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1. 发明申请

WO2010120881A3 SYSTEM AND METHOD FOR VISUALIZING TISSUE DURING ABLATION PROCEDURES 审中-公开
标题翻译：系统和方法，用于在组织过程中可视化组织
公开(公告)号：WO2010120881A3
公开(公告)日：2011-02-10
申请号：PCT/US2010031032
申请日：2010-04-14
申请人： CARDIO FOCUS INC , MELSKY GERALD , SAGON STEPHEN W , SINOFSKY EDWARD L , FARR NORMAN E
发明人： MELSKY GERALD , SAGON STEPHEN W , SINOFSKY EDWARD L , FARR NORMAN E
IPC分类号： A61B1/05 , A61B1/06 , A61B17/125
CPC分类号： A61B18/24 , A61B1/00087 , A61B1/00165 , A61B1/0638 , A61B1/07 , A61B5/0044 , A61B5/0075 , A61B5/0084 , A61B5/4836 , A61B5/7264 , A61B5/743 , A61B2017/00057 , A61B2018/00011 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/0069 , A61B2018/00904 , A61B2018/00982 , A61B2576/023
摘要： Systems for visualizing cardiac tissue during an ablation procedure are provided. In general, the systems include an imaging module configured to measure absorbance data at first and second wavelengths wherein the ratio of these absorbance values identifies the nature of the tissue (e.g., lesion, de novo tissue, etc.). The imaging module can also include a video system having at least two chips with corresponding bandpass filters centered at the first and second target wavelengths. The system can also include a processor and/or video monitor for combining the images produced by the various chips, determining treated and non-treated tissue based on the ratio of absorbance values at the target wavelengths, and displaying images of the treatment area. Methods of visualizing cardiac treatment areas during ablation procedures are also provided herein.
摘要翻译：提供了在消融过程中可视化心脏组织的系统。通常，该系统包括成像模块，该成像模块被配置为测量第一和第二波长处的吸光度数据，其中这些吸光度值的比率识别组织的性质（例如病变，从头组织等）。成像模块还可以包括具有至少两个具有以第一和第二目标波长为中心的带通滤波器的芯片的视频系统。该系统还可以包括用于组合由各种芯片产生的图像的处理器和/或视频监视器，基于目标波长处的吸光度值的比率和显示处理区域的图像来确定处理和未处理的组织。本文还提供了在消融过程中可视化心脏治疗区域的方法。

