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1. 发明申请

WO2016004111A1 SYSTEM AND METHODS FOR THE SYNCHRONIZATION OF A NON-REAL TIME OPERATING SYSTEM PC TO A REMOTE REAL-TIME DATA COLLECTING MICROCONTROLLER 审中-公开
标题翻译：用于将非实时时间操作系统PC同步到远程实时数据收集微控制器的系统和方法
公开(公告)号：WO2016004111A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/038673
申请日：2015-06-30
申请人： CERORA, INC. , SIMON, Adam, J. , KATH, Gary, S.
发明人： SIMON, Adam, J. , KATH, Gary, S. , DEVILBISS, David, M.
IPC分类号： A61B5/16
CPC分类号： G06F1/14 , A61B5/0006 , A61B5/0017 , A61B5/002 , A61B5/02405 , A61B5/044 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0533 , A61B5/1176 , A61B5/125 , A61B5/16 , A61B5/162 , A61B5/163 , A61B5/167 , A61B5/168 , A61B5/4803 , A61B5/4884 , A61B5/6803 , A61B5/7405 , A61B5/7475 , G09C1/00 , G16H50/20 , H04L67/12 , H04W4/70
摘要： A system synchronizes a PC exhibiting latency of operations to a biosensor enabled microcontroller with real-time clock by providing an encoding scheme that captures the subject's absolute reaction time transmits the subject's reaction time from the PC exhibiting latency to the microcontroller with real-time clock. The system includes a transmitter that transmits a stimulus signal from the PC exhibiting latency, an input device indicating the subject's response to the stimulus signal, an encoding circuit adapted to encode a difference in time between the stimulus signal and the subject's response to the stimulus signal, an emitter adapted to transmit the encoded difference signal representing the subject's reaction time, and a complementary receiver adapted to detect the encoded difference signal. The receiver includes a decoding circuit that decodes the encoded difference signal to determine the subject's reaction time, and the receiver provides the subject's reaction time to the microcontroller with real-time clock for synchronization with received biosensor data such as EEG data.
摘要翻译：系统通过提供捕获被摄体的绝对反应时间的编码方案将显示运行延迟的PC与具有实时时钟的生物传感器使能的微控制器同步，将来自显示潜伏期的PC的对象的反应时间从实时时钟发送到微控制器。该系统包括发送来自显示等待时间的来自PC的刺激信号的发射机，指示对象对刺激信号的响应的输入设备，编码电路，其适于编码刺激信号与被摄体对刺激信号的响应之间的时间差，适于发送表示被摄体反应时间的编码差分信号的发射器，以及适于检测编码差分信号的互补接收器。该接收机包括解码电路，其对编码的差分信号进行解码以确定被摄体的反应时间，并且接收机将该受试者的反应时间提供给具有实时时钟的微控制器，用于与所接收的生物传感器数据如EEG数据同步。

