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1. 发明申请

WO1985000985A1 REVERSE OSMOSIS MEMBRANE AND PROCESS FOR MAKING 审中-公开
标题翻译：反向麻醉膜和制备方法
公开(公告)号：WO1985000985A1
公开(公告)日：1985-03-14
申请号：PCT/US1984001379
申请日：1984-08-27
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J.
IPC分类号： B01D13/04
CPC分类号： B01D69/02 , B01D69/125
摘要： A reverse osmosis membrane (10) with improved physical characteristics which is particularly useful in water purification. This membrane includes a thin, active layer (20) of a relatively inert, film forming, polymer, preferably cellulose triacetate, which is capable of dissolving a limited amount of water. The active layer is used in association with a porous support (12), preferably polyvinylidene fluoride. This active layer is disposed on a hydrogel layer (16) which serves to facilitate the movement of water away from the active layer generally toward the pores in the support. The support used is an asymmetric layer or membrane in which the porosity increases with the distance from the hydrogel layer. The complete membrane may be made by employing solvent solutions which are successively applied to the support layer or membrane and from which the solvent is removed.
摘要翻译：具有改善的物理特性的反渗透膜（10），其在水净化中特别有用。该膜包括能够溶解有限量的水的相对惰性的成膜聚合物，优选纤维素三乙酸酯的薄的活性层（20）。活性层与多孔载体（12）结合使用，优选聚偏二氟乙烯。该有源层设置在水凝胶层（16）上，该水凝胶层（16）用于促进水从活性层的移动通常朝向载体中的孔。所使用的载体是不对称层或膜，其中孔隙率随着与水凝胶层的距离而增加。完整的膜可以通过使用依次施加到载体层或膜上并从其中除去溶剂的溶剂溶液来制备。

2. 发明申请

WO1988002653A1 ULTRAFILTRATION THIN FILM MEMBRANES 审中-公开
标题翻译：超薄膜薄膜
公开(公告)号：WO1988002653A1
公开(公告)日：1988-04-21
申请号：PCT/US1987002627
申请日：1987-10-13
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J.
IPC分类号： B01D13/04
CPC分类号： B01D67/0093 , B01D69/02 , B01D69/122 , B01D69/125 , B01D2323/30
摘要： Mono-layer thin film membranes which are ultraporous. Such mono-layers are formed having a thickness on the order of about 1.2 to 150 nanometers, by a variety of polymerization, cross-linking, and film treatment processes to achieve the development of controlled pore sizes in the ultraporous size range corresponding to a molecular weight cutoff values of from about 500 to about 1,000,000. Such thin film mono-layer membranes (1) are ordinarily supported on a microporous support material, desirably a microporous polymer membrane (3) having a smooth, microporous skin (4) with pore sizes in the range of from about 0.1 microns to about 3 microns, preferably from about 0.1 microns to about 0.5 microns, in diameter. There may be an intermediate gel layer (2). These membranes are useful for ultrafiltration, dialysis, and molecular separations.

3. 发明申请

WO1991005806A1 INTERFACIAL CONDENSATION OF BIOACTIVE COMPOUNDS AND THE SITE-SPECIFIC COMPOUNDS AND CONJUGATES THEREOF 审中-公开
标题翻译：生物活性化合物的界面浓缩及其特异性化合物及其结合
公开(公告)号：WO1991005806A1
公开(公告)日：1991-05-02
申请号：PCT/US1990005544
申请日：1990-10-02
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J.
IPC分类号： C07K17/02
CPC分类号： A61K47/6803 , A61K47/68 , A61K47/6889
摘要： This invention provides a method of preparing conjugates of bioactive compounds and site-specific compounds in which covalent bonding between the compounds is effected by interfacial condensation while protecting the active binding sites from the condensation reaction. This provides very high yields of the bioactive, site-specific conjugate, the products are homogeneous and it provides novel conjugate products. It is of particular advantage for monoclonal antibodies conjugated with cytotoxic agents.

4. 发明申请

WO1989000592A1 POLYTETRAFLUOROETHYLENE COATING OF POLYMER SURFACES 审中-公开
标题翻译：聚四氟乙烯聚合物表面涂料
公开(公告)号：WO1989000592A1
公开(公告)日：1989-01-26
申请号：PCT/US1988000227
申请日：1988-01-27
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J. , HOFFMAN, Frieder, K. , MYSELS, Karol, J.
IPC分类号： C08J07/04
CPC分类号： B01D67/0088 , B05D7/02 , C08J3/03 , C08J7/047 , C08J2327/18 , C08J2427/00
摘要： Adherent, PTFE coatings on polymer surfaces can be produced at temperatures well below the sintering temperature of PTFE, by contacting the surface with a dilute dispersion of PTFE particles and heating the surface to its softening point (in the vicinity of its glass transition temperature) to dry it and to cause the individual particles to become embedded in and surrounded by the polymer.

