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1. 发明申请

WO2008027630A1 SYSTEM TO REDUCE DEVICE THERAPY PAIN 审中-公开
标题翻译：减少器械治疗疼痛的系统
公开(公告)号：WO2008027630A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/069007
申请日：2007-05-16
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yunlong , SCHWARTZ, Mark
发明人： ZHANG, Yunlong , SCHWARTZ, Mark
IPC分类号： A61N1/34 , A61N1/36 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3601 , A61N1/36071
摘要： Systems and methods include sensing whether a shock to a heart is needed, and prior to delivering the shock, causing at least a partial contraction of a musculature in a chest, and delivering the shock while the musculature is at least partially contracted.
摘要翻译：系统和方法包括检测是否需要对心脏的休克，以及在传递休克之前，引起胸部肌肉组织的至少部分收缩，以及在肌肉组织至少部分收缩期间递送休克。

2. 发明申请

WO2009154730A1 VASCULAR INTERVENTION CATHETERS WITH PACING ELECTRODES 审中-公开
标题翻译：具有电极电极的血管干预导管
公开(公告)号：WO2009154730A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/003590
申请日：2009-06-16
申请人： CARDIAC PACEMAKERS, INC. , EIDENSCHINK, Tracee, E. , BROMAN, David, J. , HEIDNER, Matthew, C. , SCHWARTZ, Mark , TOMASCHKO, Daniel, K. , BAYNHAM, Tamara, C. , OLSON, Richard, J.
发明人： EIDENSCHINK, Tracee, E. , BROMAN, David, J. , HEIDNER, Matthew, C. , SCHWARTZ, Mark , TOMASCHKO, Daniel, K. , BAYNHAM, Tamara, C. , OLSON, Richard, J.
IPC分类号： A61N1/05 , A61N1/362 , A61M25/10 , A61M29/02 , A61M25/09 , A61B17/3207 , A61B17/22 , A61F2/84
CPC分类号： A61N1/056 , A61B2017/22001 , A61B2017/22051 , A61B2017/320716 , A61F2/86 , A61F2/95 , A61N1/3627
摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with myocardial infarction (MI) and revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through pacign electrodes incorporated onto percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure. Examples of the PTVI devices include a guide catheter, a guide wire, and an angioplasty catheter such as a balloon catheter used in the revascularization procedure. The pacing electrodes are incorporated onto such PTVI devices in various ways.
摘要翻译：心脏保护起搏应用于预防和/或减少与心肌梗塞（MI）和血运重建术相关的心脏损伤。起搏脉冲由心脏起搏器产生并通过血管重建手术中并入经皮腔内血管介入（PTVI）装置的平板电极进行输送。 PTVI装置的实例包括引导导管，导丝和血管成形术导管，例如用于血运重建术中的气囊导管。起搏电极以各种方式结合到这样的PTVI装置上。

3. 发明申请

WO2009025819A1 OPTICAL DEPOLARIZATION OF CARDIAC TISSUE 审中-公开
标题翻译：心脏组织的光学分离
公开(公告)号：WO2009025819A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/009908
申请日：2008-08-20
申请人： CARDIAC PACEMAKERS, INC. , FOLEY, John , STOLEN, Craig , SCHWARTZ, Mark
发明人： FOLEY, John , STOLEN, Craig , SCHWARTZ, Mark
IPC分类号： C12N15/79 , A61N5/06 , A61B5/0452
CPC分类号： A61N5/0622 , A61B5/04012 , A61B5/418 , A61N5/0601 , A61N5/062 , A61N2005/063 , A61N2005/0651
摘要： The invention provides a cardiac rhythm management system for stimulating a heart having photosensitive tissue, vectors useful to photosensitize cells expressing the vectors, and methods for light induced depolarization of cells.
摘要翻译：本发明提供了一种用于刺激具有光敏组织的心脏的心律管理系统，用于光敏表达载体的细胞的载体，以及光诱导的细胞去极化的方法。

4. 发明申请

WO2009025812A2 APPARATUS TO TREAT AND PREVENT ATRIAL TACHYARRHYTHMIAS 审中-公开
标题翻译：用于治疗和预防心房心律失常的装置
公开(公告)号：WO2009025812A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009898
申请日：2008-08-20
申请人： CARDIAC PACEMAKERS, INC. , QU, Jihong , SIH, Haris J. , SCHWARTZ, Mark , SINHA, Prashant
发明人： QU, Jihong , SIH, Haris J. , SCHWARTZ, Mark , SINHA, Prashant
IPC分类号： A61K47/48
CPC分类号： A61N1/3621 , A61M5/14276 , A61N1/0568 , A61N1/0587 , A61N1/3962
摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.
摘要翻译：本发明提供了一种心律管理系统，其包括快速心律失常检测和分类电路，该快速心律失常检测和分类电路被编程为检测和分类快速性心律失常;生物治疗输送装置，其被配置为输送或调节适于终止或预防的表达盒心房颤动（AF）以及耦合到快速性心律失常检测和分类电路以及生物治疗传递装置的控制电路。还提供了一种用于具有心血管系统的身体的可植入医疗装置，该装置包括可植入装置主体，该可植入装置主体包括至少一个配置成位于心血管系统内的心血管部分，以及一个并入可植入装置的心血管部分中的表达盒选择表达盒以表达终止或防止AF的基因产物。进一步提供了使用特定表达盒来预防，抑制或治疗AF的方法。

