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1. 发明申请

WO2011082260A3 IMPLANTABLE LEADS WITH A CONDUCTOR COIL HAVING TWO OR MORE SECTIONS 审中-公开
公开(公告)号：WO2011082260A3
公开(公告)日：2011-07-07
申请号：PCT/US2010/062420
申请日：2010-12-29
申请人： CARDIAC PACEMAKERS, INC. , HAARER, Joshua , SHVELIDZE, Yevgeniya , WILLOUGHBY, Patrick , DE KOCK, Andrew , MORRIS, Kimberly A. , HAASL, Benjamin J. , SCHMIDT, Brian L. , AVILES, Emilio , MORALES, Fabian , KUNKEL, Ronald W.
发明人： HAARER, Joshua , SHVELIDZE, Yevgeniya , WILLOUGHBY, Patrick , DE KOCK, Andrew , MORRIS, Kimberly A. , HAASL, Benjamin J. , SCHMIDT, Brian L. , AVILES, Emilio , MORALES, Fabian , KUNKEL, Ronald W.
IPC分类号： A61N1/05
摘要： Various coiled conductors having two or more sections and methods and devices for constructing such conductors are disclosed. The various embodiments of coiled conductors and related methods include two or more sections that can have different mechanical, structural, and/or electrical characteristics.

2. 发明申请

WO2013078139A1 FIBROUS MATRIX COATING MATERIALS 审中-公开
标题翻译：纤维基质涂料
公开(公告)号：WO2013078139A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/065896
申请日：2012-11-19
申请人： CARDIAC PACEMAKERS, INC. , POLKINGHORNE, Jeannette C. , ARNHOLT, Devon N. , ROHL, James P. , SCHMIDT, Brian L. , SEPPALA, Jan , TADSEN, Richard L. , WILLOUGHBY, Patrick , ZHANG, Steve , DESAI, Shrojalkumar , DELANEY, JR., Joseph T. , WULFMAN, David R.
发明人： POLKINGHORNE, Jeannette C. , ARNHOLT, Devon N. , ROHL, James P. , SCHMIDT, Brian L. , SEPPALA, Jan , TADSEN, Richard L. , WILLOUGHBY, Patrick , ZHANG, Steve , DESAI, Shrojalkumar , DELANEY, JR., Joseph T. , WULFMAN, David R.
IPC分类号： A61N1/05 , A61L29/08
CPC分类号： A61N1/04 , A61L29/085 , A61L29/14 , A61L2400/12 , A61N1/05 , C08L75/04
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a polyisobutylene urethane, urea or urethane/urea copolymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚异丁烯氨基甲酸酯，脲或氨基甲酸酯/脲共聚物形成。

3. 发明申请

WO2006002148A1 METHOD FOR INTERCONNECTING ANODES AND CATHODES IN A FLAT CAPACITOR 审中-公开
标题翻译：在平面电容器中互连阳极和阴极的方法
公开(公告)号：WO2006002148A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/021898
申请日：2005-06-20
申请人： CARDIAC PACEMAKERS, INC. , SHERWOOD, Gregory J. , SCHMIDT, Brian L. , POPLETT, James M. , WAYTASHEK, Brian V.
发明人： SHERWOOD, Gregory J. , SCHMIDT, Brian L. , POPLETT, James M. , WAYTASHEK, Brian V.
IPC分类号： H01G9/00
CPC分类号： H01G9/008 , A61N1/375 , A61N1/3956
摘要： A method includes connecting together one or more anode connection members (206) of one or more anode foils (202) and one or more cathode connection members (306, 306b) of one or more cathode foils (302, 302b) and electrically isolating the one or more anode foils from the one or more cathode foils. A capacitor stack (102, 402, 402b) includes a plurality of cathode layers (302, 302b) having cathode connection members and a plurality of anode layers (202) having anode connection members (206). The anode connection members are connected to the cathode connection members and configured such that the anode layers can be electrically separated from the cathode layers by cutting only the anode connection members or the cathode connection members.
摘要翻译：一种方法包括将一个或多个阳极箔（202）的一个或多个阳极连接构件（206）和一个或多个阴极箔（302,302b）的一个或多个阴极连接构件（306,306b）连接在一起，并将一个或多个阳极箔来自一个或多个阴极箔。电容器堆叠（102,402,402b）包括具有阴极连接构件的多个阴极层（302,302b）和具有阳极连接构件（206）的多个阳极层（202）。阳极连接构件连接到阴极连接构件，并且构造成使得阳极层可以仅通过仅切割阳极连接构件或阴极连接构件而与阴极层电分离。

4. 发明申请

WO2019084003A1 MEDICAL DEVICES FOR CANCER THERAPY WITH ELECTRIC FIELD SHAPING ELEMENTS 审中-公开
公开(公告)号：WO2019084003A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057104
申请日：2018-10-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： SCHMIDT, Brian L. , LUDWIG, Jacob M. , HAASL, Benjamin J. , KANE, Michael J.
IPC分类号： A61N5/02 , A61B18/14 , A61B18/18
摘要： Embodiments herein relate to medical device systems including electric field shaping elements for use in treating cancerous tumors within a bodily tissue. In an embodiment, a medical device system for treating a cancerous tumor is described. The medical device system can include one or more electric field generating electrodes and an electric field shaping element configured to be implanted along with the one or more electric field generating electrodes. The electric field shaping element can be made from a material that alters the spatial area of tissue exposed to the electric field. Other embodiments are also included herein.