2. 发明申请

WO2004110258A3 GUIDED CARDIAC ABLATION CATHETERS 审中-公开
标题翻译：指导性戒毒导管
公开(公告)号：WO2004110258A3
公开(公告)日：2005-08-25
申请号：PCT/US2004018471
申请日：2004-06-10
申请人： CARDIOFOCUS INC , MELSKY GERALD , ARNOLD JEFFREY M , SINOFSKY EDWARD L , FARR NORMAN E
发明人： MELSKY GERALD , ARNOLD JEFFREY M , SINOFSKY EDWARD L , FARR NORMAN E
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/24 , A61B19/00 , A61N7/02
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/0022 , A61B2018/00982 , A61B2018/0212 , A61B2090/3937 , A61N7/02
摘要： Guided ablation instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias, including atrial fibrillation. In one aspect of the invention, a percutaneous catheter is disclosed with an endoscope positionable in the instrument's distal end region to obtain an image. The image allows the clinician to determine whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) before ablation begins or while ablation is occurring. In one embodiment, percutaneous ablation catheters are disclosed having at least one central lumen and one or more balloon structures at the distal end region of the instrument. Also disposed in the distal end region are an illuminating light source and an endoscope capable of collecting sufficient light to relay an image to the user. The instruments can further include an ablation element. The ablation element can be a contact ablation element, or a radiant energy emitter, which is preferably independently positionable within the lumen of the instrument and adapted to project ablative energy through a transmissive region of the instrument body (and/or balloon) to a target tissue site proximate to the pulmonary veins. The energy can delivered without the need for contact between the energy emitter and the target tissue so long as a clear transmission pathway is established. The endoscope element of the instrument allows the clinician to determine the position of the instrument and, if radiant energy is to be employed, see if such a pathway is clear. Moreover, because the position of the radiant energy emitter can be varied, endoscopic guidance permits the clinician to select a desired location and dose for the lesion.
摘要翻译：公开了引导消融器械用于在组织中产生损伤，特别是用于治疗心律失常的心脏组织，包括房颤。在本发明的一个方面，公开了一种经皮导管，其具有可置于仪器的远端区域中的内窥镜，以获得图像。图像允许临床医生确定在消融开始之前还是在消融期间已经实现了接触（或者从消融能量传递路径中清除血液）。在一个实施例中，公开了经皮消融导管，其在器械的远端区域具有至少一个中心腔和一个或多个气囊结构。还设置在远端区域中的是能够收集足够的光以将图像中继给用户的照明光源和内窥镜。仪器还可以包括消融元件。消融元件可以是接触消融元件或辐射能发射器，其优选地可独立地定位在器械的内腔内并且适于将烧蚀能量穿过器械主体（和/或气囊）的透射区域投射到靶靠近肺静脉的组织部位。只要建立清晰的传输路径，能量可以传送而不需要能量发射器和目标组织之间的接触。仪器的内窥镜元件允许临床医生确定仪器的位置，并且如果要使用辐射能量，看看这样的通路是否清晰。此外，由于辐射能发射器的位置可以改变，所以内窥镜引导允许临床医生选择病变的期望位置和剂量。

3. 发明申请

WO0103599A2 PHOTOABLATION SYSTEM 审中-公开
公开(公告)号：WO0103599A2
公开(公告)日：2001-01-18
申请号：PCT/US0019285
申请日：2000-07-14
申请人： CARDIOFOCUS INC , SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E , MACLEAN BRIAN , MCINTYRE JON T , WIELER WILLIAM E
发明人： SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E , MACLEAN BRIAN , MCINTYRE JON T , WIELER WILLIAM E
IPC分类号： A61B18/20 , A61B17/00 , A61B18/00 , A61B18/22 , A61B18/24 , A61B19/00 , A61M25/00 , A61N5/06
CPC分类号： A61B18/245 , A61B2017/00061 , A61B2018/0097 , A61B2018/2266 , A61B2018/2272 , A61B2090/065
摘要： Methods and apparatus are disclosed for forming annular lesions in tissue. The methods include introduction of an optical apparatus proximate to a tissue site, via, for example, a catheter. The optical apparatus includes a pattern-forming optical waveguide in communication with a light transmitting optical fiber. Energy is transmitted through the optical fiber, such that radiation is propagated through the optical fiber and the waveguide projects an annular light pattern, e.g., a circle or a halo.

