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1. 发明申请

WO2005007844A1 METHOD OF SCREENING FOR AGENTS THAT MODULATE IMMUNOPHILIN/PEPTIDYLPROLINE CIS-TRANS ISOMERASE (PPIASE)-HOMER INTERACTION 审中-公开
标题翻译：筛选免疫球蛋白/肽蛋白CIS-TRANS异构体（PPIASE） - 细胞相互作用的试剂的筛选方法
公开(公告)号：WO2005007844A1
公开(公告)日：2005-01-27
申请号：PCT/US2003/019499
申请日：2003-06-18
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , WORLEY, Paul, F.
发明人： WORLEY, Paul, F.
IPC分类号： C12N9/90
CPC分类号： G01N33/573 , A61K38/00 , C07K16/18 , C07K16/286 , C12Q1/533 , G01N33/6872 , G01N33/6896 , G01N2333/99 , G01N2500/02
摘要： The invention features a method of identifying, evaluating and screening for compounds or agents for the treatment of disorders involving the Homer signaling pathway in the modulation of immunosupression and neuroprotection. The method inlcudes evaluating the ability of agents to modulate Homer protein activity, Homer protein/immunophilin-peptidylproline cis-trans isomerase interaction, and/or Homer protein/proline-type Homer ligand consensus sequence interaction to identify agents for such treatment. The invention also discloses treatment modalities involving agents identified by such methods.
摘要翻译：本发明的特征在于在调节免疫抑制和神经保护中鉴定，评价和筛选用于治疗涉及荷马信号通路的病症的化合物或药剂的方法。该方法包括评估试剂调节荷马蛋白活性的能力，荷马蛋白/免疫亲和肽 - 肽基脯氨酸顺反异构酶相互作用和/或荷马蛋白/脯氨酸型荷马配体共有序列相互作用以鉴定用于此类治疗的药剂。本发明还公开了涉及通过这些方法鉴定的试剂的治疗方式。

2. 发明申请

WO2003076593A2 GENOMIC SCREEN FOR EPIGENETICALLY SILENCED GENES ASSOCIATED WITH CANCER 审中-公开
标题翻译：用于与癌症相关的特异性沉默基因的基因组筛选
公开(公告)号：WO2003076593A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/007244
申请日：2003-03-07
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , BAYLIN, Stephen, B. , HERMAN, James, G. , SUZUKI, Hiromu
发明人： BAYLIN, Stephen, B. , HERMAN, James, G. , SUZUKI, Hiromu
IPC分类号： C12N
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/154 , C12Q2537/164
摘要： A method of identifying epigenetically silenced genes, e.g., methylation silenced genes,in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided.
摘要翻译：提供了一种在癌细胞中鉴定表观基因沉默基因，例如甲基化沉默基因的方法。此外，提供了通过检测基因表达的表观遗传学沉默来鉴定癌症的方法，以及治疗患有这种癌症的受试者例如结肠直肠癌和/或胃癌的方法。也提供了实施这种方法的试剂。

3. 发明申请

WO2003066821A2 MOLECULES INTERACTING WITH CASL (MICAL) POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USING THE SAME 审中-公开
标题翻译：与CASL（MICAL）POLYNUCLEOTIDES，POLYPEPTIDES及其使用方法相互作用的分子
公开(公告)号：WO2003066821A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003551
申请日：2003-02-04
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , KOLODKIN, Alex, L. , TERMAN, Jon, Richard , MAO, Tianyi , PASTERKAMP, Ronald, Jeroen , YU, Hung-Hsiang
发明人： KOLODKIN, Alex, L. , TERMAN, Jon, Richard , MAO, Tianyi , PASTERKAMP, Ronald, Jeroen , YU, Hung-Hsiang
IPC分类号： C12N
CPC分类号： C12N9/0071 , C07K14/47
摘要： The present invention provides MICAL and MICAL-Like polypeptides and polynucleotides. Also provided are methods that for identifying agents that affect axon growth and placement. Furthermore, provided herein are methods for affecting axon growth and placement.
摘要翻译：本发明提供MICAL和MICAL-like多肽和多核苷酸。还提供了用于鉴定影响轴突生长和放置的试剂的方法。此外，本文提供了影响轴突生长和放置的方法。