5. 发明申请

WO2017106693A1 CONDUCTED COMMUNICATION IN A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：在医疗设备系统中进行通信
公开(公告)号：WO2017106693A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/067248
申请日：2016-12-16
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , SCHMIDT, Brian L. , KOOP, Brendan Early
IPC分类号： A61N1/372
CPC分类号： A61N1/37288 , A61N1/362 , A61N1/37217 , A61N1/3756
摘要： An implantable medical device for implantation into a patient may include a housing, a pulse generation circuit disposed at least partially within the housing, a plurality of electrodes electrically coupled to the pulse generation circuit, the plurality of electrodes being exposed external to the housing, and a controller operatively coupled to the pulse generation circuit. The controller may be configured to command the pulse generation circuit to deliver a phasic conducted communication pulse via at least two of the plurality of electrodes. Additionally, the phasic conducted communication pulse may comprise a first phase having a first polarity followed by a second phase having an opposite second polarity, wherein the second phase may have a duration of less than 60 microseconds, and wherein the first phase having may have a duration of between five percent and eighty percent of the duration of the second phase.
摘要翻译：用于植入患者体内的可植入医疗装置可包括壳体，至少部分地设置在壳体内的脉冲发生电路，电耦合到脉冲发生电路的多个电极，多个电极在壳体外部暴露，以及可操作地耦合到脉冲发生电路的控制器。控制器可以被配置为命令脉冲发生电路通过多个电极中的至少两个发送阶段性传导通信脉冲。另外，相位传导通信脉冲可以包括具有第一极性的第一相，接着是具有相反的第二极性的第二相，其中第二相可以具有小于60微秒的持续时间，并且其中第一相可以具有持续时间在第二阶段持续时间的百分之五至百分之八十之间。

6. 发明申请

WO2017087661A1 DELIVERY DEVICES AND METHODS FOR LEADLESS CARDIAC DEVICES 审中-公开
标题翻译：用于无线心脏设备的递送设备和方法
公开(公告)号：WO2017087661A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062515
申请日：2016-11-17
申请人： CARDIAC PACEMAKERS, INC.
发明人： SOLTIS, Brian , HAASL, Benjamin J. , SHUROS, Allan C. , SCHMIDT, Brian L. , GOODMAN, James P.
IPC分类号： A61N1/375
CPC分类号： A61N1/059 , A61M25/0074 , A61M25/0097 , A61M25/0136 , A61M2025/0006 , A61N1/3756
摘要： Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an intermediate tubular member and an inner tubular member slidably disposed within a lumen of the intermediate tubular member. A distal holding section may extend distally of a distal end of the intermediate tubular member and define a cavity therein for receiving an implantable leadless pacing device. The device may further include a handle assembly including at least an intermediate hub portion affixed adjacent to the proximal end of the intermediate tubular member and a proximal hub portion affixed adjacent to the proximal end of the inner tubular member. A longitudinally extending groove having a proximal end and a distal end may be disposed in the intermediate hub portion. A first locking mechanism may be configured to releasably couple the intermediate hub portion and the proximal hub portion.
摘要翻译：公开了用于输送可植入式无引线起搏装置的输送装置，系统和方法。示例性输送装置可以包括中间管状构件和可滑动地设置在中间管状构件的管腔内的内部管状构件。远侧保持部分可以在中间管状部件的远端的远侧延伸，并且在其中限定用于接收可植入式无引线起搏装置的空腔。该装置还可以包括手柄组件，该手柄组件至少包括邻近中间管状部件的近端固定的中间毂部分和邻近内部管状部件的近端固定的近侧毂部分。具有近端和远端的纵向延伸的凹槽可以设置在中间毂部分中。第一锁定机构可构造成可释放地联接中间毂部分和近侧毂部分。