5. 发明申请

WO2004047918A1 PACING THERAPY FOR EXTENDING ATRIAL REFRACTORY PERIOD 审中-公开
标题翻译：用于延长ATRIAL REFRACTORY期间的治疗
公开(公告)号：WO2004047918A1
公开(公告)日：2004-06-10
申请号：PCT/US2003/037155
申请日：2003-11-20
申请人： CARDIAC PACEMAKERS, INC.
发明人： SCHWARTZ, Mark , SRA, Jasbir
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： A device and method are presented for prolonging the atrial effective refractory period with pacing therapy. Such refractory period prolongation renders the atrial tissue less susceptible to the onset of atrial fibrillation. A particularly useful application is during the period after application of electrical therapy to the atria.to terminate an episode of atrial fibrillation.
摘要翻译：提出了一种用于起搏治疗延长心房有效不应期的装置和方法。这种不应期延长使得心房组织对心房颤动发作不太敏感。特别有用的应用是在电疗法应用于心房后终止心房颤动发作期间。

6. 发明申请

WO2013006195A1 METHODS OF DETECTING GENE FUSIONS 审中-公开
标题翻译：检测基因融合的方法
公开(公告)号：WO2013006195A1
公开(公告)日：2013-01-10
申请号：PCT/US2011/063803
申请日：2011-12-07
申请人： HTG MOLECULAR DIAGNOSTICS, INC. , SELIGMANN, Bruce , KERNS, BJ , LUECKE, John , ROUNSEVILLE, Matt , BOTROS, Ihab , SCHWARTZ, Mark
发明人： SELIGMANN, Bruce , KERNS, BJ , LUECKE, John , ROUNSEVILLE, Matt , BOTROS, Ihab , SCHWARTZ, Mark
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q1/6827 , C12Q1/6886 , C12Q2600/156 , C12Q2521/307 , C12Q2537/16 , C12Q2565/102
摘要： Disclosed herein are methods of detecting presence of a gene fusion in a sample from a subject. In some embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize a fusion probe that spans the point of fusion between two nucleic acids or genes, and detecting the fusion probe after nuclease treatment. In other embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize two or more probes that flank the point of fusion between two nucleic acids or genes, and detecting these probes after nuclease treatment. In additional embodiments, the methods can include determining the percentage of gene fusion in the sample relative to the first nucleic acid or the second nucleic acid.
摘要翻译：本文公开了检测来自受试者的样品中基因融合物的存在的方法。在一些实施方案中，检测来自受试者的样品中融合基因的存在的方法利用跨越两个核酸或基因之间的融合点的融合探针，并在核酸酶处理后检测融合探针。在其他实施方案中，检测来自受试者的样品中融合基因的存在的方法利用在两个核酸或基因之间的融合点侧面的两个或更多个探针，并在核酸酶处理后检测这些探针。在另外的实施方案中，所述方法可以包括确定样品中相对于第一核酸或第二核酸的基因融合的百分比。

7. 发明申请

WO2012088443A1 SYSTEM AND METHOD FOR AUTOMATED CAPTURE AND COMPACTION OF INSTRUCTIONAL PERFORMANCES 审中-公开
标题翻译：用于自动捕获和指导性能压缩的系统和方法
公开(公告)号：WO2012088443A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/066903
申请日：2011-12-22
申请人： KEVADIYA, INC. , PATEL, Nilesh , KROLL, Scott , SCHWARTZ, Mark
发明人： PATEL, Nilesh , KROLL, Scott , SCHWARTZ, Mark
IPC分类号： G09B5/00
CPC分类号： G06F3/017 , G09B5/00 , G09B7/02
摘要： The system comprises functionality for instructors to record their lessons in an easy method while allowing them to capture their teaching techniques with a tool which improves the effectiveness of the playback, by reverse scripting of the teachers motions and use of educational tools including blackboards, whiteboards, and tablet computers among others and automating highlight of the relevant multiple media channels for best emphasis during presentation. Access to the centralized lesson database will permit students to learn from the best teachers and instructors and can execute the system right on their desktops or portable computers or access it through a dedicated website. Playback may be personalized to the needs and preferences of each student and the conceptual content is essentially highlighted in video and audio to maximize didactic effectiveness of presentation.
摘要翻译：该系统包括用于教师以简单的方法记录他们的课程的功能，同时允许他们通过改进播放的有效性的工具来捕获他们的教学技术，通过教师动作的反向脚本和教学工具的使用，包括黑板，白板，和平板电脑等，并自动化相关多媒体频道的亮点，以便在演示过程中获得最佳的重视。访问集中式课程数据库将允许学生从最好的教师和教师那里学习，并可以在桌面或便携式计算机上执行系统，或通过专用网站进行访问。播放可以根据每个学生的需求和偏好进行个性化，并且基本上在视频和音频中突出显示概念内容，以最大化教学效果。

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