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    • 10. 发明申请
    • METHODS AND DEVICES FOR ROTATOR CUFF REPAIR
    • ROTATOR CUFF维修的方法和设备
    • WO2007092464A2
    • 2007-08-16
    • PCT/US2007/003185
    • 2007-02-05
    • TEPHA, INC.COLEMAN, StruanMARTIN, David, P.RIZK, SaidAHUJA, AjayWILLIAMS, Simon, F.
    • COLEMAN, StruanMARTIN, David, P.RIZK, SaidAHUJA, AjayWILLIAMS, Simon, F.
    • A61L27/00A61F2/08
    • A61F2/08A61B17/0401A61B17/0469A61B17/064A61B17/0642A61B2017/00893A61L27/18A61L2430/10C08L67/04
    • Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti- adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
    • 已经开发了用于腱和韧带修复的包括肩袖修复的插入和增强装置以及使用关节镜方法进行输送的方法。 该装置优选衍生自生物相容性聚羟基链烷酸酯,优选衍生自4-羟基丁酸酯的共聚物或均聚物。 这些装置可以关节镜地传送,并且提供额外的益处,例如支持手术修复,高初始强度,体内延长的强度保持力,柔韧性,抗粘连性,改善的生物相容性,体内重塑健康组织的能力,最小 疾病传播的风险或增强感染的选择,包括足够高的强度的选项,以防止缝合线拉出或植入装置的其他脱离,最终吸收消除异物反应的未来风险或干扰后续程序,有竞争力的成本, 长期的机械稳定性。 这些装置还特别适用于儿科人群,其最终吸收不应阻碍生长。