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1. 发明申请

WO1998008108A1 AN ELECTRONIC AUTOROUTING NAVIGATION SYSTEM FOR VISUALLY IMPAIRED PERSONS 审中-公开
标题翻译：用于视觉受损人员的电子自动导航系统
公开(公告)号：WO1998008108A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014525
申请日：1997-08-19
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , HANCOCK, Michael, B.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： G01S03/02
CPC分类号： G01C21/20 , G01S1/70
摘要： The present invention is an autorouting navigation system (100) for directing one or more visually impaired persons to a physical location. The present invention includes a portable autonavigation unit (100) that includes an input device (106) for selecting a target location corresponding to a physical location of a plurality of location beacons, a receiver (101) configured to receive signals from location beacons, a memory (103) storing information correlating the locations of the location beacons, and an output device (104) for communicating with the user. A microcontroller (105) or microprocessor under program control processes the signals received from the location beacons, analyzes those signals and correlation data, and determines a routing path from the user's present position to the target location. The microcontroller (105) may also provide an indication, such as an audible sound, to the user of whether or not the user is following the routing path to the target location.
摘要翻译：本发明是一种用于将一个或多个视障人员引导到物理位置的自动布线导航系统（100）。本发明包括便携式自动导航单元（100），其包括用于选择对应于多个位置信标的物理位置的目标位置的输入设备（106），被配置为从位置信标接收信号的接收机（101）存储器（103）存储与位置信标的位置相关的信息，以及用于与用户通信的输出设备（104）。在程序控制下的微控制器（105）或微处理器处理从位置信标接收到的信号，分析这些信号和相关数据，并且确定从用户的当前位置到目标位置的路由路径。微控制器（105）还可以向用户提供关于用户是否遵循到目标位置的路由路径的指示，例如可听见的声音。

2. 发明申请

WO2001077154A2 METHODS AND COMPOSITIONS FOR STAT-1 CONFERRED RESISTANCE TO IMMUNOTOXICITY 审中-公开
标题翻译： STAT-1对免疫毒素抗性的方法和组合
公开(公告)号：WO2001077154A2
公开(公告)日：2001-10-18
申请号：PCT/US2001011845
申请日：2001-04-10
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CHEN, Guoxun , NEWGARD, Christopher, B.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C07K14/00
CPC分类号： C07K14/4705 , A61K48/00 , C07K2319/00
摘要： The present invention describes methods and compositions for preventing immunocytotoxicity of transplanted cells. The invention provides cells and expression constructs encoding STAT-1α polypeptides that prevent cytokine-mediated cytotoxicity. Thus, the invention provides treatment methods for preventing the rejection of transplanted cells by a host. In a particular embodiment, the invention provides for treatment of diabetes by transplanting into a subject insulinoma cells that secrete insulin in response to glucose and further express STAT-1α, thereby conferring resistance to inflammatory cytokines involved in the cell-rejection response.
摘要翻译：本发明描述了用于预防移植细胞的免疫细胞毒性的方法和组合物。本发明提供编码能够阻止细胞因子介导的细胞毒性的STAT-1α多肽的细胞和表达构建体。因此，本发明提供了防止宿主移植细胞排斥的治疗方法。在一个具体实施方案中，本发明提供了通过移植到对葡萄糖分泌胰岛素并进一步表达STAT-1α的受试者胰岛素瘤细胞来治疗糖尿病，从而赋予参与细胞排斥反应的炎性细胞因子的抗性。

