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1. 发明申请

WO2006027693A2 TUMOR SPECIFIC GENES AND VARIANT RNAS AND USES THEREOF AS TARGETS FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译：肿瘤特异性基因和变异RNAs及其作为癌症治疗和诊断目标的用途
公开(公告)号：WO2006027693A2
公开(公告)日：2006-03-16
申请号：PCT/IB2005002934
申请日：2005-09-07
申请人： EXONHIT THERAPEUTICS SA , MCGOWAN KEVIN , KOTRAIAH VINAYAKA , BRENNER MICHAEL , EINSTEIN RICHARD , BRACCO LAURENT
发明人： MCGOWAN KEVIN , KOTRAIAH VINAYAKA , BRENNER MICHAEL , EINSTEIN RICHARD , BRACCO LAURENT
IPC分类号： C12N15/11
CPC分类号： C07K14/4748
摘要： Genes and variant RNAs that are differentially expressed in human colon tumor tissues compared with normal colon tissue and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment, diagnosis or prophylaxis of colon cancer.
摘要翻译：鉴定与正常结肠组织和相应蛋白质相比，在人结肠肿瘤组织中差异表达的基因和变体RNA。这些基因和相应的抗原是治疗，诊断或预防结肠癌的合适靶标。

2. 发明申请

WO1998017652A1 OXADIAZOLES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：恶二唑，生产与应用，药物的方法
公开(公告)号：WO1998017652A1
公开(公告)日：1998-04-30
申请号：PCT/EP1997005693
申请日：1997-10-15
申请人： BOEHRINGER INGELHEIM PHARMA KG , BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BRENNER, Michael , MAIER, Roland , WIENRICH, Marion , WEISER, Thomas , PALLUK, Rainer , BECHTEL, Wolf-Dietrich , SAGRADA, Angelo , ENSINGER, Helmut , PSCHORN, Uwe , CESANA, Raffaele
发明人： BOEHRINGER INGELHEIM PHARMA KG , BOEHRINGER INGELHEIM INTERNATIONAL GMBH
IPC分类号： C07D271/06
CPC分类号： C07D271/06 , C07D413/04
摘要： The invention concerns oxadiazole derivatives of general formula (I) in which X, Y, Z and R have the definitions given in the description and the claims. The invention further concerns processes for preparing these substances and their use as medicaments.
摘要翻译：本发明涉及恶二唑的通式（I），其特征在于，所定义的X，Y，Z和R的衍生物<1>载于说明书和权利要求中，它们的制备以及它们作为药物的用途。

3. 发明申请

WO2006004806A1 LUBRICANT ADDITIVE COMPOSITION SUITABLE FOR LUBRICATING, PREVENTING DEPOSIT FORMATION, OR CLEAN-UP OF TWO-STROKE ENGINES 审中-公开
标题翻译：润滑剂添加剂组合物适用于润滑，防止沉积物形成或清洁发动机
公开(公告)号：WO2006004806A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/023035
申请日：2005-06-29
申请人： THE LUBRIZOL CORPORATION , SVARCAS, Laimute, R. , BRENNER, Michael, S. , NAU, Thomas, A.
发明人： SVARCAS, Laimute, R. , BRENNER, Michael, S. , NAU, Thomas, A.
IPC分类号： C10M163/00
CPC分类号： C10M163/00 , C10M2205/026 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/285 , C10M2207/286 , C10M2207/289 , C10M2207/30 , C10M2215/064 , C10M2215/224 , C10M2217/043 , C10N2230/04 , C10N2240/105
摘要： A lubricant composition with a total nitrogen content of 0.1 to 0.25 percent by weight suitable for lubricating a two-stroke engine comprising an oil of lubricating viscosity, a synthetic ester, at least one condensation product of a fatty acid having 12 to 24 carbon atoms with a polyamine, and a Mannich dispersant.
摘要翻译：总氮含量为0.1至0.25重量％的润滑剂组合物，其适用于润滑含有润滑粘度的油，合成酯，至少一种具有12至24个碳原子的脂肪酸的缩合产物的二冲程发动机与多胺和曼尼希分散剂。

4. 发明申请

WO2005053735A1 METHOD OF REMOVING TRANSITION METALS, ESPECIALLY FROM METATHESIS REACTION PRODUCTS 审中-公开
标题翻译：从金属反应产物中特别去除过渡金属的方法
公开(公告)号：WO2005053735A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/012972
申请日：2004-11-16
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , BRENNER, Michael , MEINECK, Siegfried , WIRTH, Thomas
发明人： BRENNER, Michael , MEINECK, Siegfried , WIRTH, Thomas
IPC分类号： A61K38/55
CPC分类号： C07K5/0808 , C07D215/233 , C07D487/08 , C07F15/0046 , C07K5/0827 , C07K5/123
摘要： A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound. The added compound is a solubility-enhancing compound that enhances the solubility of said complex in a second solution. Thereafter the solution containing said complex can be extracted with the second solution.
摘要翻译：一种通过加入任选的稠合和/或任选取代的杂环化合物从含有所述络合物的溶液中降低金属络合物浓度的方法。添加的化合物是增强所述配合物在第二溶液中的溶解度的溶解度增强化合物。此后，可以用第二溶液萃取含有所述复合物的溶液。

