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1. 发明申请

WO2006107309A3 METHOD AND APPARATUS FOR INTERACTIVE HYPERSPECTRAL IMAGE SUBTRACTION 审中-公开
公开(公告)号：WO2006107309A3
公开(公告)日：2006-10-12
申请号：PCT/US2005/014448
申请日：2005-04-28
申请人： CHEMIMAGE CORPORATION , BANGALORE, Arjun, S. , TUSCHEL, David
发明人： BANGALORE, Arjun, S. , TUSCHEL, David
IPC分类号： H01L27/00 , G01J3/44 , G01N21/65
摘要： The disclosure relates to method and apparatus for interactive hyperspectral image subtraction. In one embodiment, the disclosure relates to a method for obtaining a spectral image of a first specie from a frame of a plurality of pixels defining a composition ~f the first specie with a second specie. The method may include (i) identifying, for each of the first and second species, an appropriate Raman wavelength; (ii) defining at least owe background wavelength for the frame; (iii) identifying pixels defied oily by background wavelength; (iv) identifying pixels defined only by the first specie or the second specie; (v) identifying the remaining pixels, the remaining pixels defined by at least a combination of the first and second species; and (vi) forming a spectral image for the first specie.

2. 发明申请

WO2006052464A2 CONTROL AND MONITORING OF NON-RESONANT RADIATION-INDUCED NUCLEATION, CRYSTALLIZATION, AND POLYMORPH FORMATION 审中-公开
标题翻译：非共振辐射诱导的核化，结晶化和多晶形成的控制和监测
公开(公告)号：WO2006052464A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/038694
申请日：2005-10-26
申请人： CHEMIMAGE CORPORATION , TUSCHEL, David , BANGALORE, Arjun, S.
发明人： TUSCHEL, David , BANGALORE, Arjun, S.
IPC分类号： C07C41/00 , C07C45/00
CPC分类号： B01D9/00 , B01D9/0077 , C07B61/00 , C07C45/81 , C07C49/255 , G01N21/65 , G01N2021/656 , G11B7/245
摘要： The invention relates to methods of assessing the polymorphic form of a substance by assessing Raman-shifted radiation scattered by a particle of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials. The invention also relates to methods of selecting and controlling polymorph formation by illuminating a material with non-resonant (i.e., non-absorbed) laser radiation as it is thermally driven through a phase transition temperature.
摘要翻译：本发明涉及通过评估物质颗粒散射的拉曼位移辐射来评估物质的多晶形式的方法。该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。本发明还涉及通过在通过相变温度热驱动的情况下照射具有非共振（即，未吸收的）激光辐射的材料来选择和控制多晶型形成的方法。

3. 发明申请

WO2006083716A2 METHOD AND APPARATUS FOR A MICROSCOPE IMAGE SELECTOR 审中-公开
标题翻译：一种显微镜图像选择器的方法和装置
公开(公告)号：WO2006083716A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002976
申请日：2006-01-30
申请人： CHEMIMAGE CORPORATION , WANG, Xinghua , VOIGHT, Thomas , TUSCHEL, David , WANG, Chenhui , TREADO, Patrick, J.
发明人： WANG, Xinghua , VOIGHT, Thomas , TUSCHEL, David , WANG, Chenhui , TREADO, Patrick, J.
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

4. 发明申请

WO2006005022A2 DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
标题翻译：生物细胞和其他物质的动态化学成像
公开(公告)号：WO2006005022A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023638
申请日：2005-06-30
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
发明人： MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像的方法，包括细胞成像的方法。该方法包括用基本上单色的光照射单元的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。拉曼位移光可以在每个离散时间的多个拉曼位移（RS）值处被评估，并且RS值可以被选择为在每个离散时间处的预选分量的特征。由此获得的图像的拉曼光谱特征的多变量分析可以产生组件在视场中的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见的显微图像）组合或覆盖。

5. 发明申请

WO2007078936A2 METHOD AND APPARATUS FOR COUNTERFEITING PROTECTION 审中-公开
标题翻译：用于防止损坏的方法和设备
公开(公告)号：WO2007078936A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/048381
申请日：2006-12-20
申请人： CHEMIMAGE CORPORATION , TUSCHEL, David , VOIGT, Thomas, C.
发明人： TUSCHEL, David , VOIGT, Thomas, C.
IPC分类号： G06F17/00
CPC分类号： G06K19/10
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.
摘要翻译：本公开一般涉及用于防止假冒产品的方法和设备以及用于为对象提供防伪保护的方法和设备。在一个实施例中，该方法包括以下步骤：（a）访问包括具有第一部分和第二部分的识别标记的对象，其中所述第二部分包括加密特征; （b）读取第一部分，从而获得第一组信息; （c）将第一组信息传输到远程位置; （d）从远程位置接收第二组信息; 和（e）使用第二组信息读取第二部分，从而确定对象的真实性。

