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1. 发明申请

WO2009007088A1 METHOD OF MEASURING A DEVIATION OF AN OPTICAL SURFACE FROM A TARGET SHAPE 审中-公开
标题翻译：测量目标形状的光学表面偏差的方法
公开(公告)号：WO2009007088A1
公开(公告)日：2009-01-15
申请号：PCT/EP2008/005548
申请日：2008-07-08
申请人： CARL ZEISS SMT AG , ARNOLD, Ralf , SCHULTE, Stefan , DOERBAND, Bernd
发明人： ARNOLD, Ralf , SCHULTE, Stefan , DOERBAND, Bernd
IPC分类号： B24B13/06
CPC分类号： G01B9/021 , G01B9/02039 , G01B11/2441 , G01M11/025 , G01M11/0271 , Y10T29/49771
摘要： A method of aligning at least two wave shaping elements, a method of measuring a deviation of an optical surface from a target shape and a measuring apparatus for interferometrically measuring a deviation of an optical surface from a target shape are provided. The method of aligning at least two wave shaping elements, each of which wave shaping elements comprises a diffractive measurement structure for adapting part of a wave front of incoming light to a respective portion of the target shape, comprises the steps of: providing a first one of the wave shaping elements with a diffractive alignment structure, arranging the wave shaping elements relative to each other such that each of the diffractive measurement structures is traversed by a separate subset of rays of the incoming light during operation of the measuring apparatus, and aligning the first wave shaping element in a second one of the wave shaping elements relative to each other by evaluating alignment light having consecutively interacted with the diffractive alignment structure and with the second wave shaping element.
摘要翻译：提供了对准至少两个波形整形元件的方法，测量光学表面与目标形状的偏差的方法以及用于干涉测量光学表面与目标形状的偏差的测量装置。对准至少两个波形整形元件的方法，其中每个波形整形元件包括用于将入射光的波前部分的一部分适配到目标形状的相应部分的衍射测量结构，包括以下步骤：提供第一个的具有衍射对准结构的波形成形元件，将波形整形元件相对于彼此布置，使得每个衍射测量结构在测量装置的操作期间被入射光的单独的子集子穿过，并将通过评估与衍射对准结构和第二波形整形元件连续相互作用的对准光，第二波形成形元件中的第一波形整形元件相对于彼此。

2. 发明申请

WO2009006919A1 METHOD OF MEASURING A DEVIATION AN OPTICAL SURFACE FROM A TARGET SHAPE 审中-公开
标题翻译：测量目标形状的光学表面的方法
公开(公告)号：WO2009006919A1
公开(公告)日：2009-01-15
申请号：PCT/EP2007/006069
申请日：2007-07-09
申请人： CARL ZEISS SMT AG , ARNOLD, Ralf , SCHULTE, Stefan , DOERBAND, Bernd
发明人： ARNOLD, Ralf , SCHULTE, Stefan , DOERBAND, Bernd
IPC分类号： G01B9/021 , G01B11/24
CPC分类号： G01B9/021 , G01B9/02039 , G01B11/2441 , G01M11/025 , G01M11/0271 , Y10T29/49771
摘要： A method of aligning at least two wave shaping elements, a method of measuring a deviation of an optical surface from a target shape and a measuring apparatus for interferometrically measuring a deviation of an optical surface from a target shape are provided. The method of aligning at least two wave shaping elements, each of which wave shaping elements comprises a diffractive measurement structure for adapting part of a wave front of incoming light to a respective portion of the target shape, comprises the steps of: providing a first one of the wave shaping elements with a diffractive alignment structure, arranging the wave shaping elements relative to each other such that each of the diffractive measurement structures is traversed by a separate subset of rays of the incoming light during operation of the measuring apparatus, and aligning the first wave shaping element in a second one of the wave shaping elements relative to each other by evaluating alignment light having consecutively interacted with the diffractive alignment structure and with the second wave shaping element.
摘要翻译：提供了对准至少两个波形整形元件的方法，测量光学表面与目标形状的偏差的方法以及用于干涉测量光学表面与目标形状的偏差的测量装置。对准至少两个波形整形元件的方法，其中每个波形整形元件包括用于将入射光的波前部分的一部分适配到目标形状的相应部分的衍射测量结构，包括以下步骤：提供第一个的具有衍射对准结构的波形成形元件，将波形整形元件相对于彼此布置，使得每个衍射测量结构在测量装置的操作期间被入射光的单独的子集子穿过，并将通过评估与衍射对准结构和第二波形整形元件连续相互作用的对准光，第二波形成形元件中的第一波形整形元件相对于彼此。

