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1. 发明申请

WO2006122198A2 IMPLANTABLE CARDIOVERTER DEFIBRILLATOR WITH PROGRAMMABLE CAPACITOR CHARGING LEVEL 审中-公开
标题翻译：带可编程电容充电电位器的可移植式减载器
公开(公告)号：WO2006122198A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/018115
申请日：2006-05-11
申请人： CARDIAC PACEMAKERS, INC. , YOUKER, Nick, A. , HAYES, Kenneth , LINDER, William, J.
发明人： YOUKER, Nick, A. , HAYES, Kenneth , LINDER, William, J.
IPC分类号： A61N1/39 , A61N1/372
CPC分类号： A61N1/3708 , A61N1/37235 , A61N1/3925 , A61N1/3956 , A61N1/3975 , A61N1/3981
摘要： An implantable cardioverter defibrillator (ICD) has a programmable ICD energy level corresponding to the maximum defibrillation energy deliverable with each defibrillation shock pulse. The ICD energy level is programmable within the maximum energy capacity of the defibrillation capacitor(s) of the ICD. In various embodiments, after a uses enters the ICD energy level, one or more corresponding ICD performance parameters are presented. Restrictions are applied to the energy level programming of the ICD to ensure the predictability of the one or more ICD performance parameters.
摘要翻译：植入式心律转复除颤器（ICD）具有对应于每个除颤冲击脉冲可递送的最大除颤能量的可编程ICD能量水平。 ICD能量级可在ICD的除颤电容器的最大能量容量内编程。在各种实施例中，在使用进入ICD能级之后，呈现一个或多个相应的ICD性能参数。限制适用于ICD的能量级编程，以确保一个或多个ICD性能参数的可预测性。

2. 发明申请

WO2012003124A2 THERAPY CIRCUIT PROTECTION FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗设备的电路保护
公开(公告)号：WO2012003124A2
公开(公告)日：2012-01-05
申请号：PCT/US2011/041414
申请日：2011-06-22
申请人： CARDIAC PACEMAKERS, INC. , LUDWIG, Jacob, M. , LINDER, William, J. , BRANDNER, Douglas, J. , STESSMAN, Nicholas, J. , HANNAN, Douglas, Michael , STUBBS, Scott, R. , STAHMANN, Jeffrey, E. , FOSTER, Arthur
发明人： LUDWIG, Jacob, M. , LINDER, William, J. , BRANDNER, Douglas, J. , STESSMAN, Nicholas, J. , HANNAN, Douglas, Michael , STUBBS, Scott, R. , STAHMANN, Jeffrey, E. , FOSTER, Arthur
IPC分类号： A61N1/08
CPC分类号： A61N1/3931 , A61N1/025 , A61N1/3706 , A61N1/3937 , A61N1/3962 , A61N2001/083
摘要： A medical device can include a therapy circuit configured to provide a specified electrostimulation therapy to a tissue site, the specified electrostimulation therapy including a scheduled completion, the therapy circuit including a protection circuit configured to adjust specification of the electrostimulation therapy being provided so as to provide an adjusted electrostimulation therapy before the scheduled completion. The medical device can include a monitoring circuit comprising a comparator. The monitoring circuit can be configured to trigger the protection circuit to inhibit the therapy circuit when the therapy circuit output parameter exceeds the specified threshold as indicated by the comparator.
摘要翻译：医疗装置可以包括被配置为向组织部位提供指定的电刺激治疗的治疗电路，该指定的电刺激治疗包括预定完成，该治疗电路包括保护电路，该保护电路被配置为调整提供电刺激治疗以便在预定完成之前提供调整的电刺激治疗。医疗设备可以包括包含比较器的监视电路。当治疗电路输出参数超过由比较器指示的指定阈值时，监控电路可被配置为触发保护电路以禁止治疗电路。

