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1. 发明申请

WO1989004963A1 PROCESS FOR DETECTING CANCER AND FOR MONITORING THE EFFECTIVENESS OF CANCER THERAPY 审中-公开
标题翻译：检测癌症和监测癌症治疗效果的方法
公开(公告)号：WO1989004963A1
公开(公告)日：1989-06-01
申请号：PCT/US1988003766
申请日：1988-10-24
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , OH, Se'Kyung
IPC分类号： G01N33/53
CPC分类号： G01N33/6863 , G01N33/57488 , G01N33/74 , Y10S436/813
摘要： A process for detecting cancer in a human patient is provided wherein a blood serum is recovered from the patient and is reacted with a monoclonal antibody comprising anti-haptoglobin variant under conditions to effect an immunoreaction when an immunosuppressive factor having a molecular weight of about 850-900 K Daltons is present in the serum. The presence of immunosuppressive factor at concentration levels substantially exceeding normal concentration levels indicates the existence of immuno-incompetence due to widely spread cancer. The effectiveness of cancer therapy is monitored by monitoring the change in levels of the immunosuppressive haptoglobin variant factor in the serum from the patient being treated.

2. 发明申请

WO1994001579A1 ASSAY FOR NON-FAMILIAL ALZHEIMER'S DISEASE 审中-公开
标题翻译：测定非特异性阿尔茨海默病
公开(公告)号：WO1994001579A1
公开(公告)日：1994-01-20
申请号：PCT/US1993005881
申请日：1993-06-18
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , SIMONS, Elizabeth, R. , DAVIES, Theresa, A.
IPC分类号： C12Q01/44
CPC分类号： G01N33/6896 , G01N33/5091 , G01N2800/2821
摘要： A method of assaying for non-familial Alzheimer's disease in a live patient, by preparing washed platelets from the blood of the patient; inserting a pH probe in the platelets in the form of a fluorescent dye such as 2',7'-bis (carboxyethyl)- 5(6)-carboxyfluorescein; inhibiting alkalinization of platelet response by blocking Na+/H+ transfer across the platelet membranes with dimethyl amiloride; stimulating the platelets with (alpha)-thrombin so that the cytoplasm of the stimulated platelets shows a characteristic acidification response or change in cytoplasmic pH; measuring the cytoplasmic pH of the platelets following stimulation; and comparing the measured pH with the corresponding stimulated cytoplasmic pH in platelets from normal individuals.
摘要翻译：一种在活体患者中测定非家族性阿尔茨海默氏病的方法，通过从患者的血液中制备洗涤的血小板; 以2'，7'-双（羧乙基）-5（6） - 羧基荧光素等荧光染料的形式将pH探针插入血小板; 通过用二甲基阿米洛利阻断Na + / H +转移穿过血小板膜来抑制血小板反应的碱化; 用（α）凝血酶刺激血小板，使得受激血小板的细胞质显示出特征酸化反应或细胞质pH的变化; 测量刺激后血小板的细胞质pH值; 并将测量的pH与来自正常个体的血小板中相应的刺激的细胞质pH进行比较。

3. 发明申请

WO1988003821A1 ELECTRODE ASSEMBLY FOR TRANSDERMAL DRUG DELIVERY 审中-公开
标题翻译：电极组件用于转管药物递送
公开(公告)号：WO1988003821A1
公开(公告)日：1988-06-02
申请号：PCT/US1987002925
申请日：1987-11-06
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , POWERS, Whitney, R. , SISUN, Henry
IPC分类号： A61N01/30
CPC分类号： A61N1/18 , A61K41/00
摘要： A novel electrode and electrode assembly (4a, 10a, 20a, 4b, 10b, 20b) which preferably uses alternating and direct electrical energy (2) for transdermal delivery of pharmacologically active ligands and for stimulation of tissues in vivo. Methods and systems are also disclosed which allow a broad range of therapeutic agents to be transmitted to tissues and organs superficially or deep within the body.

