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1. 发明申请

WO0164642A3 BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA 审中-公开
标题翻译：噻唑类和相关抑制因子XA
公开(公告)号：WO0164642A3
公开(公告)日：2002-05-02
申请号：PCT/US0106247
申请日：2001-02-28
申请人： COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
发明人： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC分类号： A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/18 , A61K31/44 , C07C257/18 , C07D203/18 , C07D205/04 , C07D213/79 , C07D213/80 , C07D231/40 , C07D233/26 , C07D295/18 , C07D317/44 , C07D401/14 , C07D403/12
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Benzamide compounds of formula A-Q-D-E-G-J-X, where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：描述式A-Q-D-E-G-J-X的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。还描述了含有这些化合物的组合物。化合物和组合物在体外或体内可用于预防或治疗凝血障碍。

2. 发明申请

WO0164643A3 BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA 审中-公开
标题翻译：噻唑类和相关抑制因子XA
公开(公告)号：WO0164643A3
公开(公告)日：2002-04-04
申请号：PCT/US0106255
申请日：2001-02-28
申请人： COR THERAPEUTICS INC , ZHU BING YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
发明人： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERICK , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC分类号： A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , A61K31/44
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Benzamide compounds of the formulae (VI) and (VII), where the variables are as defined in the claims, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：描述式（VI）和（VII）的苯甲酰胺化合物，其中变量如权利要求中所定义，包括其对哺乳动物因子Xa具有活性的药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。还描述了含有这些化合物的组合物。化合物和组合物可用于体内或体内用于预防或治疗凝血障碍。

3. 发明申请

WO0226720A3 PIPERAZINE BASED INHIBITORS OF FACTOR Xa 审中-公开
标题翻译：哌嗪基因抑制因子Xa
公开(公告)号：WO0226720A3
公开(公告)日：2002-10-31
申请号：PCT/US0130315
申请日：2001-10-01
申请人： MILLENNIUM PHARM INC , ZHU BING-YAN , JIA ZHAOZHONG JON , ZHANG PENGLIE , HUANG WENRONG , WU YANHONG , ZUCKETT JINGMEI FAN , GOLDMAN ERIK A , WANG LINGYAN , SONG YONGHONG , SCARBOROUGH ROBERT M
发明人： ZHU BING-YAN , JIA ZHAOZHONG JON , ZHANG PENGLIE , HUANG WENRONG , WU YANHONG , ZUCKETT JINGMEI FAN , GOLDMAN ERIK A , WANG LINGYAN , SONG YONGHONG , SCARBOROUGH ROBERT M
IPC分类号： A61P7/02 , C07D205/04 , C07D209/30 , C07D233/06 , C07D239/06 , C07D295/26 , C07D333/62 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , A61K31/496 , C07D295/22
CPC分类号： C07D239/06 , C07D205/04 , C07D209/30 , C07D233/06 , C07D295/26 , C07D333/62 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14
摘要： Novel compounds of the general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
摘要翻译：描述了具有抗哺乳动物因子Xa活性的通式（I）或（II）的新化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。还描述了含有这些化合物的组合物。这些化合物和组合物可用于体外或体内用于预防或治疗以不希望的血栓形成为特征的哺乳动物的病症。

4. 发明申请

WO0226718A3 BICYCLIC PYRIMIDIN-4-ONE BASED INHIBITORS OF FACTOR XA 审中-公开
标题翻译：基于双环嘧啶-4-酮的因子XA抑制剂
公开(公告)号：WO0226718A3
公开(公告)日：2002-08-29
申请号：PCT/US0130335
申请日：2001-10-01
申请人： MILLENNIUM PHARM INC , ZHANG PENGLIE , LI WENHAO , HUANG WENRONG , WANG LINGYAN , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M , ZHU BING-YAN
发明人： ZHANG PENGLIE , LI WENHAO , HUANG WENRONG , WANG LINGYAN , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M , ZHU BING-YAN
IPC分类号： A61P7/02 , C07D239/91 , C07D401/04 , C07D401/14 , C07D409/14 , C07D487/04 , A61K31/517 , A61K31/519 , C07D409/04 , C07D495/04
CPC分类号： C07D401/04 , C07D239/91 , C07D401/14 , C07D409/14 , C07D487/04
摘要： Novel bicyclic pyrimidin-4-one-containing compounds of formulae (I) or (II): including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
摘要翻译：描述了式（I）或（II）的新的含双环嘧啶-4-酮的化合物：包括其具有抗哺乳动物因子Xa活性的药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。还描述了含有这些化合物的组合物。这些化合物和组合物可用于体外或体内预防或治疗以不希望的血栓形成为特征的哺乳动物的病症。