3. 发明申请

WO2009075868A1 PAINLESS NON-STIMULATING LEAD IMPEDANCE MEASUREMENT 审中-公开
标题翻译：无刺激性铅阻抗测量
公开(公告)号：WO2009075868A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/013617
申请日：2008-12-11
申请人： CARDIAC PACEMAKERS, INC. , LINDER, William, J. , MUTTONEN, Angela, M.
发明人： LINDER, William, J. , MUTTONEN, Angela, M.
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3937 , A61N2001/083
摘要： This document discusses, among other things, an apparatus comprising, a plurality of electrodes configured to deliver defibrillation countershock energy to a subject, an impedance measurement circuit communicatively coupled to the electrodes and configured to measure the impedance between any two of the electrodes using a non-stimulating excitation signal, and a controller communicatively coupled to the impedance measurement circuit and configured to calculate the impedance of a shock vector, wherein the shock vector includes a first electrode and a second electrode electrically connected together, and a third electrode, and wherein the controller calculates the impedance using measured impedances between the three electrodes when none of them are electrically connected.
摘要翻译：本文件尤其讨论了一种装置，其包括多个电极，其被配置为向受试者传递去颤颤的反相能量;阻抗测量电路，其通信地耦合到所述电极并且被配置为使用非电极来测量任何两个电极之间的阻抗， - 激励激励信号，以及控制器，其通信地耦合到所述阻抗测量电路并且被配置为计算冲击矢量的阻抗，其中所述冲击矢量包括电连接在一起的第一电极和第二电极以及第三电极，并且其中控制器使用三个电极之间的测量阻抗计算阻抗，当它们都没有电连接时。

4. 发明申请

WO2006127248A1 IMPLANTABLE NEURAL STIMULATOR WITH MODE SWITCHING 审中-公开
标题翻译：具有模式切换的可植入神经刺激器
公开(公告)号：WO2006127248A1
公开(公告)日：2006-11-30
申请号：PCT/US2006/017637
申请日：2006-05-08
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , KRAMER, Andrew, P. , LINDER, William, J. , STAHMANN, Jeffrey, E.
发明人： LIBBUS, Imad , KRAMER, Andrew, P. , LINDER, William, J. , STAHMANN, Jeffrey, E.
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/36128 , A61M5/1723 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3688
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及可植入装置。各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。响应于触发事件，控制器适于在至少两种模式之间切换。本文提供了其它方面和实施例。

5. 发明申请

WO2008063470A1 DEVICE FOR SIMULATED EXERCISE 审中-公开
标题翻译：用于模拟练习的装置
公开(公告)号：WO2008063470A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/023769
申请日：2007-11-13
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , PASTORE, Joseph, M. , VON ARX, Jeffrey, A. , SPINELLI, Julio, C. , LINDER, William, J.
发明人： SHUROS, Allan, C. , PASTORE, Joseph, M. , VON ARX, Jeffrey, A. , SPINELLI, Julio, C. , LINDER, William, J.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365 , A61N1/372
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/3682 , A61N1/3684 , A61N1/3688 , A61N1/37205
摘要： A device and method for delivering pacing therapy to the heart in order to improve cardiac function in heart failure and post-MI patients. The pacing therapy is delivered in a manner that mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The simulated exercise pacing may be delivered on an intermittent basis in accordance with a defined schedule and/or in response to detected conditions or events.
摘要翻译：用于向心脏输送起搏治疗以改善心力衰竭和MI后患者的心脏功能的装置和方法。起搏疗法以模仿运动效果的方式进行，即使在运动不耐受的患者中也能改善症状。可以根据定义的时间表和/或响应于检测到的条件或事件以间歇的方式递送模拟锻炼起搏。

6. 发明申请

WO2003045497A3 REFORMING WET-TANTALUM CAPACITORS IN IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2003045497A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/037279
申请日：2002-11-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： HARGUTH, Robert, S. , BALCZEWSKI, Ron, A. , LINDER, William, J. , MUNSON, Gregory, S. , PARIS, Michael, W.
IPC分类号： A61N1/39
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Critical to this function, aluminum-electrolytic capacitors store and deliver life-saving bursts of electric charge to the heart. This type of capacitor requires regular "reform" to preserve its charging efficiency over time. Because reform expends valuable battery energy, manufacturers developed wet-tantalum capacitors, which are generally understood not to require reform. Yet, the present inventors discovered through extensive study that wet-tantalum capacitors exhibit progressively worse charging efficiency over time. Accordingly, to address this problem, the inventors devised unique reform techniques for wet-tantalum capacitors. One exemplary technique entails charging wet-tantalum capacitors to a voltage equal to about 90% of their rated voltage and allowing the charge to dissipate through system leakage for a period of time, before discharging through a non-therapeutic load .

