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1. 发明申请

WO2008143795A1 HUMAN MESENCHYMAL CHRONDROSARCOMA XENOGRAFT MODEL AND ITS USE IN CHEMOSENSITIVITY TESTING 审中-公开
标题翻译：人体中心CHRONDROSARCOMA XENOGRAFT模型及其在化学测试中的应用
公开(公告)号：WO2008143795A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/005935
申请日：2008-05-09
申请人： CHAMPIONS BIOTECHNOLOGY, INC. , SIDRANSKY, David
发明人： SIDRANSKY, David
IPC分类号： G01N33/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
摘要： The invention provides an immunodeficient mouse having a xenograft of human mesenchymal chondrosarcoma, and uses thereof.
摘要翻译：本发明提供了具有人间充质软骨肉瘤异种移植物的免疫缺陷小鼠及其应用。

2. 发明申请

WO2008140751A1 HUMAN LEIOSARCOMA AND NON SMALL CELL LUNG CANCER LUNG XENOGRAFT MODELS 审中-公开
标题翻译：人类淋巴瘤和非小细胞肺癌肺癌XENOGRAFT模型
公开(公告)号：WO2008140751A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/005936
申请日：2008-05-09
申请人： CHAMPIONS BIOTECHNOLOGY, INC. , SIDRANSKY, David
发明人： SIDRANSKY, David
IPC分类号： G01N33/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , G01N2800/52
摘要： The invention provides immunodeficient mice having a xenograft of either human leiomyosarcoma or non-small cell lung cancer, and uses thereof.
摘要翻译：本发明提供具有人平滑肌肉瘤或非小细胞肺癌异种移植物的免疫缺陷小鼠及其用途。

3. 发明申请

WO2015195768A1 HUMANIZED MOUSE MODEL AND USES THEREOF 审中-公开
标题翻译：人造鼠模型及其用途
公开(公告)号：WO2015195768A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036180
申请日：2015-06-17
申请人： CHAMPIONS BIOTECHNOLOGY, INC.
发明人： BAIA, Gilson, S. , PAZ, Keren , SIDRANSKY, David
IPC分类号： A61K49/00
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2207/15 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , A61K49/0008
摘要： The invention relates generally to a humanized mouse model and uses thereof. Specifically, the invention relates to methods for generating, maintaining, and expanding a culture of leukocytes in heterologous animals. This invention also relates to use of these animals as models of human immune system for testing molecules in order to treat a disease or disorder such as cancer.
摘要翻译：本发明一般涉及人源化小鼠模型及其用途。具体地说，本发明涉及产生，维持和扩大异源动物白细胞培养的方法。本发明还涉及这些动物作为人类免疫系统的模型来测试分子以便治疗诸如癌症的疾病或病症的用途。

4. 发明申请

WO2016191286A1 HUMANIZED MICE AND USES THEREOF 审中-公开
标题翻译：人类会议及其用途
公开(公告)号：WO2016191286A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/033562
申请日：2016-05-20
申请人： CHAMPIONS BIOTECHNOLOGY, INC.
发明人： GILSON, Baia S. , PAZ, Keren , SIDRANSKY, David
IPC分类号： A01K67/027 , A61K49/00
CPC分类号： A01K67/0271 , A01K67/0278 , A01K2207/12 , A01K2227/105 , A01K2267/0331 , A01K2267/0387 , A61K49/0008
摘要： The invention relates to methods for generating, expanding and maintaining a culture of leukocytes in heterologous animals. The invention also relates to the use of these animals as models of human immune system for testing molecules in order to treat a disease or disorder such as cancer.
摘要翻译：本发明涉及用于产生，扩增和维持异源动物白细胞培养的方法。本发明还涉及这些动物作为用于测试分子的人类免疫系统的模型以用于治疗诸如癌症的疾病或病症的用途。

