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1. 发明申请

WO2007001657A1 METHOD, SYSTEM, APPARATUS, AND KIT FOR REMOTE THERAPEUTIC DELIVERY 审中-公开
标题翻译：方法，系统，设备和远程治疗手段
公开(公告)号：WO2007001657A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/018593
申请日：2006-05-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , PALASIS, Maria , MICKLEY, Timothy, J.
发明人： FREYMAN, Toby , PALASIS, Maria , MICKLEY, Timothy, J.
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M25/1006 , A61B17/12136 , A61B2017/22067 , A61M25/0032 , A61M25/0045 , A61M25/1002 , A61M2025/0004 , A61M2025/0034 , A61M2025/0076 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052
摘要： A therapeutic delivery catheter system method or kit for delivery of therapeutic to a target location is provided. In various embodiments of the present invention the invention may include a catheter with a therapeutic delivery lumen and a therapeutic delivery orifice. The lumen and the orifice may be in fluid communication with each other and may be configured such that therapeutic delivered therethrough may be done at pressures mimicking pressures existing or otherwise normal at the target locations receiving the therapeutic. In some embodiments the catheter may be part of a kit that may include instructions regarding the proper manner of operation of the catheter. These instructions may include suggested target pressures for therapeutic delivery as well as delivery times, and suggested lengths of time for the device to reside at the target area after delivery to allow for proper uptake of the therapeutic.
摘要翻译：提供了用于将治疗剂递送到目标位置的治疗性递送导管系统方法或试剂盒。在本发明的各种实施例中，本发明可以包括具有治疗性输送腔和治疗性输送孔的导管。管腔和孔可以彼此流体连通，并且可以被配置为使得通过其传递的治疗可以在模拟接收治疗剂的目标位置处存在或以其他方式正常的压力下进行。在一些实施例中，导管可以是套件的一部分，其可以包括关于导管的适当操作方式的指令。这些说明书可以包括用于治疗性递送以及递送时间的建议目标压力，以及设备在递送之后驻留在目标区域的建议时间长度，以允许治疗剂的适当摄取。

2. 发明申请

WO2005102426A1 NEEDLES 审中-公开
公开(公告)号：WO2005102426A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/007707
申请日：2005-03-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MICKLEY, Timothy, J. , USCHOLD, John, E.
发明人： MICKLEY, Timothy, J. , USCHOLD, John, E.
IPC分类号： A61M5/32
CPC分类号： A61M5/3286
摘要： A needle (10) having a shaft (20) with a distal end (40) defining a distal opening (60). The shaft has a longitudinal axis (X) that extends through the distal opening and the distal opening has a projected area that is smaller than a cross-sectional area of a section of the shaft proximal to the distal end of the shaft.
摘要翻译：具有轴（20）的针（10），其具有限定远端开口（60）的远端（40）。轴具有延伸穿过远端开口的纵向轴线（X），并且远端开口具有小于轴的近端远离轴的截面积的横截面面积的投影面积。

3. 发明申请

WO2012125184A1 STENT AND DELIVERY SYSTEM 审中-公开
标题翻译： STENT和交付系统
公开(公告)号：WO2012125184A1
公开(公告)日：2012-09-20
申请号：PCT/US2011/052785
申请日：2011-09-22
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： BOISMIER, Dennis, A. , HEMERICK, James, F. , GREGORICH, Daniel , MEYER, Michael, P. , MICKLEY, Timothy, J. , WEBER, Jan , TISCHLER, Brian
IPC分类号： A61F2/90 , A61F2/84
CPC分类号： A61F2/91 , A61F2/844 , A61F2/958 , A61F2002/9583 , A61F2220/0075 , A61F2220/0091 , A61F2230/006
摘要： Techniques are disclosed that allow a stent to be folded within a balloon of a stent delivery system. In one example, a stent has first and second columns that extend from a proximal end to a distal end along a longitudinal axis. Each of the first columns extend substantially parallel to the longitudinal axis and comprise a plurality of elements (38) that each have a substantially polygonal shape. Each of the second columns extend substantially parallel to the longitudinal axis and are between adjacent first columns. Each of the respective second columns include a plurality of first connectors (32) that have a curvilinear shape and that extend in a substantially circumferential direction to connect adjacent first columns. The stent also has a plurality of second connectors, wherein at least one of the second connectors (50) extends between a first element and a second element.
摘要翻译：公开了允许支架在支架输送系统的球囊内折叠的技术。在一个示例中，支架具有沿着纵向轴线从近端延伸到远端的第一和第二柱。每个第一列基本上平行于纵向轴线延伸并且包括多个元件（38），每个元件具有基本上多边形的形状。每个第二列基本上平行于纵向轴线延伸并且在相邻的第一列之间。每个相应的第二列包括多个第一连接器（32），其具有曲线形状并且沿大致圆周方向延伸以连接相邻的第一列。支架还具有多个第二连接器，其中第二连接器（50）中的至少一个在第一元件和第二元件之间延伸。

