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1. 发明申请

WO2010090896A1 CROSS-CHANNEL NOISE DETECTOR IN IMPLANTABLE DEVICES 审中-公开
标题翻译：交叉通道噪声检测器在可移植设备中
公开(公告)号：WO2010090896A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/022028
申请日：2010-01-26
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , PERSCHBACHER, David, L.
发明人： LI, Dan , PERSCHBACHER, David, L.
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3704 , A61N1/3718 , A61N1/3925
摘要： An apparatus comprises a primary cardiac signal sensing circuit to sense a first cardiac signal, a secondary cardiac signal sensing to sense a second cardiac signal, and an arrhythmia detection circuit. The primary sensing circuit includes at least first and second implantable electrodes, and the secondary sensing circuit includes a third implantable electrode to deliver high-energy shock therapy. The arrhythmia detection circuit detects tachyarrhythmia using the primary sensing circuit, determines correspondence between events sensed with the primary sensing circuit and events sensed with the secondary sensing circuit, and deems whether a detected rhythm is indicative of noise or is indicative of an arrhythmia according to the determined correspondence.
摘要翻译：一种装置包括用于感测第一心脏信号的主要心脏信号感测电路，感测第二心脏信号的次要心脏信号感测和心律失常检测电路。主感测电路至少包括第一和第二可植入电极，并且次级感测电路包括用于输送高能量休克疗法的第三可植入电极。心律失常检测电路使用主感测电路检测快速性心律失常，确定用主感测电路感测的事件与由次级感测电路感测的事件之间的对应关系，并且考虑检测到的节奏是指示噪声还是指示心律失常根据确定的信件。

2. 发明申请

WO2014085125A1 METHOD AND SYSTEM FOR ARRHYTHMIA DISCRIMINATION 审中-公开
标题翻译： ARRHYTHMIA歧视的方法与系统
公开(公告)号：WO2014085125A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/070564
申请日：2013-11-18
申请人： CARDIAC PACEMAKERS, INC.
发明人： EBERLE, LeAnne M. , PERSCHBACHER, David L. , LI, Dan , BYRNES, Alicia Elaine
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/0422 , A61B5/7264 , A61N1/36114 , A61N1/3621
摘要： A method and system for discriminating ventricular arrhythmia is disclosed. In an embodiment, the method can include implementing an arrhythmia discrimination algorithm that can discriminate between supraventricular tachycardia (SVT) and ventricular tachycardia (VT) using at least one programmable parameter programmed to a first value. The method can include analyzing an SVT event, where analyzing the SVT event can include sensing a physiological signal during the SVT event and identifying characteristics of the sensed physiological signal. The method can further include analyzing a cardiac signal to classify the cardiac signal as either an SVT or a VT using the arrhythmia discrimination algorithm with the programmable parameter programmed to a second value. The second value can be determined from the identified characteristics of the sensed physiological signal.
摘要翻译：公开了用于区分室性心律失常的方法和系统。在一个实施例中，该方法可以包括实现心律失常鉴别算法，其可以使用被编程为第一值的至少一个可编程参数来区分室上性心动过速（SVT）和室性心动过速（VT）。该方法可以包括分析SVT事件，其中分析SVT事件可以包括在SVT事件期间感测生理信号并识别感测到的生理信号的特征。该方法还可以包括分析心脏信号以将心脏信号分类为SVT或VT，使用心律失常鉴别算法，将可编程参数编程为第二值。可以根据感测到的生理信号的识别特征来确定第二值。

3. 发明申请

WO2011088337A1 AUTOMATIC MECHANICAL ALTERNANS DETECTION 审中-公开
标题翻译：自动机械检测
公开(公告)号：WO2011088337A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021324
申请日：2011-01-14
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , SHUROS, Allan, C. , SHARMA, Arjun
发明人： LI, Dan , SHUROS, Allan, C. , SHARMA, Arjun
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/0215 , A61B5/0452 , A61B5/0538 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , G06F19/00
摘要： This document discusses, among other things, a cardiac mechanical alternans (MA) detector circuit. In an example, the mechanical alternans detector circuit is configured to determine a mechanical alternans (MA) condition. In an example, the MA detector circuit can include a physiologic impedance input configured to receive physiologic information indicative of mechanical alternans. In an example, the MA detector circuit can include an intravascular pressure input configured to receive physiologic information indicative of mechanical alternans.
摘要翻译：本文件还讨论了心脏机械交替（MA）检测器电路。在一个示例中，机械交替检测器电路被配置为确定机械交替（MA）条件。在一个示例中，MA检测器电路可以包括构造成接收指示机械交替的生理信息的生理阻抗输入。在一个示例中，MA检测器电路可以包括构造成接收指示机械交替的生理信息的血管内压力输入。