5. 发明申请

WO2013130517A1 DNA HYPERMETHYLATION OF PROMOTERS OF TARGET GENES AND CLINICAL DIAGNOSIS AND TREATMENT OF HPV RELATED DISEASE 审中-公开
标题翻译：目的基因促进剂的DNA高效液相色谱法和临床诊断与治疗HPV相关疾病
公开(公告)号：WO2013130517A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/027897
申请日：2013-02-27
申请人： THE JOHNS HOPKINS UNIVERSITY , GUERRERO-PRESTON, Rafael Enrique , SIDRANSKY, David
发明人： SIDRANSKY, David
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/50
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6886 , C12Q2600/154
摘要： The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive Pap smears or cytology, and allowing earlier diagnosis and treatment of the subject. The present invention also provides methods of determination of a global promoter DNA methylation in a cervical tissue sample from a subject, using a variety of methods which can detect DNA methylation. Further, the invention provides methods of diagnosis of cervical cancer in a subject, by comparing the global promoter DNA methylation in a cervical tissue sample obtained from a subject to the global promoter DNA methylation of standard controls. In addition, the present invention also provides a method of diagnosis of cervical cancer in a subject suspected of having cervical cancer after obtaining a biological sample of cervical tissue comprising DNA from the subject and detecting the amount of promoter methylation on at least one or more DNA target sites selected from the group consisting of ZNF516, INTS1, and FKBP6; and comparing the amount of promoter methylation on at least one or more DNA target sites in the sample of the subject. These methods allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive Pap smears or cytology, and allowing earlier diagnosis and treatment of the subject.
摘要翻译：本发明提供了可以在无症状或不确定的巴氏涂片或细胞学检查的患者中诊断宫颈癌的基因位点阵列，并允许对受试者进行早期诊断和治疗。本发明还提供了使用可以检测DNA甲基化的多种方法来测定来自受试者的子宫颈组织样品中的全身启动子DNA甲基化的方法。此外，本发明通过将从受试者获得的宫颈组织样品中的全局启动子DNA甲基化与标准对照的全局启动子DNA甲基化比较来提供受试者宫颈癌诊断方法。此外，本发明还提供了在获得包含来自受试者的DNA的宫颈组织的生物学样品并检测至少一种或多种DNA的启动子甲基化的量后，在怀疑患有宫颈癌的受试者中诊断子宫颈癌的方法从ZNF516，INTS1和FKBP6组成的组中选择的靶位点; 以及比较受试者样品中至少一个或多个DNA靶位点上启动子甲基化的量。这些方法可以在可能无症状或不确定的巴氏涂片或细胞学检查的患者中诊断子宫颈癌，并允许早期诊断和治疗受试者。

6. 发明申请

WO2006113671A2 METHYLATION MARKERS FOR DIAGNOSIS AND TREATMENT OF CANCERS 审中-公开
标题翻译：用于诊断和治疗癌症的甲基标记物
公开(公告)号：WO2006113671A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014493
申请日：2006-04-17
申请人： ONCOMETHYLOME SCIENCES, S.A. , THE JOHNSON HOPKINS UNIVERSITY , CRIEKINGE, Wim, Van , STRAUB, Josef , SIDRANSKY, David
发明人： CRIEKINGE, Wim, Van , STRAUB, Josef , SIDRANSKY, David
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154
摘要： Two hundred ten markers are provided which are epigenetically silenced in one or more cancer types. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the silenced gene is a tumor- suppressor gene. Restoration can be accomplished by supplying non-methylated copies of the silenced genes or polynucleotides encoding their encoded products. Alternatively, restoration can be accomplished using chemical demethylating agents or methylation inhibitors. Kits for testing for epigenetic silencing can be used in the context of diagnostics, prognostics, or for selecting "personalized medicine" treatments.
摘要翻译：提供了二百个十个标记物，其在一种或多种癌症类型中被表观遗传沉默。标记物可以在诊断，预后，治疗和选择为个体患者定制的治疗中使用。沉默基因的表达恢复在治疗上是有用的，例如，如果沉默的基因是肿瘤抑制基因。可以通过提供沉默的基因的非甲基化拷贝或编码其编码产物的多核苷酸来实现恢复。或者，可以使用化学去甲基化剂或甲基化抑制剂来实现恢复。用于测试表观遗传学沉默的试剂盒可用于诊断，预后或选择“个性化药物”治疗的上下文中。

7. 发明申请

WO2003076594A3 GENOMIC SCREEN FOR EPIGENETICALLY SILENCED TUMOR SUPPRESSOR GENES 审中-公开
公开(公告)号：WO2003076594A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/007245
申请日：2003-03-07
申请人： THE JOHNS HOPKINS UNIVERSITY , SIDRANSKY, David , BAYLIN, Stephen, B. , HERMAN, James , SUZUKI, Hiromu
发明人： SIDRANSKY, David , BAYLIN, Stephen, B. , HERMAN, James , SUZUKI, Hiromu
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
摘要： Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for example, an esophageal squamous cell carcinoma or a head and neck squamous cell carcinoma, as are methods of treating a subject having such a cancer.

