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1. 发明申请

WO2010014512A2 PREPARATION OF TEST PLATES FOR MATRIX ASSISTED LASER DESORPTION IONIZATION 审中-公开
标题翻译：基体辅助激光解吸电离试验板的制备
公开(公告)号：WO2010014512A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/051740
申请日：2009-07-24
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , AGAR, Nathalie
发明人： AGAR, Nathalie
IPC分类号： G01N1/36 , G01N27/62
CPC分类号： H01J49/0418 , G01N1/32
摘要： The present invention is directed, sample test plates that can be used in matrix assisted laser desorption ionization. These plates have an etched surface and a layer of MALDI matrix material. The invention also includes methods for making these sample test plates and to methods for using the plates in the MS imaging of cell and tissue samples.
摘要翻译：本发明涉及可用于基质辅助激光解吸电离的样品测试板。这些板具有蚀刻表面和一层MALDI基质材料。本发明还包括制备这些样品测试板的方法以及在细胞和组织样品的MS成像中使用该板的方法。

2. 发明申请

WO2014204638A2 SYSTEM AND METHOD FOR ANALYZING TISSUE FOR THE PRESENCE OF CANCER USING BIO-MARKER PROFILES 审中-公开
标题翻译：使用生物标记物分析癌症存在的分析系统和方法
公开(公告)号：WO2014204638A2
公开(公告)日：2014-12-24
申请号：PCT/US2014/040501
申请日：2014-06-02
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , AGAR, Nathalie
发明人： AGAR, Nathalie
IPC分类号： G01N30/72
CPC分类号： G01N33/57415 , G01N33/6848 , G01N33/92 , G01N2405/00 , G01N2560/00
摘要： A system and method for intra-operative sample analysis including acquiring a tissue sample, preparing the tissue sample for mass spectrometry imaging, conducting a mass spectrometry imaging procedure on the tissue sample to produce an image, and analyzing the image to determine the presence or absence of a bio-marker.
摘要翻译：一种用于手术中样本分析的系统和方法，包括获取组织样本，准备用于质谱成像的组织样本，对组织样本进行质谱成像程序以产生图像，以及分析图像以确定存在或不存在的生物标记物。

3. 发明申请

WO2014106165A1 SYSTEM AND METHOD FOR ANALYSIS OF BIO-METABOLITES FOR-USE IN IMAGE-GUIDED SURGERY 审中-公开
标题翻译：用于图像引导手术中生物代谢物分析的系统和方法
公开(公告)号：WO2014106165A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/078260
申请日：2013-12-30
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , AGAR, Nathalie
发明人： AGAR, Nathalie
IPC分类号： G01N33/483 , G06F19/28 , H01J49/26 , A61K31/194
CPC分类号： G01N33/57484 , A61B5/061 , A61B10/02 , A61B34/20 , G01N33/574 , G06F19/18 , G06F19/24 , H01J49/04 , H01J49/26
摘要： A system for identifying a bio-marker using mass spectroscopy is provided that includes a sample receptacle configured to receive a tissue sample, a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data, and a computer system that includes a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions. The instructions cause the computer processor to: receive the mass spectrometry data from the mass spectrometry apparatus; analyze the mass spectrometry data to determine a presence of 2-Hydroxyglutarate (2-HG) in the tissue sample; and generate a report indicating a health of the tissue sample based on the presence of 2-HG in the tissue sample.
摘要翻译：提供了一种用于使用质谱鉴定生物标记的系统，其包括构造成接收组织样本的样品容器，配置成接收组织样品并使用质谱法分析组织样品的质谱仪，以产生质谱数据以及计算机系统，其包括计算机处理器，该计算机处理器可访问其上存储有指令的非暂时的计算机可读存储介质。指令使计算机处理器从质谱仪器接收质谱数据; 分析质谱数据以确定组织样品中2-羟基戊二酸（2-HG）的存在; 并且基于组织样品中2-HG的存在产生指示组织样品的健康状况的报告。

4. 发明申请

WO2010021951A2 INTEGRATED SURGICAL SAMPLING PROBE 审中-公开
标题翻译：集成的手术采样探头
公开(公告)号：WO2010021951A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/053967
申请日：2009-08-17
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , JOLESZ, Ferenc , GOLBY, Alexandra , AGAR, Nathalie
发明人： JOLESZ, Ferenc , GOLBY, Alexandra , AGAR, Nathalie
IPC分类号： A61B10/02 , A61B18/00 , A61M1/00 , A61B6/00 , A61B5/055
CPC分类号： A61B10/02 , A61B17/320068 , A61B2034/2051 , A61B2034/2055
摘要： The present invention is directed to devices for collecting tissue samples from patients. The devices create tissue fragments which are then collected by aspiration. The devices include signal emitters that allow the exact position where a biopsy sample was obtained to be determined. In addition the invention includes methods for obtaining tissue samples using these devices.
摘要翻译：本发明涉及用于从患者收集组织样本的装置。该装置产生组织碎片，然后通过抽吸收集。这些设备包括信号发射器，可以确定获得活检样本的准确位置。此外，本发明包括使用这些装置获得组织样本的方法。

