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1. 发明申请

WO2007048978A3 METHOD FOR DETECTING CANCER 审中-公开
标题翻译：检测癌症的方法
公开(公告)号：WO2007048978A3
公开(公告)日：2007-09-07
申请号：PCT/FR2006051108
申请日：2006-10-26
申请人： BIOMERIEUX SA , EXONHIT THERAPEUTICS SA , KRAUSE ALEXANDER , LEISSNER PHILIPPE , PAYE MALICK , MOUGIN BRUNO , SCHWEIGHOFFER FABIEN , BRACCO LAURENT
发明人： KRAUSE ALEXANDER , LEISSNER PHILIPPE , PAYE MALICK , MOUGIN BRUNO , SCHWEIGHOFFER FABIEN , BRACCO LAURENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： The invention concerns methods and compositions that can be used for detecting cancer in mammals, particularly humans. The invention particularly concerns serum markers of cancers and their use in diagnostic procedures. The invention also concerns tools and/or kits that can be used for carrying out these methods (reagents, probes, primers, antibodies, chips, cells, etc.), the preparation thereof and their uses. The invention can be used for detecting the presence or the progression of a cancer in mammals, particularly breast cancer including during early stages.
摘要翻译：本发明涉及可用于检测哺乳动物，特别是人类的癌症的方法和组合物。本发明特别涉及癌症的血清标志物及其在诊断程序中的用途。本发明还涉及可用于实施这些方法（试剂，探针，引物，抗体，芯片，细胞等），其制备及其用途的工具和/或试剂盒。本发明可用于检测哺乳动物，特别是乳腺癌中的癌症的存在或进展，包括在早期阶段。

2. 发明申请

WO2007132120A3 PROCEDURE AND METHODS FOR DETECTING ALZHEIMER'S DISEASE 审中-公开
标题翻译：检测阿尔茨海默病的程序和方法
公开(公告)号：WO2007132120A3
公开(公告)日：2008-05-08
申请号：PCT/FR2007051263
申请日：2007-05-14
申请人： EXONHIT THERAPEUTICS SA , SCHWEIGHOFFER FABIEN , BRACCO LAURENT
发明人： SCHWEIGHOFFER FABIEN , BRACCO LAURENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/158
摘要： This application concerns methods and compositions that can be used for detecting the Alzheimer disease in mammals, particularly in humans. It describes in particular serum markers for Alzheimer's disease and the way they are used for diagnostic procedures. It also concerns tools and/or kits that can be used for applying these procedures (reagents, probes, primers, antibodies, chips, cells, etc.) with the preparation thereof and the way to use them. The invention can be used to detect the presence or the progression of Alzheimer illness in mammals, including at early stages of the disease.
摘要翻译：本申请涉及可用于检测哺乳动物，特别是人类中的阿尔茨海默病的方法和组合物。它特别描述了阿尔茨海默病的血清标志物及其用于诊断程序的方法。它还涉及可用于应用这些程序（试剂，探针，引物，抗体，芯片，细胞等）及其使用方法的工具和/或试剂盒。本发明可用于检测哺乳动物中阿尔茨海默病的存在或进展，包括在疾病的早期阶段。

3. 发明申请

WO2004040018A3 QUALITATIVE DIFFERENTIAL SCREENING FOR THE DETECTION OF RNA SPLICE SITES 审中-公开
标题翻译：用于检测RNA片段的定性差异筛选
公开(公告)号：WO2004040018A3
公开(公告)日：2004-08-19
申请号：PCT/IB0305268
申请日：2003-10-29
申请人： EXONHIT THERAPEUTICS SA , TOCQUE BRUNO , BRACCO LAURENT , EDON FLORENCE , SCHWEIGHOFFER FABIEN
发明人： TOCQUE BRUNO , BRACCO LAURENT , EDON FLORENCE , SCHWEIGHOFFER FABIEN
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1072 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142 , C12Q2539/105 , C12Q2565/501 , C12Q2537/113 , C12Q2521/301
摘要： The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions, deletions located in RNA transcribed genome regions, between two physiological situations, comprising either hybridization of RNA derived from the test situation with cDNA's derived from the reference situation and/or reciprocally, or double-strand hybridization of cDNA derived from the test situation with cDNA's derived from the reference situation; and identifying and/or cloning nucleic acids representing qualitative differences. The invention also concerns compositions or banks of nucleic acids representing qualitative differences between two physiological situations, obtainable by the above method, and their use as probe, for identifying genes or molecules of interest, or still for example in methods of pharmacogenomics, and profiling of molecules relative to their therapeutic and/or toxic effects. The invention further concerns the use of dysregulation of splicing RNA as markers for predicting molecule toxicity and/or efficacy, and as markers in pharmacogenomics.
摘要翻译：本发明涉及用于鉴定和/或克隆代表与选择性剪接事件相关的定性差异的核酸区域的方法和/或在两个生理情境之间的位于RNA转录基因组区域中的插入，缺失的方法，其包括衍生自测试的RNA的杂交来自参考情况的cDNA的情况和/或来自测试情况的cDNA的双链杂交和/或来自参考情况的cDNA的双链杂交; 以及鉴定和/或克隆代表定性差异的核酸。本发明还涉及表示通过上述方法获得的两种生理情况之间的定性差异的核酸组合物或组，以及它们作为探针的用途，用于鉴定感兴趣的基因或分子，或者仍然例如在药物基因组学的方法中，以及分子相对于其治疗和/或毒性作用。本发明还涉及使用拼接RNA的调节作为用于预测分子毒性和/或功效的标记物，以及作为药物基因组学中的标记物。