7. 发明申请

WO2017040153A1 SYSTEMS AND METHODS FOR BEHAVIORALLY RESPONSIVE SIGNAL DETECTION AND THERAPY DELIVERY 审中-公开
标题翻译：行为有效的信号检测和治疗方法的系统和方法
公开(公告)号：WO2017040153A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/048444
申请日：2016-08-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , LINDER, William J. , JUFFER, Lance Eric , HAASL, Benjamin J. , SCHMIDT, Brian L. , HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/375 , A61N1/378 , A61B5/11 , A61N1/365
CPC分类号： A61N1/36535 , A61B5/1116 , A61B5/1118 , A61B2560/0209 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/37247 , A61N1/3756 , A61N1/378
摘要： Systems, devices, and methods for adjusting functionality of an implantable medical device based on posture are disclosed. In some instances, a method for operating a leadless cardiac pacemaker implanted into a patient, where the patient has two or more predefined behavioral states, may include detecting a change in the behavioral state of the patient, and in response, changing a sampling rate of a sensor signal generated by a sensor of the leadless cardiac pacemaker. In some embodiments, the method may further include using the sampled sensor signal to determine an updated pacing rate of the leadless cardiac pacemaker and providing pacing to the patient at the updated pacing rate.
摘要翻译：公开了用于基于姿势来调整可植入医疗装置的功能的系统，装置和方法。在一些情况下，用于操作植入患者中的无引线心脏起搏器的方法，其中患者具有两个或更多个预定义的行为状态，可以包括检测患者的行为状态的变化，并且作为响应，改变患者的行为状态的变化由无引线心脏起搏器的传感器产生的传感器信号。在一些实施例中，该方法还可以包括使用采样的传感器信号来确定无引线心脏起搏器的更新的起搏速率并且以更新的起搏速率向患者提供起搏。

8. 发明申请

WO2022204035A1 RECHARGEABLE SYSTEMS FOR DELIVERING ELECTRICAL STIMULATION THERAPY FOR CANCER THERAPY 审中-公开
公开(公告)号：WO2022204035A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/021161
申请日：2022-03-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： SCHMIDT, Brian L. , ARNHOLT, Devon N. , AVILES DELGADO, Emilio A. , COLLAZO RODRIGUEZ, David
IPC分类号： A61N1/36 , A61N1/378 , A61N1/05
摘要： Embodiments herein relate to rechargeable electrical stimulation-based cancer therapy systems and related methods. In a first aspect, an electrical stimulation-based cancer therapy system is included having an implantable electrical field generator unit including a housing, a header coupled to the housing, and electrical field generation circuitry is disposed within the housing. The system can also include an implantable recharge lead, wherein the implantable recharge lead is removably coupled to the header. The system can also include a plurality of therapy leads, the therapy leads including a plurality of electrodes, wherein the plurality of therapy leads area also removably coupled to the header. The system can also include an external recharger unit. Other embodiments are also included herein.

9. 发明申请

WO2019084021A1 ELECTRIC FIELD CANCER THERAPY DEVICES WITH FEEDBACK MECHANISMS AND DIAGNOSTICS 审中-公开
公开(公告)号：WO2019084021A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057127
申请日：2018-10-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： SCHMIDT, Brian L. , LUDWIG, Jacob M. , HAASL, Benjamin J. , KANE, Michael J.
IPC分类号： A61N1/36 , A61B5/053 , A61B5/00 , A61B5/021 , A61B5/0245 , A61B5/026 , A61B5/042 , A61B5/145 , A61N1/20
摘要： Embodiments herein relate to medical device systems including electric field shaping elements for use in treating cancerous tumors within a bodily tissue. In an embodiment, a method for treating a cancerous tumor is provided. The method can include implanting one or more electrodes within a patient and measuring the impedance of tissue within the patient along a vector passing through or near a cancerous tumor. The method can also include administering an electric field to the cancerous tumor of the patient based on the measured impedance. Other embodiments are also included herein.

10. 发明申请

WO2017031221A1 SYSTEMS AND METHODS FOR COMMUNICATION BETWEEN MEDICAL DEVICES 审中-公开
标题翻译：医疗器械通讯系统与方法
公开(公告)号：WO2017031221A1
公开(公告)日：2017-02-23
申请号：PCT/US2016/047386
申请日：2016-08-17
申请人： CARDIAC PACEMAKERS, INC.
发明人： SCHMIDT, Brian L. , JUFFER, Lance Eric , MAILE, Keith R. , KANE, Michael J. , KOOP, Brendan Early
IPC分类号： A61N1/372 , A61N1/375 , H04B13/00
CPC分类号： H04B13/005 , A61B5/0028 , A61B5/0031 , A61N1/37205 , A61N1/37211 , A61N1/37217 , A61N1/37223 , A61N1/37252 , A61N1/3756 , H04B17/318 , H04L67/12 , H04W76/25
摘要： Systems and methods for conducted communication are described. In one embodiment, a method of communicating with a medical device implanted within a patient comprises receiving, at a medical device via electrodes connected to the patient, a conducted communication signal, wherein the conducted communication signal comprises a signal component and a noise component. The method may further comprise adjusting, by the medical device, a receive threshold based at least in part on an amplitude of the received conducted communication signal so as to reduce an amplitude of the noise component of the conducted communication signal.
摘要翻译：描述用于进行通信的系统和方法。在一个实施例中，与植入患者内的医疗设备进行通信的方法包括在医疗设备处经由连接到患者的电极接收传导通信信号，其中传导通信信号包括信号分量和噪声分量。该方法还可以包括至少部分地基于所接收的传导通信信号的幅度来调整医疗设备的接收阈值，以便降低传导通信信号的噪声分量的幅度。

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