5. 发明申请

WO1989000188A1 CELL GROWTH REACTOR WITH THREE COMPARTMENTS FORMED BY HYDROPHOBIC AND HYDROPHILIC MEMBRANES 审中-公开
标题翻译：具有由疏水性和疏水性膜形成的三个间隔的细胞生长反应器
公开(公告)号：WO1989000188A1
公开(公告)日：1989-01-12
申请号：PCT/US1988002209
申请日：1988-06-28
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J. , HOFMANN, Frieder, K. , DeWINTER, Dirk, M.
IPC分类号： C12M03/00
CPC分类号： C12M29/04 , C12M23/24 , C12M23/34
摘要： A continuous, integrated membrane bioreactor system for the culture of hybridoma or mammalian cells which meets the nutritional and physical needs of hybridomas or mammalian cells, allows for the harvesting of products, and maintains sterile integrity of the system by combining several individual apparatus having separate functions into an integrated, functioning unit. Central to this bioreactor is the compact size of the cell enclosure which is made possible by the high cell densities achieved in the layered membrane design and the continuous feed and bleed nutrient medium system which minimizes the nutrient medium volume inside the bioreactor. Maximized product output per unit of volume minimizes the space necessary to house the bioreactor. Oxygen is passed through the bioreactor as air or another gas mixture, rather than dissolved in the nutrient medium.
摘要翻译：用于培养满足杂交瘤或哺乳动物细胞的营养和物理需要的杂交瘤或哺乳动物细胞的连续的，整合的膜生物反应器系统允许产品的收获，并且通过组合具有单独功能的几个单独的装置来维持系统的无菌完整性成为一个综合功能单位。该生物反应器的中心是细胞外壳的紧凑尺寸，其通过在分层膜设计中实现的高细胞密度和连续进料和排出营养培养基系统而实现，其使生物反应器内的营养培养基体积最小化。最大化每单位体积的产品输出可最大限度地减少安装生物反应器所需的空间。氧气通过生物反应器作为空气或另一种气体混合物，而不是溶解在营养培养基中。

6. 发明申请

WO1988008738A1 PREPARATION OF POROUS ARAMIDE MEMBRANES 审中-公开
标题翻译：多孔亚胺膜的制备
公开(公告)号：WO1988008738A1
公开(公告)日：1988-11-17
申请号：PCT/US1988000228
申请日：1988-01-27
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J.
IPC分类号： B01D13/04
CPC分类号： B01D71/56 , B01D67/0011 , B01D2323/12 , B01D2323/16
摘要： Fully aromatic polyamide (aramid) resins can be cast into ultraporous and microporous membranes by forming a solution of the resin in an amount sufficient to cast a coherent membrane, diluting the solution with a liquid pore modifier which is a nonsolvent for the resin so as to produce a metastable dispersion of the resin, adding a precipitant to form a turbid casting dope, casting the dope onto a surface, and gelling the so-cast film.
摘要翻译：全芳族聚酰胺（芳族聚酰胺）树脂可以通过形成足以浇铸粘结膜的量的树脂溶液而浇铸成超疏水和微孔膜，用液体孔改性剂稀释溶液，该液体孔改性剂是树脂的非溶剂，以便产生树脂的亚稳分散体，加入沉淀剂以形成浑浊的浇注液，将涂料浇注到表面上，并使溶胶胶凝胶化。

7. 发明申请

WO1992005804A1 CHELATING AGENTS 审中-公开
标题翻译：焊接剂
公开(公告)号：WO1992005804A1
公开(公告)日：1992-04-16
申请号：PCT/US1991007016
申请日：1991-09-26
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J. , SILVEIRA, Michael, H.
IPC分类号： A61K43/00
CPC分类号： G01N33/532 , A61K47/6887 , A61K49/04 , A61K51/0482 , A61K51/1093 , A61K2121/00 , A61K2123/00
摘要： Metal chelates and therapeutic or diagnostic conjugates of site-specific compounds, metal chelates, and metal ions are described. The metal chelates consist of at least two molecular components linked together. One molecular component is a chelate having a high affinity for metal ions and a high Ks value. The other molecular component is a chelate having a low Ks value and the ability to undergo rapid metal exchange.
摘要翻译：描述了金属螯合物和位点特异性化合物，金属螯合物和金属离子的治疗或诊断缀合物。金属螯合物由连接在一起的至少两个分子组分组成。一种分子成分是对金属离子具有高亲和力和高Ks值的螯合物。另一种分子组分是具有低Ks值和经历快速金属交换的能力的螯合物。

8. 发明申请

WO1991000112A1 ANTIBODY-LACTATE OXIDASE CONJUGATES 审中-公开
标题翻译：抗氧化剂氧化酶结合
公开(公告)号：WO1991000112A1
公开(公告)日：1991-01-10
申请号：PCT/US1990001056
申请日：1990-02-22
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , DUNCAN, John, D. , WRASIDLO, Wolfgang, J.
IPC分类号： A61K47/48
CPC分类号： A61K47/6815
摘要： Conjugates of antibodies and lactate oxidase, linked together by linker molecules, which are designed for therapeutic purposes. The bacterial lactate oxidase linked to an antibody produces the cytotoxic substance hydrogen peroxide at the site of action as dictated by antibody specificity.
摘要翻译：通过连接分子连接在一起的抗体和乳酸氧化酶的结合物，其被设计用于治疗目的。与抗体连接的细菌乳酸氧化酶在抗体特异性所规定的作用部位产生细胞毒性物质过氧化氢。

9. 发明申请

WO1988007075A1 THIN FILM MEMBRANE, ENZYME REACTORS 审中-公开
标题翻译：薄膜，酶反应器
公开(公告)号：WO1988007075A1
公开(公告)日：1988-09-22
申请号：PCT/US1988000229
申请日：1988-01-27
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J. , HOFFMAN, Frieder, K.
IPC分类号： C12M01/40
CPC分类号： C12M25/14 , C12M21/18 , C12M29/04 , Y10S435/817
摘要： An enzyme reactor system is provided based on the entrapment of an enzyme in a hydrogel layer coated on a support, and confined by an ultraporous thin film membrane diffusion barrier. The diffusion barrier confines the enzyme, but lets substrate and reaction products diffuse freely into and out of the hydrogel layer. In an alternate embodiment, the support is formed of an ultraporous thin film membrane diffusion barrier on a microporous or macroporous support, through which the reaction products can diffuse freely, but through which neither enzyme nor substrate can pass. In this embodiment, the product is recovered in high purity, free of substrate and enzyme.

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