3. 发明申请

WO1998045433A1 PROTEINS AND COMPOSITIONS FOR MODULATING MITOSIS 审中-公开
标题翻译：调理麻醉剂的蛋白质和组合物
公开(公告)号：WO1998045433A1
公开(公告)日：1998-10-15
申请号：PCT/US1998006727
申请日：1998-04-03
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CLARK, Gary, M. , ALLRED, D., Craig , HILSENBECK, Susan, G. , CHAMNESS, Gary, C. , OSBORNE, C., Kent
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , A61K38/00
摘要： The protein encoded by the human gene HEC ( h ighly e xpressed in c ancer) contains a long series of leucine heptad repeats and appears to be crucial for normal mitosis. HEC localizes to the nuclei of interphase cells and redistributes to centromeres during M phase. Ectopic expression of a mutant HEC containing only the heptad repeats results in the inability of cells to divide more than once. Inactivation of HEC results in disordered sister chromatid alignment and separation, as well as in the formation of nonviable cells with multiple, fragmented micronuclei. HEC interacts through its leucine heptad repeats with several proteins involved in mitosis, including nek2, sb1.8, and two different regulatory subunits of the 26S proteasome, MSS1 and p45. These biochemical properties of HEC suggest its potential roles in modulating proteins important for spindle attachment to kinetochores, sister chromatid movement, and M phase progression.
摘要翻译：由人类基因HEC（高表达胰岛素）表达的蛋白质编码的蛋白质含有长序列的亮氨酸七肽重复序列，似乎是对正常有丝分裂至关重要 HEC定位于相间细胞核，并在M期期间重新分布至着丝粒。仅含有七重复重复的突变体HEC的异位表达导致细胞不能分裂多于一次。 HEC的失活导致无序的姐妹染色单体比对和分离，以及形成具有多个片段微核的不可维持细胞。 HEC通过其亮氨酸七肽重复与涉及有丝分裂的几种蛋白质相互作用，包括nek2，sb1.8和26S蛋白酶体，MSS1和p45的两个不同调节亚基。 HEC的这些生物化学性质表明其在调节重要的心脏附着到动粒细胞，姐妹染色单体运动和M期进展中的蛋白质的潜在作用。

4. 发明申请

WO1998028423A2 COMPOSITIONS AND METHODS OF USE FOR OSTEOCLAST INHIBITORY FACTORS 审中-公开
标题翻译： OSTEOCLAST抑制因子的组合物和使用方法
公开(公告)号：WO1998028423A2
公开(公告)日：1998-07-02
申请号：PCT/US1997023666
申请日：1997-12-18
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ROODMAN, G., David , REDDY, Sakamuri, V. , CHOI, Sun-Jin
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C12N15/12
CPC分类号： C12N9/6472 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K2319/02
摘要： It has been found that two proteins produced by human osteoclasts inhibit osteoclast formation in bone marrow cultures and inhibit bone resorption in a fetal long bone assay. One of the proteins is identical to an Ly6 gene family protein and homologous to the Sca2 antigen, Ly6A. The second, protein is OIP-2. The discovery of the osteoclast inhibition property of the OIP proteins suggests the therapeutic potential for patients with disordered osteoclast activity in such conditions as osteoporosis.
摘要翻译：已经发现，人类破骨细胞产生的两种蛋白质在骨髓培养物中抑制破骨细胞形成，并在胎儿长骨测定中抑制骨吸收。其中一种蛋白质与Ly6基因家族蛋白质相同，与Sca2抗原Ly6A同源。第二个蛋白质是OIP-2。 OIP蛋白的破骨细胞抑制性质的发现表明在诸如骨质疏松症的病症中具有无序破骨细胞活性的患者的治疗潜力。

