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1. 发明申请

WO2008027297A3 SYSTEM FOR NEURAL STIMULATION DURING DISORDERED BREATHING 审中-公开
公开(公告)号：WO2008027297A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/018697
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS, INC. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan , HAEFNER, Paul, A. , JAMES, Kristofer, J.
发明人： LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan , HAEFNER, Paul, A. , JAMES, Kristofer, J.
IPC分类号： A61N1/36
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.

2. 发明申请

WO2008027233A1 SYSTEM FOR NEURAL STIMULATION 审中-公开
标题翻译：神经刺激系统
公开(公告)号：WO2008027233A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/018371
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , KRAMER, Andrew, P. , CAPARSO, Anthony V. , JAMES, Kristofer J. , RUBLE, Stephen , ZHAO, Weiying
发明人： LIBBUS, Imad , KRAMER, Andrew, P. , CAPARSO, Anthony V. , JAMES, Kristofer J. , RUBLE, Stephen , ZHAO, Weiying
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，设备包括至少一个端口，其中每个端口适于将引线与电极连接到设备。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道递送到电极。刺激电路适于通过刺激通道输送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

3. 发明申请

WO2009036326A1 ADHERENT ATHLETIC MONITOR 审中-公开
标题翻译：附属运动员监视器
公开(公告)号：WO2009036326A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076240
申请日：2008-09-12
申请人： CORVENTIS, INC. , JAMES, Kristofer J. , AMURTHUR, Badri , BLY, Mark J. , LIBBUS, Imad
发明人： JAMES, Kristofer J. , AMURTHUR, Badri , BLY, Mark J. , LIBBUS, Imad
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/02055 , A61B5/04085 , A61B5/6833 , A61B2560/0412 , A61B2562/164
摘要： ABSTRACT OF THE DISCLOSURE A system is provided for tracking an individual, engaged in extreme physical activity, physiological status and detecting and predicting negative physiological events. A monitoring system is provided that includes a plurality of sensors. Each sensor has a sensor output, and a combination of the sensor outputs is used to determine distress of the monitored individual engaged in extreme physical activity. A wireless communication device is coupled to the plurality of sensors and transfers data directly or indirectly from the plurality of sensors to a remote monitoring system. A remote monitoring system is coupled to the wireless communication device and configured to receive the processed data.
摘要翻译：发明内容提供一种系统，用于跟踪个体，从事极端身体活动，生理状态，检测和预测负面生理事件。提供了包括多个传感器的监视系统。每个传感器都有一个传感器输出，并且传感器输出的组合用于确定从事极端身体活动的受监视人员的困扰。无线通信设备耦合到多个传感器并将数据直接或间接地从多个传感器传送到远程监视系统。远程监控系统耦合到无线通信设备并被配置为接收处理后的数据。

4. 发明申请

WO2009036319A1 ADHERENT EMERGENCY PATIENT MONITOR 审中-公开
标题翻译：临床紧急病人监护人
公开(公告)号：WO2009036319A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076233
申请日：2008-09-12
申请人： CORVENTIS, INC. , LIBBUS, Imad , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , MANICKA, Yatheendhar, D. , MAZAR, Scott, T. , WANG, Jerry, S.
发明人： LIBBUS, Imad , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , MANICKA, Yatheendhar, D. , MAZAR, Scott, T. , WANG, Jerry, S.
IPC分类号： A61B5/08
CPC分类号： A61B5/04087 , A61B5/6833
摘要： An adherent device comprises an adhesive patch to adhere to a skin of the patient. At least two electrodes are connected to the patch and capable of electrically coupling to the patient. Electrocardiogram circuitry can be coupled to at the least two electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate an accelerometer signal in response to at least one of an activity or a position of the patient. A processor comprising a tangible medium can be configured to communicate with the electrocardiogram circuitry and the accelerometer to generate an alarm signal in response to the electrocardiogram signal and the accelerometer signal.
摘要翻译：粘附装置包括粘附到患者皮肤上的粘贴剂。至少两个电极连接到贴片并且能够电耦合到患者。心电图电路可耦合到至少两个电极以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生加速度计信号。包括有形介质的处理器可以被配置为与心电图电路和加速度计通信以响应于心电图信号和加速度计信号产生报警信号。

5. 发明申请

WO2007127831A3 IMPLANTABLE THERMOELECTRIC POWER SYSTEM 审中-公开
标题翻译：可植入式热电系统
公开(公告)号：WO2007127831A3
公开(公告)日：2008-04-03
申请号：PCT/US2007067481
申请日：2007-04-26
申请人： CARDIAC PACEMAKERS INC , ERBSTOESZER BLAIR , JAMES KRISTOFER J , MORITA GLENN
发明人： ERBSTOESZER BLAIR , JAMES KRISTOFER J , MORITA GLENN
IPC分类号： A61N1/00
CPC分类号： A61N1/3785
摘要： The present subject matter includes a first housing portion which is thermally conductive and which has a first housing opening, a second housing portion which is thermally conductive and which has a second housing opening, the second housing opening being hermetically sealed to the first housing opening, with the first housing portion and the second housing portion at least partially defining an interior volume, cardiac rhythm management electronics disposed in the interior volume, and a thermoelectric energy converter disposed in the interior volume, the thermoelectric energy converter having a hot pole and a cold pole, with the hot pole thermally connected to the first housing portion, and the cold pole thermally connected to the second housing portion.
摘要翻译：本主题包括第一壳体部分，其是导热的并且具有第一壳体开口，第二壳体部分是导热的并且具有第二壳体开口，第二壳体开口被密封地密封到第一壳体开口，其中第一壳体部分和第二壳体部分至少部分地限定内部体积，设置在内部体积中的心律管理电子器件和布置在内部体积中的热电能量转换器，热电能量转换器具有热极和冷的所述热极热连接到所述第一壳体部分，并且所述冷极热连接到所述第二壳体部分。

