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2. 发明申请

WO2005034206A3 SELECTIVE FUNCTIONALIZATION OF CARBON NANOTUBE TIPS ALLOWING FABRICATION OF NEW CLASSES OF NANOSCALE SENSING AND MANIPULATION TOOLS 审中-公开
标题翻译：碳纳米管提示的选择性功能化，允许制造新型纳米级感测和操作工具
公开(公告)号：WO2005034206A3
公开(公告)日：2006-06-01
申请号：PCT/US2004005193
申请日：2004-02-20
申请人： CALIFORNIA INST OF TECHN , WADE LAWRENCE A , SHAPIRO IAN R , COLLIER CHARLES PATRICK , ESPLANDIU MARIA J , BITTNER JR VERN GARRETT
发明人： WADE LAWRENCE A , SHAPIRO IAN R , COLLIER CHARLES PATRICK , ESPLANDIU MARIA J , BITTNER JR VERN GARRETT
IPC分类号： B05D3/00 , B82B3/00 , C12M1/00 , G01B5/00 , G01B7/00 , G01Q60/00 , G01Q70/12 , H01L20060101
CPC分类号： G01Q70/12
摘要： Embodiments in accordance with the present invention relate to techniques for the growth and attachment of single wall carbon nanotubes (SWNT), facilitating their use as robust and well-characterized tools for AFM imaging and other applications. In accordance with one embodiment, SWNTs attached to an AFM tip can function as a structural scaffold for nanoscale device fabrication on a scanning probe. Such a probe can trigger, with nanometer precision, specific biochemical reactions or conformational changes in biological systems. The consequences of such triggering can be observed in real time by single-molecule fluorescence, electrical, and/or AFM sensing. Specific embodiments in accordance with the present invention utilize sensing and manipulation of individual molecules with carbon nanotubes, coupled with single-molecule fluorescence imaging, to allow observation of spectroscopic signals in response to mechanically induced molecular changes. Biological macromolecules such as proteins or DNA can be attached to nanotubes to create highly specific single-molecule probes for investigations of intermolecular dynamics, for assembling hybrid biological and nanoscale materials, or for developing molecular electronics. In one example, electrical wiring of single redox enzymes to carbon nanotube scanning probes allows observation and electrochemical control over single enzymatic reactions by monitoring fluorescence from a redox-active cofactor or the formation of fluorescent products. Enzymes "nanowired" to the tips of carbon nanotubes in accordance with embodiments of the present invention, may enable extremely sensitive probing of biological stimulus-response with high spatial resolution, including product-induced signal transduction.
摘要翻译：根据本发明的实施方案涉及用于生长和附着单壁碳纳米管（SWNT）的技术，便于其用作用于AFM成像和其它应用的鲁棒且良好表征的工具。根据一个实施例，附接到AFM尖端的SWNT可以用作扫描探针上的纳米级器件制造的结构支架。这样的探针可以以纳米精度触发生物系统的特定生化反应或构象变化。通过单分子荧光，电学和/或AFM感测可以实时观察到这种触发的后果。根据本发明的具体实施方案利用与单分子荧光成像耦合的碳纳米管的单个分子的感测和操作，以便响应机械诱导的分子变化观察光谱信号。可以将生物大分子如蛋白质或DNA连接到纳米管上，以产生用于分子间动力学研究的高度特异性单分子探针，用于组装混合生物和纳米级材料，或用于开发分子电子学。在一个实例中，单个氧化还原酶与碳纳米管扫描探针的电气配线允许通过监测来自氧化还原活性辅助因子的荧光或荧光产物的形成来观察和电化学控制单个酶反应。根据本发明的实施方案，“纳米线”针对碳纳米管的尖端的酶可以实现具有高空间分辨率（包括产物诱导的信号转导）的生物刺激反应的极度敏感的探测。

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