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1. 发明申请

WO2008079840A2 RATE ADAPTIVE CARDIAC PACING SYSTEMS AND METHODS 审中-公开
标题翻译：速率自适应心脏起搏系统和方法
公开(公告)号：WO2008079840A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088042
申请日：2007-12-19
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , HOPPER, Donald, L. , KANE, Michael, John
发明人： SHUROS, Allan, Charles , HOPPER, Donald, L. , KANE, Michael, John
IPC分类号： G06F19/00
CPC分类号： A61N1/36585 , G06F19/00 , G06F19/3418 , G06F19/3481
摘要： The invention relates to cardiac rhythm management systems, and more particularly, to rate adaptive cardiac pacing systems and methods. In an embodiment, the invention includes a method for providing rate-adaptive cardiac pacing therapy from an implantable medical device, the method including sensing a pulmonary function of a patient; determining a rate of change in the pulmonary function; sensing a cardiac function of the patient; determining a rate of change in the cardiac function; and calculating a target pacing rate based on an existing pacing rate, the rate of change in the pulmonary function, and the rate of change in the cardiac function. In an embodiment, the invention includes a method of controlling a cardiac rhythm management device in response to exertion of a patient, the method including sensing the patient's pulmonary function at a first time t 1 and at a second time t 2 ; calculating a rate of change of the pulmonary function between time t 1 and time t 2 ; sensing the patient's cardiac function at time t 3 and t 4 ; calculating a rate of change of the cardiac function between time t 3 and time t 4 ; and setting a desired pacing rate. Embodiments of the invention also include cardiac rhythm management devices.
摘要翻译：本发明涉及心律管理系统，并且更具体地涉及对自适应心脏起搏系统和方法进行评级。在一个实施例中，本发明包括一种用于从可植入医疗设备提供速率自适应心脏起搏治疗的方法，所述方法包括感测患者的肺功能; 确定肺功能的变化率; 感测患者的心脏功能; 确定心脏功能的变化率; 并且基于现有的起搏速率，肺功能的变化率以及心功能的变化率来计算目标起搏速率。在一个实施例中，本发明包括响应于患者的运动而控制心律管理装置的方法，该方法包括在第一时间t 1和第二时间检测患者的肺功能 t _{2 ; 计算在时间t 1和时间t 2之间的肺功能的变化率; 在时间t 3和t 4时感测患者的心脏功能; 计算在时间t 3和时间t 4之间的心脏功能的变化率; 并设定所需的起搏速率。本发明的实施例还包括心律管理装置。}

2. 发明申请

WO2009012094A1 OSMOMETRIC HEART MONITORING DEVICE AND METHODS 审中-公开
标题翻译： OSMOMETRIC心脏监测装置及方法
公开(公告)号：WO2009012094A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/069499
申请日：2008-07-09
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Michael, John , QU, Jihong
发明人： SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Michael, John , QU, Jihong
IPC分类号： A61B5/07 , A61N1/365 , A61N1/37 , G01N13/04 , G01N33/84 , A61N1/05 , A61B5/00
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an osmometric sensor, the osmometric sensor configured to generate a signal corresponding to the osmotic strength of a bodily fluid, and a controller in communication with the osmometric sensor, the controller configured to receive and process the signal corresponding to the osmotic strength of a bodily fluid. Other aspects and embodiments are provided herein.
摘要翻译：本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括渗透传感器，所述渗透传感器被配置为产生对应于体液的渗透强度的信号，以及与所述渗透传感器通信的控制器，所述控制器被配置为接收和处理对应于体液渗透强度的信号。本文提供了其它方面和实施例。

3. 发明申请

WO2008083082A1 INTRAVASCULAR FLOW SENSOR 审中-公开
标题翻译：血管内流感传感器
公开(公告)号：WO2008083082A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088581
申请日：2007-12-21
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , KANE, Michael, John
发明人： SHUROS, Allan, Charles , KANE, Michael, John
IPC分类号： A61B5/026 , A61B5/00 , A61B5/07
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/026 , A61B5/0261 , A61B5/6855 , A61B2562/0261
摘要： Disclosed herein, among other things, are intravascular flow sensors and related methods. In an embodiment, there is an intravascular flow sensor including a strain gauge and a positioning element configured to be expandable from a first diameter to a second diameter. In an embodiment, there is an intravascular flow sensor including a deflection member configured to be positioned within a lumen defined by a tissue wall, the deflection member including a flexible shaft and a shaft tip; and a positioning member configured to prevent -the shaft tip from contacting the tissue wall. In an embodiment, there is an implantable medical device including a pulse generator and an intravascular flow sensor in communication with the pulse generator, the intravascular flow sensor including a strain gauge. Other aspects and embodiments are provided herein.
摘要翻译：本文中公开的是血管内流量传感器和相关方法。在一个实施例中，存在包括应变计和定位元件的血管内流量传感器，所述定位元件被构造成可从第一直径扩展到第二直径。在一个实施例中，存在血管内流量传感器，其包括被配置为定位在由组织壁限定的腔内的偏转构件，所述偏转构件包括柔性轴和轴尖; 以及定位构件，其构造成防止所述轴尖端接触所述组织壁。在一个实施例中，存在可植入医疗装置，其包括与脉冲发生器连通的脉冲发生器和血管内流量传感器，血管内流量传感器包括应变计。本文提供了其它方面和实施例。

