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1. 发明申请

WO2009029172A1 IMPLANTABLE INSPIRATORY MUSCLE STIMULATION SYSTEM 审中-公开
标题翻译：可植入的肌肉刺激系统
公开(公告)号：WO2009029172A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/009725
申请日：2008-08-14
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , ARCOT-KRISHNAMURTHY, Shantha , LIU, Lili , BECK, Kenneth , LEE, Kent , KWOK, Jonathan , LIN, Zheng
发明人： ZHANG, Yi , ARCOT-KRISHNAMURTHY, Shantha , LIU, Lili , BECK, Kenneth , LEE, Kent , KWOK, Jonathan , LIN, Zheng
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/0558
摘要： An inspiratory muscle stimulation system uses an implantable medical device to deliver stimulation to control diaphragmatic contractions for slower and deeper breathing, thereby conditioning and strengthening inspiratory muscles. In various embodiments, respiratory and/or cardiac performance are monitored for controlling parameters of the stimulation.
摘要翻译：吸气肌肉刺激系统使用可植入医疗装置来输送刺激，以控制膈肌收缩以减慢和深呼吸，从而调节和加强吸气肌肉。在各种实施例中，监测呼吸和/或心脏性能以控制刺激的参数。

2. 发明申请

WO2009048610A1 RESPIRATORY STIMULATION FOR TREATING PERIODIC BREATHING 审中-公开
标题翻译：呼吸刺激治疗周期性呼吸
公开(公告)号：WO2009048610A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011641
申请日：2008-10-10
申请人： CARDIAC PACEMAKERS, INC. , LIN, Zheng , BECK, Kenneth C. , KWOK, Jonathan , LEE, Kent , PU, Yachuan , STAHMANN, Jeffrey E.
发明人： LIN, Zheng , BECK, Kenneth C. , KWOK, Jonathan , LEE, Kent , PU, Yachuan , STAHMANN, Jeffrey E.
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/0816 , A61N1/3601
摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.
摘要翻译：描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

3. 发明申请

WO2010054359A2 REVERSE HYSTERESIS AND MODE SWITCHING FOR INTERMITTENT PACING THERAPY 审中-公开
标题翻译：用于间歇性治疗的逆向滞后和模式切换
公开(公告)号：WO2010054359A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/063830
申请日：2009-11-10
申请人： CARDIAC PACEMAKERS, INC. , ARCOT-KRISHNAMURTHY, Shantha , SEIM, Gary T. , LEE, Kent , DONG, Yanting , SHUROS, Allan C. , WHITEHOUSE, David L.
发明人： ARCOT-KRISHNAMURTHY, Shantha , SEIM, Gary T. , LEE, Kent , DONG, Yanting , SHUROS, Allan C. , WHITEHOUSE, David L.
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing. A method and device for applying reverse hysteresis and mode switching to the delivery of such cardioprotective pacing are described.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的期望的心脏保护作用。描述了一种用于将逆向滞后和模式切换应用于这种心脏保护起搏的递送的方法和装置。

4. 发明申请

WO2008027339A2 SYSTEM FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 审中-公开
标题翻译：神经刺激系统与呼吸反馈
公开(公告)号：WO2008027339A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018846
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS, INC. , HAEFNER, Paul, A. , JAMES, Kristofer, J. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan
发明人： HAEFNER, Paul, A. , JAMES, Kristofer, J. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

5. 发明申请

WO2006138069A1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 审中-公开
标题翻译：神经控制系统
公开(公告)号：WO2006138069A1
公开(公告)日：2006-12-28
申请号：PCT/US2006/021323
申请日：2006-06-01
申请人： CARDIAC PACEMAKERS, INC. , CAPARSO, Anthony , LIBBUS, Imad , BROOKE, M., Jason , LEE, Kent , KWOK, Jonathan , PU, Yachuan
发明人： CAPARSO, Anthony , LIBBUS, Imad , BROOKE, M., Jason , LEE, Kent , KWOK, Jonathan , PU, Yachuan
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

6. 发明申请

WO2008027297A3 SYSTEM FOR NEURAL STIMULATION DURING DISORDERED BREATHING 审中-公开
公开(公告)号：WO2008027297A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/018697
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS, INC. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan , HAEFNER, Paul, A. , JAMES, Kristofer, J.
发明人： LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan , HAEFNER, Paul, A. , JAMES, Kristofer, J.
IPC分类号： A61N1/36
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.