4. 发明申请

WO2004069072A2 COAXIAL CATHETER INSTRUMENTS FOR ABLATION WITH RADIANT ENERGY 审中-公开
标题翻译：用辐射能消除共轴导管仪器
公开(公告)号：WO2004069072A2
公开(公告)日：2004-08-19
申请号：PCT/US2004003141
申请日：2004-02-03
申请人： CARDIOFOCUS INC , ARNOLD JEFFREY M , SINOFSKY EDWARD L , BAXTER LINCOLN S , FARR NORMAN E
发明人： ARNOLD JEFFREY M , SINOFSKY EDWARD L , BAXTER LINCOLN S , FARR NORMAN E
IPC分类号： A61B17/00 , A61B18/00 , A61B18/22 , A61B18/24 , A61B19/00 , A61F2/958 , A61L2/10 , A61L29/08 , A61N5/06 , A61N7/02
CPC分类号： A61B18/24 , A61B18/245 , A61B2017/00057 , A61B2017/00061 , A61B2018/0097 , A61B2018/2261 , A61B2018/2266 , A61B2018/2272 , A61B2090/065 , A61L2/10 , A61L29/085 , A61N7/02 , C08L27/12
摘要： Ablation methods and instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias and the like. Percutaneous ablation instruments in the form of coaxial catheter bodies are disclosed having at least one central lumen therein and having one or more balloon structures at the distal end region of the instrument. The instruments include an energy emitting element which is independently positionable within the lumen of the instrument and adapted to project radiant energy through a transmissive region of a projection balloon to a target tissue site. An ablative fluid can also be employed outside of the instrument to ensure efficient transmission of the radiant energy when the instrument is deployed. In another aspect of the invention, mechanisms are disclosed for determining whether the instrument has been properly seated within the heart. This contact-sensing feature can be implemented by an illumination source situated within the instrument and an optical detector that monitors the level of reflected light. Measurements of the reflected light can thus be used to determine whether contact has been achieved and whether such contact is continuous over a desired ablation path.
摘要翻译：公开了消融方法和器械用于在组织中产生损伤，特别是用于治疗心律不齐等的心脏组织。公开了同轴导管体形式的经皮消融器械，其具有至少一个中心内腔并且在器械的远端区域处具有一个或多个气囊结构。器械包括能量发射元件，其能够独立地定位在器械的内腔内并且适于将辐射能量通过投射球囊的透射区域投射到目标组织部位。仪器外部也可以使用消融液，以确保仪器部署时辐射能量的有效传输。在本发明的另一方面中，公开了用于确定器械是否已被正确安置在心脏内的机构。该接触感测特征可以通过位于仪器内的照明源和监测反射光水平的光学检测器来实现。因此可以使用反射光的测量来确定接触是否已经实现以及这种接触是否在期望的消融路径上是连续的。

5. 发明申请

WO0108575A3 OPTICAL FIBER BASKET DEVICE FOR CARDIAC PHOTOABLATION 审中-公开
公开(公告)号：WO0108575A3
公开(公告)日：2001-08-16
申请号：PCT/US0020887
申请日：2000-07-31
申请人： CARDIOFOCUS INC , SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E
发明人： SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E
IPC分类号： A61B17/00 , A61B18/00 , A61B18/22 , A61B18/24 , A61B19/00
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2017/00243 , A61B2017/00853 , A61B2017/00907 , A61B2018/00642 , A61B2018/2238
摘要： The present invention is drawn to methods for ablating tissue within an organ, e.g., a heart, using a catheter. The catheter includes a tubular catheter having a proximal end, a distal end and a lumen therebetween, a plurality of independent flexible guide members, and an energy emitter. The method includes introducing the catheter into an organ, e.g., a heart, and performing ablation of tissue, e.g. diseased tissue. The energy emitter is slidably positioned within one or more of the flexible guide members so that the energy emitter is located proximate to the tissue site. Energy is emitted through the emitter, thereby treating, e.g., phototherapeutically, e.g., ablating, the tissue with minimal or no harm to the surrounding healthy tissue. A method may be used for therapeutic or prophylactic treatment of tissue.

