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1. 发明申请

WO2009102776A2 TISSUE-FASTENING ARTICLES AND DEVICES, AND RELATED METHODS 审中-公开
标题翻译：组织紧固制品和装置及相关方法
公开(公告)号：WO2009102776A2
公开(公告)日：2009-08-20
申请号：PCT/US2009033777
申请日：2009-02-11
申请人： CELONOVA BIOSCIENCES INC , FRITZ ULF , FRITZ OLAF , WOJCIK RONALD , GASKINS RALPH E
发明人： FRITZ ULF , FRITZ OLAF , WOJCIK RONALD , GASKINS RALPH E
IPC分类号： A61B17/068 , A61B17/04
CPC分类号： A61L31/06 , A61B17/06166 , A61B17/064 , A61B17/1227 , A61L17/06 , A61L17/145 , A61L31/10 , C08L85/02
摘要： Suitable tissue-fastening articles and devices that can incorporate and/or be encapsulated by one or more potyphosphazenes are provided, including various surgical fastening devices ('SFD'), sutures, surgical staples, screws, and other equivalent tissue-fastening devices, which exhibit exceilent mechanical and physical tolerance properties, in order to improve the biocompatibiiity of such sheathed implanted devices, and to prevent or diminish various secondary injuries following a treatment or an implantation. The poiyphosphazenes coating of various tissue-fastening articles and devices imparts substantial advantages to such articles and devices, including the prevention or minimization of uncontroiled cellular growth, and reduction in various inflammatory reactions following the implantation of a foreign material into a patient's body, and thereby, reducing the amount of antibiotics necessary to treat infections attendant with such implantation and subsequent inflammatory reactions.
摘要翻译：提供了可以包含和/或被一种或多种磷酰胺封装的合适的组织紧固制品和装置，包括各种外科紧固装置（'SFD'），缝合线，外科缝合钉，螺钉以及其他等同的组织紧固装置表现出优异的机械和物理耐受性能，以便改善这种护套植入装置的生物相容性，并预防或减少治疗或植入后的各种继发性损伤。各种组织紧固制品和装置的聚磷腈涂层赋予这些制品和装置显着的优点，包括防止或最小化不受抑制的细胞生长，以及在将异物植入患者体内之后减少各种炎症反应，并由此，减少治疗伴随着这种植入和随后的炎症反应伴随的感染所必需的抗生素的量。

2. 发明申请

WO2009110858A2 VASODILATOR ELUTING DYNAMIC BLOOD HANDLING DEVICES WITH A SPECIFIC POLYPHOSPHAZENE COATING AND METHODS FOR THEIR MANUFACTURE AND USE 审中-公开
标题翻译：具有特殊多磷酸涂层的血管加压器动态血液处理装置及其制造和使用方法
公开(公告)号：WO2009110858A2
公开(公告)日：2009-09-11
申请号：PCT/US2007083192
申请日：2007-10-31
申请人： CELONOVA BIOSCIENCES INC , FRITZ OLAF , FRITZ ULF , DENK ROMAN , WILSON TERESA , GASKINS RALPH E
发明人： FRITZ OLAF , FRITZ ULF , DENK ROMAN , WILSON TERESA , GASKINS RALPH E
IPC分类号： A61L33/06 , A61J1/05
CPC分类号： A61L29/085 , C08L85/02
摘要： The present invention is directed to medical devices in which flow is channeled of blood and blood products for the purpose of effecting a chemical exchange to remove desired chemicals from the blood or blood products, and to impart nitric oxide, other smooth muscle relaxant compounds, or other desired chemicals to the blood or blood products to achieve vascular dilatation, reduce adverse reactions, reduce thrombosis, reduce red blood cell injuries, and improve blood handling capabilities. In the present invention, such chemical exchanges occur over semipermeable membranes associated with channeled flow of blood and blood products. Various embodiments of the present invention thus apply to the clinical settings for filters, cannulae, tubing, and blood handling components for dynamic blood handling, filtering, and processing devices including, but not limited to, cardiopulmonary bypass pumps, left ventricular assist devices, artificial hearts, ECMO devices, renal or hepatic hemodialysis systems, and hemofiltration systems.
摘要翻译：本发明涉及医疗装置，其中为了进行化学交换以从血液或血液制品中除去所需化学物质，以及赋予一氧化氮，其它平滑肌松弛剂化合物或血液和血液制品其他需要化学物质的血液或血液制品实现血管扩张，减少不良反应，减少血栓形成，减少红细胞损伤，改善血液处理能力。在本发明中，这种化学交换发生在与血液和血液制品的通道流动相关的半透膜上。因此，本发明的各种实施例适用于用于动态血液处理，过滤和处理装置的过滤器，套管，管道和血液处理组件的临床设置，包括但不限于体外循环泵，左心室辅助装置，人造心脏，ECMO装置，肾或肝血液透析系统和血液滤过系统。

