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1. 发明申请

WO0046147A2 THERAPEUTIC CALCIUM PHOSPHATE PARTICLES AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：治疗性磷酸钙颗粒及其制造和使用方法
公开(公告)号：WO0046147A2
公开(公告)日：2000-08-10
申请号：PCT/US0002742
申请日：2000-02-03
申请人： BIOSANTE PHARMACEUTICALS INC , BELL STEVE J D , WAGNER BARTAK CLAUS , MORCOL TULIN , HE QING
发明人： BELL STEVE J D , WAGNER-BARTAK CLAUS , MORCOL TULIN , HE QING
IPC分类号： A61K9/00 , A61K9/12 , A61K9/16 , A61K9/51 , A61K38/28 , A61K39/00 , A61K39/145 , A61K39/245 , A61K39/39 , C01B20060101 , C01B25/32
CPC分类号： A61K39/39 , A61K9/0043 , A61K9/12 , A61K9/1611 , A61K9/167 , A61K9/1676 , A61K9/5078 , A61K9/51 , A61K9/5115 , A61K36/064 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/208 , A61K38/28 , A61K39/04 , A61K39/12 , A61K39/145 , A61K39/245 , A61K2039/53 , A61K2039/541 , A61K2039/55505 , A61K2039/55555 , C12N15/87 , C12N2710/16234 , C12N2710/16634 , C12N2740/16034 , C12N2760/16134 , Y10T428/2982
摘要： Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically active material, and as controlled release matrices for biologically active material are disclosed. The core particles may have a surface modifying agent and/or biologically active material, such as antigenic material or natural immunoenhancing factor, polynucleotide material, or therapeutic proteins or peptides, partially coating the particle or impregnated therein. The core particles have a diameter between about 300 nm and about 4000 nm, more particularly between about 300 nm and about 2000 nm, and even more particularly between about 300 nm and about 1000 nm, are substantially spherical in shape, and have a substantially smooth surface.
摘要翻译：公开了新型磷酸钙核心颗粒，其制备方法以及将它们用作疫苗佐剂的方法，作为核心，作为生物活性材料的载体以及作为生物活性材料的控释基质。核心颗粒可以具有表面改性剂和/或生物活性材料，例如抗原性材料或天然免疫增强因子，多核苷酸材料或治疗性蛋白质或肽，部分包覆颗粒或浸渍在其中。核心颗粒的直径在约300nm与约4000nm之间，更特别地在约300nm与约2000nm之间，甚至更特别地在约300nm与约1000nm之间，基本上为球形，并且具有基本光滑的表面。

2. 发明申请

WO2006050368A3 THERAPEUTIC CALCIUM PHOSPHATE PARTICLES IIN USE FOR AESTHETIC OR COSMETIC MEDICINE, AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：治疗性钙磷酸盐颗粒IIN用于美容或美容医学，以及制造和使用方法
公开(公告)号：WO2006050368A3
公开(公告)日：2006-09-14
申请号：PCT/US2005039496
申请日：2005-11-01
申请人： BIOSANTE PHARMACEUTICALS INC , BELL STEVE J D
发明人： BELL STEVE J D
IPC分类号： A61K6/00 , A61F13/00 , A61K8/02 , A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K8/24 , A61K8/0245 , A61K8/36 , A61K8/66 , A61K8/671 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/85 , A61K8/981 , A61K2800/10 , A61K2800/651 , A61Q19/00 , A61Q19/08
摘要： Calcium phosphate ("CAP") particles for use in cosmetic, nutraceutic or aesthetic medicine. The particles may be used as carriers for cosmetic, nutraceutic or a factors, as controlled release matrices for the material, and as fillers in cosmetic treatments. The particles may be applied topically or injected or by any other appropriate delivery method.
摘要翻译：用于化妆品，营养品或美容医学的磷酸钙（“CAP”）颗粒。该颗粒可以用作化妆品，营养保健品或因子的载体，作为材料的控制释放基质，以及作为美容处理中的填充剂。颗粒可以局部施用或注射或通过任何其他适当的递送方法施用。