3. 发明申请

WO2009007087A9 OPTICAL ELEMENT AND METHOD OF CALIBRATING A MEASURING APPARATUS COMPRISING A WAVE SHAPING STRUCTURE 审中-公开
公开(公告)号：WO2009007087A9
公开(公告)日：2009-01-15
申请号：PCT/EP2008/005547
申请日：2008-07-08
申请人： CARL ZEISS SMT AG , HETZLER, Jochen , SCHILLKE, Frank , SCHULTE, Stefan , FREIMANN, Rolf , DÖRBAND, Bernd
发明人： HETZLER, Jochen , SCHILLKE, Frank , SCHULTE, Stefan , FREIMANN, Rolf , DÖRBAND, Bernd
IPC分类号： B24B13/06
摘要： An optical element has an optical surface, which optical surface is adapted to a non-spherical target shape, such that a long wave variation of the actual shape of the optical surface with respect to the target shape is limited to a maximum value of 0,2 nm, wherein the long wave variation includes only oscillations having a spatial wavelength equal to or larger than a minimum spatial wavelength of 10 mm.

4. 发明申请

WO2009007087A1 OPTICAL ELEMENT AND METHOD OF CALIBRATING A MEASURING APPARATUS COMPRISING A WAVE SHAPING STRUCTURE 审中-公开
标题翻译：光学元件和校准包含波形结构的测量装置的方法
公开(公告)号：WO2009007087A1
公开(公告)日：2009-01-15
申请号：PCT/EP2008/005547
申请日：2008-07-08
申请人： CARL ZEISS SMT AG , HETZLER, Jochen , SCHILLKE, Frank , SCHULTE, Stefan , FREIMANN, Rolf , DÖRBAND, Bernd
发明人： HETZLER, Jochen , SCHILLKE, Frank , SCHULTE, Stefan , FREIMANN, Rolf , DÖRBAND, Bernd
IPC分类号： B24B13/06
CPC分类号： G01B9/021 , G01B9/02039 , G01B11/2441 , G01M11/025 , G01M11/0271 , Y10T29/49771
摘要： An optical element has an optical surface, which optical surface is adapted to a non-spherical target shape, such that a long wave variation of the actual shape of the optical surface with respect to the target shape is limited to a maximum value of 0,2 nm, wherein the long wave variation includes only oscillations having a spatial wavelength equal to or larger than a minimum spatial wavelength of 10 mm.
摘要翻译：光学元件具有光学表面，该光学表面适于非球形目标形状，使得光学表面的实际形状相对于目标形状的长波变化被限制为最大值0， 2nm，其中长波变化仅包括具有等于或大于10mm的最小空间波长的空间波长的振荡。

5. 发明申请

WO2004046641A1 VERFAHREN ZUM KALIBRIEREN EINES INTERFEROMETERS, VERFAHREN ZUM QUALIFIZIEREN EINES OBJEKTS UND VERFAHREN ZUM HERSTELLEN EINES OBJEKTS 审中-公开
标题翻译：程序用于校准干涉，方法符合条件的对象及其制造方法的对象
公开(公告)号：WO2004046641A1
公开(公告)日：2004-06-03
申请号：PCT/EP2002/013091
申请日：2002-11-21
申请人： CARL ZEISS SMT AG , FREIMANN, Rolf , DÖRBAND, Bernd , SCHILLKE, Frank , BEIERSDÖRFER, Susanne , SCHULTE, Stefan
发明人： FREIMANN, Rolf , DÖRBAND, Bernd , SCHILLKE, Frank , BEIERSDÖRFER, Susanne , SCHULTE, Stefan
IPC分类号： G01B9/02
CPC分类号： G01B9/02072 , G01B9/02039 , G01M11/005
摘要： Es wird ein Verfahren zum Kalibrieren eines Interferometers mit einem Kompensationssystem zur Vermessung einer asphärischen Oberfläche vorgeschlagen, welches umfasst: Bereitstellen des Interferometers (1) mit dem Kompensationssystem (25). Anordnen einer Referenzoptik-Baugruppe (29), welche einen Spiegel (37) mit einer vorbestimmten Spiegelfläche und ein von der Spiegelfläche (37) separates vorbestimmtes Diffraktionsmuster (39) Überlagern der zurücklaufenden Wellenfronten nach deren Durchlaufen des Kompensationssystems (25) mit einer Referenzwellenfront zu einem Interferenzmuster, und Bestimmen von optischen Eigenschaften des Interferometers (1) und des Kompensationssystems (25) aus dem Interferenzmuster.
摘要翻译：建议用的补偿系统，用于测量非球面表面，用于校准的干涉仪的方法，包括：提供所述干涉仪（1）到补偿系统（25）。布置参比光学装置组件（29），其包括具有预定反射镜表面和从反射镜表面（37）的反射镜（37）分开的预定的衍射图案（39）通过所述补偿系统（25）与参考波阵面到叠加其通过后返回的波前干涉图案，以及确定干涉仪（1）和从所述干涉图案的补偿系统（25）的光学特性。