4. 发明申请

WO2009005529A1 OSMOTIC DEVICES AND METHODS FOR DIURETIC THERAPY 审中-公开
标题翻译：用于DIYTIC治疗的OSMOTIC DEVICES和方法
公开(公告)号：WO2009005529A1
公开(公告)日：2009-01-08
申请号：PCT/US2007/074502
申请日：2007-07-26
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Micheal, J.
发明人： SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Micheal, J.
IPC分类号： A61B17/12 , A61F2/02
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译：本发明的实施方案涉及用于调节肾功能的装置和方法等。在一个实施例中，本发明包括可植入闭塞装置，其包括限定封闭容积的壁构件，所述壁构件可包括半透膜。该装置还可以包括溶液和溶质，该溶质设置在壁构件的封闭体积内。半透膜对溶剂是可渗透的，并且对溶质是不可渗透的。封闭体积可以配置为响应于体液渗透压的变化而膨胀和收缩。该装置可以包括定位构件，其被配置为相对于淋巴管的纵向轴线保持可植入闭塞装置的位置。在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩不渗透膜。本文提供了其它方面和实施例。

5. 发明申请

WO2009045811A1 METHOD AND APPARATUS TO PERFORM TRANSVASCULAR HEMODYNAMIC SENSING 审中-公开
标题翻译：方法和装置进行横向血液动力学检测
公开(公告)号：WO2009045811A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/077492
申请日：2008-09-24
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , KANE, Michael, J.
发明人： SHUROS, Allan, Charles , KANE, Michael, J.
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/418 , A61N1/36514
摘要： An implantable transvascular pressure sensing device may include at least one deflection sensor (224) configured to output a deflection signal indicative of vascular wall (272) deflections. An implantable transvascular pressure sensing device may further include an implantable sensor support member (222) attached to the deflection sensor, the sensor support member configured to facilitate contact between the deflection sensor and a first vessel wall at a portion of a first vessel (202) proximate a second vessel (201), wherein the portion of the first vessel wall is adjacent to the second vessel such that wall deflections of the second vessel deflect the portion of the first vessel wall. A method of measuring a parameter of a vessel can include generating a deflection signal from a sensor within a vein, the deflection signal indicative of venous wall deflections of the vein, and determining a parameter value associated with a vessel contacting the vein using the deflection signal.
摘要翻译：可植入的经血管压力感测装置可以包括被配置为输出指示血管壁（272）偏转的偏转信号的至少一个偏转传感器（224）。可植入的经血管压力感测装置还可以包括附接到偏转传感器的可植入传感器支撑构件（222），所述传感器支撑构件构造成促进偏转传感器与第一血管（202）的一部分处的第一血管壁之间的接触，靠近第二容器（201），其中所述第一容器壁的所述部分与所述第二容器相邻，使得所述第二容器的壁偏转偏转所述第一容器壁的所述部分。测量血管参数的方法可以包括从静脉内的传感器产生偏转信号，所述偏转信号指示静脉的静脉壁偏转，以及使用偏转信号确定与接触静脉的血管相关联的参数值。

6. 发明申请

WO2009126642A2 HIGH-ENERGY ANTI-TACHYCARDIA THERAPY 审中-公开
标题翻译：高能量抗惊厥药治疗
公开(公告)号：WO2009126642A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/039798
申请日：2009-04-07
申请人： CARDIAC PACEMAKERS, INC , SHUROS, Allan, Charles , ARCOT-KRISHNAMURTHY, Shantha , LI, Dan
发明人： SHUROS, Allan, Charles , ARCOT-KRISHNAMURTHY, Shantha , LI, Dan
IPC分类号： A61N1/39 , A61N1/365
CPC分类号： A61N1/3621 , A61N1/3906
摘要： A solution for performing a data correction on a hierarchical integrated circuit layout is provided. A method includes: receiving a CD compensation map for the long range critical dimension variation prior to the data correction; grouping compensation amounts of the CD compensation into multiple compensation ranges; generating multiple target layers corresponding to the multiple compensation ranges; super-imposing a region of the CD compensation map having a compensation amount falling into a compensation range over a respective target layer to generate a target shape; performing the data correction on the layout to generate a data corrected layout; performing the data correction on the target shape separately to generate a data corrected target shape; and combining the data corrected layout and the data corrected target shape based on the CD compensation map.
摘要翻译：提供了一种用于在分层集成电路布局上执行数据校正的解决方案。一种方法包括：在数据校正之前接收用于长距离临界尺寸变化的CD补偿图; 将CD补偿的补偿量分组为多个补偿范围; 产生对应于多个补偿范围的多个目标层; 超级CD补偿图的区域具有落在相应目标层上的补偿范围内的补偿量以产生目标形状; 在布局上执行数据校正以生成数据校正布局; 分别对目标形状进行数据校正，生成数据校正对象形状; 并且基于CD补偿图组合数据校正布局和数据校正目标形状。

7. 发明申请

WO2009123951A1 TEMPERATURE BASED SYSTEMS AND METHODS FOR TACHYCARDIA DISCRIMINATION AND THERAPY 审中-公开
标题翻译：基于温度的系统和方法用于卡卡里亚歧视和治疗
公开(公告)号：WO2009123951A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/038743
申请日：2009-03-30
申请人： CARDIAC PACEMAKERS, INC. , SALO, Rodney, W. , SHUROS, Allan, Charles , LI, Dan
发明人： SALO, Rodney, W. , SHUROS, Allan, Charles , LI, Dan
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3962
摘要： Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及可植入医疗系统等等。在一个实施例中，本发明包括处理器，电传感器和温度传感器。处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动，用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度，确定心律失常是否为血液动力学稳定或血液动力学不稳定，如果心律失常是血液动力学不稳定的话，开始进行高压休克治疗。本文还包括其它实施例。

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