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    • 8. 发明申请
    • METHODS AND SYSTEMS FOR MOLECULAR FINGERPRINTING
    • 用于分子指纹的方法和系统
    • WO0175176A3
    • 2003-08-07
    • PCT/US0110881
    • 2001-04-04
    • CALIFORNIA INST OF TECHNQUAKE STEPHEN RCHOU HOU-PU
    • QUAKE STEPHEN RCHOU HOU-PU
    • C12Q1/68B01L3/00
    • C12Q1/683
    • This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacteria typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device that analyzes the polynucleotides according to restriction fragment length polymorphism. In a microfabricated device according to the invention, DNA fragments or other molecules can be rapidly and accurately typed using relatively small samples, by measuring for example the signal of an optically-detectable (e.g., fluorescent) reporter associated with the polynucleotide fragments.
    • 本发明一般涉及分子指纹图谱的方法。 该方法可用于法医鉴定(例如DNA指纹图谱,特别是VNTR),细菌分型和人/动物病原体诊断。 更具体地,可以按照限制性片段长度多态性分析多核苷酸的微制造装置中的大小来评估或分类分子,例如多核苷酸(例如DNA)。 在根据本发明的微制造装置中,通过测量例如与多核苷酸片段相关的可光学检测(例如,荧光)报告基因的信号,可以使用相对小的样品快速和精确地分类DNA片段或其他分子。