8. 发明申请

WO2003044232A1 METHOD OF DETECTION OF PROSTATE CANCER 审中-公开
标题翻译：检测前列腺癌的方法
公开(公告)号：WO2003044232A1
公开(公告)日：2003-05-30
申请号：PCT/US2002/036784
申请日：2002-11-15
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , SIDRANSKY, David
发明人： SIDRANSKY, David
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6851 , C12Q1/6886 , C12Q2523/125 , C12Q2600/154
摘要： The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma.
摘要翻译：本发明提供了通过测量生物标志物的甲基化水平，特别是用于检测前列腺腺癌的GSTP1的启动子区域来检测赘生物的方法和试剂盒。

9. 发明申请

WO2011112901A2 HYPERMETHYLATION BIOMARKERS FOR DETECTION OF CERVICAL CANCER 审中-公开
标题翻译：用于检测宫颈癌的超临床生物标志物
公开(公告)号：WO2011112901A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/028045
申请日：2011-03-11
申请人： THE JOHNS HOPKINS UNIVERSITY , GUERRERO-PRESTON, Rafael, Enrique , SIDRANSKY, David , BREBI-MIEVILLE, Priscilla
发明人： GUERRERO-PRESTON, Rafael, Enrique , SIDRANSKY, David , BREBI-MIEVILLE, Priscilla
IPC分类号： C12Q1/68 , C12N15/12
CPC分类号： C12Q1/6886 , C12Q1/6869 , C12Q2600/106 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125
摘要： Pap smears and HPV infection tests do not distinguish between lesions that will progress to an invasive carcinoma and those that will not. We aimed to identify epigenetic biomarkers for diagnosis and progression monitoring of premalignant lesions in cervical cancer. Hypermethylated genes were identified as potential biomarkers after validation by MSP, including GGTLA4 and ZNF516. The methylation frequency for these two genes was higher in tumor: GGTLA4 (100%) and ZNF516 (96%); than in normal samples: GGTLA4 (12%) and ZNF516 (16%). The methylation status of GGTLA4 showed a progression in methylation frequency from normal samples to invasive carcinoma. The immunohistochemical expression was lower in tumor for both: GGTLA4 (50.8%) and ZNF516 (66.2%); than in normal samples: GGTLA4 (71.2%) and ZNF516 (88.1%) (p
摘要翻译：巴氏涂片和HPV感染测试不区分将进展为浸润性癌症的病变和不会侵犯癌症的病变。我们旨在确定子宫颈癌前期病变的诊断和进展监测的表观遗传学生物标志物。超甲基化基因在MSP验证后被鉴定为潜在的生物标志物，包括GGTLA4和ZNF516。这两个基因的甲基化频率在肿瘤中较高：GGTLA4（100％）和ZNF516（96％）; 比正常样品：GGTLA4（12％）和ZNF516（16％）。 GGTLA4的甲基化状态显示甲基化频率从正常样本到侵袭性癌的进展。肿瘤组织中GGTLA4（50.8％）和ZNF516（66.2％）的免疫组织化学表达均较低。比正常样品：GGTLA4（71.2％）和ZNF516（88.1％）（p <0.05）。总之，我们确定了甲基化生物标志物进行子宫颈癌的分子筛选和表征。

10. 发明申请

WO2011112880A3 HYPERMETHYLATION BIOMARKERS FOR DETECTION OF HEAD AND NECK SQUAMOUS CELL CANCER 审中-公开
公开(公告)号：WO2011112880A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/028011
申请日：2011-03-11
申请人： THE JOHNS HOPKINS UNIVERSITY , GUERRERO-PRESTON, Rafael Enrique , SIDRANSKY, David , SOUDRY, Ethan
发明人： GUERRERO-PRESTON, Rafael Enrique , SIDRANSKY, David , SOUDRY, Ethan
IPC分类号： C12Q1/68 , C12N15/12 , C40B40/08
摘要： Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadChip, publicly available methylation and expression array data, and Quantitative Methylation Specific PCR to uncover differential methylation in OSCC clinical samples with heterogeneous risk profiles. A two stage-design consisting of Discovery and Prevalence screens was used to identify differential promoter methylation and deregulated pathways in patients diagnosed with OSCC and head and neck squamous cell carcinoma. This Phase I Biomarker Development Trial identified a panel of differentially methylated genes in normal and OSCC clinical samples from patients with heterogeneous risk profiles. This panel may be useful for early detection and cancer prevention studies.

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