7. 发明申请

WO2003045497A2 REFORMING WET-TANTALUM CAPACITORS IN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：改造可植入医疗器械中的湿式电容器
公开(公告)号：WO2003045497A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/037279
申请日：2002-11-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： HARGUTH, Robert, S. , BALCZEWSKI, Ron, A. , LINDER, William, J. , MUNSON, Gregory, S. , PARIS, Michael, W.
IPC分类号： A61N1/39
CPC分类号： H01G9/042 , A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Critical to this function, aluminum-electrolytic capacitors store and deliver life-saving bursts of electric charge to the heart. This type of capacitor requires regular "reform" to preserve its charging efficiency over time. Because reform expends valuable battery energy, manufacturers developed wet-tantalum capacitors, which are generally understood not to require reform. Yet, the present inventors discovered through extensive study that wet-tantalum capacitors exhibit progressively worse charging efficiency over time. Accordingly, to address this problem, the inventors devised unique reform techniques for wet-tantalum capacitors. One exemplary technique entails charging wet-tantalum capacitors to a voltage equal to about 90% of their rated voltage and allowing the charge to dissipate through system leakage for a period of time, before discharging through a non-therapeutic load .
摘要翻译：微型除颤器和心脏转复器检测异常心律，并自动应用电疗法恢复正常的心脏功能。这个功能至关重要的是，铝电解电容器可以将心脏中的电荷充满拯救生命。这种类型的电容器需要经常的“改造”以保持其充电效率随着时间的推移。由于改革耗费了宝贵的电池能量，所以制造商开发了湿钽电容器，通常被认为不需要改造。然而，本发明人通过广泛的研究发现，湿钽电容器随着时间的推移呈现逐渐变差的充电效率。因此，为了解决这个问题，本发明人为湿钽电容器设计了独特的改进技术。一个示例性技术需要将湿钽电容器充电至等于其额定电压的约90％的电压，并且在通过非治疗负载放电之前允许电荷通过系统泄漏耗散一段时间。

8. 发明申请

WO1997000097A1 AFTER POTENTIAL REMOVAL IN CARDIAC RHYTHM MANAGEMENT DEVICE 审中-公开
标题翻译：在心脏血液管理装置中进行潜在移除后
公开(公告)号：WO1997000097A1
公开(公告)日：1997-01-03
申请号：PCT/US1996010574
申请日：1996-06-19
申请人： CARDIAC PACEMAKERS, INC.
发明人： CARDIAC PACEMAKERS, INC. , HAEFNER, Paul, A. , STOCKBURGER, Mark, A. , LINDER, William, J.
IPC分类号： A61N01/37
CPC分类号： A61N1/3704 , Y10S128/901
摘要： An apparatus effectively removes after potential occurring after a electrical pulse is delivered in a cardiac rhythm management system such as a pacemaker system or cardioverter/defibrillator system having an electrode used for both sensing electrical activity of the heart and carrying the electrical pulse to the heart and a sense amplifier for detecting the electrical activity from the electrode. The apparatus includes a lowpass filter coupled to the electrode to filter the sensed electrical activity. A highpass filter is coupled between the lowpass filter and the sense amplifier to further filter the electrical activity passed from the lowpass filter. Equilibrium circuitry is included to allow passive filter components of the lowpass filter and the highpass filter to return to an equilibrium state following delivery of the electrical pulse.
摘要翻译：一种装置在电脉冲在诸如起搏器系统或心脏转复器/除颤器系统的心律管理系统中传递之后有效地消除，所述心脏起搏器系统或心脏转复器/除颤器系统具有用于感测心脏的电活动并将心电的脉搏传送到心脏的电极，用于检测来自电极的电活动的读出放大器。该装置包括耦合到电极的低通滤波器以滤波感测的电活动。低通滤波器耦合在低通滤波器和读出放大器之间，以进一步滤除从低通滤波器传递的电活动。包括平衡电路，以允许低通滤波器的无源滤波器组件和高通滤波器在电脉冲传递后恢复平衡状态。