6. 发明申请

WO0108575A9 OPTICAL FIBER BASKET DEVICE FOR CARDIAC PHOTOABLATION 审中-公开
标题翻译：用于心脏光化的光纤篮子装置
公开(公告)号：WO0108575A9
公开(公告)日：2001-09-13
申请号：PCT/US0020887
申请日：2000-07-31
申请人： CARDIOFOCUS INC , SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E
发明人： SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E
IPC分类号： A61B17/00 , A61B18/00 , A61B18/22 , A61B18/24 , A61B19/00
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2017/00243 , A61B2017/00853 , A61B2017/00907 , A61B2018/00642 , A61B2018/2238
摘要： The present invention is drawn to methods for ablating tissue within an organ, e.g., a heart, using a catheter. The catheter includes a tubular catheter having a proximal end, a distal end and a lumen therebetween, a plurality of independent flexible guide members, and an energy emitter. The method includes introducing the catheter into an organ, e.g., a heart, and performing ablation of tissue, e.g. diseased tissue. The energy emitter is slidably positioned within one or more of the flexible guide members so that the energy emitter is located proximate to the tissue site. Energy is emitted through the emitter, thereby treating, e.g., phototherapeutically, e.g., ablating, the tissue with minimal or no harm to the surrounding healthy tissue. A method may be used for therapeutic or prophylactic treatment of tissue.
摘要翻译：本发明涉及使用导管消融器官（例如心脏）内的组织的方法。导管包括具有近端，远端和其间的内腔的管状导管，多个独立的柔性引导构件和能量发射器。该方法包括将导管引入例如心脏的器官中，并进行组织的消融，例如，患病组织。能量发射器可滑动地定位在一个或多个柔性引导构件内，使得能量发射器位于组织部位附近。通过发射器发射能量，由此治疗例如光治疗，例如消融组织，而对周围健康组织的损害最小或没有损害。一种方法可以用于组织的治疗或预防性治疗。

7. 发明申请

WO0103599A9 PHOTOABLATION SYSTEM 审中-公开
标题翻译：照相系统
公开(公告)号：WO0103599A9
公开(公告)日：2001-06-14
申请号：PCT/US0019285
申请日：2000-07-14
申请人： CARDIOFOCUS INC , SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E , MACLEAN BRIAN , MCINTYRE JON T , WIELER WILLIAM E
发明人： SINOFSKY EDWARD L , BAXTER LICOLN S , FARR NORMAN E , MACLEAN BRIAN , MCINTYRE JON T , WIELER WILLIAM E
IPC分类号： A61B18/20 , A61B17/00 , A61B18/00 , A61B18/22 , A61B18/24 , A61B19/00 , A61M25/00 , A61N5/06
CPC分类号： A61B18/245 , A61B2017/00061 , A61B2018/0097 , A61B2018/2266 , A61B2018/2272 , A61B2090/065
摘要： Methods and apparatus are disclosed for forming annular lesions in tissue. The methods include introduction of an optical apparatus proximate to a tissue site, via, for example, a catheter. The optical apparatus includes a pattern-forming optical waveguide in communication with a light transmitting optical fiber. Energy is transmitted through the optical fiber, such that radiation is propagated through the optical fiber and the waveguide projects an annular light pattern, e.g., a circle or a halo.
摘要翻译：公开了用于在组织中形成环形损伤的方法和设备。该方法包括通过例如导管引入靠近组织部位的光学设备。该光学设备包括与光传输光纤通信的图案形成光波导。能量通过光纤传输，使得辐射通过光纤传播并且波导投射例如圆形或光环的环形光图案。

8. 发明申请

WO0108576A9 LASER METHOD AND APPARATUS FOR TREATMENT OF TISSUE 审中-公开
标题翻译：用于治疗组织的激光方法和设备
公开(公告)号：WO0108576A9
公开(公告)日：2001-06-14
申请号：PCT/US0020926
申请日：2000-07-31
申请人： CARDIOFOCUS INC , SINOFSKY EDWARD L , BROWN JEFFREY W , BAXTER LINCOLN S
发明人： SINOFSKY EDWARD L , BROWN JEFFREY W , BAXTER LINCOLN S
IPC分类号： A61B17/00 , A61B18/22 , A61B18/24
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2018/2272
摘要： The present invention describes methods and apparatus for phototherapeutically treating, e.g., ablating, coagulating, and/or phototherapeutically modulating a target tissue, e.g., cardiac tissue. The methods include introducing a flexible elongate member into a predetermined tissue site with the flexible elongate member having a proximal end, a distal end and a longitudinal first lumen extending therebetween. A portion of the distal end of the flexible elongate member contains holes, such that the porous portion is positioned proximate to the tissue site. A solution is injected through the porous portion, thereby diluting body fluid(s) and/or blood about the tissue site. An energy emitter is slidably positioned through the lumen proximate to the tissue site and energy is transmitted through the holes of the distal end of the elongate member through the energy emitter.
摘要翻译：本发明描述了用于光治疗治疗例如消融，凝结和/或光治疗调节靶组织例如心脏组织的方法和装置。该方法包括将柔性细长构件引入预定组织部位，其中柔性细长构件具有近端，远端和在其间延伸的纵向第一腔。柔性细长构件的远端的一部分包含孔，使得多孔部分位于组织部位附近。溶液通过多孔部分注入，从而稀释体液和/或血液在组织部位周围。能量发射器通过靠近组织部位的管腔可滑动地定位，并且能量通过能量发射器穿过细长构件的远端的孔传输。