6. 发明申请

WO2008110239A1 DIFFRACTIVE COMPONENT, INTERFEROMETER ARRANGEMENT, METHOD FOR QUALIFYING A DUAL DIFFRACTION GRATING, METHOD OF MANUFACTURING AN OPTICAL ELEMENT, AND INTERFEROMETRIC METHOD 审中-公开
标题翻译：衍射成分，干涉仪布置，双折射光栅的鉴定方法，制造光学元件的方法和干涉法
公开(公告)号：WO2008110239A1
公开(公告)日：2008-09-18
申请号：PCT/EP2008/001022
申请日：2008-02-11
申请人： CARL ZEISS SMT AG , SCHULTE, Stefan , HETZLER, Jochen , FREIMANN, Rolf , DREHER, Matthias , DÖRBAND, Bernd
发明人： SCHULTE, Stefan , HETZLER, Jochen , FREIMANN, Rolf , DREHER, Matthias , DÖRBAND, Bernd
IPC分类号： G01B9/02 , G02B5/18 , G02B5/32
CPC分类号： G02B27/4233 , G01N21/4788 , G01N2021/4792 , G02B5/1819 , G02B5/1823 , G02B27/4261
摘要： A diffractive component comprises a grating (25) including plural regions (A, A', B) of different types, wherein the gratings in the different regions differ with respect to lattice period and orientation. The different regions can be arranged according to an irregular pattern. Further, the gratings of the different types can be inverse to each other, or parameters of grating forming structures can vary between regions of the different types. A structural parameter of a dual grating is determined using a first phase function of the dual grating. A deviation of a surface of an optical element from a target surface is determined in an interferometric measurement using a second phase function of the dual grating taking into account the determined structural parameter of the grating. In an interferometric method using a diffraction grating harbouring different phase functions in different types of regions arranged in a superlattice for measuring a surface of an object perturbing superlattice diffraction orders are destructively interfered by adapting the diffraction grating having a periodicity of the superlattice that varies across the grating.
摘要翻译：衍射分量包括包括不同类型的多个区域（A，A'，B）的光栅（25），其中不同区域中的光栅相对于晶格周期和取向不同。可以根据不规则图案布置不同的区域。此外，不同类型的光栅可以彼此相反，或者光栅形成结构的参数可以在不同类型的区域之间变化。使用双光栅的第一相位函数来确定双光栅的结构参数。考虑到确定的光栅的结构参数，使用双光栅的第二相位函数在干涉测量中确定光学元件与目标表面的偏差。在使用在布置在超晶格中的不同类型的区域中具有不同相位函数的衍射光栅的干涉测量方法中，用于测量物体扰动超晶格衍射级的表面的衍射光栅通过使具有超过晶格周期性变化的周期性的衍射光栅受到破坏性干扰光栅。