3. 发明申请

WO2008045953A8 COMPOSITIONS AND DEVICES COMRISING SILICONE AND SPECIFIC POLYPHOSPHAZENES 审中-公开
标题翻译：组合物和器件共聚硅胶和特殊多晶硅
公开(公告)号：WO2008045953A8
公开(公告)日：2009-08-06
申请号：PCT/US2007080976
申请日：2007-10-10
申请人： CELONOVA BIOSCIENCES INC , GORDY THOMAS A , UNG NENG S , FRITZ ULF , FRITZ OLAF , WOJCIK RONALD
发明人： GORDY THOMAS A , UNG NENG S , FRITZ ULF , FRITZ OLAF , WOJCIK RONALD
IPC分类号： A61L27/26
CPC分类号： A61L27/26 , C08G77/045 , C08G77/12 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/24 , C08G77/26 , C08G77/28 , C08G77/30 , C08G77/32 , C08G77/70 , C08G77/80 , C08L83/04 , C08L85/02 , C08L83/00
摘要： The present invention relates to compositions and medical devices comprising both polyorganosiloxane and polyphosphazene compounds. When incorporated into or onto medical devices, these compositions reduce cell encrustation on the device and reduce the severity of thrombosis when the devices are in contact with body fluids, and impart anti-rejection properties to the device.
摘要翻译：本发明涉及包含聚有机硅氧烷和聚磷腈化合物的组合物和医疗装置。当结合到医疗装置中或其上时，这些组合物减少装置上的细胞结垢并且当装置与体液接触时降低血栓形成的严重性，并赋予装置抗拒性能。

4. 发明申请

WO2009054853A9 LOADABLE POLYMERIC PARTICLES FOR COSMETIC AND RECONSTRUCTIVE TISSUE AUGMENTATION APPLICATIONS AND METHODS OF PREPARING AND USING THE SAME 审中-公开
标题翻译：用于化妆品和重构组织增强的可载荷聚合物颗粒应用和制备和使用该组合物的方法
公开(公告)号：WO2009054853A9
公开(公告)日：2009-07-16
申请号：PCT/US2007082651
申请日：2007-10-26
申请人： CELONOVA BIOSCIENCES INC , GORDY THOMAS A , FRITZ OLAF , FRITZ ULF , WOJCIK RONALD , WILSON TERESA , JACOBSON HARRY R
发明人： GORDY THOMAS A , FRITZ OLAF , FRITZ ULF , WOJCIK RONALD , WILSON TERESA , JACOBSON HARRY R
IPC分类号： C08G79/00 , A61K49/00 , A61L31/00 , C08G79/02 , C08J3/00 , C08J3/12 , C08L85/00 , C08L85/02
CPC分类号： A61L24/0015 , A61K8/84 , A61K49/0089 , A61K2800/91 , A61L24/0031 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/442 , A61L2300/602 , A61L2300/622 , A61L2400/06 , A61Q19/00 , C08F220/14 , C08F222/1006 , C08G79/025 , C08J3/00 , C08J3/12 , C08J2333/04 , C08J2333/14 , C08L33/04 , C08L33/14 , C09D185/02 , C08L85/02
摘要： Particles are provided for use in therapeutic cosmetic and/or reconstructive procedures to augment defects in tissue to restore contours and/or function. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired tissues. Moreover, such particles may be loaded to provide localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided or used in conjunction with tissue adhesives or photoinitiator agents that may be activated by electromagnetic radiation or other energy sources to allow post-implantation cross-linking of the polymeric particles to cause their amalgamation to maintain their shape and location following implantation.
摘要翻译：提供颗粒用于治疗化妆品和/或重建程序以增加组织中的缺陷以恢复轮廓和/或功能。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或存在于颗粒的外部涂层内。颗粒还可以包括具有由丙烯酸基聚合物形成的水凝胶的核。这样的颗粒可以以各种颜色或以定制的着色来提供给使用者以匹配期望的组织。而且，这些颗粒可以被加载以在特定的临床用途中用活性成分试剂提供局部治疗。本发明的颗粒可以进一步提供或结合组织粘合剂或光引发剂使用，所述组合物可以通过电磁辐射或其它能量源活化，以允许聚合物颗粒的植入后交联以使它们的合并保持其形状和植入后的位置。