5. 发明申请

WO1998027994A1 PROTEINS AND COMPOSITIONS FOR MODULATING MITOSIS 审中-公开
标题翻译：调理麻醉剂的蛋白质和组合物
公开(公告)号：WO1998027994A1
公开(公告)日：1998-07-02
申请号：PCT/US1997023385
申请日：1997-12-18
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LEE, Wen-Hwa , CHEN, Yumay , RILEY, Daniel, J. , CHEN, Phang-Lang
IPC分类号： A61K38/08
CPC分类号： C07K14/4702
摘要： The protein encoded by the human gene HEC( h ighly e xpressed in c ancer) contains a long series of leucine heptad repeats and appears to be crucial for normal mitosis. HEC localizes to the nuclei of interphase cells and redistributes to centromeres during M phase. Ectopic expression of a mutant HEC containing only the heptad repeats results in the inability of cells to divide more than once. Inactivation of HEC results in disordered sister chromatid alignment and separation, as well as in the formation of non viable cells with multiple, fragmented micronuclei. HEC interacts through its leucine heptad repeats with several proteins involved in mitosis, including nek2, sb1.8, and two different regulatory subunits of the 26S proteasome, MSS1 and p45. These biochemical properties of HEC suggest its potential roles in modulating proteins important for spindle attachment to kinetochores, sister chromatic movement, and M phase progression.
摘要翻译：由人类基因HEC（高表达胰岛素）表达的蛋白质编码的蛋白质含有长序列的亮氨酸七肽重复序列，似乎是对正常有丝分裂至关重要 HEC定位于相间细胞核，并在M期期间重新分布至着丝粒。仅含有七重复重复的突变体HEC的异位表达导致细胞不能分裂多于一次。 HEC的失活导致无序的姐妹染色单体比对和分离，以及形成具有多个片段微核的非活细胞。 HEC通过其亮氨酸七肽重复与涉及有丝分裂的几种蛋白质相互作用，包括nek2，sb1.8和26S蛋白酶体，MSS1和p45的两个不同调节亚基。 HEC的这些生物化学性质表明其在调节重要的心脏附着到动粒细胞，姐妹色彩运动和M期进展中的蛋白质的潜在作用。

6. 发明申请

WO1998021359A1 GLUTATHIONE S-TRANSFERASE (GST) GENES IN CANCER 审中-公开
标题翻译：癌症中的GLUTATHIONE S转移（GST）基因
公开(公告)号：WO1998021359A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020987
申请日：1997-11-12
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE UNIVERSITY OF MISSISSIPPI
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE UNIVERSITY OF MISSISSIPPI , ALI-OSMAN, Francis , LOPEZ-BERESTEIN, Gabriel , BUOLAMWINI, John, K. , ANTOUN, Gamil , LO, Hui-Wen , KELLER, Charles , AKANDE, Olanike
IPC分类号： C12Q01/00
CPC分类号： C12Q1/48 , G01N33/5011 , G01N33/57484
摘要： Complementary DNA and genomic clones for three variants of GST- pi are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer. This permits the detection and treatment of certain classes of tumors using new compositions such as GST- pi genes, oligonucleotides, peptides and antibodies.
摘要翻译：公开了三种GST-p变体的互补DNA和基因组克隆。证明某些这些变体在神经胶质瘤中过表达，从而表明参与了该形式的癌症。这允许使用新的组合物如GST-pi基因，寡核苷酸，肽和抗体来检测和治疗某些类型的肿瘤。

7. 发明申请

WO1998017806A1 MINI-E1A GENES AND GENE PRODUCTS 审中-公开
标题翻译： MINI-E1A基因和基因产物
公开(公告)号：WO1998017806A1
公开(公告)日：1998-04-30
申请号：PCT/US1997019042
申请日：1997-10-20
申请人： TARGETED GENETICS CORPORATION , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , HUNG, Mien-Chie , CHEN, Hua , YU, Di-Hua , PAUL, Ralph, Wilfred , LOOMIS, Aaron, Garth , LAFOE, Daniel, Nathan, Andrew
发明人： TARGETED GENETICS CORPORATION , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C12N15/34
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C12N2710/10322 , C12N2710/10343
摘要： The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A responsible for the suppression of transformation, and provides mini-E1A constructs that can be used for tumor suppression. The invention also discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.
摘要翻译：本发明提供抑制致癌转化，肿瘤发生和转移的方法和组合物。本发明公开了负责抑制转化的E1A的功能域，并提供可用于肿瘤抑制的微型E1A构建体。本发明还公开了与化疗药物和/或酪氨酸激酶抑制剂组合使用mini-E1A的新方法。

