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    • 1. 发明申请
    • MEDICAL DEVICES HAVING CROSSLINKED POLYMERIC SURFACES
    • 具有交联聚合物表面的医疗装置
    • WO2008141141A2
    • 2008-11-20
    • PCT/US2008063191
    • 2008-05-09
    • BOSTON SCIENT SCIMED INCSUTERMEISTER DEREKRASSAT JAY
    • SUTERMEISTER DEREKRASSAT JAY
    • A61L31/04A61L31/10
    • A61L31/048A61L31/10Y10T428/261Y10T428/2809C08L53/00
    • According to an aspect of the invention, medical devices are provided which contain at least one polymeric region. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer. Moreover, the polymeric region contains at least one surface sub- region that is crosslinked and at least one bulk sub-region that is substantially non- crosslinked. According to another aspect of the invention, a method is provided which includes exposing a polymeric region of a medical device to energetic species such that at least one surface sub-region of the polymeric region becomes crosslinked and at least one bulk sub-region remains substantially non-crosslinked. The polymeric region contains at least one copolymer, which includes at least one high Tg vinyl aromatic monomer and at least one low Tg monomer.
    • 根据本发明的一个方面,提供了包含至少一个聚合物区域的医疗装置。 聚合物区域含有至少一种共聚物,其包括至少一种高Tg乙烯基芳族单体和至少一种低Tg单体。 此外,聚合物区域含有至少一个交联的表面亚区域和基本上未交联的至少一个整体亚区域。 根据本发明的另一方面,提供了一种方法,其包括将医疗装置的聚合物区域暴露于能量物质,使得聚合物区域的至少一个表面亚区域变得交联,并且至少一个体积亚区域基本上保持 非交联。 聚合物区域含有至少一种共聚物,其包括至少一种高Tg乙烯基芳族单体和至少一种低Tg单体。
    • 6. 发明申请
    • DRUG-COATED MEDICAL DEVICES FOR DIFFERENTIAL DRUG RELEASE
    • 用于不同药物释放的药物包装医疗器械
    • WO2009099935A3
    • 2010-11-11
    • PCT/US2009032604
    • 2009-01-30
    • BOSTON SCIENT SCIMED INC
    • SUTERMEISTER DEREKARCAND BENJAMINRIZQ RAEDWENTLAND ADAMRASSAT JAY
    • A61L31/10A61L31/16
    • A61L31/10A61L31/16A61L2300/61
    • The embodiments described herein relate generally to medical devices that are useful for delivering one or more therapeutic agents to a body tissue of a subject, and methods for making and using such devices. In particular, the embodiments relate to a medical device such as a stent having a sidewall structure comprising a plurality of struts, in which one or more therapeutic agents are released from different surfaces of the struts at different release profiles. More particularly, the embodiments relate to a stent having a sidewall structure comprising a plurality of struts, in which the two side surfaces of each strut are coated with a coating composition that is different from the coating composition used to coat the outer surface and/or inner surface of the strut.
    • 本文所述的实施方案一般涉及可用于将一种或多种治疗剂递送至受试者的身体组织的医疗装置,以及用于制造和使用这些装置的方法。 具体地,实施例涉及医疗装置,例如具有侧壁结构的支架,其包括多个支柱,其中一个或多个治疗剂在不同释放曲线下从支柱的不同表面释放。 更具体地,实施例涉及一种具有侧壁结构的支架,该侧壁结构包括多个支柱,其中每个支柱的两个侧表面涂覆有与用于涂覆外表面的涂料组合物不同的涂料组合物和/或 支柱的内表面。