4. 发明申请

WO1992016966A1 A METHOD FOR THE PREPARATION AND DOPING OF HIGHLY INSULATING MONOCRYSTALLINE GALLIUM NITRIDE THIN FILMS 审中-公开
标题翻译：高绝缘单晶氮化镓薄膜的制备和掺杂方法
公开(公告)号：WO1992016966A1
公开(公告)日：1992-10-01
申请号：PCT/US1992002242
申请日：1992-03-18
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , MOUSTAKAS, Theodore, D.
IPC分类号： H01L21/203
CPC分类号： H01L33/32 , C30B23/02 , C30B29/403 , C30B29/406 , H01L21/0237 , H01L21/02381 , H01L21/0242 , H01L21/02433 , H01L21/02458 , H01L21/0254 , H01L21/0262 , H01L21/02631 , H01L33/007 , H01L33/0075 , Y10S148/113
摘要： This invention relates to a method of preparing highly insulating GaN single crystal films in a molecular beam epitaxial growth chamber. A single crystal substrate is provided with the appropriate lattice match for the desired crystal structure of GaN. A molecular beam source of Ga and source of activated atomic and ionic nitrogen are provided within the growth chamber. The desired film is deposited by exposing the substrate to Ga and nitrogen sources in a two step growth process using a low temperature nucleation step and a high temperature growth step. The low temperature process is carried out at 100-400 DEG C and the high temperature process is carried out at 600-900 DEG C. The preferred source of activated nitrogen is an electron cyclotron resonance microwave plasma.
摘要翻译：本发明涉及在分子束外延生长室中制备高绝缘GaN单晶膜的方法。为单晶衬底提供GaN的所需晶体结构的适当晶格匹配。 Ga的分子束源和激活的原子和离子氮的源被提供在生长室内。通过使用低温成核步骤和高温生长步骤在两步生长方法中将基底暴露于Ga和氮源来沉积所需的膜。低温过程在100-400℃进行，高温过程在600-900℃进行。活性氮的优选来源是电子回旋共振微波等离子体。

5. 发明申请

WO1992003542A1 PROTEASES CAUSING ABNORMAL DEGRADATION OF AMYLOID 'beta'-PROTEIN PRECURSOR 审中-公开
标题翻译：蛋白质引起异丙肾上腺素β-丙氨酸前体的异常降解
公开(公告)号：WO1992003542A1
公开(公告)日：1992-03-05
申请号：PCT/US1991005932
申请日：1991-08-19
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , ABRAHAM, Carmela, R.
IPC分类号： C12N09/50
CPC分类号： C12N9/6472 , A61K38/55 , C07K14/4711
摘要： A proteolytic factor is capable of cleaving beta -protein precursor at a site near the beta -protein N-terminus. Also, a method for treating Alzheimer's disease in a patient includes steps of reducing DOLLAR (b)-protein precursor proteolysis outside the beta -protein domain at a site near the beta -protein N-terminus. Also, a method for purifying en enzyme from a sample includes steps of incubating the sample with a labelled substrate of the enzyme or with a labelled fragment of a substrate to which the enzyme binds, treating the sample with a crosslinking agent to crosslink any enzyme-substrate complexes in the sample, and recovering labelled complexes. Also, a method for diagnosis in a subject of a disease characterized by accumulation of amyloid includes determining the level, in a sample of tissue or body fluid from the subject, of an AD proteolytic factor. Also, a method for screening for an agent useful in treatment of a disease characterized by accumulation of amyloid includes steps of incubating an AD protease with a peptide having an amino acid sequence corresponding to the sequence spanning the beta -protein N-terminus in the presence of a candidate agent, and determining the degradation of the peptide.
摘要翻译：蛋白水解因子能够在β-蛋白N末端附近的位点切割β-蛋白前体。此外，在患者中治疗阿尔茨海默氏病的方法包括在β-蛋白N-末端附近的位点处，在β-蛋白质结构域外部减少DOLLAR（b） - 蛋白前体蛋白水解的步骤。此外，从样品中纯化en酶的方法包括将样品与酶的标记底物或酶结合的底物的标记片段一起孵育的步骤，用交联剂处理样品以交联任何酶 - 底物复合物，并回收标记的复合物。另外，以淀粉样蛋白积累为特征的疾病的受试者的诊断方法包括确定AD蛋白水解因子在受试者的组织或体液样品中的水平。此外，用于筛选可用于治疗以淀粉样蛋白积累为特征的疾病的药剂的方法包括以下步骤：在存在的情况下将AD蛋白酶与具有对应于跨越β-蛋白N-末端的序列的氨基酸序列的肽一起孵育的候选试剂，并确定肽的降解。