4. 发明申请

WO2009144424A3 PROCESS AND METHOD FOR DIAGNOSING ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于诊断阿尔茨海默病的方法和方法
公开(公告)号：WO2009144424A3
公开(公告)日：2010-02-25
申请号：PCT/FR2009050530
申请日：2009-03-30
申请人： EXONHIT THERAPEUTICS SA , JARRIGE-LE PRADO ANNE-CHARLOTT , BEURDELEY PASCALE , PALLARES DIEGO , ROUET FABIEN , BRACCO LAURENT
发明人： JARRIGE-LE PRADO ANNE-CHARLOTTE , BEURDELEY PASCALE , PALLARES DIEGO , ROUET FABIEN , BRACCO LAURENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/106 , C12Q2600/158 , C12Q2539/105
摘要： The present application relates to the methods and compositions useful for diagnosing Alzheimer's disease in mammals, particularly humans. The application particularly describes serous markers for Alzheimer's disease and the uses thereof in methods of diagnosis. The application also relates to the tools and/or kits useful for implementing these methods (reagents, probes, primers, antibodies, chips, cells, etc.) and the preparation and uses thereof. The invention is useful for detecting the presence or development of Alzheimer's disease in mammals, including during the early phase, and for predicting the effectiveness of Alzheimer's disease treatment.
摘要翻译：本申请涉及用于诊断哺乳动物，特别是人类中的阿尔茨海默氏病的方法和组合物。本申请特别描述了阿尔茨海默病的浆液性标志物及其在诊断方法中的用途。该应用还涉及可用于实施这些方法（试剂，探针，引物，抗体，芯片，细胞等）的工具和/或试剂盒及其制备和用途。本发明可用于检测哺乳动物中阿尔茨海默病的存在或发展，包括在早期阶段，以及预测阿尔茨海默病治疗的有效性。

5. 发明申请

WO2006027693A2 TUMOR SPECIFIC GENES AND VARIANT RNAS AND USES THEREOF AS TARGETS FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译：肿瘤特异性基因和变异RNAs及其作为癌症治疗和诊断目标的用途
公开(公告)号：WO2006027693A2
公开(公告)日：2006-03-16
申请号：PCT/IB2005002934
申请日：2005-09-07
申请人： EXONHIT THERAPEUTICS SA , MCGOWAN KEVIN , KOTRAIAH VINAYAKA , BRENNER MICHAEL , EINSTEIN RICHARD , BRACCO LAURENT
发明人： MCGOWAN KEVIN , KOTRAIAH VINAYAKA , BRENNER MICHAEL , EINSTEIN RICHARD , BRACCO LAURENT
IPC分类号： C12N15/11
CPC分类号： C07K14/4748
摘要： Genes and variant RNAs that are differentially expressed in human colon tumor tissues compared with normal colon tissue and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment, diagnosis or prophylaxis of colon cancer.
摘要翻译：鉴定与正常结肠组织和相应蛋白质相比，在人结肠肿瘤组织中差异表达的基因和变体RNA。这些基因和相应的抗原是治疗，诊断或预防结肠癌的合适靶标。

6. 发明申请

WO2007105114A8 METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCERS 审中-公开
标题翻译：检测和治疗癌症的方法和组合
公开(公告)号：WO2007105114A8
公开(公告)日：2009-08-13
申请号：PCT/IB2007001721
申请日：2007-03-15
申请人： EXONHIT THERAPEUTICS SA , HOPITAUX UNIVERSITAIRES DE GEN , UNIV GENEVE , PIGUET VINCENT , CORREA ROCHA RAFAEL , BRACCO LAURENT
发明人： PIGUET VINCENT , CORREA ROCHA RAFAEL , BRACCO LAURENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to methods and compositions for the detection and treatment of melanoma and skin cancers. More particularly, the invention discloses that BCSC-1 expression is altered in melanoma and skin cancer cells, allowing the design of effective detection methods and kits for such conditions. The invention also shows that restoring or increasing expression of BCSC-1 in melanoma and skin cancer cells suppresses tumorigenicity and represents a novel and effective approach for the treatment of melanoma and skin cancers. The invention may be used to detect the presence, stage or type of melanoma and skin cancers, as well as any predisposition thereto. The invention may be used in any mammalian subject, particularly human subjects.
摘要翻译：本发明涉及用于检测和治疗黑素瘤和皮肤癌的方法和组合物。更具体地，本发明公开了BCSC-1表达在黑素瘤和皮肤癌细胞中改变，允许为这种条件设计有效的检测方法和试剂盒。本发明还显示，恢复或增加黑素瘤和皮肤癌细胞中BCSC-1的表达抑制致瘤性，并且代表治疗黑素瘤和皮肤癌的新颖有效的方法。本发明可用于检测黑素瘤和皮肤癌的存在，阶段或类型，以及其任何倾向。本发明可用于任何哺乳动物受试者，特别是人类受试者。