6. 发明申请

WO2006110135A1 SYSTEM AND METHOD FOR CHEMICAL IMAGING OF MICROARRAYS 审中-公开
标题翻译：微量化学成像系统及方法
公开(公告)号：WO2006110135A1
公开(公告)日：2006-10-19
申请号：PCT/US2005/011922
申请日：2005-04-08
申请人： CHEMIMAGE CORPORATION , TUSCHEL, David , VOIGT, Thomas, C.
发明人： TUSCHEL, David , VOIGT, Thomas, C.
IPC分类号： G01J3/00 , G01J3/12 , G01J3/44
CPC分类号： G01J3/42 , G01J3/2823 , G01J3/44 , G01N21/253 , G01N21/6452 , G01N21/65
摘要： The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array (300). The system includes an illumination source (310) for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array (300) for receiving said plurality of samples, the array (300) having an external dimension such that the samples are within a simultaneous field of view of the optical device (320); an optical device (320) for collecting the interacted photons and directing the photons to an imaging device (350), the imaging device (350) simultaneously forming a plurality of images corresponding to each of the plurality of samples.
摘要翻译：本公开涉及用于微阵列的化学成像的系统和方法。在一个实施例中，本公开涉及一种用于同时对阵列（300）上布置的多个样本进行光谱成像的系统。该系统包括用于向所述多个样品提供照明光子的照明源（310），所述照明光子与所述多个样品中的每一个相互作用以发射相互作用的光子; 用于接收所述多个样本的阵列（300），所述阵列（300）具有使得所述样本在所述光学装置（320）的同时视场内的外部尺寸; 用于收集相互作用的光子并将光子引导到成像装置（350）的光学装置（320），成像装置（350）同时形成对应于多个样本中的每一个的多个图像。

7. 发明申请

WO2006113537A3 METHOD AND APPLICATIONS TO ENHANCE AND IMAGE OPTICAL SIGNALS FROM BIOLOGICAL OBJECTS 审中-公开
公开(公告)号：WO2006113537A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014252
申请日：2006-04-14
申请人： CHEMIMAGE CORPORATION , DEMUTH, Joseph , TUSCHEL, David , MAIER, John, S. , TREADO, Patrick, J.
发明人： DEMUTH, Joseph , TUSCHEL, David , MAIER, John, S. , TREADO, Patrick, J.
IPC分类号： G01J3/44
摘要： A method and apparatus for imaging biological objects (100). A SERS surface (102) is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5 x 105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material (100) is deposited on the SERS surface (102). The biological material on the SERS surface is illuminated using a monochromatic light source (110) producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter (135) into a plurality of predetermined wavelength bands. A two-dimensional array detector (145) detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.

8. 发明申请

WO2006085894A1 APPARATUS AND METHOD FOR CHEMICAL IMAGING OF A BIOLOGICAL SAMPLE 审中-公开
标题翻译：生物样品化学成像的装置和方法
公开(公告)号：WO2006085894A1
公开(公告)日：2006-08-17
申请号：PCT/US2005/014447
申请日：2005-04-28
申请人： CHEMIMAGE CORPORATION , TUSCHEL, David , MAIER, John
发明人： TUSCHEL, David , MAIER, John
IPC分类号： G01N15/06
CPC分类号： G01N21/6428 , G01J3/10 , G01J3/2823 , G01J3/4406 , G01N21/31 , G01N21/65 , G01N2021/6419 , G01N2021/6421 , G01N2021/6423
摘要： In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.
摘要翻译：在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

9. 发明申请

WO2008051478A3 PHOTOBLEACHING BY HIGH POWER PULSES 审中-公开
公开(公告)号：WO2008051478A3
公开(公告)日：2008-05-02
申请号：PCT/US2007/022345
申请日：2007-10-19
申请人： CHEMIMAGE CORPORATION , TUSCHEL, David , BANGALORE, Arjun
发明人： TUSCHEL, David , BANGALORE, Arjun
IPC分类号： G01N21/63 , G01N21/65
摘要： A pulse photobleaching methodology wherein a monochromatic illumination (e.g., laser illumination) having a higher power intensity (photobleaching power) just below the photodamage threshold of a luminescent sample is initially used to significantly attenuate sample luminescence without photothermally destroying the sample material. Thereafter, the laser power density may be reduced to a significantly lower level (analytical power level) to carry out spectroscopic measurements (e.g., collection of Raman scattered photons) on the sample. In one embodiment, the laser illumination wavelength remains the same despite changes in laser power intensity. Some figures-of-merit may be computed from optical measurements made at the analytical power level to guide the photobleaching process. Sample-dependent combinations of laser power density and short exposure times may be obtained to significantly expedite photobleaching to assist in collection of sample spectral data in the field without a long wait. Portable spectroscopy systems employing pulse photobleaching may be devised for expeditious collection of spectral data from luminescent samples in the field.

10. 发明申请

WO2007078935A2 METHOD AND APPARATUS FOR COUNTERFEITING PROTECTION 审中-公开
公开(公告)号：WO2007078935A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/048379
申请日：2006-12-20
申请人： CHEMIMAGE CORPORATION , TUSCHEL, David , HUTCHISON, Wesley , VOIGT, Thomas, C
发明人： TUSCHEL, David , HUTCHISON, Wesley , VOIGT, Thomas, C
IPC分类号： G06F17/00
CPC分类号： G06K15/00 , G06K19/06037 , G06K19/06046 , G06K19/10 , G06K19/14
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

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