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1. 发明申请

WO1991000108A1 ANTIBODY-OXIDASE CONJUGATES WITH NON-SYSTEMIC SUBSTRATES 审中-公开
标题翻译：抗体氧化酶与非系统性基质结合
公开(公告)号：WO1991000108A1
公开(公告)日：1991-01-10
申请号：PCT/US1990001527
申请日：1990-03-21
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , DUNCAN, John, D. , HOFMANN, Frieder, K.
IPC分类号： A61K39/395
CPC分类号： B82Y5/00 , A61K47/67 , A61K47/6893 , A61K47/6899
摘要： Enzyme-immunoconjugates which can be used for therapeutic purposes without significant patient side effects due to their administration. The general type of enzyme-immunoconjugate is composed of any antibody or fragment thereof linked to an oxidase whose natural substrate is not normally present in the body fluids or otherwise available in the extracellular spaces of the body. The therapeutic action of such oxidases lies in their ability to produce the cytotoxic yet biologically rapidly degrading agent hydrogen peroxide. Such oxidase-immunoconjugates would be specifically targeted to the desired tissues by use of the antibody component but would not be active until such time as a substrate of exogenous source is administered to the patient, whereupon hydrogen peroxide would be produced by the enzymatic process wherever the oxidase-immunoconjugate is present.
摘要翻译：酶免疫偶联物，其可以用于治疗目的而没有由于其给药而显着的患者副作用。酶免疫缀合物的一般类型由与天然底物通常不存在于体液中或在体外的细胞外空间中可用的氧化酶连接的任何抗体或其片段组成。这种氧化酶的治疗作用在于其产生细胞毒性但生物学上快速降解剂过氧化氢的能力。这样的氧化酶 - 免疫偶联物将通过使用抗体组分而特异性地靶向所需的组织，但是直到向患者施用外源性底物的时间才会是有效的，于是过氧化氢将通过酶法产生，存在氧化酶 - 免疫偶联物。

2. 发明申请

WO1989000188A1 CELL GROWTH REACTOR WITH THREE COMPARTMENTS FORMED BY HYDROPHOBIC AND HYDROPHILIC MEMBRANES 审中-公开
标题翻译：具有由疏水性和疏水性膜形成的三个间隔的细胞生长反应器
公开(公告)号：WO1989000188A1
公开(公告)日：1989-01-12
申请号：PCT/US1988002209
申请日：1988-06-28
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J. , HOFMANN, Frieder, K. , DeWINTER, Dirk, M.
IPC分类号： C12M03/00
CPC分类号： C12M29/04 , C12M23/24 , C12M23/34
摘要： A continuous, integrated membrane bioreactor system for the culture of hybridoma or mammalian cells which meets the nutritional and physical needs of hybridomas or mammalian cells, allows for the harvesting of products, and maintains sterile integrity of the system by combining several individual apparatus having separate functions into an integrated, functioning unit. Central to this bioreactor is the compact size of the cell enclosure which is made possible by the high cell densities achieved in the layered membrane design and the continuous feed and bleed nutrient medium system which minimizes the nutrient medium volume inside the bioreactor. Maximized product output per unit of volume minimizes the space necessary to house the bioreactor. Oxygen is passed through the bioreactor as air or another gas mixture, rather than dissolved in the nutrient medium.
摘要翻译：用于培养满足杂交瘤或哺乳动物细胞的营养和物理需要的杂交瘤或哺乳动物细胞的连续的，整合的膜生物反应器系统允许产品的收获，并且通过组合具有单独功能的几个单独的装置来维持系统的无菌完整性成为一个综合功能单位。该生物反应器的中心是细胞外壳的紧凑尺寸，其通过在分层膜设计中实现的高细胞密度和连续进料和排出营养培养基系统而实现，其使生物反应器内的营养培养基体积最小化。最大化每单位体积的产品输出可最大限度地减少安装生物反应器所需的空间。氧气通过生物反应器作为空气或另一种气体混合物，而不是溶解在营养培养基中。

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