7. 发明申请

WO2007105114A3 METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCERS 审中-公开
标题翻译：检测和治疗癌症的方法和组合
公开(公告)号：WO2007105114A3
公开(公告)日：2008-03-13
申请号：PCT/IB2007001721
申请日：2007-03-15
申请人： EXONHIT THERAPEUTICS SA , HOPITAUX UNIVERSITAIRES DE GEN , UNIV GENEVE , PIGUET VINCENT , CORREA ROCHA RAFAEL , BRACCO LAURENT
发明人： PIGUET VINCENT , CORREA ROCHA RAFAEL , BRACCO LAURENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to methods and compositions for the detection and treatment of melanoma and skin cancers. More particularly, the invention discloses that BCSC-1 expression is altered in melanoma and skin cancer cells, allowing the design of effective detection methods and kits for such conditions. The invention also shows that restoring or increasing expression of BCSC-1 in melanoma and skin cancer cells suppresses tumorigenicity and represents a novel and effective approach for the treatment of melanoma and skin cancers. The invention may be used to detect the presence, stage or type of melanoma and skin cancers, as well as any predisposition thereto. The invention may be used in any mammalian subject, particularly human subjects.
摘要翻译：本发明涉及用于检测和治疗黑素瘤和皮肤癌的方法和组合物。更具体地，本发明公开了BCSC-1表达在黑素瘤和皮肤癌细胞中改变，允许为这种条件设计有效的检测方法和试剂盒。本发明还显示，恢复或增加黑素瘤和皮肤癌细胞中BCSC-1的表达抑制致瘤性，并且代表治疗黑素瘤和皮肤癌的新颖有效的方法。本发明可用于检测黑素瘤和皮肤癌的存在，阶段或类型，以及其任何倾向。本发明可用于任何哺乳动物受试者，特别是人类受试者。

8. 发明申请

WO2006027693A8 TUMOR SPECIFIC GENES AND VARIANT RNAS AND USES THEREOF AS TARGETS FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译：肿瘤特异性基因和变异RNA及其作为癌症治疗和诊断的靶点
公开(公告)号：WO2006027693A8
公开(公告)日：2006-06-22
申请号：PCT/IB2005002934
申请日：2005-09-07
申请人： EXONHIT THERAPEUTICS SA , MCGOWAN KEVIN , KOTRAIAH VINAYAKA , BRENNER MICHAEL , EINSTEIN RICHARD , BRACCO LAURENT
发明人： MCGOWAN KEVIN , KOTRAIAH VINAYAKA , BRENNER MICHAEL , EINSTEIN RICHARD , BRACCO LAURENT
IPC分类号： C12N15/11
CPC分类号： C07K14/4748
摘要： Genes and variant RNAs that are differentially expressed in human colon tumor tissues compared with normal colon tissue and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment, diagnosis or prophylaxis of colon cancer.
摘要翻译：鉴定与正常结肠组织和相应蛋白相比在人结肠肿瘤组织中差异表达的基因和变体RNA。这些基因和相应的抗原是治疗，诊断或预防结肠癌的合适靶点。

9. 发明申请

WO2004056989A3 HUMAN VARIANTS OF KALLIKREIN-2 AND KALLIKREIN-3 AND USES THEREOF 审中-公开
标题翻译： KALLIKREIN-2和KALLIKREIN-3的人类变异及其用途
公开(公告)号：WO2004056989A3
公开(公告)日：2005-01-06
申请号：PCT/FR0303775
申请日：2003-12-17
申请人： EXONHIT THERAPEUTICS , BRACCO LAURENT , BRINKMAN BRIGITTA , COIGNARD FANNY
发明人： BRACCO LAURENT , BRINKMAN BRIGITTA , COIGNARD FANNY
IPC分类号： C12N9/64 , C12N15/57 , C07K16/40 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C12N9/6445 , C12N2310/111
摘要： The invention concerns the field of biology, genetics and medicine. It concerns in particular novel methods for detecting, characterizing and/or treating cancer pathologies, in particular prostatic cancer. The invention also concerns methods for identifying or screening compounds active in said pathologies. The invention further concerns compounds, genes, cells, plasmids or compositions useful for implementing said methods. The invention concerns in particular the role of human variants of kallikrein-2 and kallikrein-3, also referred to as PSA, in said pathologies and their uses as therapeutic, diagnostic or experimental targets.
摘要翻译：本发明涉及生物学，遗传学和医学领域。特别涉及用于检测，表征和/或治疗癌症病理学，特别是前列腺癌的新颖方法。本发明还涉及用于鉴定或筛选在所述病理学中活性的化合物的方法。本发明还涉及可用于实施所述方法的化合物，基因，细胞，质粒或组合物。本发明特别涉及激肽释放酶-2和激肽释放酶-3（也称为PSA）的人类变体在所述病理学中的作用及其作为治疗，诊断或实验目标的用途。

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