6. 发明申请

WO1991018282A1 MEASURING CONNECTIVE TISSUE BREAKDOWN PRODUCTS IN BODY FLUIDS 审中-公开
标题翻译：测量身体液体中的连接组织破裂产品
公开(公告)号：WO1991018282A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003310
申请日：1991-05-13
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , STONE, Phillip, J. , FRANZBLAU, Carl , BRYAN-RHADFI, Julianne
IPC分类号： G01N23/00
CPC分类号： G01N33/68 , G01N30/02 , G01N33/60 , Y10T436/25
摘要： A method for determining a connective tissue breakdown product in a body fluid from an animal includes steps of providing a standard comprising the breakdown product having a radioactive label, the standard having a known specific radioactivity, combining the standard and a sample of the body fluid, removing from the combined standard and sample a purified breakdown product fraction containing labelled breakdown product from the standard together with breakdown product from the sample, and measuring the specific radioactivity of the fraction as a measure of the quantity of the breakdown product in the sample. Also, methods for assessing a condition of a selected connective tissue in an animal in vivo, and for assessing in vivo a disease process that includes destruction of a specified connective tissue component, and for assessing in vivo the efficacy of a therapy for treatment of such a disease process, include the steps of the method for determining a connective tissue breakdown product.

7. 发明申请

WO1994010635A1 NEURAL NETWORKS WITH SUBDIVISION 审中-公开
标题翻译：细分的神经网络
公开(公告)号：WO1994010635A1
公开(公告)日：1994-05-11
申请号：PCT/US1993010581
申请日：1993-11-02
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , BAR-YAM, Yaneer
IPC分类号： G06F15/00

8. 发明申请

WO1990003665A2 INTEGRATED MICROMECHANICAL PIEZOELECTRIC MOTOR 审中-公开
标题翻译：集成微电子压电电机
公开(公告)号：WO1990003665A2
公开(公告)日：1990-04-05
申请号：PCT/US1989004129
申请日：1989-09-21
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , SMITS, Johannes, G.
IPC分类号： H01L41/09
CPC分类号： H01L41/22 , A61B17/28 , A61B17/32 , A61B34/70 , A61B2017/00106 , A61B2017/00345 , H01L41/0946 , H02N2/021 , H02N2/101
摘要： Small piezoelectric machines comprised of pairs of cantilever beams covered with a piezoelectric material are driven to perform various mechanical tasks. A robot utilizes a plurality of pairs of these piezoelectrically driven beams to move itself and grab, carry or manipulate other objects.

9. 发明申请

WO1988010476A1 SYSTEM FOR CATEGORY RECOGNITION OF ANALOG PATTERN 审中-公开
标题翻译：类别识别模拟模式的系统
公开(公告)号：WO1988010476A1
公开(公告)日：1988-12-29
申请号：PCT/US1988001962
申请日：1988-06-09
申请人： BOSTON UNIVERSITY
发明人： BOSTON UNIVERSITY , CARPENTER, Gail, A. , GROSSBERG, Stephen
IPC分类号： G06K09/66
CPC分类号： G06K9/4628 , G06N3/0409
摘要： A neural network includes a feature representation field which receives input patterns. Signals from the feature representation field select a category from a category representation field through a first adaptive filter. Based on the selected category, a template pattern is applied to the feature representation field, and a match between the template and the input is determined. If the angle between the template vector and a vector within the representation field is too great, the selected category is reset. Otherwise the category selection and template pattern are adapted to the input pattern as well as the previously stored template. A complex representation field includes signals normalized relative to signals across the field and feedback for pattern contrast enhancement.

10. 发明申请

WO1996004789A1 A METHOD OF SELECTIVELY DESTROYING NEOPLASTIC CELLS 审中-公开
标题翻译：一种选择性破坏神经细胞的方法
公开(公告)号：WO1996004789A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010365
申请日：1995-08-15
申请人： THE GENERAL HOSPITAL CORPORATION , BOSTON UNIVERSITY , DANA FARBER CANCER INSTITUTE
发明人： THE GENERAL HOSPITAL CORPORATION , BOSTON UNIVERSITY , DANA FARBER CANCER INSTITUTE , CHIOCCA, E., Antonio , WAXMAN, David, J. , WEI, Ming, X. , BREAKEFIELD, Xandra, O. , CHEN, Ling
IPC分类号： A01N43/04
CPC分类号： C12N9/0079 , A61K38/00 , A61K48/00 , A61K2300/00 , C12N2799/027
摘要： A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene product targets the cells for selective killing, by rendering the cells sensitive to a chemotherapeutic agent.
摘要翻译：提供了选择性地杀死神经系统和外周肿瘤细胞的方法。病毒载体用于通过使细胞对化学治疗剂敏感的肿瘤细胞中选择性表达细胞色素P450基因，其肿瘤细胞的基因产物靶向选择性杀伤细胞。

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