5. 发明申请

WO2023076662A1 SYSTEM AND METHOD FOR QUANTITATIVE PATHOLOGY USING MASS SPECTROMETRY IMAGING 审中-公开
公开(公告)号：WO2023076662A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/048392
申请日：2022-10-31
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： AGAR, Nathalie , BASU, Sankha, S. , STOPKA, Sylwia, A. , SANTAGATA, Sandro , HAIGIS, Marcia, C. , REGAN, Michael , BAQUER, Gerard
IPC分类号： H01J49/00 , H01J49/26
摘要： An apparatus for facilitating quantitative anatomic pathology using mass spectrometry imaging includes a solid support having at least one flat surface, a tissue homogenate having a thickness mounted to the at least one flat surface of the solid support, and a quantitative array having a thickness and comprising a tissue microarray having a plurality of wells and a series of varying concentrations of an isotopically labeled metabolite deposited in the plurality of wells. The quantitative array is mounted over the tissue homogenate on the solid support.

6. 发明申请

WO2015061597A1 SYSTEM AND METHOD FOR ANALYZING TISSUE INTRA-OPERATIVELY USING MASS SPECTROMETRY 审中-公开
标题翻译：使用质谱分析手术分析组织的系统和方法
公开(公告)号：WO2015061597A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/062017
申请日：2014-10-23
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： AGAR, Nathalie
IPC分类号： G01N35/10 , H01J49/26 , G01N33/483 , G06F19/10
CPC分类号： G01N33/4833 , A61B10/02 , A61B17/320068 , A61B34/20 , A61B90/36 , A61B90/37 , A61B2034/2051 , A61B2090/374 , A61B2090/3762 , A61B2218/007 , G01N33/57496 , G01N2800/52 , G06F19/703 , H01J49/26
摘要： A system and method for ample analysis including acquiring a tissue sample, preparing the tissue sample for mass spectrometry imaging, conducting a mass spectrometry procedure on the tissue sample to produce an image, analyzing the image to determine the presence or absence of a biomarker; and generating a report indicating a presence or absence of cancer.
摘要翻译：一种用于充分分析的系统和方法，包括获取组织样品，制备用于质谱成像的组织样品，对组织样品进行质谱分析程序以产生图像，分析图像以确定生物标志物的存在或不存在; 并产生指示癌症存在或不存在的报告。

7. 发明申请

WO2010114976A1 METHOD AND SYSTEM FOR SURFACE SAMPLING 审中-公开
标题翻译：表面采样方法与系统
公开(公告)号：WO2010114976A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029586
申请日：2010-04-01
申请人： PROSOLIA, INC. , WISEMAN, Justin , AGAR, Nathalie
发明人： WISEMAN, Justin , AGAR, Nathalie
IPC分类号： H01J49/04
CPC分类号： H01J49/0459 , G01N35/1095 , Y10T29/49826
摘要： A system for releasing and sampling analyte material from a target surface, e.g., for analysis, includes a sampling probe that applies irrigation fluid and ultrasonic or vibrational energy to the target, and aspirates desorbed material into a pick-up conduit. The irrigation fluid is provided at the site by an irrigation conduit or capillary co-located with or coaxially disposed about the inlet of the pick-up, and a suction source at the distal end of the pick-up capillary aspirates analyte which has been released from the target into the irrigation fluid, thus efficiently sampling a broad range of materials from an arbitrary target to produce an analyzable effluent analyte stream. The effluent analyte stream may be ionized and provided to the inlet of an ion-type analysis instrument, or may be fed directly to an instrument such as a flow cytometer, IR or fluorescence spectrophotometer, or other analyzer.
摘要翻译：用于从目标表面释放和取样分析物质例如用于分析的系统包括将冲洗流体和超声波或振动能施加到靶上并将解吸附材料抽吸到拾取管道中的取样探针。冲洗流体通过与拾取器的入口共同定位或同轴设置的冲洗管道或毛细管在该位置处提供，并且拾取毛细管远端处的抽吸源吸出已被释放的分析物从目标进入冲洗流体，从而有效地从任意目标采样各种材料，以产生可分析的流出物分析物流。流出物分析物流可以离子化并提供给离子型分析仪器的入口，或者可以直接进料到诸如流式细胞仪，IR或荧光分光光度计或其它分析仪的仪器。

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