5. 发明申请

WO2005118184B1 Metal and alloy nanoparticles and synthesis methods thereof 审中-公开
标题翻译：金属和合金纳米颗粒及其合成方法
公开(公告)号：WO2005118184B1
公开(公告)日：2006-06-15
申请号：PCT/US2005013563
申请日：2005-04-21
申请人： HONDA MOTOR CO LTD , UNIV NEW YORK STATE RES FOUND , HE TING , ZHONG CHUAN-JIAN , LUO JIN , MAYE MATHEW M , HAN LI , KARIUKI NANCY N , WANG LINGYAN
发明人： HE TING , ZHONG CHUAN-JIAN , LUO JIN , MAYE MATHEW M , HAN LI , KARIUKI NANCY , WANG LINGYAN
IPC分类号： B22F9/20 , B01J35/00 , B22F1/00 , B22F1/02 , B22F9/24
CPC分类号： B22F9/24 , B22F1/0018 , B22F1/0088 , B82Y30/00 , Y10S977/896
摘要： The present teachings are directed toward single metal and alloy nanoparticles and synthesis methods for preparing single metal and alloy nanoparticles. The present teachings include a method of preparing metal nanoparticles which method includes contacting a metal- containing component with a reducing agent, optionally with a capping agent, in a solvent system to form a reaction mixture. The reaction mixture can be heated to reflux, cooled, and the desired metal nanoparticles can be precipitated from the reaction mixture. Optionally, the metal nanoparticles can be supported on a suitable support material, such as, a high surface area support material. The support material can be incorporated into the reaction mixture, for instance, along with the reducing agent. The present teachings include a method of preparing alloy nanoparticles which method includes contacting at least two metal-containing components with a reducing agent and at least one capping agent in a solvent system to form a reaction mixture, heating and refluxing the reaction mixture, cooling the reaction mixture, and precipitating the alloy nanoparticles from the cooled reaction mixture.
摘要翻译：本教导涉及单金属和合金纳米颗粒以及用于制备单一金属和合金纳米颗粒的合成方法。本教导包括制备金属纳米颗粒的方法，该方法包括使含金属的组分与还原剂（任选地与封端剂）在溶剂体系中接触以形成反应混合物。反应混合物可以加热回流，冷却，并且可以从反应混合物中沉淀所需的金属纳米颗粒。任选地，金属纳米颗粒可以被支撑在合适的支撑材料，例如高表面积的支撑材料上。载体材料可以与还原剂一起并入反应混合物中。本教导包括制备合金纳米颗粒的方法，该方法包括在溶剂系统中使至少两种含金属的组分与还原剂和至少一种封端剂接触以形成反应混合物，加热和回流反应混合物，冷却反应混合物，并从冷却的反应混合物中沉淀合金纳米颗粒。

6. 发明申请

WO2005118184A3 METAL AND ALLOY NANOPARTICLES AND SYNTHESIS METHODS THEREOF 审中-公开
标题翻译：金属和合金纳米粒子及其合成方法
公开(公告)号：WO2005118184A3
公开(公告)日：2006-04-27
申请号：PCT/US2005013563
申请日：2005-04-21
申请人： HONDA MOTOR CO LTD , UNIV NEW YORK STATE RES FOUND , HE TING , ZHONG CHUAN-JIAN , LUO JIN , MAYE MATHEW M , HAN LI , KARIUKI NANCY N , WANG LINGYAN
发明人： HE TING , ZHONG CHUAN-JIAN , LUO JIN , MAYE MATHEW M , HAN LI , KARIUKI NANCY N , WANG LINGYAN
IPC分类号： B22F1/00 , B01J35/00 , B22F1/02 , B22F9/20 , B22F9/24
CPC分类号： B22F9/24 , B22F1/0018 , B22F1/0088 , B82Y30/00 , Y10S977/896
摘要： The present teachings are directed toward single metal and alloy nanoparticles and synthesis methods for preparing single metal and alloy nanoparticles. The present teachings include a method of preparing metal nanoparticles which method includes contacting a metal- containing component with a reducing agent, optionally with a capping agent, in a solvent system to form a reaction mixture. The reaction mixture can be heated to reflux, cooled, and the desired metal nanoparticles can be precipitated from the reaction mixture. Optionally, the metal nanoparticles can be supported on a suitable support material, such as, a high surface area support material. The support material can be incorporated into the reaction mixture, for instance, along with the reducing agent. The present teachings include a method of preparing alloy nanoparticles which method includes contacting at least two metal-containing components with a reducing agent and at least one capping agent in a solvent system to form a reaction mixture, heating and refluxing the reaction mixture, cooling the reaction mixture, and precipitating the alloy nanoparticles from the cooled reaction mixture.
摘要翻译：本教导涉及单金属和合金纳米颗粒以及用于制备单一金属和合金纳米颗粒的合成方法。本教导包括制备金属纳米颗粒的方法，该方法包括使含金属的组分与还原剂（任选地与封端剂）在溶剂体系中接触以形成反应混合物。反应混合物可以加热回流，冷却，并且可以从反应混合物中沉淀所需的金属纳米颗粒。任选地，金属纳米颗粒可以被支撑在合适的支撑材料，例如高表面积的支撑材料上。载体材料可以与还原剂一起并入反应混合物中。本教导包括制备合金纳米颗粒的方法，该方法包括在溶剂系统中使至少两种含金属的组分与还原剂和至少一种封端剂接触以形成反应混合物，加热和回流反应混合物，冷却反应混合物，并从冷却的反应混合物中沉淀合金纳米颗粒。