7. 发明申请

WO2008098720A1 THERAPEUTIC APPLICATION OF KAZAL-TYPE SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：卡氏型丝氨酸蛋白酶抑制剂的治疗应用
公开(公告)号：WO2008098720A1
公开(公告)日：2008-08-21
申请号：PCT/EP2008/001009
申请日：2008-02-11
申请人： CSL BEHRING GMBH , SCHULTE, Stefan , KRONTHALER, Ulrich , SCHMIDBAUER, Stefan , WEIMER, Thomas , HOFMANN, Kay
发明人： SCHULTE, Stefan , KRONTHALER, Ulrich , SCHMIDBAUER, Stefan , WEIMER, Thomas , HOFMANN, Kay
IPC分类号： A61K38/57 , A61P7/02 , C07K14/81
CPC分类号： C07K14/8135 , A61K38/00 , A61K47/64 , A61K47/643
摘要： The subject of the present invention is, in the most general aspect, the therapeutic application of the Kazal-type serine protease inhibitor lnfestin or domains thereof or modified Kazal-type serine protease inhibitors based on lnfestin homologs, which prevent the formation and/or stabilization of three-dimensional arterial or venous thrombi by interfering with proteins involved in activation of the so-called intrinsic coagulation pathway. In particular the present invention relates to the use of said Kazal-type serine protease inhibitors or fragments thereof or modified Kazal-type serine protease inhibitors, in the treatment or prophylaxis of a condition or disorder related to arterial thrombus formation, i. e. stroke or myocardial infarction, inflammation, complement activation, fibrinolysis, angiogenesis and/or diseases linked to pathological kinin formation such as hypotonic shock, edema including hereditary angioedema, bacterial infections, arthritis, pancreatitis, or articular gout, Disseminated Intravasal Coagulation (DIC) and sepsis.
摘要翻译：本发明的主题在最一般的方面是基于伊斯匹林同系物的Kazal型丝氨酸蛋白酶抑制剂腹膜内酯或其结构域或修饰的Kazal型丝氨酸蛋白酶抑制剂的治疗应用，其阻止形成和/或稳定化通过干扰参与所谓的内在凝血途径的激活的蛋白质的三维动脉或静脉血栓。特别地，本发明涉及所述Kazal型丝氨酸蛋白酶抑制剂或其片段或修饰的Kazal型丝氨酸蛋白酶抑制剂在治疗或预防与动脉血栓形成相关的病症或障碍中的用途，即中风或心肌梗塞，炎症，补体激活，纤维蛋白溶解，血管生成和/或与病理激肽形成相关的疾病，例如低渗休克，包括遗传性血管性水肿，细菌感染，关节炎，胰腺炎或关节痛风的水肿，弥散性内皮内凝血（DIC）和败血症。

8. 发明申请

WO2012152953A1 METHODS TO REDUCE ADVERSE EVENTS CAUSED BY PHARMACEUTICAL PREPARATIONS COMPRISING PLASMA DERIVED PROTEINS 审中-公开
标题翻译：减少包含等离子体衍生蛋白质的药物制剂引起的不良事件的方法
公开(公告)号：WO2012152953A1
公开(公告)日：2012-11-15
申请号：PCT/EP2012/058954
申请日：2012-05-14
申请人： CSL BEHRING GMBH , SCHULTE, Stefan , KALINA, Uwe , MOSES, Michael , FEUSSNER, Annette
发明人： SCHULTE, Stefan , KALINA, Uwe , MOSES, Michael , FEUSSNER, Annette
IPC分类号： A61K31/727 , A61K35/16 , A61K38/57 , A61P7/02 , A61P1/00 , A61P11/08 , A61P9/06 , A61P9/12
CPC分类号： A61K35/16 , A61K31/727 , A61K38/385 , A61K38/57 , C12Y304/21008 , C12Y304/21027 , C12Y304/21038
摘要： The instant invention provides a method to reduce adverse events caused by a pharmaceutical preparation derived from a plasma fraction wherein the method comprises contacting the plasma fraction with heparin or a heparin-like substance thereby reducing the activity of at least one activated serine proteaseper ml of the plasma fraction.
摘要翻译：本发明提供了一种减少由衍生自血浆级分的药物制剂引起的不良事件的方法，其中所述方法包括使血浆级分与肝素或肝素样物质接触，从而降低至少一种活化丝氨酸蛋白酶的活性血浆分数。