4. 发明申请

WO2008094548A3 LOCAL DELIVERY OF THERAPEUTIC AGENT TO HEART VALVES 审中-公开
公开(公告)号：WO2008094548A3
公开(公告)日：2008-08-07
申请号：PCT/US2008/001160
申请日：2008-01-30
申请人： BOSTON SCIENTIFIC SCIMED, INC. , PALASIS, Maria , MICKLEY, Timothy, J. , FREYMAN, Toby , NAIMARK, Wendy
发明人： PALASIS, Maria , MICKLEY, Timothy, J. , FREYMAN, Toby , NAIMARK, Wendy
IPC分类号： A61M31/00 , A61F2/24
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device (502) is provided comprising a body. The body may have a portion (518) thereof including therapeutic agent (516) and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

5. 发明申请

WO2008021011A2 MEDICAL DEVICE FOR VESSEL COMPATIBILITY DURING HIGH PRESSURE VASCULAR CELL INFUSION 审中-公开
标题翻译：高压血管细胞浸润过程中血管相容性的医疗装置
公开(公告)号：WO2008021011A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/017250
申请日：2007-08-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , EPSTEIN, Samuel, J. , FREYMAN, Toby , HARRIS, Chad, G. , MICKLEY, Timothy, J.
发明人： EPSTEIN, Samuel, J. , FREYMAN, Toby , HARRIS, Chad, G. , MICKLEY, Timothy, J.
IPC分类号： A61M25/10 , A61M29/00 , A61M29/02
CPC分类号： A61M29/02 , A61B17/12022 , A61B17/1204 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B2017/1205 , A61M2025/0024 , A61M2025/1052 , A61M2025/1081 , A61M2025/1095
摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.
摘要翻译：本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。这允许递送具有降低治疗部位损伤风险的治疗剂。本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

6. 发明申请

WO2010011930A2 VARIOUS CATHETER DEVICES FOR MYOCARDIAL INJECTIONS OR OTHER USES 审中-公开
标题翻译：用于心肌注射或其他用途的各种导管装置
公开(公告)号：WO2010011930A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051700
申请日：2009-07-24
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： MICKLEY, Timothy, J. , KIM, Grace , EPSTEIN, Samuel, J. , GRIFFIN, Mark , EDRINGTON, John , FURNISH, Greg
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2018/00392 , A61B2090/036 , A61B2090/08021 , A61M25/0069 , A61M25/0074 , A61M25/0082 , A61M25/0084 , A61M2025/0089 , A61M2025/0096 , A61M2025/0681 , A61M2025/1093 , A61M2210/125 , A61M2230/04
摘要： A catheter device comprising a proboscis shaft and a proboscis disposed within the proboscis shaft. In certain embodiments, the catheter device further comprises an elongate tubular member, wherein the proboscis shaft is disposed within the elongate tubular member. In certain embodiments, the catheter device comprises a tissue surface engagement structure, which has a first configuration and a second configuration. In the second configuration, the tissue surface engagement structure presents a larger transverse profile in comparison to the first configuration. The tissue surface engagement structure may have any of various designs, including an expandable assembly and a hinged assembly. In certain embodiments, a deformable cushion is positioned at the distal end of the proboscis shaft. The deformable cushion comprises a pocket that is filled with a reshapeable material. In certain embodiments, the proboscis shaft comprises a longitudinally compressible portion.
摘要翻译：导管装置，其包括设置在所述长鼻轴内的长鼻轴和长鼻。在某些实施例中，导管装置还包括细长管状构件，其中，长鼻管轴设置在细长管状构件内。在某些实施例中，导管装置包括具有第一构造和第二构造的组织表面接合结构。在第二构造中，与第一构造相比，组织表面接合结构呈现较大的横向轮廓。组织表面接合结构可以具有各种设计中的任何一种，包括可扩张组件和铰接组件。在某些实施例中，可变形缓冲垫位于长鼻杆的远端。可变形的衬垫包括一个填充有可再形成材料的口袋。在某些实施例中，长鼻杆包括纵向可压缩部分。