6. 发明申请

WO2008027339A3 SYSTEM FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 审中-公开
标题翻译：呼吸反馈神经刺激系统
公开(公告)号：WO2008027339A3
公开(公告)日：2008-07-24
申请号：PCT/US2007018846
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS INC , HAEFNER PAUL A , JAMES KRISTOFER J , LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN
发明人： HAEFNER PAUL A , JAMES KRISTOFER J , LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN
IPC分类号： A61N1/36 , A61B5/08
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能中潜在的不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔使神经刺激脉冲的传递与呼吸周期同步。在另一个实施例中，神经刺激系统检测呼吸障碍，并作为响应调整神经刺激脉冲的传递和/或传递治疗检测到的呼吸障碍的呼吸治疗。

7. 发明申请

WO2007127831A2 IMPLANTABLE THERMOELECTRIC POWER SYSTEM 审中-公开
标题翻译：可植入式热电系统
公开(公告)号：WO2007127831A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/067481
申请日：2007-04-26
申请人： CARDIAC PACEMAKERS, INC. , ERBSTOESZER, Blair , JAMES, Kristofer J. , MORITA, Glenn
发明人： ERBSTOESZER, Blair , JAMES, Kristofer J. , MORITA, Glenn
CPC分类号： A61N1/3785
摘要： The present subject matter includes a first housing portion which is thermally conductive and which has a first housing opening, a second housing portion which is thermally conductive and which has a second housing opening, the second housing opening being hermetically sealed to the first housing opening, with the first housing portion and the second housing portion at least partially defining an interior volume, cardiac rhythm management electronics disposed in the interior volume, and a thermoelectric energy converter disposed in the interior volume, the thermoelectric energy converter having a hot pole and a cold pole, with the hot pole thermally connected to the first housing portion, and the cold pole thermally connected to the second housing portion.
摘要翻译：本主题包括第一壳体部分，其是导热的并且具有第一壳体开口，第二壳体部分是导热的并且具有第二壳体开口，第二壳体开口被密封地密封到第一壳体开口，其中第一壳体部分和第二壳体部分至少部分地限定内部体积，设置在内部体积中的心律管理电子器件和布置在内部体积中的热电能量转换器，热电能量转换器具有热极和冷的所述热极热连接到所述第一壳体部分，并且所述冷极热连接到所述第二壳体部分。

8. 发明申请

WO2011031427A1 RESPIRATORY RECTIFICATION 审中-公开
标题翻译：呼吸恢复
公开(公告)号：WO2011031427A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/045992
申请日：2010-08-19
申请人： CARDIAC CONCEPTS, INC. , GELFAND, Mark , LYNN, Mark, C. , WESTLUND, Randy, W. , JAMES, Kristofer, J. , PANTELEON, Antonis , GOBLISH, Todd, P.
发明人： GELFAND, Mark , LYNN, Mark, C. , WESTLUND, Randy, W. , JAMES, Kristofer, J. , PANTELEON, Antonis , GOBLISH, Todd, P.
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
摘要翻译：一种通过刺激呼吸肌或神经夹带呼吸系统同时使呼吸驱动完好无损来治疗呼吸障碍的手段。本发明的实施例采用频率分析来确定是否正在施加适当的刺激能量。

9. 发明申请

WO2009036334A1 ADHERENT MULTI-SENSOR DEVICE WITH EMPATHIC MONITORING 审中-公开
标题翻译：附带多传感器设备与经济监测
公开(公告)号：WO2009036334A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076248
申请日：2008-09-12
申请人： CORVENTIS, INC. , AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , LIBBUS, Imad , MANICKA, Yatheendhar, D. , MAZAR, Scott, T. , WANG, Jerry, S.
发明人： AMURTHUR, Badri , BLY, Mark, J. , JAMES, Kristofer, J. , LIBBUS, Imad , MANICKA, Yatheendhar, D. , MAZAR, Scott, T. , WANG, Jerry, S.
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/6833 , A61B2560/0412
摘要： A system and methods are provided for physiological monitoring and prediction. The system includes a detecting system and a remote monitoring system. The detecting system includes, (i) an adherent device with a plurality of sensors that provide an indication of at least one physiological event of a patient, the adherent device being coupled to the patient's thorax and (ii) a wireless communication device coupled to the plurality of sensors and configured to transfer patient data directly or indirectly from the plurality of sensors to a remote monitoring system. The remote monitoring system is coupled to the wireless communication device. Logic resources may be provided at the remote monitoring system to determine the physiological event of the patient.
摘要翻译：提供了一种用于生理监测和预测的系统和方法。该系统包括检测系统和远程监控系统。所述检测系统包括：（i）具有多个传感器的粘附装置，所述多个传感器提供患者的至少一个生理事件的指示，所述粘附装置耦合到患者的胸部，以及（ii）耦合到所述患者的胸部的无线通信装置多个传感器并且被配置为将患者数据直接或间接地从多个传感器传送到远程监视系统。远程监控系统耦合到无线通信设备。可以在远程监控系统处提供逻辑资源以确定患者的生理事件。

10. 发明申请

WO2008027339A2 SYSTEM FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 审中-公开
标题翻译：神经刺激系统与呼吸反馈
公开(公告)号：WO2008027339A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018846
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS, INC. , HAEFNER, Paul, A. , JAMES, Kristofer, J. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan
发明人： HAEFNER, Paul, A. , JAMES, Kristofer, J. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

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