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1. 发明申请

WO1989000188A1 CELL GROWTH REACTOR WITH THREE COMPARTMENTS FORMED BY HYDROPHOBIC AND HYDROPHILIC MEMBRANES 审中-公开
标题翻译：具有由疏水性和疏水性膜形成的三个间隔的细胞生长反应器
公开(公告)号：WO1989000188A1
公开(公告)日：1989-01-12
申请号：PCT/US1988002209
申请日：1988-06-28
申请人： BRUNSWICK CORPORATION
发明人： BRUNSWICK CORPORATION , WRASIDLO, Wolfgang, J. , HOFMANN, Frieder, K. , DeWINTER, Dirk, M.
IPC分类号： C12M03/00
CPC分类号： C12M29/04 , C12M23/24 , C12M23/34
摘要： A continuous, integrated membrane bioreactor system for the culture of hybridoma or mammalian cells which meets the nutritional and physical needs of hybridomas or mammalian cells, allows for the harvesting of products, and maintains sterile integrity of the system by combining several individual apparatus having separate functions into an integrated, functioning unit. Central to this bioreactor is the compact size of the cell enclosure which is made possible by the high cell densities achieved in the layered membrane design and the continuous feed and bleed nutrient medium system which minimizes the nutrient medium volume inside the bioreactor. Maximized product output per unit of volume minimizes the space necessary to house the bioreactor. Oxygen is passed through the bioreactor as air or another gas mixture, rather than dissolved in the nutrient medium.
摘要翻译：用于培养满足杂交瘤或哺乳动物细胞的营养和物理需要的杂交瘤或哺乳动物细胞的连续的，整合的膜生物反应器系统允许产品的收获，并且通过组合具有单独功能的几个单独的装置来维持系统的无菌完整性成为一个综合功能单位。该生物反应器的中心是细胞外壳的紧凑尺寸，其通过在分层膜设计中实现的高细胞密度和连续进料和排出营养培养基系统而实现，其使生物反应器内的营养培养基体积最小化。最大化每单位体积的产品输出可最大限度地减少安装生物反应器所需的空间。氧气通过生物反应器作为空气或另一种气体混合物，而不是溶解在营养培养基中。

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