7. 发明申请

WO2008016407A1 STENT RETAINING MECHANISMS 审中-公开
标题翻译： STENT保持机制
公开(公告)号：WO2008016407A1
公开(公告)日：2008-02-07
申请号：PCT/US2007/011110
申请日：2007-05-08
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： JAGGER, Karl , EIDENSCHINK, Tracee , SUTERMEISTER, Derek , GREGORICH, Daniel , ALKHATIB, Yousef , HEIDNER, Matt , JENNINGS, Adam , GUNDERSON, Richard,C. , BLIX, John , MICKLEY, Timothy, J. , OLSON, Richard , WEBBER, Jan , GODIN, Dominick
IPC分类号： A61F2/01 , A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2/97 , A61F2002/9583 , A61F2002/9665 , A61F2250/0059
摘要： A catheter system (35) comprises a catheter comprising a distal portion, a proximal portion and an inner shaft (20). The inner shaft comprises a medica device receiving region for receiving and carrying a medical device (10). Th retaining device (30) is at least partially constructed of an electroactive polymer. The retaining device is located on or adjacent to the medical devic receiving region. The electroactive polymer of the retaining device has an activated state and an inactivated state. The retaining device is capable of retaining a medical device to the catheter and releasing the medical device from the catheter by transitioning between the adtivated state and the inactivated state.
摘要翻译：导管系统（35）包括导管，其包括远端部分，近端部分和内轴（20）。内轴包括用于接收和携带医疗装置（10）的医疗装置接收区域。保持装置（30）至少部分地由电活性聚合物构成。保持装置位于医疗器械接收区域上或其附近。保持装置的电活性聚合物具有活化状态和失活状态。保持装置能够将医疗装置保持在导管上，并且通过在激活状态和非活动状态之间转换将医疗装置从导管释放。

8. 发明申请

WO2006033777A1 EXPANDABLE MULTI-PORT THERAPEUTIC DELIVERY SYSTEM AND DEVICE 审中-公开
标题翻译：可扩展的多端口治疗系统和设备
公开(公告)号：WO2006033777A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/030644
申请日：2005-08-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MICKLEY, Timothy, J. , PALASIS, Maria , FREYMAN, Toby
发明人： MICKLEY, Timothy, J. , PALASIS, Maria , FREYMAN, Toby
IPC分类号： A61M29/02 , A61M25/10
CPC分类号： A61M25/104 , A61M25/10 , A61M2025/105 , A61M2025/1072
摘要： The present invention provides methods, systems, and devices that deliver therapeutic to the inner lumens, chambers, cavities, and vessels of the body. In one embodiment, a therapeutic delivery device for delivery of therapeutic to a target site within the body of a patient is provided. This device may include a catheter, an expandable multi-port housing fluidly coupled to the catheter and a sheath. The multi-port housing in this device may be sized to travel within a lumen of a patient and may be adapted to expand from a first configuration to a second configuration. The multi-port housing may also contain at least two ejection ports coupled to an internal lumen of the multi-port housing. In some embodiments the multi-port housing is a bladder, while in others it is a frame or a group of outwardly extending arms. In each case, the device is configured to deliver therapeutic to a remote site in the body of a patient.
摘要翻译：本发明提供了将治疗剂递送到身体的内腔，腔室，空腔和血管的方法，系统和装置。在一个实施例中，提供了用于将治疗剂递送到患者体内的靶部位的治疗递送装置。该装置可以包括导管，可流体地联接到导管的可扩展多端口壳体和护套。该装置中的多端口壳体的尺寸可以设计成在患者的内腔内行进，并且可以适于从第一构型扩展到第二构造。多端口壳体还可以包含联接到多端口壳体的内腔的至少两个喷射端口。在一些实施例中，多端口壳体是膀胱，而在另一些实施例中，其是框架或一组向外延伸的臂。在每种情况下，该装置被配置为将治疗剂递送到患者体内的远端位置。

