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1. 发明申请

WO2007092417A1 TOUGHENED POLYLACTIC ACID POLYMERS AND COPOLYMERS 审中-公开
标题翻译：增韧聚酰胺聚合物和共聚物
公开(公告)号：WO2007092417A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/003100
申请日：2007-02-06
申请人： TEPHA, INC. , RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
发明人： RIZK, Said , MARTIN, David, P. , HO, Kicherl , GANATRA, Amit , WILLIAMS, Simon, F.
IPC分类号： A61L15/22 , A61L17/12 , A61L27/26 , A61L29/04 , A61L31/04 , C08L67/04
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Toughened compositions of PLA and PLA copolymers are disclosed, which also have low tensile modulus values and greater elongation to break. These toughened compositions are prepared by blending PLA and PLA copolymers with poly-4-hydroxybutyrate, and copolymers thereof. Blending of ρoly-4-hydroxybutyrate with PLA and its copolymers has been found to impart advantageous properties to the resulting blend. These compositions, and objects formed from these compositions, have improved toughness and lower stiffness than polylactic acid polymers or copolymers alone.
摘要翻译：公开了PLA和PLA共聚物的增韧组合物，其也具有低拉伸模量值和较大的断裂伸长率。这些增韧的组合物通过将PLA和PLA共聚物与聚-4-羟基丁酸酯及其共聚物共混来制备。已经发现丙烯酸4-羟基丁酸酯与PLA及其共聚物的混合赋予所得共混物有利的性质。这些组合物和由这些组合物形成的物体比单独的聚乳酸聚合物或共聚物具有改善的韧性和较低的刚度。

2. 发明申请

WO2009085823A1 MEDICAL DEVICES CONTAINING MELT-BLOWN NON-WOVENS OF POLY-R-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含有聚R-羟基丁酸酯和共聚物的熔融非织造物的医疗装置
公开(公告)号：WO2009085823A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087159
申请日：2008-12-17
申请人： TEPHA, INC. , HO, Kicherl , WILLIAMS, Simon, F. , RIZK, Said , MARTIN, David, P.
发明人： HO, Kicherl , WILLIAMS, Simon, F. , RIZK, Said , MARTIN, David, P.
IPC分类号： D04H1/56 , A61L17/10
CPC分类号： A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric non- wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4- hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly- 4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non- woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高爆裂强度，平均直径为1μm至50μm的细纤维和厚度为10μm至50mm。通过允许无纺布的纤维在网收集期间最初保持熔融，可以实现改进的纤维内聚力。在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的无纺布，其中无纺布具有大于0.1Kgff的破裂强度，其中无纺织物通过连续熔喷法得到。无纺布可以用于各种目的，包括制造医疗装置。

3. 发明申请

WO2008070428A2 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：WO2008070428A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/084991
申请日：2007-11-16
申请人： TEPHA, INC. , RIZK, Said , MARTIN, David, P. , HO, Kicherl , WILLIAMS, Simon, F.
发明人： RIZK, Said , MARTIN, David, P. , HO, Kicherl , WILLIAMS, Simon, F.
IPC分类号： A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm 2 , tensile modulus less than 181 kgf/mm 2 , and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2， 2℃，断裂伸长率为10-500％，其中该膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个膜中定向至超过膜的原始长度的25％方向。这些可以用于各种目的，包括制造医疗器械。

4. 发明申请

WO2004101002A2 POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS 审中-公开
标题翻译：聚羟基烷基酯医用纺织品和纤维
公开(公告)号：WO2004101002A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/013475
申请日：2004-04-30
申请人： TEPHA, INC. , MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
发明人： MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
IPC分类号： A61L
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和手术网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。这些装置提供比目前可获得的更广泛的体内强度保持性能，并且可以提供额外的益处，例如抗粘附性质，降低的感染风险或由于吸收和最终消除装置而导致的其他手术后问题，以及有竞争力的成本。该装置还可以特别适用于儿科人群，其吸收不应妨碍生长，并且在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合以提供具有改进的机械，生物和处理性质的植入物。