4. 发明申请

WO2010011301A2 MORPHOLOGY FEATURE EVALUATION IN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械中的形态学特征评估
公开(公告)号：WO2010011301A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/004242
申请日：2009-07-22
申请人： CARDIAC PACEMAKERS, INC. , DONG, Yanting , BROOKE, M., Jason , LI, Dan , STALSBERG, Kevin, J.
发明人： DONG, Yanting , BROOKE, M., Jason , LI, Dan , STALSBERG, Kevin, J.
IPC分类号： A61B5/00 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0002 , A61B5/04525 , A61N1/365 , A61N1/3702
摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.
摘要翻译：一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。处理器包括特征模块和检测模块。特征模块被配置为识别传感器信号中的特征并且确定传感器信号中的特征的质量的度量。所述检测模块被配置为当所述特征的质量度量满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

5. 发明申请

WO2008137166A1 SYSTEM AND METHOD TO DETERMINE HEMODYNAMIC TOLERABILITY 审中-公开
标题翻译：确定血液动力学耐受性的系统和方法
公开(公告)号：WO2008137166A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/005832
申请日：2008-05-07
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , SHUROS, Allan, C. , LI, Dan
发明人： ZHANG, Yi , SHUROS, Allan, C. , LI, Dan
IPC分类号： A61N1/365 , A61B5/0464 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0464 , A61B5/0535 , A61B5/0538 , A61B5/7264
摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.
摘要翻译：可植入医疗装置检测心脏的快速性心律失常。在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。然后，当针对心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。灌注信息也可用于改变快速性心律失常检测或分类。

6. 发明申请

WO2007078421A2 HEMODYNAMICALLY CONTROLLED ANTI-TACHYARRHYTHMIA PACING SYSTEM 审中-公开
标题翻译：血流动力学控制的抗痛觉兴奋剂起搏系统
公开(公告)号：WO2007078421A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/043459
申请日：2006-11-08
申请人： CARDIAC PACEMAKERS, INC. , LI, Dan , CARLSON, Gerrard M. , HAHN, Stephen J.
发明人： LI, Dan , CARLSON, Gerrard M. , HAHN, Stephen J.
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/36514
摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and at least one hemodynamic sensor that senses a hemodynamic signal. When a tachyarrhythmia episode is detected, the CRM system analyzes the hemodynamic signal to determine whether and/or when to deliver an ATP. In one embodiment, a hemodynamic parameter extracted from the hemodynamic signal is used to predict the potential effective of ATP in terminating the detected tachyarrhythmia episode. In another embodiment, a characteristic feature detected from the hemodynamic signal is used to determine an ATP window during which a delivery of ATP is initiated.
摘要翻译：心律管理（CRM）系统包括递送包括抗快速性心律失常起搏（ATP）的抗快速性心律失常疗法的可植入医疗装置和感测血液动力学信号的至少一个血液动力学传感器。当检测到快速性心律失常发作时，CRM系统分析血液动力学信号以确定是否和/或何时递送ATP。在一个实施例中，从血液动力学信号提取的血液动力学参数被用于预测ATP终止检测到的快速性心律失常发作的潜在有效性。在另一个实施方案中，从血液动力学信号中检测到的特征特征被用于确定开始递送ATP的ATP窗口。

7. 发明申请

WO2013009563A1 APPARATUSES AND METHODS TO PREDICT VENTRICULAR REMODELING 审中-公开
标题翻译：预测心室重构的装置和方法
公开(公告)号：WO2013009563A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/045543
申请日：2012-07-05
申请人： CARDIAC PACEMAKERS, INC. , YU, Yinghong , SHOME, Shibaji , LI, Dan , GOLD, Michael , SINGH, Jagmeet
发明人： YU, Yinghong , SHOME, Shibaji , LI, Dan , GOLD, Michael , SINGH, Jagmeet
IPC分类号： A61B5/0472 , A61N1/362 , A61N1/368
CPC分类号： A61N1/36592 , A61B5/0006 , A61B5/0422 , A61B5/0456 , A61B5/0472 , A61B5/686 , A61N1/3684
摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. The cardiac signal sensing circuit is configured to sense a cardiac signal segment using a set of electrodes connectable to the cardiac signal sensing circuit. The processor circuit is communicatively coupled to the cardiac signal sensing circuit and includes a peak detector circuit. The peak detector circuit is configured to identify, in the cardiac signal segment, a fiducial indicative of ventricular activation that is local to at least one electrode of the first set of electrodes. The fiducial includes a first large positive or negative peak greater than a specified percentage of a maximum peak of the first cardiac signal segment. The processor circuit is configured to provide an indication of local ventricular activation to at least one of a user or process.
摘要翻译：一种系统包括心脏信号感测电路和处理器电路。心脏信号感测电路被配置为使用可连接到心脏信号感测电路的一组电极来感测心脏信号段。处理器电路通信地耦合到心脏信号感测电路并且包括峰值检测器电路。峰值检测器电路被配置为在心脏信号段中识别指示心室激活的基准，其对于第一组电极的至少一个电极是局部的。基准包括大于第一心脏信号段的最大峰值的指定百分比的第一大的正或负峰值。处理器电路被配置为向用户或过程中的至少一个提供局部心室激活的指示。