9. 发明申请

WO2005082443A2 VARIABLE DEPTH INJECTION DEVICE AND METHOD 审中-公开
标题翻译：可变深度注射装置和方法
公开(公告)号：WO2005082443A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/004175
申请日：2005-02-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HARRIS, Chad, G. , HAWK, Matthew, L. , MICKLEY, Timothy, J.
发明人： HARRIS, Chad, G. , HAWK, Matthew, L. , MICKLEY, Timothy, J.
IPC分类号： A61M25/00
CPC分类号： A61M25/0606 , A61M25/0068 , A61M25/0069 , A61M25/0084 , A61M2025/0089
摘要： An apparatus for the injection of therapeutic and other agents at a target site within a patient's body. A catheter including a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also including a second elongated shaft slidingly disposed in the first elongated shaft, the second elongated shaft having a distal end and a proximal and a lumen extending therebetween. The catheter further including a third elongated shaft disposed in and attached to the second elongate shaft, the third elongated shaft to move in a one-to-one relationship with the first elongated shaft and the second elongated shaft to maintain a predetermined needle deployment length as each are subjected to various bend configurations.
摘要翻译：用于在患者体内的靶位置注射治疗剂和其它药剂的装置。一种导管，其包括具有远端和近端的第一细长轴和在其间延伸的内腔。导管还包括滑动地设置在第一细长轴中的第二细长轴，第二细长轴具有远端和近端以及在其间延伸的内腔。所述导管还包括设置在所述第二细长轴中并连接到所述第二细长轴的第三细长轴，所述第三细长轴与所述第一细长轴和所述第二细长轴以一对一关系移动，以将预定的针展开长度保持为每个都经受各种弯曲构造。

10. 发明申请

WO2009151981A1 PRECISION PEN HEIGHT CONTROL FOR MICRO-SCALE DIRECT WRITING TECHNOLOGY 审中-公开
标题翻译：精密笔高度控制用于微尺寸直接写入技术
公开(公告)号：WO2009151981A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/045614
申请日：2009-05-29
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： MICKLEY, Timothy, J. , GENOVESE, Frank , FENG, James , RICHARDSON, Leonard, B.
IPC分类号： G05B19/25
CPC分类号： G05B19/25 , G05B2219/37131 , G05B2219/45238 , H05K3/1241 , H05K2203/0126 , H05K2203/163
摘要： An apparatus for precision pen height control which includes a dispensing member, a fluid dispensing system, a vertical position sensing system, and a vertical position controller. The fluid dispensing system is in fluid communication with an opening in the dispensing member via a tubular member. A vertical position sensing system, which includes a diffraction grating and a sensor, is engaged to the tubular member. The sensor is positioned adjacent the diffraction grating. The diffraction grating is engaged to a vertical support, which is engaged to the tubular member. The sensor produces a vertical position signal based upon the position of the vertical support. The vertical position controller is engaged to the vertical position sensing system, and receives a control signal generated from the vertical position signal. The vertical position controller produces and applies vertical forces to the vertical support in response to the control signal.
摘要翻译：一种用于精密笔高度控制的装置，包括分配构件，流体分配系统，垂直位置感测系统和垂直位置控制器。流体分配系统经由管状构件与分配构件中的开口流体连通。包括衍射光栅和传感器的垂直位置传感系统与管状部件接合。传感器位于衍射光栅附近。衍射光栅接合到垂直支撑件，该支撑件与管状构件接合。传感器基于垂直支撑件的位置产生垂直位置信号。垂直位置控制器接合到垂直位置感测系统，并且接收从垂直位置信号产生的控制信号。垂直位置控制器响应于控制信号产生并向垂直支撑件施加垂直力。

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