3. 发明申请

WO2006050368B1 THERAPEUTIC CALCIUM PHOSPHATE PARTICLES IIN USE FOR AESTHETIC OR COSMETIC MEDICINE, AND METHODS OF MANUFACTURE AND USE 审中-公开
公开(公告)号：WO2006050368B1
公开(公告)日：2006-11-16
申请号：PCT/US2005039496
申请日：2005-11-01
申请人： BIOSANTE PHARMACEUTICALS INC , BELL STEVE J D
发明人： BELL STEVE J D
IPC分类号： A61K6/00 , A61F13/00 , A61K8/02 , A61K9/14 , A61K9/16 , A61K9/50
CPC分类号： A61K8/24 , A61K8/0245 , A61K8/36 , A61K8/66 , A61K8/671 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/85 , A61K8/981 , A61K2800/10 , A61K2800/651 , A61Q19/00 , A61Q19/08
摘要： Calcium phosphate ("CAP") particles for use in cosmetic, nutraceutic or aesthetic medicine. The particles may be used as carriers for cosmetic, nutraceutic or a factors, as controlled release matrices for the material, and as fillers in cosmetic treatments. The particles may be applied topically or injected or by any other appropriate delivery method.

4. 发明申请

WO2005099668B1 METHODS OF MANUFACTURE AND USE OF CALCIUM PHOSPHATE PARTICLES CONTAINING ALLERGENS 审中-公开
标题翻译：制造和使用含有过敏原的磷酸钙颗粒的方法
公开(公告)号：WO2005099668B1
公开(公告)日：2006-07-06
申请号：PCT/US2005012267
申请日：2005-04-12
申请人： BIOSANTE PHARMACEUTICALS INC , BELL STEVE J D
发明人： BELL STEVE J D
IPC分类号： A61K9/00 , A61K9/16 , A61K9/51 , A61K39/145 , A61K39/245 , A61K39/39
CPC分类号： A61K9/5115 , A61K9/0034 , A61K9/0043 , A61K9/1611 , A61K9/167 , A61K9/1676 , A61K39/35 , A61K39/39 , A61K2039/541 , A61K2039/55505 , A61K2039/55555
摘要： The present invention relates to the use of calcium phosphate particles in formulation with allergens for allergic desensitization. Particularly, the invention relates to novel calcium phosphate core particles, particularly nano- and micron-sized particles, as allergen adjuvants and in compositions for inducing allergic desensitization. Methods of making such particles and to methods of inducing a specific immune response using the particles of this invention are also provided. Optionally a surface modifying agent such as cellobiose or polyethylene glycol (PEG) may be used.
摘要翻译：本发明涉及磷酸钙颗粒在过敏原过敏性脱敏制剂中的应用。特别地，本发明涉及新的磷酸钙核心颗粒，特别是纳米和微米尺寸的颗粒，作为变应原佐剂和用于诱导过敏性脱敏的组合物。还提供了使用本发明的颗粒制备这种颗粒的方法和诱导特异性免疫应答的方法。任选地，可以使用表面改性剂如纤维二糖或聚乙二醇（PEG）。

5. 发明申请

WO2005099668A2 METHODS OF MANUFACTURE AND USE OF CALCIUM PHOSPHATE PARTICLES CONTAINING ALLERGENS 审中-公开
标题翻译：制造和使用含有过敏原的磷酸钙颗粒的方法
公开(公告)号：WO2005099668A2
公开(公告)日：2005-10-27
申请号：PCT/US2005012267
申请日：2005-04-12
申请人： BIOSANTE PHARMACEUTICALS INC , BELL STEVE J D
发明人： BELL STEVE J D
IPC分类号： A61K9/00 , A61K9/16 , A61K9/51 , A61K39/145 , A61K39/245 , A61K39/39
CPC分类号： A61K9/5115 , A61K9/0034 , A61K9/0043 , A61K9/1611 , A61K9/167 , A61K9/1676 , A61K39/35 , A61K39/39 , A61K2039/541 , A61K2039/55505 , A61K2039/55555
摘要： The present invention relates to the use of calcium phosphate particles in formulation with allergens for allergic desensitization. Particularly, the invention relates to novel calcium phosphate core particles, particularly nano- and micron-sized particles, as allergen adjuvants and in compositions for inducing allergic desensitization. Methods of making such particles and to methods of inducing a specific immune response using the particles of this invention are also provided.
摘要翻译：本发明涉及磷酸钙颗粒在过敏原过敏性脱敏制剂中的应用。特别地，本发明涉及新的磷酸钙核心颗粒，特别是纳米和微米尺寸的颗粒，作为变应原佐剂和用于诱导过敏性脱敏的组合物。还提供了使用本发明的颗粒制备这种颗粒的方法和诱导特异性免疫应答的方法。