4. 发明申请

WO2003065870A2 DIGITAL AMPLIFICATION FOR DETECTION OF MISMATCH REPAIR DEFICIENT TUMOR CELLS 审中-公开
标题翻译：用于检测缺陷修复缺血性肿瘤细胞的数字放大
公开(公告)号：WO2003065870A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/001062
申请日：2003-01-29
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , VOGELSTEIN, Bert , TRAVERSO, Giovanni, C. , KINZLER, Kenneth, W.
发明人： VOGELSTEIN, Bert , TRAVERSO, Giovanni, C. , KINZLER, Kenneth, W.
IPC分类号： A61B
CPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q1/686 , C12Q2600/156 , C12Q2549/119 , C12Q2527/143
摘要： The detection of mutations in fecal DNA represents a promising, non-invasive approach for detecting colorectal cancers in average risk populations. One of the first practical applications of this technology involves the examination of microsatellite markers to sporadic cancers with mismatch repair deficiencies. As such cancers nearly always occur in the proximal colon, this test is useful as an adjunct to sigmoidoscopy, which detects only distal colorectal lesions.
摘要翻译：检测粪便DNA中的突变代表了一种有希望的非侵入性方法，用于检测平均危险人群中的结肠直肠癌。该技术的第一个实际应用之一涉及将微卫星标记物检查到具有错配修复缺陷的散发性癌症。因为这样的癌症几乎总是发生在近端结肠，这个测试是有用的乙状结肠镜检查的附件，只检测远端结肠直肠病变。

5. 发明申请

WO2003048332A2 METHODS FOR ANALYZING METHYLATED CpG ISLANDS AND GC RICH REGIONS 审中-公开
标题翻译：用于分析甲基化CpG岛和GC丰富地区的方法
公开(公告)号：WO2003048332A2
公开(公告)日：2003-06-12
申请号：PCT/US2002/038713
申请日：2002-12-02
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , FEINBERG, Andrew, P.
发明人： FEINBERG, Andrew, P.
IPC分类号： C12N
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： The present invention provides CpG islands and GC rich regions and methods for identifying methylation states for these CpG islands and GC rich regions. The present invention also provides methods for identifying genes regulated by these CpG islands and GC rich regions, and provides methods for identifying a population of CpG islands and GC rich regions in a genome.
摘要翻译：本发明提供了CpG岛和GC富集区以及用于鉴定这些CpG岛和GC富集区的甲基化状态的方法。本发明还提供了鉴定由这些CpG岛和富含GC区域调节的基因的方法，并且提供了用于鉴定基因组中CpG岛群和GC富集区的群体的方法。

6. 发明申请

WO2003022863A1 SECRETED AND CELL SURFACE GENES EXPRESSED IN BENIGN AND MALIGNANT COLORECTAL TUMORS 审中-公开
标题翻译：分泌和细胞表面基因表达于胆管和恶性色素性肿瘤
公开(公告)号：WO2003022863A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028518
申请日：2002-09-09
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , BUCKHAULTS, Phillip , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
发明人： BUCKHAULTS, Phillip , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C07H21/04
CPC分类号： C07K14/495 , C07K14/47 , C07K14/705
摘要： Serial analysis of gene expression (SAGE) was used to identify transcripts encoding secreted or cell-surface proteins that were expressed in benign and malignant tumors of the colorectum. A total of 290,394 tags were analyzed from normal, adenomatous and cancerous colonic epithelium. Of the 21,343 different transcripts observed, 957 were found to be differentially expressed between normal and adenoma or between normal and cancer. Forty-nine transcripts were elevated ≥ 20-fold in adenomas, 40 transcripts were elevated ≥ 20-fold in cancers, and nine transcripts were elevated ≥ 20-fold in both. Product of six these nine transcripts (TGFBI, LYS, RDP, MIC-1, REGA, and DEHL) were predicted to be secreted or to reside on the cell surface and these were analyzed in more detail. The abnormal expression levels predicted by SAGE were confirmed by quantitative PCR analyses of each of these six genes. Moreover, the cell types responsible for the elevated expression were identified by in situ hybridization and by PCR analyses of epithelial cells immunoaffinity purified from primary tumors.
摘要翻译：基因表达（SAGE）的序列分析用于鉴定在结肠直肠癌和恶性肿瘤中表达的编码分泌的或细胞表面蛋白的转录物。从正常，腺瘤和癌性结肠上皮分析总共290,394个标签。在观察到的21,343种不同的转录物中，957被发现在正常和腺瘤之间或在正常和癌症之间差异表达。在腺瘤中，49个转录本升高了20倍，40个转录物在癌症中升高了20倍，而9个转录物在两者中升高了20倍。预计这六种转录本（TGFBI，LYS，RDP，MIC-1，REGA和DEHL）的六种产物被分泌或驻留在细胞表面上，并且更详细地分析这些转录物的产物。通过对这6种基因中的每一种进行定量PCR分析证实SAGE预测的异常表达水平。此外，通过原位杂交和通过从原发性肿瘤纯化的上皮细胞免疫亲和素的PCR分析来鉴定负责升高的表达的细胞类型。