8. 发明申请

WO2012166901A1 AN OFF-LINE SENSING METHOD AND ITS APPLICATIONS IN DETECTING UNDERSENSING, OVERSENSING, AND NOISE 审中-公开
标题翻译：离线感测方法及其在检测，过滤和噪声检测中的应用
公开(公告)号：WO2012166901A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040186
申请日：2012-05-31
申请人： CARDIAC PACEMAKERS, INC , DONG, Yanting , ZHANG, Shijie , MAHAJAN, Deepa , LIU, Chenguang , LI, Dan , LIN, Yayun , BOHN, Derek D.
发明人： DONG, Yanting , ZHANG, Shijie , MAHAJAN, Deepa , LIU, Chenguang , LI, Dan , LIN, Yayun , BOHN, Derek D.
IPC分类号： A61N1/37
CPC分类号： A61B5/0245 , A61B5/042 , A61B5/0452 , A61B5/7217 , A61N1/3704 , F04C2270/041
摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.
摘要翻译：一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。多遍处理确定心电图的至少第一个通道的位置。然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

9. 发明申请

WO2011088043A1 USE OF SIGNIFICANT POINT METHODOLOGY TO PREVENT INAPPROPRIATE THERAPY 审中-公开
标题翻译：使用重要的方法来预防不明原因的治疗
公开(公告)号：WO2011088043A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/020834
申请日：2011-01-11
申请人： CARDIAC PACEMAKERS, INC. , SWEENEY, Robert J. , LI, Dan
发明人： SWEENEY, Robert J. , LI, Dan
IPC分类号： A61N1/365 , A61N1/39 , A61B5/00
CPC分类号： A61N1/36507 , A61B5/0464 , A61N1/3925
摘要： An apparatus example comprises a cardiac signal sensing circuit configured to provide a sensed cardiac signal representative of cardiac depolarization events of a subject, a sampling circuit coupled to the cardiac signal sensing circuit, a therapy circuit, and a controller communicatively coupled to the sampling circuit and the therapy circuit. The controller includes a detection module configured to detect tachyarrhythmia using the cardiac signal and a signal analysis module configured to establish significant points (SPs) of the sampled cardiac signal, estimate heart rate during the tachyarrhythmia using the SPs, and provide an indication of whether noise is present in the cardiac signal using the SPs. The controller is configured to select a therapy for delivery by the therapy circuit in response to the tachyarrhythmia detection and to modify the selected therapy according to the heart rate estimation and the noise indication.
摘要翻译：装置示例包括心脏信号感测电路，其被配置为提供表示对象的心脏去极化事件的感测心脏信号，耦合到心脏信号感测电路的采样电路，治疗电路和通信地耦合到采样电路的控制器，以及治疗电路。所述控制器包括检测模块，所述检测模块被配置为使用所述心脏信号来检测快速性心律失常;以及信号分析模块，所述信号分析模块被配置为建立所述采集的心脏信号的有效点（SP），使用所述SP在所述快速性心律失常期间估计心率，并且提供噪声使用SP存在于心脏信号中。控制器被配置为选择治疗电路响应于快速性心律失常检测的递送的治疗，并且根据心率估计和噪声指示修改所选择的治疗。

10. 发明申请

WO2010138332A1 ADAPTIVE EVENT STORAGE IN AN IMPLANTABLE DEVICE 审中-公开
标题翻译：自适应事件存储在可移植设备中
公开(公告)号：WO2010138332A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/035133
申请日：2010-05-17
申请人： CARDIAC PACEMAKERS, INC. , DONG, Yanting , PERSCHBACHER, David L. , STAHMANN, Jeffrey E. , LI, Dan , MAHAJAN, Deepa
发明人： DONG, Yanting , PERSCHBACHER, David L. , STAHMANN, Jeffrey E. , LI, Dan , MAHAJAN, Deepa
IPC分类号： A61N1/372 , A61B5/00
CPC分类号： A61N1/37252 , A61B5/02 , A61B5/04 , A61B5/0452 , A61B5/6846 , A61N1/025 , A61N1/3621 , A61N1/3702 , A61N1/372 , A61N1/3925
摘要： Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring, using the physiological monitor, another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.
摘要翻译：使用植入式生理监测器监测生理参数，以便检测预测可能的未来病理发作的状况，并收集与预测可能的未来病理发作相关的条件相关的附加生理数据。使用生理监测器监测另一种生理参数，以便检测指示本病理发作开始的病症并响应于该病症收集额外的病理数据。确定预测未来事件的条件和指示当前情节的状况是相关联的，并且响应于此，存储所有收集的生理数据。

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