7. 发明申请

WO2008103351A3 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译：异源ASPARTYL蛋白酶抑制剂
公开(公告)号：WO2008103351A3
公开(公告)日：2009-07-23
申请号：PCT/US2008002182
申请日：2008-02-20
申请人： SCHERING CORP , PHARMACOPEIA INC , ZHU ZHAONING , MCKITTRICK BRIAN , SUN ZHONG-YUE , YE YUANZAN C , VOIGT JOHANNES H , STRICKLAND COREY , SMITH ELIZABETH M , STAMFORD ANDREW , GREENLEE WILLIAM J , MAZZOLA JR ROBERT D , CALDWELL JOHN , CUMMING JARED N , WANG LINGYAN , WU YUSHENG , ISERLOH ULRICH , LIU XIAOXIANG , HUANG YING , LI GUOQING , PAN JIANPING , MISIASZEK JEFFREY A , GUO TAO , LE THUY X H , SAIONZ KURT W , BABU SURESH D , HUNTER RACHAEL C , MORRIS MICHELLE L , GU HUIZHONG , QIAN GANG , TADESSE DAWIT , LAI GAIFA , DUO JINGQI , QU CHUANXING , SHAO YUEFEI
发明人： ZHU ZHAONING , MCKITTRICK BRIAN , SUN ZHONG-YUE , YE YUANZAN C , VOIGT JOHANNES H , STRICKLAND COREY , SMITH ELIZABETH M , STAMFORD ANDREW , GREENLEE WILLIAM J , MAZZOLA JR ROBERT D , CALDWELL JOHN , CUMMING JARED N , WANG LINGYAN , WU YUSHENG , ISERLOH ULRICH , LIU XIAOXIANG , HUANG YING , LI GUOQING , PAN JIANPING , MISIASZEK JEFFREY A , GUO TAO , LE THUY X H , SAIONZ KURT W , BABU SURESH D , HUNTER RACHAEL C , MORRIS MICHELLE L , GU HUIZHONG , QIAN GANG , TADESSE DAWIT , LAI GAIFA , DUO JINGQI , QU CHUANXING , SHAO YUEFEI
IPC分类号： C07D233/88 , A61K31/513 , A61P25/28 , C07D239/22 , C07D401/06 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, -C(=S)-, -S(O)-, -S(O)2-, -C(=O)-, -O-, -C(R6)(R7)-, -N(R5)- or -C(=N(R5))-; X is -O-, -N(R5)- or -C(R6)(R7)-; provided that when X is -O-, U is not -O-, -S(O)-, -S(O)2-, -C(=O)- or -C(=NR5)-; U is a bond, -S(O)-, -S(O)2-, -C(O)-, -O-, -P(O)(OR15)-, -C(=NR5)-, -(C(R6)(R7))b- or -N(R5)-; wherein b is 1 or 2; provided that when W is -S(O)-, -S(O)2-, -O-, or -N(R5)-, U is not -S(O)-, -S(O)2-, -O-, or -N(R5)-; provided that when X is -N(R5)- and W is -S(O)-, -S(O)2-, -O-, or -N(R5)-, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula (I). Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中W是一个键，-C（= S） - ， - S（O） - ， - S（O） - ， - （= O） - ， - O - ， - C（R6）（R7） - ， - N（R5） - 或-C（= N（R5） X是-O - ， - N（R 5） - 或-C（R 6）（R 7） - ; 条件是当X是-O-时，U不是-O-，-S（O） - ， - S（O）2 - ， - C（= O） - 或-C（= NR5） - ; U是一个键，-S（O） - ， - S（O）2 - ， - C（O） - ， - O - ， - O（OR）（C（R6）（R7））b-或-N（R5） - ; 其中b为1或2; 条件是当W是-S（O） - ， - S（O）2 - ， - O-或-N（R 5） - 时，U不是-S（O） - ， - S（O） -O-或-N（R 5） - ; 条件是当X为-N（R5） - 且W为-S（O） - ， - S（O）2 - ， - O-或-N（R5） - 时，则U不为键; 并且R1，R2，R3，R4，R5，R6和R7如说明书中所定义; 和包含式（I）化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

