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1. 发明申请

WO2008063535A3 CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION USING CARDIAC ACTIVATION SEQUENCE INFORMATION 审中-公开
标题翻译：使用心脏激活序列信息的心脏再生治疗优化
公开(公告)号：WO2008063535A3
公开(公告)日：2008-07-10
申请号：PCT/US2007023988
申请日：2007-11-15
申请人： CARDIAC PACEMAKERS INC , ARCOT-KRISHNAMURTHY SHANTHA , ZHANG YI , DING JIANG , YU YINGHONG , DONG YANTING
发明人： ARCOT-KRISHNAMURTHY SHANTHA , ZHANG YI , DING JIANG , YU YINGHONG , DONG YANTING
IPC分类号： A61N1/362 , A61B5/04 , A61B5/0452 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

2. 发明申请

WO2012125273A2 HIS CAPTURE VERIFICATION USING ELECTRO-MECHANICAL DELAY 审中-公开
标题翻译：使用电子机械延迟的捕获验证
公开(公告)号：WO2012125273A2
公开(公告)日：2012-09-20
申请号：PCT/US2012026571
申请日：2012-02-24
申请人： CARDIAC PACEMAKERS INC , MASKARA BARUN , DING JIANG , ARCOT-KRISHNAMURTHY SHANTHA , SHUROS ALLAN C
发明人： MASKARA BARUN , DING JIANG , ARCOT-KRISHNAMURTHY SHANTHA , SHUROS ALLAN C
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译：可以向His束提供刺激能量以激活自然心脏收缩机制。间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。

3. 发明申请

WO2006078519A3 CONTROL OF ELECTRICAL STIMULATION USING HEART RATE VARIABILITY 审中-公开
标题翻译：使用心率变化控制电刺激
公开(公告)号：WO2006078519A3
公开(公告)日：2007-04-19
申请号：PCT/US2006000963
申请日：2006-01-12
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
发明人： PASTORE JOSEPH M , SALO RODNEY W , CARLSON GERRARD M , KRAMER ANDREW P , DING JIANG , YU YINGHONG
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to evaluate a plurality of parameter values for selecting an approximately optimal parameter value. In another embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode. In another embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于评估用于选择近似最佳参数值的多个参数值。在另一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。在另一个实施例中，HRV参数用作安全检查以在认为其可能有害以继续治疗时停止电疗法。

4. 发明申请

WO2004069333A3 METHOD AND APPARATUS FOR SETTING PACING PARAMETERS 审中-公开
标题翻译：方法和设备的设置参数
公开(公告)号：WO2004069333A3
公开(公告)日：2005-02-10
申请号：PCT/US2004002332
申请日：2004-01-28
申请人： CARDIAC PACEMAKERS INC , DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
发明人： DING JIANG , YU YINGHONG , KRAMER ANDREW P , BAUMANN LAWRENCE
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus is disclosed for automatically setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way is the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes.
摘要翻译：公开了一种用于自动设置可植入心脏装置在输送心脏再同步治疗中使用的起搏参数的方法和装置。起搏参数的选择至少部分地基于固有心脏传导参数的测量。可以以这种方式选择的起搏参数是在心房跟踪和AV顺序起搏模式中使用的心房延迟间隔。

5. 发明申请

WO2010042364A3 DYNAMIC CARDIAC RESYNCHRONIZATION THERAPY BY TRACKING INTRINSIC CONDUCTION 审中-公开
标题翻译：通过追踪内部电导进行动态心脏再生治疗
公开(公告)号：WO2010042364A3
公开(公告)日：2011-06-23
申请号：PCT/US2009059005
申请日：2009-09-30
申请人： CARDIAC PACEMAKERS INC , MASKARA BARUN , DING JIANG
发明人： MASKARA BARUN , DING JIANG
IPC分类号： A61N1/362
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3684
摘要： Systems and methods for pacing the heart using resynchronization pacing delays that achieve improvement of cardiac function are described. An early activation pacing interval is calculated based on an optimal AV delay and an atrial to early ventricular activation interval between an atrial event and early activation of a ventricular depolarization. The early activation pacing interval for the ventricle is calculated by subtracting the measured AVEA from the calculated optimal AV delay. The early activation pacing interval is initiated responsive to sensing early activation of the ventricle and pacing is delivered relative to expiration of the early activation pacing interval.
摘要翻译：描述了实现心脏功能改善的再同步起搏延迟来起搏心脏的系统和方法。基于最佳AV延迟和心房事件与心室去极化的早期激活之间的早期心室激活间隔来计算早期激活起搏间隔。通过从计算的最佳AV延迟中减去测量的AVEA来计算心室的早期激活起搏间隔。响应于感测心室的早期激活而启动早期激活起搏间隔，并且相对于早期激活起搏间隔的期满而递送起搏。

6. 发明申请

WO2014099595A2 METHOD AND APPARATUS FOR RIGHT VENTRICULAR RESYNCHRONIZATION 审中-公开
标题翻译：用于右心室再生的方法和装置
公开(公告)号：WO2014099595A2
公开(公告)日：2014-06-26
申请号：PCT/US2013074618
申请日：2013-12-12
申请人： CARDIAC PACEMAKERS INC
发明人： SHUROS ALLAN C , DING JIANG , MASKARA BARUN , YU YINGHONG
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/365 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： An apparatus comprises a cardiac signal sensing circuit and a first implantable electrode pair. At least one electrode of the first implantable electrode pair is configured for placement at a location in a right branch of a His bundle of the subject. The apparatus can include a therapy circuit and a control circuit. The control circuit can include an AH delay calculation circuit configured to calculate an optimal paced AH delay interval. The pacing stimulation location is distal to a location of RV conduction block in a right branch of the His bundle. The control circuit initiates delivery of an electrical stimulation pulse to the stimulation location in the His bundle according to the calculated paced AH delay interval and in response to an intrinsic depolarization event sensed in an atrium of the subject.
摘要翻译：一种装置包括心脏信号感测电路和第一可植入电极对。第一可植入电极对的至少一个电极被配置用于放置在受试者的His束的右分支中的位置处。该装置可以包括治疗电路和控制电路。控制电路可以包括AH延迟计算电路，配置为计算最佳起搏AH延迟间隔。起搏刺激位置在His束的右侧分支中位于RV传导阻滞位置的远端。控制电路根据计算的起搏AH延迟间隔和响应于在受试者的心房中感测到的内在去极化事件，开始将电刺激脉冲传送到His束中的刺激位置。

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