9. 发明申请

WO2010051463A3 SYSTEM AND METHOD FOR OPTICAL FIBER DIFFUSION 审中-公开
标题翻译：光纤扩散的系统和方法
公开(公告)号：WO2010051463A3
公开(公告)日：2010-06-24
申请号：PCT/US2009062803
申请日：2009-10-30
申请人： SINOFSKY EDWARD L
发明人： SINOFSKY EDWARD L
IPC分类号： G02B6/00 , A61B18/22 , A61B18/24
CPC分类号： G02B6/001 , A61B18/22 , A61B2018/2261
摘要： An optical fiber diffusion system and a method of manufacturing an optical fiber diffusion device that has a precisely-controlled emission region are disclosed. An optical fiber diffusion device is produced by subjecting a light emission region (40) of an optical fiber (30) to a series of controlled cycles of stress, heating, elongation and cooling, resulting in a pattern of deformation and modification of the fiber and cladding.
摘要翻译：公开了一种光纤扩散系统和制造具有精确控制的发射区域的光纤扩散装置的方法。通过对光纤（30）的发光区域（40）进行应力，加热，延伸和冷却的一系列受控循环的制造来制造光纤扩散装置，导致纤维的变形和变形的图案，包层。

10. 发明申请

WO0108576A2 LASER METHOD AND APPARATUS FOR TREATMENT OF TISSUE 审中-公开
标题翻译：激光治疗组织的方法和装置
公开(公告)号：WO0108576A2
公开(公告)日：2001-02-08
申请号：PCT/US0020926
申请日：2000-07-31
申请人： CARDIOFOCUS INC , SINOFSKY EDWARD L , BROWN JEFFREY W , BAXTER LICOLN S
发明人： SINOFSKY EDWARD L , BROWN JEFFREY W , BAXTER LICOLN S
IPC分类号： A61B17/00 , A61B18/22 , A61B18/24 , A61B18/00
CPC分类号： A61B18/24 , A61B2017/00057 , A61B2018/2272
摘要： The present invention describes methods and apparatus for phototherapeutically treating, e.g., ablating, coagulating, and/or phototherapeutically modulating a target tissue, e.g., cardiac tissue. The methods include introducing a flexible elongate member into a predetermined tissue site with the flexible elongate member having a proximal end, a distal end and a longitudinal first lumen extending therebetween. A portion of the distal end of the flexible elongate member contains holes, such that the porous portion is positioned proximate to the tissue site. A solution is injected through the porous portion, thereby diluting body fluid(s) and/or blood about the tissue site. An energy emitter is slidably positioned through the lumen proximate to the tissue site and energy is transmitted through the holes of the distal end of the elongate member through the energy emitter.
摘要翻译：本发明描述了用于光疗法治疗例如消融，凝结和/或光治疗调节靶组织例如心脏组织的方法和装置。所述方法包括将柔性细长构件引入预定的组织部位，其中柔性细长构件具有在其间延伸的近端，远端和纵向第一腔。柔性细长构件的远端的一部分包含孔，使得多孔部分位于组织部位附近。通过多孔部分注入溶液，从而稀释组织部位周围的体液和/或血液。能量发射器可靠地靠近组织部位可滑动地定位，并且能量通过能量发射器传递通过细长构件的远端的孔。

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