9. 发明申请

WO2011032572A1 METHOD OF MEASURING A SHAPE OF AN OPTICAL SURFACE AND INTERFEROMETRIC MEASURING DEVICE 审中-公开
标题翻译：测量光学表面和干涉测量装置形状的方法
公开(公告)号：WO2011032572A1
公开(公告)日：2011-03-24
申请号：PCT/EP2009/006754
申请日：2009-09-18
申请人： CARL ZEISS SMT GMBH , FREIMANN, Rolf , DÖRBAND, Bernd , SCHULTE, Stefan , HOF, Albrecht , RIEPENHAUSEN, Frank , MANGER, Matthias , NEUGEBAUER, Dietmar , ISSLER, Helmut , BICH, Armin
发明人： FREIMANN, Rolf , DÖRBAND, Bernd , SCHULTE, Stefan , HOF, Albrecht , RIEPENHAUSEN, Frank , MANGER, Matthias , NEUGEBAUER, Dietmar , ISSLER, Helmut , BICH, Armin
IPC分类号： G01B9/02 , G01B11/24 , G02B26/06 , G01M11/02
CPC分类号： G01B11/2441 , G01B9/02027 , G01B9/02039 , G01B9/02057 , G01B9/02072 , G01B2290/15 , G01M11/005 , G01M11/025 , G01M11/0271 , G02B3/02 , G02B5/10
摘要： A method of measuring a shape of an optical surface (14) of a test object (12) is provided. The method comprises the steps of: providing an interferometric measuring device (16) generating a measurement wave (18), arranging the interferometric measuring device (16) and the test object (12) consecutively at different measurement positions relative to each other, such that different regions (20) of the optical surface (14) are illuminated by the measurement wave (18), measuring the positional coordinates of the measuring device (16) at the different measurement positions in relation to the test object (12), obtaining surface region measurements by interferometrically measuring the wavefront of the measurement wave (18) after interaction with the respective region (20) of the optica! surface (14) using the measuring device (16) in each of the measurement positions, and determining the actual shape of the optical surface (14) by computationally combining the sub-surface measurements based on the measured positional coordinates of the interferometric measuring device (16) at each of the measurement positions.
摘要翻译：提供了一种测量被测物体（12）的光学表面（14）的形状的方法。该方法包括以下步骤：提供产生测量波的干涉测量装置（16），将干涉测量装置（16）和测试对象（12）相对于彼此连续地布置在不同的测量位置，使得通过测量波（18）照射光学表面（14）的不同区域（20），测量相对于测试对象（12）的不同测量位置处的测量设备（16）的位置坐标，获得表面通过在与光学器件的相应区域（20）相互作用之后通过干涉测量测量波（18）的波前进行区域测量。在每个测量位置中使用测量装置（16）的表面（14），并且通过基于所测量的干涉测量装置的位置坐标（基于所述测量装置的测量位置坐标）计算地组合所述子表面测量来确定所述光学表面（14）的实际形状 16）在每个测量位置。

10. 发明申请

WO2007090584A1 MODIFIED COAGULATION FACTOR VILA WITH EXTENDED HALF-LIFE 审中-公开
标题翻译：改进的凝血因子维拉与延伸的生命
公开(公告)号：WO2007090584A1
公开(公告)日：2007-08-16
申请号：PCT/EP2007/000937
申请日：2007-02-03
申请人： ZLB BEHRING GMBH , WEIMER, Thomas , SCHULTE, Stefan , KRONTHALER, Ulrich , LANG, Wiegand , LIEBING, Uwe , WORMSBÄCHER, Wilfried
发明人： WEIMER, Thomas , SCHULTE, Stefan , KRONTHALER, Ulrich , LANG, Wiegand , LIEBING, Uwe , WORMSBÄCHER, Wilfried
IPC分类号： C12N15/62 , C07K14/76 , C12N9/64 , C07K19/00 , A61K38/48
CPC分类号： A61K38/4846 , A61K9/0019 , A61K38/00 , A61K38/385 , C07K14/76 , C07K2319/00 , C07K2319/31 , C12N9/6437 , C12N9/96 , C12N15/62 , C12Y304/21021
摘要： The present invention relates to the fields of Factor VII (FVII) and Factor Vila (FVIIa) albumin linked polypeptides. More specifically, the invention relates to cDNA sequences coding for human Factor VII and Factor Vila and derivatives genetically fused to a cDNA coding for human serum albumin which may be linked by oligonucleotides which code for intervening peptidic linkers such encoded derivatives exhibiting improved stability and extended functional plasma half-life, recombinant expression vectors containing such cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and prolonged shelf-life and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.
摘要翻译：本发明涉及因子VII（FVII）和因子VIIa（FVIIa）白蛋白连接多肽的领域。更具体地，本发明涉及编码人因子VII和因子VIIa的cDNA序列和与编码人血清白蛋白的cDNA遗传融合的衍生物，其可以通过寡核苷酸连接，所述寡核苷酸编码插入的肽接头体，所述衍生物表现出改善的稳定性和延伸的功能血浆半衰期，含有这些cDNA序列的重组表达载体，用这种重组表达载体转化的宿主细胞，确实具有未修饰的野生型蛋白的生物活性但具有改善的稳定性和延长的保存期限的重组多肽和衍生物制备这些重组蛋白及其衍生物。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。

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