6. 发明申请

WO02064112A3 THERAPEUTIC AGENTS COMPLEXED WITH CALCIUM PHOSPHATE AND ENCASED BY CASEIN 审中-公开
标题翻译：与磷酸钙复合并由CASEIN加成的治疗药物
公开(公告)号：WO02064112A3
公开(公告)日：2003-02-06
申请号：PCT/US0203506
申请日：2002-02-07
申请人： BIOSANTE PHARMACEUTICALS INC , MORCOL TULIN , BELL STEVE J D
发明人： MORCOL TULIN , BELL STEVE J D
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K39/39
CPC分类号： B82Y5/00 , A61K9/1611 , A61K9/1676 , A61K9/5052 , A61K9/5073 , A61K9/5078 , A61K9/5115 , A61K9/5169 , A61K9/5192 , A61K39/39 , A61K2039/55505
摘要： The present invention relates generally to an oral drug delivery system which incorporates a therapeutic bioactive agent with biodegradable calcium phosphate particles, the particles then encapsulated by casein. The resulting particles provide a carrier designed to protect the therapeutic agent in the harsh, acidic environment of the stomach before releasing the agent into the small intestine. The therapeutic agent may be any therapeutically effective agent, such as a natural isolate or synthetic chemical or biological agent, such as a therapeutic agent, and in particular, may be a protein or a peptide such as insulin. Also incorporated with the particles may be additional surface modifying agents to assist binding, controlled release, or to otherwise modify the particles. The particles generally support the therapeutic agent for form controlled- or sustained-release particles for the oral or mucosal delivery of the therapeutic agent over time, wherein the therapeutic agent is incorporated into the structure of the particle core, disposed on the surface of the particle, or both.
摘要翻译：本发明一般涉及一种口服药物递送系统，其将治疗性生物活性剂与可生物降解的磷酸钙颗粒结合，该颗粒然后被酪蛋白包封。所得颗粒提供设计用于在将试剂释放到小肠之前在胃的恶劣的酸性环境中保护治疗剂的载体。治疗剂可以是任何治疗有效的药剂，例如天然分离物或合成的化学物质或生物制剂，例如治疗剂，特别是蛋白质或肽，例如胰岛素。还与颗粒结合的可以是附加的表面改性剂以辅助结合，控制释放或以其它方式改性颗粒。颗粒通常支持用于治疗剂随时间的口服或粘膜递送的用于形成控释或缓释颗粒的治疗剂，其中将治疗剂并入设置在颗粒表面上的颗粒核心的结构中，或两者。

7. 发明申请

WO03051394A2 CALCIUM PHOSPHATE PARTICLES AS MUCOSAL ADJUVANTS 审中-公开
标题翻译：磷酸钙颗粒作为粘膜佐剂
公开(公告)号：WO03051394A2
公开(公告)日：2003-06-26
申请号：PCT/US0225526
申请日：2002-08-12
申请人： BIOSANTE PHARMACEUTICALS INC
发明人： BELL STEVE J D , HE QING
IPC分类号： A61K9/00 , A61K9/16 , A61K9/51 , A61K39/145 , A61K39/245 , A61K39/39
CPC分类号： A61K39/39 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/1611 , A61K9/1676 , A61K9/51 , A61K9/5115 , A61K39/12 , A61K39/145 , A61K39/245 , A61K2039/541 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , C12N2710/16634 , C12N2760/16134
摘要： The present invention relates to mucosal immune protection, mucosal vaccine delivery, and mucosal drug delivery. Novel calcium phosphate core particles, particularly nanoparticles are used as vaccine adjuvants and compositions for inducing protective mucosal immunity. Methods of inducing an immune response to an antigen by devivering the antigen to a mucosal surface using the particles of this invention are also useful for delivering compositions, such as a pharmacologically active agent, to the mucosal surfaces of a patient in need thereof, to methods of delivering such compositions, and to methods of making such particles.
摘要翻译：本发明涉及粘膜免疫保护，粘膜疫苗递送和粘膜药物递送。新颖的磷酸钙核心颗粒，特别是纳米颗粒被用作疫苗佐剂和用于诱导保护性粘膜免疫的组合物。通过使用本发明的颗粒将抗原分配到粘膜表面来诱导针对抗原的免疫应答的方法也可用于将组合物例如药理学活性剂递送至有需要的患者的粘膜表面，方法递送这样的组合物，以及制造这种颗粒的方法。

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