5. 发明申请

WO2007092464A2 METHODS AND DEVICES FOR ROTATOR CUFF REPAIR 审中-公开
标题翻译： ROTATOR CUFF维修的方法和设备
公开(公告)号：WO2007092464A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003185
申请日：2007-02-05
申请人： TEPHA, INC. , COLEMAN, Struan , MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
发明人： COLEMAN, Struan , MARTIN, David, P. , RIZK, Said , AHUJA, Ajay , WILLIAMS, Simon, F.
IPC分类号： A61L27/00 , A61F2/08
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0642 , A61B2017/00893 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti- adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
摘要翻译：已经开发了用于腱和韧带修复的包括肩袖修复的插入和增强装置以及使用关节镜方法进行输送的方法。该装置优选衍生自生物相容性聚羟基链烷酸酯，优选衍生自4-羟基丁酸酯的共聚物或均聚物。这些装置可以关节镜地传送，并且提供额外的益处，例如支持手术修复，高初始强度，体内延长的强度保持力，柔韧性，抗粘连性，改善的生物相容性，体内重塑健康组织的能力，最小疾病传播的风险或增强感染的选择，包括足够高的强度的选项，以防止缝合线拉出或植入装置的其他脱离，最终吸收消除异物反应的未来风险或干扰后续程序，有竞争力的成本，长期的机械稳定性。这些装置还特别适用于儿科人群，其最终吸收不应阻碍生长。

6. 发明申请

WO2011119742A3 COATINGS FOR THE MANUFACTURE AND APPLICATION OF POLYHYDROXYALKANOATE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2011119742A3
公开(公告)日：2011-09-29
申请号：PCT/US2011/029638
申请日：2011-03-23
申请人： TEPHA, INC. , MARTIN, David, P. , RIZK, Said , MONTCRIEFF, Jon, I. , CONNELLY, Dennis, W.
发明人： MARTIN, David, P. , RIZK, Said , MONTCRIEFF, Jon, I. , CONNELLY, Dennis, W.
IPC分类号： A61L17/10 , D01F6/62 , A61L27/18
摘要： Biocompatible coatings and spin finishes that can be applied to polyhydroxyalkanoate (PHA) polymers, and medical devices made from PHA polymers, have been developed. The coatings impart good lubricity to PHA polymers, particularly to fibers and braids made from these materials, making the coatings ideal for use on medical devices such as PHA braided sutures. The spin finishes can be applied to PHA fibers to facilitate their manufacture, and also for their conversion to other products, including medical textiles. The spin finishes serve to protect multifilament fiber bundles, and keep them intact following extrusion, and also to impart lubricity to the fiber bundles and monofilament fibers so that they are not damaged in subsequent processing steps particularly in textile processing. The coating reduces tissue drag of, for example, braided sutures.

7. 发明申请

WO2006015276A2 NON-CURLING POLYHYDROXYALKANOATE SUTURES 审中-公开
标题翻译：不卷曲的聚羟基烷酸酯交联剂
公开(公告)号：WO2006015276A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027120
申请日：2005-07-29
申请人： TEPHA, INC. , RIZK, Said
发明人： RIZK, Said
IPC分类号： A61L17/00
CPC分类号： D01F6/625 , A61L17/105 , C08G63/06 , Y10T428/2913 , Y10T442/10
摘要： Absorbable polyester fibers, braids, and surgical meshes with improved handling properties have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available and have a decreased tendency to curl, in the preferred embodiement, due to the inclusion of relaxation and annealing steps following extrusion and orientation of the fiber. Filaments prepared according to these methods are characterized by the following physical properties: (i) elongation to break from about 17% to about 85% (ii) Young’s modulus of less than 350,000 psi, (iii) knot to straight ratio (knot strength/tensile strength) of 55-80% or (iv) load at break from 1100 to 4200 grams.
摘要翻译：已开发出具有改进的处理性能的可吸收聚酯纤维，编织物和外科手术网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。在优选实施例中，这些装置提供了比目前可用的更宽范围的体内强度保持特性，并且由于在挤出和取向之后包括松弛和退火步骤，所以在优选实施方式中具有降低的卷曲倾向纤维。根据这些方法制备的长丝的特征在于以下物理性质：（i）从约17％至约85％的断裂伸长率（ii）小于350,000psi的杨氏模量，（iii）结与直线比（结强度/ 拉伸强度）为55-80％或（iv）从1100至4200克的断裂负荷。