2. 发明申请

WO2016004117A1 SYSTEM AND SIGNATURES FOR A MULTI-MODAL PHYSIOLOGICAL PERIODIC BIOMARKER ASSESSMENT 审中-公开
标题翻译：多模态生理周期生物标记评估的系统和标志
公开(公告)号：WO2016004117A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/038684
申请日：2015-06-30
申请人： CERORA, INC. , SIMON, Adam, J.
发明人： SIMON, Adam, J. , DEVILBISS, David, M.
IPC分类号： A61B5/0484 , G06F19/24
CPC分类号： G06F1/14 , A61B5/0006 , A61B5/0017 , A61B5/002 , A61B5/02405 , A61B5/044 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0533 , A61B5/1176 , A61B5/125 , A61B5/16 , A61B5/162 , A61B5/163 , A61B5/167 , A61B5/168 , A61B5/4803 , A61B5/4884 , A61B5/6803 , A61B5/7405 , A61B5/7475 , G09C1/00 , G16H50/20 , H04L67/12 , H04W4/70
摘要： Methods for diagnosing Autism and/or Autism Spectrum Disorder (ASD) of a subject include establishing baseline brain wave patterns of the subject by having the subject perform a series of task and measuring brain waves during the tasks using an EEG measurement device, applying a light stimulus or images to the subject's eyes and capturing eye movements and/or changes in facial expression in response to the light stimulus or images, and giving a neuropsychological and cognition battery of tasks to the subject to generate a provoked cognitive assessment of the subject. A processing device correlates the baseline brain wave patterns, eye movements and/or facial expressions, and provoked cognitive assessment of the subject to profile data indicative of Autism and/or ASD. The corresponding system may also include an auditory testing device that tests the subject's sensitivity to sound and records the subject's speech in response to verbal tasks. The processing device performs language processing of the recorded speech and correlates the processed language to the profile data indicative of Autism and/or ASD.
摘要翻译：用于诊断受试者的自闭症和/或自闭症谱系障碍（ASD）的方法包括通过使受试者在使用EEG测量装置的任务期间执行一系列任务并测量脑波来建立受试者的基线脑波模式，应用光对受试者的眼睛的刺激或图像，并响应于光刺激或图像捕获眼睛运动和/或面部表情的变化，以及向受试者给予神经心理和认知任务的电池以产生受试者的挑衅认知评估。处理装置将基线脑波模式，眼睛运动和/或面部表情相关联，并将受试者的认知评估引导到指示自闭症和/或ASD的剖面数据。相应的系统还可以包括听觉测试装置，其测试受试者对声音的敏感度，并响应于口头任务记录受试者的言语。处理装置执行记录的语音的语言处理，并将处理的语言与指示自闭症和/或ASD的简档数据相关联。

3. 发明申请

WO2015184333A1 MULTIMODAL HEALTH ASSESSMENT WITH NEURO-OPTHALMOLOGICAL SACCADE TESTS 审中-公开
标题翻译：具有神经 - 眼科学SACCADE测试的多元健康评估
公开(公告)号：WO2015184333A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/033294
申请日：2015-05-29
申请人： CERORA, INC. , SIMON, Adam, J.
发明人： SIMON, Adam, J. , DEVILBISS, David, M.
IPC分类号： A61B3/02 , A61B5/04 , G06K9/00
CPC分类号： A61B5/4064 , A61B3/02 , A61B5/04842 , A61B5/0496 , A61B5/1103 , A61B5/1128
摘要： A system and method for assessing brain health includes presenting a saccade test to a subject and capturing biological sensor data of the subject in response to the saccade test using a plurality of biological sensors. Saccade cards are employed to measure the brain health of a subject through collection of eye tracking data, for example. Saccade cards using a variety of design elements besides numbers are used for collection of the eye tracking data and other biological data. The captured biological data is used to create a multi-variate signature of the brain health condition of the subject.
摘要翻译：用于评估脑健康的系统和方法包括：对受试者进行扫视测试，并响应于使用多个生物传感器的扫视测试来捕获对象的生物传感器数据。例如，通过收集眼睛跟踪数据，可以使用Saccade卡来测量受试者的大脑健康状况。使用除数字以外的各种设计元素的Saccade卡用于收集眼睛跟踪数据和其他生物数据。捕获的生物数据用于创建受试者的大脑健康状况的多变量签名。

4. 发明申请

WO2017184609A1 PROTOCOL AND SIGNATURES FOR THE MULTIMODAL PHYSIOLOGICAL STIMULATION AND ASSESSMENT OF TRAUMATIC BRAIN INJURY 审中-公开
标题翻译：多形性生理刺激和评估创伤性脑损伤的方案和签名
公开(公告)号：WO2017184609A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028147
申请日：2017-04-18
申请人： SIMON, Adam, J. , DEVILBISS, David, M.
发明人： SIMON, Adam, J. , DEVILBISS, David, M.
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0478 , A61B5/0484 , A61B5/16 , A61B7/04
CPC分类号： A61B5/0484 , A61B5/4064 , A61B5/7207 , A61B5/7257
摘要： A system and method for assessing brain function is disclosed that comprises electronically recording biologic information of a user with one or more electronics modules as the user progresses through a series of cognitive, sensory, activation, and/or stimulation tasks. The method includes extracting one or more data features from the record biologic information to obtain extracted data features. The method includes analyzing the extracted data features for each task so to develop a predictive outcome assessment of one or more brain conditions of the user, wherein predictive outcome assessment is at least one of a) an injury determination, b) a brain injury index, or c) a brain health assessment. Medical therapy is provided to the user in accordance with the predictive outcome assessment.
摘要翻译：公开了一种用于评估脑功能的系统和方法，其包括在用户通过一系列认知，感觉，激活和/或预测时进行电子记录具有一个或多个电子模块的用户的生物信息刺激任务。该方法包括从记录生物信息提取一个或多个数据特征以获得提取的数据特征。该方法包括分析用于每个任务的提取的数据特征，以便开发用户的一个或多个大脑状况的预测性结果评估，其中预测性结果评估是以下中的至少一个：a）损伤确定，b）脑损伤指数，或c）大脑健康评估。根据预测结果评估向用户提供药物治疗。