8. 发明申请

WO1998013039A1 DFMO FOR THE TREATMENT OR PREVENTION OF CERVICAL INTRAEPITHELIAL NEOPLASIA 审中-公开
标题翻译： DFMO治疗或预防宫内膜异位症
公开(公告)号：WO1998013039A1
公开(公告)日：1998-04-02
申请号：PCT/US1997017156
申请日：1997-09-24
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FOLLEN-MITCHELL, Michele , LOTAN, Reuben , LI, Yang
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： A61K31/195
CPC分类号： A61K31/198 , A61K31/195 , A61K31/165 , A61K2300/00
摘要： Methods for treating, preventing, controlling the growth of and/or reducing the risk of developing cervical cancer, particularly in patients with cervical intraepithelial neoplasia are provided employing pharmaceutically acceptable preparations of DFMO. Methods for treating a patient having cervical intraepithelial neoplasia, which methods comprise administering DFMO alone or in combination with a cytotoxic or cytostatic agent, are also provided.
摘要翻译：使用DFMO的药学上可接受的制剂提供治疗，预防，控制宫颈癌发展和/或降低宫颈癌特别是宫颈上皮内瘤变患者的风险的方法。还提供了用于治疗患有宫颈上皮内瘤变的患者的方法，该方法包括单独施用DFMO或与细胞毒性或细胞生长抑制剂组合施用。

9. 发明申请

WO1998000128A1 PARENTERAL PACLITAXEL IN A STABLE NON-TOXIC FORMULATION 审中-公开
标题翻译： PARILTERAL PACLITAXEL在稳定的非毒性配方中
公开(公告)号：WO1998000128A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011503
申请日：1997-06-26
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ANDERSSON, Borje, S.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： A61K31/335
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/337 , A61K47/10 , A61K47/18
摘要： Disclosed is a stable and effective formulation of a taxane analog, preferably paclitaxel. The formulation comprises a dimethylacetamide and polyethylene glycol solution of the drug that is diluted into an aqueous lipid emulsion prior to use. The formulation is effective as a parenteral drug against taxane sensitive tumors.
摘要翻译：公开了紫杉烷类似物，优选紫杉醇的稳定和有效的制剂。该制剂包含药物的二甲基乙酰胺和聚乙二醇溶液，其在使用前被稀释成含水脂质乳剂。该制剂作为抗紫杉烷敏感性肿瘤的胃肠外药物是有效的。

10. 发明申请

WO1997050109A2 VERTICAL-CAVITY SURFACE-EMITTING LASER DIODE ARRAY WITH WAVELENGTH CONTROL THROUGH LATERAL INDEX-CONFINEMENT AND LONGITUDINAL RESONANCE 审中-公开
标题翻译：垂直表面发射激光二极管阵列，具有通过横向指标和纵向共振的波长控制
公开(公告)号：WO1997050109A2
公开(公告)日：1997-12-31
申请号：PCT/US1997010023
申请日：1997-06-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DEPPE, Dennis, G. , HUFFAKER, Diana, L.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： H01L00/00
CPC分类号： H01S5/18341 , B82Y20/00 , H01S5/026 , H01S5/18308 , H01S5/18311 , H01S5/18338 , H01S5/18358 , H01S5/18369 , H01S5/2086 , H01S5/34313 , H01S5/4087 , H01S5/423 , H01S2301/18
摘要： Disclosed is a method for controlling the emission wavelength of a vertical-cavity surface-emitting laser through the lateral mode size to achieve optical signal generation from two or more devices at two or more distinct wavelengths.
摘要翻译：公开了一种用于通过横向模式尺寸控制垂直腔表面发射激光器的发射波长的方法，以实现两个或更多个不同波长的两个或更多个器件的光信号生成。

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