基本信息:
- 专利标题： METHODS FOR PRODUCING REJUVENATED RED BLOOD CELLS
- 专利标题（中）：生产注射红血细胞的方法
- 申请号：PCT/US2013/058234 申请日：2013-09-05
- 公开(公告)号：WO2014039660A1 公开(公告)日：2014-03-13
- 发明人： GRAY, Alan , DUMONT, Larry
- 申请人： BIOMET BIOLOGICS, LLC
- 申请人地址： 56 East Bell Drive Warsaw, Indiana 46582 US
- 专利权人： BIOMET BIOLOGICS, LLC
- 当前专利权人： BIOMET BIOLOGICS, LLC
- 当前专利权人地址： 56 East Bell Drive Warsaw, Indiana 46582 US
- 代理机构： SUTER, David, L. et al.
- 优先权： US61/697,644 20120906; US13/756,021 20130131; US61/766,586 20130219
- 主分类号： A01N1/00
- IPC分类号： A01N1/00 ; A61K35/18 ; A61K31/70 ; A61K31/19
摘要：
Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells. Incubation may be performed for a period of time sufficient to increase the level of a metabolically-significant compound in the RBCs in the leukoreduced blood to a level essentially equal to levels found in fresh blood, the level being greater than the level of the compound in non-leukoreduced blood mixed with the RBC enhancement composition and incubated for the period of time.
摘要（中）：
治疗血液的方法 所述方法包括从供体获得全血，将全血与红细胞增强组合物混合，并培养全血和红细胞增强组合物的混合物。 该方法可以在接近来自供体的血液的时间，或在血液已经储存一段时间之后的时间进行。 该方法使红细胞恢复活力。 孵育可以进行一段时间，足以将白细胞减少的血液中的RBC中的代谢有意义的化合物的水平提高到基本上等于新鲜血液中发现的水平的水平，该水平大于化合物的水平 将非白细胞减少的血液与RBC增强组合物混合并孵育一段时间。