5. 发明申请

WO2013012739A1 SYSTEMS AND METHODS FOR THE PHYSIOLOGICAL ASSESSMENT OF BRIAN HEALTH AND THE REMOTE QUALITY CONTROL OF EEG SYSTEMS 审中-公开
标题翻译： BRIAN健康生理评估系统与方法及脑电系统远程质量控制
公开(公告)号：WO2013012739A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046723
申请日：2012-07-13
申请人： SIMON, Adam, J. , DEVILBISS, David, M.
发明人： SIMON, Adam, J. , DEVILBISS, David, M.
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/0006 , A61B5/048 , A61B5/4088 , A61B5/7221 , A61B2560/0223 , G01D18/002
摘要： A system for calibrating and/or verifying system performance of a remote portable EEG system having at least one EEG sensor. Embodiments of the invention can provide various reference signals to calibrate and quality control the remote performance of the data acquisition EEG system. In addition a calibration cable connects a reference signal source to the EEG sensors to enable remote calibration and quality control assessment. Further, a diagnostic biomarker is included to assess the state or function of a subject's brain and enables the classification, prognosis, diagnosis, monitoring of treatment, or response to therapy applied to the brain by measuring any one of a list of candidate features extracted from a given cognitive or sensory task, and measuring changes in the EEG feature and task combination over time, among multiple states, or compared to a normative database.
摘要翻译：一种用于校准和/或验证具有至少一个EEG传感器的远程便携式EEG系统的系统性能的系统。本发明的实施例可以提供各种参考信号来校准和质量控制数据采集EEG系统的远程性能。此外，校准电缆将参考信号源连接到EEG传感器，以实现远程校准和质量控制评估。此外，包括诊断性生物标志物以评估受试者的大脑的状态或功能，并且通过测量从大脑中提取的候选特征的列表中的任一个来进行分类，预后，诊断，治疗监测或对大脑应用的反应给定的认知或感官任务，并且在多个状态之间测量EEG特征和任务组合的变化，或与规范数据库进行比较。

6. 发明申请

WO2017184609A8 PROTOCOL AND SIGNATURES FOR THE MULTIMODAL PHYSIOLOGICAL STIMULATION AND ASSESSMENT OF TRAUMATIC BRAIN INJURY 审中-公开
公开(公告)号：WO2017184609A8
公开(公告)日：2017-10-26
申请号：PCT/US2017/028147
申请日：2017-04-18
申请人： CERORA, INC.
发明人： DEVILBISS, David, M. , SIMON, Adam, J.
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0478 , A61B5/0484 , A61B5/16 , A61B7/04
摘要： A system and method for assessing brain function is disclosed that comprises electronically recording biologic information of a user with one or more electronics modules as the user progresses through a series of cognitive, sensory, activation, and/or stimulation tasks. The method includes extracting one or more data features from the record biologic information to obtain extracted data features. The method includes analyzing the extracted data features for each task so to develop a predictive outcome assessment of one or more brain conditions of the user, wherein predictive outcome assessment is at least one of a) an injury determination, b) a brain injury index, or c) a brain health assessment. Medical therapy is provided to the user in accordance with the predictive outcome assessment.

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