专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2014120919A1 METHODS FOR REJUVENATING RED BLOOD CELLS 审中-公开
标题翻译：重新获得红细胞的方法
公开(公告)号：WO2014120919A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/013845
申请日：2014-01-30
申请人： BIOMET BIOLOGICS, LLC
发明人： GRAY, Alan , HIGGINS, Joel C. , LANDRIGAN, Matthew D. , CUNNINGHAM, Grant
IPC分类号： A61K35/14 , A61K31/19 , A61K31/70 , A61K31/7076 , C12N5/078 , A61P7/00
CPC分类号： A61K35/18 , A61K31/19 , A61K31/70 , A61K31/7076 , A61K35/14 , A61K2035/124 , G01N33/80 , G01N2800/7019 , A61K2300/00
摘要： Methods, uses and systems for transfusing blood to a mammalian subject. The method includes obtaining a volume of donated red blood cells (RBCs), adding an enhancement composition, such as comprising inosine, to the RBCs to form a treated blood composition, incubating the treated blood composition to form an incubated blood composition, and administering the incubated blood composition to a patient. In some embodiments, the method is performed at the point of care. Embodiments, include obtaining a unit of blood, rejuvenating the blood with an enhancement composition, measuring 2,3-DPG concentration of the blood, and delivering the blood to a subject. Uses include use of an enhancement composition for the treatment of ischemia or disorders characterized by reduced tissue oxygenation in a mammalian subject.
摘要翻译：向哺乳动物受试者输血的方法，用途和系统。该方法包括获得一定量的捐献的红细胞（RBC），向RBC中加入增强组合物，例如包含肌苷，以形成经处理的血液组合物，孵育经处理的血液组合物以形成培养的血液组合物，将血液组合物孵育至患者。在一些实施方案中，该方法在护理点进行。实施例包括获得血液单位，用增强组合物使血液振兴，测量血液的2,3-DPG浓度，以及将血液输送给受试者。用途包括使用增强组合物来治疗缺血或以哺乳动物受试者的组织氧合减少为特征的病症。

2. 发明申请

WO2014039652A1 METHODS FOR PRODUCING AND USING REJUVENATED RED BLOOD CELLS 审中-公开
标题翻译：用于生产和使用已注射的红血细胞的方法
公开(公告)号：WO2014039652A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/058225
申请日：2013-09-05
申请人： BIOMET BIOLOGICS, LLC
发明人： GRAY, Alan
IPC分类号： A01N1/00 , A61K35/18 , A61K31/70 , A61K31/19
CPC分类号： A61K35/18 , A01N1/00 , A01N1/0226 , A61K31/19 , A61K31/70 , A61K2035/124 , C12N5/0641 , C12N2501/999
摘要： Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells.
摘要翻译：治疗血液的方法所述方法包括从供体获得全血，将全血与红细胞增强组合物混合，并培养全血和红细胞增强组合物的混合物。该方法可以在接近来自供体的血液的时间，或在血液已经储存一段时间之后的时间进行。该方法使红细胞恢复活力。

3. 发明申请

WO2014120431A1 FUNCTIONALLY-CLOSED, STERILE BLOOD PROCESSING SOLUTION SYSTEM AND METHOD 审中-公开
标题翻译：功能闭合，无血液加工解决方案系统和方法
公开(公告)号：WO2014120431A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/011451
申请日：2014-01-14
申请人： BIOMET BIOLOGICS, LLC
发明人： GRAY, Alan
IPC分类号： A61M1/02
CPC分类号： A61M1/0209 , A61J1/1443 , A61M1/02 , A61M1/0218 , A61M1/0259 , A61M1/0272 , A61M1/0281 , A61M39/14 , A61M39/143 , A61M39/146 , A61M2202/0429 , A61M2205/60 , A61M2205/6009 , A61M2205/7518 , B65B1/04 , Y10S29/048 , Y10S200/42 , Y10S220/29 , Y10S604/905
摘要： Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.
摘要翻译：向血液袋中的血液提供血液处理溶液包括将第一管连接到一端的通风尖端和在第二端处连接到Y形管连接器。在线微生物屏障过滤器在其端部之间连接到第一管。第二管在一端连接到传送袋，并在其另一端连接到Y形管连接器。第三管连接到Y形管连接器的输出端并在其远端密封。血袋包括在远端密封的第四管。使用无菌管焊机将第三管焊接到第四管，其中维持血液处理溶液可以通过其流入血袋的功能封闭的无菌流动路径。

4. 发明申请

WO2014039660A1 METHODS FOR PRODUCING REJUVENATED RED BLOOD CELLS 审中-公开
标题翻译：生产注射红血细胞的方法
公开(公告)号：WO2014039660A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/058234
申请日：2013-09-05
申请人： BIOMET BIOLOGICS, LLC
发明人： GRAY, Alan , DUMONT, Larry
IPC分类号： A01N1/00 , A61K35/18 , A61K31/70 , A61K31/19
CPC分类号： A61K31/19 , A01N1/00 , A61K31/70 , A61K35/18
摘要： Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells. Incubation may be performed for a period of time sufficient to increase the level of a metabolically-significant compound in the RBCs in the leukoreduced blood to a level essentially equal to levels found in fresh blood, the level being greater than the level of the compound in non-leukoreduced blood mixed with the RBC enhancement composition and incubated for the period of time.
摘要翻译：治疗血液的方法所述方法包括从供体获得全血，将全血与红细胞增强组合物混合，并培养全血和红细胞增强组合物的混合物。该方法可以在接近来自供体的血液的时间，或在血液已经储存一段时间之后的时间进行。该方法使红细胞恢复活力。孵育可以进行一段时间，足以将白细胞减少的血液中的RBC中的代谢有意义的化合物的水平提高到基本上等于新鲜血液中发现的水平的水平，该水平大于化合物的水平将非白细胞减少的血液与RBC增强组合物混合并孵育一段时间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式