8. 发明申请

WO2006065277A3 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译：异源ASPARTYL蛋白酶抑制剂
公开(公告)号：WO2006065277A3
公开(公告)日：2007-01-25
申请号：PCT/US2005020446
申请日：2005-06-09
申请人： SCHERING CORP , PHARMACOPEIA DRUG DISCOVERY , ZHU ZHAONING , MCKITTRICK BRIAN , SUN ZHONG-YUE , YE YUANZAN C , VOIGT JOHANNES H , STRICKLAND COREY , SMITH ELIZABETH M , STAMFORD ANDREW , GREENLEE WILLIAM J , MAZZOLA ROBERT , CALDWELL JOHN , CUMMING JARED , WANG LINGYAN , WU YUSHENG , ISERLOH ULRICH , GUO TAO , LE THUY X H , SAIONZ KURT W , BABU SURESH D , HUNTER RACHAEL C , MORRIS MICHELLE L , GU HUIZHONG , QIAN GANG , TADESSE DAWIT
发明人： ZHU ZHAONING , MCKITTRICK BRIAN , SUN ZHONG-YUE , YE YUANZAN C , VOIGT JOHANNES H , STRICKLAND COREY , SMITH ELIZABETH M , STAMFORD ANDREW , GREENLEE WILLIAM J , MAZZOLA ROBERT , CALDWELL JOHN , CUMMING JARED , WANG LINGYAN , WU YUSHENG , ISERLOH ULRICH , GUO TAO , LE THUY X H , SAIONZ KURT W , BABU SURESH D , HUNTER RACHAEL C , MORRIS MICHELLE L , GU HUIZHONG , QIAN GANG , TADESSE DAWIT
IPC分类号： A61K31/4168 , A61K31/4178 , C07D233/46 , C07D233/88 , C07D239/22 , C07D271/06 , C07D273/00 , C07D401/10 , C07D403/06 , C07D403/12 , C07D407/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D413/12
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D233/46 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D271/07 , C07D273/00 , C07D295/15 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/06
摘要： Disclosed are compounds of the formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, and pharmaceutical compositions comprising the compounds of formula (I). Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula (I) in combination with a cholinesterase inhibitor or a muscarinic m 1 agonist or m 2 antagonist.
摘要翻译：公开了式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，以及包含式（I）化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶的方法。还公开了使用式（I）化合物与胆碱酯酶抑制剂或毒蕈碱m 1激动剂或m 2 H 2拮抗剂组合来治疗认知或神经退行性疾病的方法。

9. 发明申请

WO0119788A3 BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa 审中-公开
标题翻译：因子的相关抑制剂Xa
公开(公告)号：WO0119788A3
公开(公告)日：2001-08-09
申请号：PCT/US0025196
申请日：2000-09-15
申请人： COR THERAPEUTICS INC
发明人： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERIC , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC分类号： A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/33
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：式A-Q-D-E-G-J-X的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; X是取代或未取代的苯基或萘基或杂环体系; 并且其它变量如权利要求中所定义，其公开了与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。

10. 发明申请

WO0071516B1 INHIBITORS OF FACTOR Xa 审中-公开
标题翻译：因子Xa的抑制剂
公开(公告)号：WO0071516B1
公开(公告)日：2001-03-01
申请号：PCT/US0014209
申请日：2000-05-24
申请人： COR THERAPEUTICS INC
发明人： ZHU BING-YAN , SCARBOROUGH ROBERT M , WANG LINGYAN
IPC分类号： A61K31/155 , A61K31/18 , A61K31/275 , A61K31/401 , A61K31/402 , A61K31/451 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D401/04 , C07D403/04 , C07D413/04 , A61K31/40 , A61P7/00 , C07C311/39
CPC分类号： C07D401/04 , C07C311/46 , C07D207/16 , C07D211/60 , C07D241/04 , C07D243/08 , C07D403/04 , C07D413/04
摘要： Compounds, e.g. described in claim 5, formula (I) and formula (II), where A-B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：化合物，例如如权利要求5，式（I）和式（II）所述，其中A-B是（1），公开了它们的盐和与其有关的组合物，其具有抗哺乳动物因子Xa的活性。这些化合物可用于体外或体内用于预防或治疗凝血病症。

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