7. 发明申请

WO2006115607A1 THORACIC OR INTRACARDIAC IMPEDANCE SELECTING VECTOR AUTOMATICALLY 审中-公开
标题翻译： THORACIC或INTRACARDIAC阻抗自动选择矢量
公开(公告)号：WO2006115607A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/009646
申请日：2006-03-16
申请人： CARDIAC PACEMAKERS, INC. , KWOK, Jonathan , LEE, Kent , HARTLEY, Jesse W. , STAHMANN, Jeffrey E. , YU, Yinghong , DING, Jiang
发明人： KWOK, Jonathan , LEE, Kent , HARTLEY, Jesse W. , STAHMANN, Jeffrey E. , YU, Yinghong , DING, Jiang
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61B5/0205 , A61B5/053 , A61B5/0538 , A61N1/36185 , A61N1/36521 , A61N1/3686
摘要： A cardiac function management device or other implantable medical device includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.
摘要翻译：心脏功能管理装置或其他可植入医疗装置包括测试模式和诊断模式。在测试模式期间，器件循环通过各种电极配置来收集胸部阻抗数据。从每个这样的电极配置的阻抗数据计算至少一个品质因数。在一个例子中，仅使用非心律失常节拍来计算品质因数。使用品质因数自动选择特定的电极配置。在诊断模式下，设备使用所选择的电极配置收集阻抗数据。在一个示例中，品质因数包括心搏幅度和呼吸振幅的比值。还描述了品质因数的其它实例。

8. 发明申请

WO2008054580A3 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR HEALTH MANAGEMENT 审中-公开
公开(公告)号：WO2008054580A3
公开(公告)日：2008-05-08
申请号：PCT/US2007/020425
申请日：2007-09-20
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , HATLESTAD, John, D. , CARLSON, Gerrard, M. , DALAL, Yousufali , BROCKWAY, Marina, V. , LEE, Kent , KUENZLER, Richard, O. , HARO, Carlos , SIEJKO, Krzysztof, Z. , PATANGAY, Abhilash
发明人： ZHANG, Yi , HATLESTAD, John, D. , CARLSON, Gerrard, M. , DALAL, Yousufali , BROCKWAY, Marina, V. , LEE, Kent , KUENZLER, Richard, O. , HARO, Carlos , SIEJKO, Krzysztof, Z. , PATANGAY, Abhilash
IPC分类号： A61B5/02
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. Baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. Prediction processing may be performed by the at-least one implantable device or by an external device in communication therewith. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

9. 发明申请

WO2004049930A2 DETECTION OF DISORDERED BREATHING 审中-公开
标题翻译：检测出异常呼吸
公开(公告)号：WO2004049930A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038438
申请日：2003-12-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： NI, Quan , HATLESTAD, John, D. , HARTLEY, Jesse, W. , STAHMANN, Jeffrey, E. , KIM, Jaeho , LEE, Kent
IPC分类号： A61B5/0205
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/4806 , A61B5/4809 , A61B5/7264
摘要： Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signal associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.
摘要翻译：用于检测无序呼吸的装置和方法涉及确定患者睡着并且感测与患者睡着时指示睡眠呼吸紊乱的无序呼吸相关联的一个或多个信号。使用与无序呼吸相关的感测信号来检测睡眠呼吸障碍。与无序呼吸相关联的感测信号也可用于获取一个或多个呼吸循环的呼吸模式。确定呼吸模式的特征。根据呼吸模式的特点，呼吸模式被分类为无序呼吸发作。使用可植入装置进行涉及无序呼吸检测的一个或多个过程。

10. 发明申请

WO2007064682A1 METHOD AND SYSTEM FOR HEART FAILURE STATUS EVALUATION BASED ON A DISORDERED BREATHING INDEX 审中-公开
标题翻译：基于异常呼吸指数的心脏失效状态评估方法与系统
公开(公告)号：WO2007064682A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/045646
申请日：2006-11-29
申请人： CARDIAC PACEMAKERS, INC.
发明人： KWOK, Jonathan , BROCKWAY, Marina , LEE, Kent , NI, Quan , PU, Yachuan , STAHMANN, Jeffrey E. , ZHANG, Yi , HARTLEY, Jesse
IPC分类号： A61N1/365 , A61N1/362 , A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordere d breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序的呼吸事件确定不良呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

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