5. 发明申请

WO2009105761A3 MULTI-FUNCTIONAL WOUND DRESSING MATRICES AND RELATED METHODS 审中-公开
标题翻译：多功能伤口敷料矩阵及相关方法
公开(公告)号：WO2009105761A3
公开(公告)日：2009-11-26
申请号：PCT/US2009034893
申请日：2009-02-23
申请人： CELONOVA BIOSCIENCES INC , FRITZ ULF , FRITZ OLAF , GORDY THOMAS A
发明人： FRITZ ULF , FRITZ OLAF , GORDY THOMAS A
IPC分类号： A61L15/22 , A61F13/02 , A61L15/42
CPC分类号： A61F13/00063 , A61F13/0206 , A61L15/26 , C08L85/02
摘要： Various embodiments are directed to multi-functional wound-care dressing matrices that can protect and promote new tissue growth at a wound site. The multi-functional wound care matrix can incorporate poiyphosphazenes of formula I, as a component that can be configured into various forms, including as fibrous mats, porous membranes, nonporous films, particulate formulations, and equivalents, The multifunctional wound-care dressing matrix of the present disclosure exhibit high-performance properties conferred by poiyphosphazenes of formula L Exceptional biocompatible properties of poiyphosphazenes of formula I provide an ideal tissue-contacting surface for the multi-functional wound- care dressing matrix of interest.
摘要翻译：各种实施方案涉及多功能伤口护理敷料基质，其可以保护和促进伤口部位处的新组织生长。多功能伤口护理基质可以掺入式I的聚磷腈作为可以配置成各种形式的组分，包括纤维垫，多孔膜，无孔膜，颗粒制剂和等同物。多功能伤口护理敷料基质本公开内容呈现由式L的聚磷腈所赋予的高性能性质。式I的聚磷腈的特殊生物相容性性质为感兴趣的多功能伤口护理敷料基质提供理想的组织接触表面。

6. 发明申请

WO2008045949A2 BIOPROSTHETIC HEART VALVE WITH POLYPHOSPHAZENE 审中-公开
标题翻译：具有多磷酸盐的生物心脏瓣膜
公开(公告)号：WO2008045949A2
公开(公告)日：2008-04-17
申请号：PCT/US2007080969
申请日：2007-10-10
申请人： CELONOVA BIOSCIENCES INC , GORDY THOMAS A , UNG NENG S , FRITZ ULF , FRITZ OLAF
发明人： GORDY THOMAS A , UNG NENG S , FRITZ ULF , FRITZ OLAF
CPC分类号： A61L27/3641 , A61L27/34 , A61L27/3604 , A61L27/3645 , A61L27/3683 , A61L27/40 , A61L27/507 , C08L85/02
摘要： This disclosure encompasses a bioprosthetic heart valve having a polyphosphazene polymer such as poly[bis(trifluoroethoxy)phosphazene], which exhibits improved antithrombogenic, biocompatibility, and hemocompatibility properties. A method of manufacturing a bioprosthetic heart valve having a polyphosphazene polymer is also described.
摘要翻译：该公开内容包括具有聚磷腈聚合物如聚[双（三氟乙氧基）磷腈]的生物假体心脏瓣膜，其具有改善的抗血栓形成，生物相容性和血液相容性。还描述了制造具有聚磷腈聚合物的生物假体心脏瓣膜的方法。