7. 发明申请

WO2002068694A1 DIFFERENTIALLY METHYLATED SEQUENCES IN PANCREATIC CANCER 审中-公开
标题翻译：胰腺癌中的差异化甲基化序列
公开(公告)号：WO2002068694A1
公开(公告)日：2002-09-06
申请号：PCT/US2002/005681
申请日：2002-02-25
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , GOGGINS, Michael, G. , UEKI, Takashi
发明人： GOGGINS, Michael, G. , UEKI, Takashi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having said cellular proliferative, thereby detecting a cellular proliferative disorder in the subject.
摘要翻译：本发明提供了一种用于检测受试者中细胞增殖性疾病的方法。该方法包括使来自受试者的含有核酸的样品与提供基因的至少一个基因或相关调节区的甲基化状态的测定并鉴定基因或调节区的区域的异常甲基化的试剂接触，其中当与不具有所述细胞增殖的受试者的基因或相关调节区的相同区域相比时，异常甲基化被鉴定为不同，从而检测受试者的细胞增殖性疾病。

8. 发明申请

WO1997046705A1 METHYLATION SPECIFIC DETECTION 审中-公开
标题翻译：甲基特异性检测
公开(公告)号：WO1997046705A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009533
申请日：1997-06-03
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , HERMAN, James, G. , BAYLIN, Stephen, B.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125 , C12Q2531/113 , C12Q2525/185 , C12Q2535/125 , C12Q2521/331
摘要： The present invention provides a method of PCR, methylation specific PCR (MSP), for rapid identification of DNA methylation patterns in a CpG-containing nucleic acid. MSP uses the PCR reaction itself to distinguish between methylated and unmethylated DNA, which adds an improved sensitivity of methylation detection.
摘要翻译：本发明提供了PCR，甲基化特异性PCR（MSP）的方法，用于快速鉴定含CpG的核酸中的DNA甲基化模式。 MSP使用PCR反应本身区分甲基化和非甲基化DNA，增加甲基化检测的灵敏度。

9. 发明申请

WO1997040855A1 MAMMALIAN REGULATOR OF NONSENSE-MEDIATED RNA DECAY 审中-公开
标题翻译：非延迟介导的RNA抑制剂的MAMMALIAN调节剂
公开(公告)号：WO1997040855A1
公开(公告)日：1997-11-06
申请号：PCT/US1996015769
申请日：1996-10-01
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , DIETZ, Harry, C.
IPC分类号： A61K48/00
CPC分类号： G01N33/5008 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/14 , G01N33/5091 , G01N33/68
摘要： All eukaryotes that have been studied to date possess the ability to detect and degrade transcripts that contain a premature signal for the determination of translation. This process of nonsense-mediated RNA decay (NMRD) has been most comprehensively studied in the yeast Saccharomyces cerevisiae where at least three trans-acting factors (Upf1p through Upf3p) are required. The present invention provides cDNAs encoding human and murine RENT1( re gulator of n onsense t ranscripts). RENT1 is the first identified mammalian protein that contains all of the putative functional elements in Upf1p including zinc finger-like motifs and NTPase domains as well as all motifs common to members of helicase superfamily I. Moreover, expression of a chimeric protein, containing the central region of RENT1 flanked by the extreme N- and C-termini of Upf1p, complements the Upf1p-deficient phenotype in yeast.
摘要翻译：迄今为止研究的所有真核生物具有检测和降解包含用于确定翻译的过早信号的转录物的能力。在酵母酿酒酵母（Saccharomyces cerevisiae）中对这种无义介导的RNA衰变（NMRD）的这一过程进行了最全面的研究，其中需要至少三种反式作用因子（Upf1p至Upf3p）。本发明提供了编码人和鼠RENT1（正义转录本）的cDNA的cDNA。 RENT1是第一种鉴定的哺乳动物蛋白质，其中包含Upf1p中的所有推定的功能元件，包括锌指状基序和NTPase结构域以及解旋酶超家族成员共同的所有基序。此外，含有中枢的嵌合蛋白 RENT1的侧翼是Upf1p的极端N-和C-末端的区域，补充了酵母中的Upf1p缺陷表型。

10. 发明申请

WO1997035007A1 FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR-3 (FHF-3) AND METHODS OF USE 审中-公开
标题翻译： FIBROBLAST生长因子HOMOLOGOUS FACTOR-3（FHF-3）及其使用方法
公开(公告)号：WO1997035007A1
公开(公告)日：1997-09-25
申请号：PCT/US1997004641
申请日：1997-03-21
申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
发明人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE , NATHANS, Jeremy , SMALLWOOD, Philip, M. , TONG, Patrick
IPC分类号： C12N15/12
CPC分类号： C07K14/50 , A61K38/00 , C12N2799/027
摘要： A novel protein, fibroblast growth factor homologous factor-3 (FHF-3), the polynucleotide sequence encoding FHF-3, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-3 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-3.
摘要翻译：公开了一种新型蛋白质，成纤维细胞生长因子同源因子-3（FHF-3），编码FHF-3的多核苷酸序列和推定的氨基酸序列。还公开了使用FHF-3多肽和特异性结合FHF-3的多核苷酸序列和抗体的诊断和治疗方法。

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