9. 发明申请

WO1997006850A1 SEPARATE GAIN CONTROL AND THRESHOLD TEMPLATING 审中-公开
标题翻译：单独的增益控制和阈值模式
公开(公告)号：WO1997006850A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013095
申请日：1996-08-12
申请人： CARDIAC PACEMAKERS, INC.
发明人： CARDIAC PACEMAKERS, INC. , HAEFNER, Paul, A. , STOCKBURGER, Mark, A. , LINDER, William, J.
IPC分类号： A61N01/37
CPC分类号： A61N1/3704
摘要： A system and method automatically adjusts a sensing threshold in a cardioverter/defibrillator which receives electrical activity of the heart and delivers shock pulses in response thereto. An amplifier amplifies the electrical activity according to a variable gain. A detection circuit detects depolarizations in the amplified electrical activity and provides a detect signal representing a cardiac event indicative of a depolarization when the amplified electrical activity exceeds a variable sensing threshold. Slow gain control circuitry adjusts the variable gain in discrete steps based on stored peak history information representing peak values of the amplified electrical activity. Template generation circuitry responds quickly to set the variable sensing threshold to a level proportional to a peak valve of the amplitude of the amplified electrical activity and then decreases the variable sensing threshold from the level in discrete steps until the variable sensing threshold is at a low threshold value.
摘要翻译：系统和方法在接收心脏的电活动并响应于其的脉冲脉冲输出的心律转换器/除颤器中自动调节感测阈值。放大器根据可变增益放大电气活动。检测电路检测放大的电活动中的去极化，并且当放大的电活动超过可变感测阈值时提供表示指示去极化的心脏事件的检测信号。缓慢增益控制电路根据表示放大的电活动峰值的存储的峰值历史信息来调整离散步长中的可变增益。模板生成电路快速响应，将可变感测阈值设置为与放大的电活动的幅度的峰值成比例的电平，然后从离散步骤的电平减小可变感测阈值，直到变量感测阈值处于低阈值值。

10. 发明申请

WO2018089308A1 SYSTEMS, DEVICES, AND METHODS FOR SETTING CARDIAC PACING PULSE PARAMETERS FOR A CARDIAC PACING DEVICE 审中-公开
标题翻译：用于设置心脏起搏装置的心脏起搏脉冲参数的系统，装置和方法
公开(公告)号：WO2018089308A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060211
申请日：2017-11-06
申请人： CARDIAC PACEMAKERS, INC.
发明人： JUFFER, Lance, Eric , LINDER, William, J. , BALCZEWSKI, Ron, A. , MAILE, Keith, R.
IPC分类号： A61N1/37 , A61N1/375
摘要： Systems, devices, and methods for pacing a heart of a patient are disclosed. A device may include a leadless cardiac pacemaker (LCP) that includes a power supply, a pair of electrodes, and a controller operably connected to the electrodes and the power supply. The controller may identify a capture threshold by setting a pace amplitude at a power supply voltage of the power supply and deliver pacing stimulation pulses with different pulse widths to identify the capture threshold. The LCP may then deliver pacing stimulation pulses based, at least in part, on a pulse amplitude and pulse width associated with the capture threshold, and also adding a capture margin. In some cases, the pulse amplitude may change over time and the LCP may adjust a pulse width along a strength-duration curve to account for the pulse amplitude change and maintain a capture threshold and capture margin.
摘要翻译：公开了用于起搏患者心脏的系统，设备和方法。装置可以包括无引线心脏起搏器（LCP），其包括电源，一对电极以及可操作地连接到电极和电源的控制器。控制器可以通过在电源的电源电压处设定步速幅度来识别捕获阈值，并且递送具有不同脉冲宽度的起搏刺激脉冲以识别捕获阈值。 LCP然后可以至少部分地基于与捕获阈值相关联的脉冲幅度和脉冲宽度来递送起搏刺激脉冲，并且还添加捕获余量。在某些情况下，脉冲幅度可能会随时间而变化，并且LCP可能会沿着强度 - 持续时间曲线调整脉冲宽度，以考虑脉冲振幅变化并保持捕捉阈值和捕捉边缘。

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