7. 发明申请

WO2008045953A2 COMPOSITIONS AND DEVICES COMRISING SILICONE AND SPECIFIC POLYPHOSPHAZENES 审中-公开
标题翻译：组合物和器件共聚硅胶和特殊多晶硅
公开(公告)号：WO2008045953A2
公开(公告)日：2008-04-17
申请号：PCT/US2007080976
申请日：2007-10-10
申请人： CELONOVA BIOSCIENCE INC , GORDY THOMAS A , UNG NENG S , FRITZ ULF , FRITZ OLAF , WOJCIK RONALD
发明人： GORDY THOMAS A , UNG NENG S , FRITZ ULF , FRITZ OLAF , WOJCIK RONALD
CPC分类号： A61L27/26 , C08G77/045 , C08G77/12 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/24 , C08G77/26 , C08G77/28 , C08G77/30 , C08G77/32 , C08G77/70 , C08G77/80 , C08L83/04 , C08L85/02 , C08L83/00
摘要： The present invention relates to compositions and medical devices comprising both polyorganosiloxane and polyphosphazene compounds. When incorporated into or onto medical devices, these compositions reduce cell encrustation on the device and reduce the severity of thrombosis when the devices are in contact with body fluids, and impart anti-rejection properties to the device.
摘要翻译：本发明涉及包含聚有机硅氧烷和聚磷腈化合物的组合物和医疗装置。当结合到医疗装置中或其上时，这些组合物减少装置上的细胞结垢并且当装置与体液接触时降低血栓形成的严重性，并赋予装置抗拒性能。

8. 发明申请

WO2006046155A3 LOADABLE POLYPHOSPHAZENE-COMPRISING PARTICLES FOR THERAPEUTIC AND/OR DIAGNOSTIC APPLICATIONS AND METHODS OF PREPARING AND USING THE SAME 审中-公开
标题翻译：用于治疗和/或诊断应用的负载型聚磷脂包封颗粒及其制备和使用方法
公开(公告)号：WO2006046155A3
公开(公告)日：2006-08-17
申请号：PCT/IB2005004007
申请日：2005-10-24
申请人： POLYZENIX GMBH , HARDER PHILLIP , FRITZ OLAF , FRITZ ULF
发明人： HARDER PHILLIP , FRITZ OLAF , FRITZ ULF
IPC分类号： A61K9/16 , A61K9/50 , A61K9/51
CPC分类号： A61K9/5031 , A61K9/1641 , A61K9/1694 , A61K9/5073 , A61K9/5078 , A61K9/5089 , A61K49/0404 , A61K49/0419
摘要： Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to the core of the particles as a coating or absorbed within the core of the particles. The particles can be used to minimize blood flow to mammalian tissues by occluding at least a portion of a blood vessel of the mammal, or to deliver an active agent to a localized area within a body of a mammal by contacting a localized area with at least one of the particles. Further, the particles are useful in sustained release formulations including active agent(s) for oral administration, as tracer particles for injection into the bloodstream of a mammal or for use in enhanced ultrasound imaging. The particles may include agents for increasing density for achieving useful buoyancy levels in suspension.
摘要翻译：颗粒被提供用于治疗和/或诊断过程。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或颗粒的外涂层内。颗粒还可以包括具有由丙烯酸类聚合物形成的水凝胶的芯。也可以将硫酸钡作为涂层提供到颗粒的芯部或者被吸收在颗粒的芯中。颗粒可以用于通过闭塞哺乳动物的血管的至少一部分来最小化对哺乳动物组织的血流，或者通过使至少一个局部区域与至少一个局部区域接触而将活性剂递送到哺乳动物体内的局部区域其中一颗颗粒。此外，该颗粒可用于持续释放制剂，包括用于口服给药的活性剂，作为用于注射到哺乳动物血流中的示踪剂颗粒或用于增强的超声成像。颗粒可以包括增加密度的试剂，以实现悬浮液中有用的浮力水平。

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