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1. 发明申请

WO2009054853A9 LOADABLE POLYMERIC PARTICLES FOR COSMETIC AND RECONSTRUCTIVE TISSUE AUGMENTATION APPLICATIONS AND METHODS OF PREPARING AND USING THE SAME 审中-公开
标题翻译：用于化妆品和重构组织增强的可载荷聚合物颗粒应用和制备和使用该组合物的方法
公开(公告)号：WO2009054853A9
公开(公告)日：2009-07-16
申请号：PCT/US2007082651
申请日：2007-10-26
申请人： CELONOVA BIOSCIENCES INC , GORDY THOMAS A , FRITZ OLAF , FRITZ ULF , WOJCIK RONALD , WILSON TERESA , JACOBSON HARRY R
发明人： GORDY THOMAS A , FRITZ OLAF , FRITZ ULF , WOJCIK RONALD , WILSON TERESA , JACOBSON HARRY R
IPC分类号： C08G79/00 , A61K49/00 , A61L31/00 , C08G79/02 , C08J3/00 , C08J3/12 , C08L85/00 , C08L85/02
CPC分类号： A61L24/0015 , A61K8/84 , A61K49/0089 , A61K2800/91 , A61L24/0031 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/442 , A61L2300/602 , A61L2300/622 , A61L2400/06 , A61Q19/00 , C08F220/14 , C08F222/1006 , C08G79/025 , C08J3/00 , C08J3/12 , C08J2333/04 , C08J2333/14 , C08L33/04 , C08L33/14 , C09D185/02 , C08L85/02
摘要： Particles are provided for use in therapeutic cosmetic and/or reconstructive procedures to augment defects in tissue to restore contours and/or function. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired tissues. Moreover, such particles may be loaded to provide localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided or used in conjunction with tissue adhesives or photoinitiator agents that may be activated by electromagnetic radiation or other energy sources to allow post-implantation cross-linking of the polymeric particles to cause their amalgamation to maintain their shape and location following implantation.
摘要翻译：提供颗粒用于治疗化妆品和/或重建程序以增加组织中的缺陷以恢复轮廓和/或功能。颗粒包括聚[双（三氟乙氧基）磷腈]和/或其衍生物，其可以存在于整个颗粒中或存在于颗粒的外部涂层内。颗粒还可以包括具有由丙烯酸基聚合物形成的水凝胶的核。这样的颗粒可以以各种颜色或以定制的着色来提供给使用者以匹配期望的组织。而且，这些颗粒可以被加载以在特定的临床用途中用活性成分试剂提供局部治疗。本发明的颗粒可以进一步提供或结合组织粘合剂或光引发剂使用，所述组合物可以通过电磁辐射或其它能量源活化，以允许聚合物颗粒的植入后交联以使它们的合并保持其形状和植入后的位置。

2. 发明申请

WO2009110858A2 VASODILATOR ELUTING DYNAMIC BLOOD HANDLING DEVICES WITH A SPECIFIC POLYPHOSPHAZENE COATING AND METHODS FOR THEIR MANUFACTURE AND USE 审中-公开
标题翻译：具有特殊多磷酸涂层的血管加压器动态血液处理装置及其制造和使用方法
公开(公告)号：WO2009110858A2
公开(公告)日：2009-09-11
申请号：PCT/US2007083192
申请日：2007-10-31
申请人： CELONOVA BIOSCIENCES INC , FRITZ OLAF , FRITZ ULF , DENK ROMAN , WILSON TERESA , GASKINS RALPH E
发明人： FRITZ OLAF , FRITZ ULF , DENK ROMAN , WILSON TERESA , GASKINS RALPH E
IPC分类号： A61L33/06 , A61J1/05
CPC分类号： A61L29/085 , C08L85/02
摘要： The present invention is directed to medical devices in which flow is channeled of blood and blood products for the purpose of effecting a chemical exchange to remove desired chemicals from the blood or blood products, and to impart nitric oxide, other smooth muscle relaxant compounds, or other desired chemicals to the blood or blood products to achieve vascular dilatation, reduce adverse reactions, reduce thrombosis, reduce red blood cell injuries, and improve blood handling capabilities. In the present invention, such chemical exchanges occur over semipermeable membranes associated with channeled flow of blood and blood products. Various embodiments of the present invention thus apply to the clinical settings for filters, cannulae, tubing, and blood handling components for dynamic blood handling, filtering, and processing devices including, but not limited to, cardiopulmonary bypass pumps, left ventricular assist devices, artificial hearts, ECMO devices, renal or hepatic hemodialysis systems, and hemofiltration systems.
摘要翻译：本发明涉及医疗装置，其中为了进行化学交换以从血液或血液制品中除去所需化学物质，以及赋予一氧化氮，其它平滑肌松弛剂化合物或血液和血液制品其他需要化学物质的血液或血液制品实现血管扩张，减少不良反应，减少血栓形成，减少红细胞损伤，改善血液处理能力。在本发明中，这种化学交换发生在与血液和血液制品的通道流动相关的半透膜上。因此，本发明的各种实施例适用于用于动态血液处理，过滤和处理装置的过滤器，套管，管道和血液处理组件的临床设置，包括但不限于体外循环泵，左心室辅助装置，人造心脏，ECMO装置，肾或肝血液透析系统和血液滤过系统。

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