-22
    • PCT/EP2007/054498
    • 2007-05-09
    • CORNING INCORPORATEDDELAUTRE, PaulLOBET, Olivier
    • DELAUTRE, PaulLOBET, Olivier
    • B01L9/00
    • B01L9/527B01J2219/0081B01J2219/0813B01L3/565B01L2200/026B01L2200/027B01L2200/028B01L2300/0816F16B2/06Y10T137/7504Y10T137/87153Y10T137/87249Y10T403/18
    • A modular mounting and connection or interconnection system for microfluidic devices (20) includes a plurality of end-butting compression-sealing fluid connectors or adapters (32), and one or more clamping structures (54, 56) each structured to hold one of the fluid connectors (32) in compression against a planar surface of a microfluidic device (20), and to press against the device, on another directly opposing planar surface thereof, either a contact pad (48) or another of the fluid connectors (32), with each clamping structure (54,56) including an individually moveable compression-providing element such as a compression screw (36) structured to provide a controlled amount of compression. The system desirably further includes one or more device frames (58) each structured so as to receive and hold a microfluidic device (20) with one or more of the clamping structures (54, 56) attached, the device frame (58) being structured to retain the device (20) and attached clamping structures (54, 56) by constraining only one or two of the clamping structures (54,56) in a manner such that no torsion or bending is applied to the device (20), and one or more system frames (70) structured so as to receive and hold a plurality of device frames (58) in proximity to each other in a three-dimensional array, such that volumes of desired fluid interconnections between devices (20) can be minimized.
    • 用于微流体装置(20)的模块化安装和连接或互连系统包括多个端对接压缩密封流体连接器或适配器(32),以及一个或多个夹紧结构(54,56),每个夹紧结构被构造成保持 流体连接器(32),其抵抗微流体装置(20)的平坦表面压缩,并且在另一个直接相对的平面表面上压靠在所述装置上的接触垫(48)或另一个流体连接器(32), ,每个夹紧结构(54,56)包括单独可移动的压缩提供元件,例如被构造成提供受控量的压缩的压缩螺钉(36)。 系统期望地还包括一个或多个装置框架(58),每个装置框架(58)被构造成接收和保持具有附接的一个或多个夹紧结构(54,56)的微流体装置(20),所述装置框架(58)被构造 通过以不使扭转或弯曲施加到装置(20)的方式仅约束一个或两个夹紧结构(54,56)来保持装置(20)和附接的夹紧结构(54,56),以及 一个或多个系统框架(70)被构造成以三维阵列接收和保持彼此靠近的多个设备框架(58),使得可以最小化设备(20)之间的所需流体互连体积 。
    • 9. 发明申请
    • INJECTOR ASSEMBLIES AND MICROREACTORS INCORPORATING THE SAME
    • 注射器组件和微型计算机
    • WO2009110990A1
    • 2009-09-11
    • PCT/US2009/001265
    • 2009-02-27
    • CORNING INCORPORATEDLOBET, OlivierPOISSY, StephaneWOEHL, Pierre
    • LOBET, OlivierPOISSY, StephaneWOEHL, Pierre
    • B01F13/02
    • B01J19/0093B01F3/0446B01F5/0077B01F5/045B01J4/002B01J2219/0081B01J2219/0086B01J2219/00891B05B7/0433
    • A microreactor assembly (100) is provided comprising a fluidic microstructure (10) and an injector assembly (20). The injector assembly (20) comprises a liquid inlet (22), a gas inlet (24), a liquid outlet (26), a gas outlet (28), a liquid flow portion (30) extending from the liquid inlet (22) to the liquid outlet (26), and a gas flow portion (40) extending from the gas inlet (24) to the gas outlet (28). Further, the injector assembly (20) defines an injection interface with a microchannel input port (14) of the fluidic microstructure (10). The injector assembly (20) is configured such that the gas outlet (28) of the gas flow portion (40) is positioned to inject gas into the liquid flow portion (30) upstream of the liquid outlet (26), into the liquid flow portion (30) at the liquid outlet (26), or into an extension (35) of the liquid flow portion (30) downstream of the liquid outlet (26). Further, the injector assembly (20) is configured such that gas is injected into the liquid flow portion (30) or the extension thereof as a series of gas bubbles. The resulting microreactor assembly (100), and the injector assemblies utilized therein, which can be used with a variety of microreactor designs, effectively improves the interfacial surface area within the microstructure without requiring excessive reduction of microchannel dimensions.
    • 提供了包括流体微结构(10)和喷射器组件(20)的微反应器组件(100)。 喷射器组件(20)包括液体入口(22),气体入口(24),液体出口(26),气体出口(28),从液体入口(22)延伸的液体流动部分(30) 到液体出口(26)和从气体入口(24)延伸到气体出口(28)的气体流动部分(40)。 此外,喷射器组件(20)限定与流体微结构(10)的微通道输入端口(14)的注入界面。 喷射器组件(20)构造成使得气体流动部分(40)的气体出口(28)定位成将气体喷射到液体出口(26)上游的液体流动部分(30)中,进入液体流 在液体出口(26)处的部分(30),或液体出口(26)下游的液体流动部分(30)的延伸部(35)中。 此外,喷射器组件(20)构造成使得气体作为一系列气泡被喷射到液体流动部分(30)或其延伸部分中。 可以与各种微反应器设计一起使用的所得微反应器组件(100)和其中使用的喷射器组件有效地改善了微结构内的界面表面积,而不需要过度减小微通道尺寸。
    • 10. 发明申请
    • FLUID PORTING ASSEMBLY AND MICROREACTOR INCORPORATING THE SAME
    • 流体成型装置和与其同时进行的微型反应器
    • WO2009070288A1
    • 2009-06-04
    • PCT/US2008/013119
    • 2008-11-25
    • CORNING INCORPORATEDLOBET, Olivier
    • LOBET, Olivier
    • B01J19/00
    • B01L3/565B01J19/0093B01J2219/0081B01J2219/00891B01L3/502707B01L2300/1894
    • A fluid porting assembly for a microreactor comprising a process fluid passageway, a pliable seal, and a cooling fluid passageway is provided. The pliable seal is positioned in the vicinity of the process fluid outlet and is configured to define a sealing interface between the process fluid outlet and a fluid port of a microreactor. The cooling fluid passageway terminates at a cooling fluid interface and defines a dispensing gap between the cooling fluid interface and the sealing interface. The cooling fluid outlet is configured to distribute cooling fluid about a periphery of the pliable seal and to direct cooling fluid away from the periphery of the pliable seal through the dispensing gap when the pliable seal of the fluid porting assembly engages a fluid port of a microreactor. The cooling fluid removes heat from areas of the microreactor in the vicinity of the fluid port and pliable seal.
    • 提供了一种用于微反应器的流体移植组件,其包括过程流体通道,柔性密封件和冷却流体通道。 柔性密封件位于过程流体出口附近,并且构造成限定过程流体出口和微反应器的流体端口之间的密封界面。 冷却流体通道终止于冷却流体界面并且限定冷却流体界面和密封界面之间的分配间隙。 冷却流体出口构造成在柔性密封件的周边分布冷却流体,并且当流体移动组件的柔性密封件接合微反应器的流体端口时,将冷却流体引导通过分配间隙远离柔性密封件的周边 。 冷却流体从流体端口附近的微反应器区域和柔性密封件移除热量。