8. 发明申请

WO2011159784A1 MEDICAL DEVICES CONTAINING DRY SPUN NON-WOVENS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含有聚-4-羟基丁酸酯和共聚物的干性非纺织物的医疗装置
公开(公告)号：WO2011159784A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/040500
申请日：2011-06-15
申请人： TEPHA, INC. , CAHIL, Ryan , GUO, Kai , MARTIN, David , RIZK, Said
发明人： CAHIL, Ryan , GUO, Kai , MARTIN, David , RIZK, Said
IPC分类号： D04H1/42 , A61L15/26 , A61L29/16 , A61L31/06
CPC分类号： D04H1/4382 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , A61L2300/00 , D04H1/42 , D04H1/435 , D04H1/56 , D04H3/16 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 μm to 50 μm, and thickness from 10 μm to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01μm to 50 μm, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下性质的一种或多种的可吸收聚合干纺非织造物的连续加工方法：高破裂强度，平均直径为0.01μm至50μm的细纤维，以及10μm至10mm的厚度。通过在卷材收集过程中控制无纺布纤维的粘性，可以改善纤维内聚力。聚合物优选为聚羟基链烷酸酯，更优选为4-羟基丁酸酯聚合物或共聚物。聚-4-羟基丁酸酯的无纺布是最优选的。无纺布具有平均直径范围为0.01μm至50μm的细纤维，并通过干纺处理得到，其中将聚合物溶液注入到高速空气流中，压力为1至 500 psi用于溶剂剥离和聚合物链衰减。无纺布可以用于各种目的，包括制造医疗装置。

9. 发明申请

WO2020242694A1 IMPLANTS ASSEMBLED FROM SKELETAL POLYHEDRON UNIT CELLS, COILED UNIT CELLS OR MESH UNIT CELLS 审中-公开
公开(公告)号：WO2020242694A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/030141
申请日：2020-04-27
申请人： TEPHA, INC.
发明人： LIMEM, Skander , RIZK, Said , WILLIAMS, Simon F.
IPC分类号： A61F2/12
摘要： Absorbable implants can be used to create volume and shape in soft tissues with regenerated tissue. The implants comprise lattices formed from multiple unit cells. Unit cells can be coils or springs, skeletal polyhedrons, foams, or structures derived from mesh and fiber. The implants may be coated or filled with cells and tissues, and preferably with autologous fat graft. The implants are particularly suitable for use in plastic surgery procedures, for example, to regenerate or augment breast tissue following mastectomy or in mastopexy procedures, and can provide an alternative to the use of permanent breast implants in these procedures.

10. 发明申请

WO2019156870A3 FULL CONTOUR BREAST IMPLANT 审中-公开
公开(公告)号：WO2019156870A3
公开(公告)日：2019-08-15
申请号：PCT/US2019/015849
申请日：2019-01-30
申请人： TEPHA, INC.
发明人： LIMEM, Skander , RIZK, Said , WILLIAMS, Simon
IPC分类号： A61F2/12
摘要： Full contour absorbable implants for breast surgery redistribute breast volume between the breast's upper and lower poles in exact and desirable ratios. The implants preferably redistribute breast volume so that the upper pole breast volume is 20-40% of the total volume, and the lower pole breast volume is 60-80% of the total volume. The implants are also designed to provide specific curvatures to the poles of the breast, and to angulate the nipple areolar complex slightly skyward so that the patient's nipple is positioned at an angle above the nipple meridian reference line. The implants are designed to be transitory, with sufficient strength retention to allow transition from support of the breast by the implant to support by regenerated host tissue growing in and around the implants, without any significant loss of support during or subsequent to remodeling. The implants may optionally be used with permanent breast implants.

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