5. 发明申请

WO2005007175A3 CADHERIN DIRECTED MOLECULAR AND CELLULAR LOCALIZATION 审中-公开
公开(公告)号：WO2005007175A3
公开(公告)日：2005-01-27
申请号：PCT/US2004/019029
申请日：2004-06-09
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , BRENNER, Michael, B. , LEE, David, M.
发明人： BRENNER, Michael, B. , LEE, David, M.
IPC分类号： A61K48/00
摘要： Methods for treating disease by administering a genetically modified cadherinexpressing cell are provided.

6. 发明申请

WO9952547A9 VACCINE COMPOSITIONS COMPRISING CD-1 ANTIGENS AND T-CELL STIMULATING COMPOUND AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含CD-1抗原和T细胞刺激化合物的疫苗组合物及其使用方法
公开(公告)号：WO9952547A9
公开(公告)日：2000-03-02
申请号：PCT/US9908112
申请日：1999-04-13
申请人： BRIGHAM WOMEN S HOSPITAL INC , PORCELLI STEVEN A , BRENNER MICHAEL B , DASCHER CHRISTOPHER C , HIROMATSU KENJI
发明人： PORCELLI STEVEN A , BRENNER MICHAEL B , DASCHER CHRISTOPHER C , HIROMATSU KENJI
IPC分类号： A61K39/00 , A61K38/04 , A61K38/38 , A61K39/005 , A61K39/015 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/102 , A61K39/118 , A61K39/39 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/16 , A61P33/02 , A61P33/06 , A61P37/04 , A61K39/002
CPC分类号： A61K38/38 , A61K38/04 , A61K39/39 , A61K39/04 , A61K39/002 , A61K39/00 , A61K2300/00
摘要： The present invention relates to immunogenic or vaccine compositions comprising a CD1 or lipid antigen and a T-cell stimulating compound (e.g., an adjuvant). The invention also pertains to methods for administering the immunogenic or vaccine compositions.
摘要翻译：本发明涉及包含CD1或脂质抗原和T细胞刺激化合物（例如佐剂）的免疫原性或疫苗组合物。本发明还涉及用于施用免疫原性或疫苗组合物的方法。

7. 发明申请

WO9954315A2 TRIAZOLONES WITH A NEUROPROTECTIVE ACTION 审中-公开
标题翻译：具有神经保护作用三唑酮
公开(公告)号：WO9954315A2
公开(公告)日：1999-10-28
申请号：PCT/EP9902498
申请日：1999-04-14
申请人： BOEHRINGER INGELHEIM PHARMA , BRENNER MICHAEL , BECHTEL WOLF DIETRICH , PALLUK RAINER , WIENRICH MARION , WEISER THOMAS
发明人： BRENNER MICHAEL , BECHTEL WOLF-DIETRICH , PALLUK RAINER , WIENRICH MARION , WEISER THOMAS
IPC分类号： A61K31/41 , A61K31/4427 , A61K31/4439 , A61P9/10 , A61P25/00 , C07D249/12 , C07D401/04
CPC分类号： C07D401/04 , C07D249/12
摘要： The invention relates to the use of triazolones as medicaments, especially as medicaments with a neuroprotective action, to novel triazolones and to methods for producing them.
摘要翻译：本发明涉及使用三唑酮作为药物，特别是作为具有神经保护作用的药物组合物，以及新的三唑酮和它们的制备方法。

8. 发明申请

WO2018201130A1 TARGETING GAMMA-DELTA T CELLS IN OBESITY AND CACHEXIA 审中-公开
公开(公告)号：WO2018201130A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/030153
申请日：2018-04-30
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , BRENNER, Michael
发明人： BRENNER, Michael , LYNCH, Lydia , KOHLGRUBER, Ayano
IPC分类号： A61K38/00 , A61K39/395 , A61P17/06 , A61P37/00 , C07K16/24
CPC分类号： A61P17/06 , A61K38/1774 , A61K38/1793 , A61K38/191 , A61K38/20 , A61K2039/505 , A61P37/00 , C07K16/241 , C07K16/244 , C07K16/2866 , C07K16/2878 , C07K2317/75 , C07K2317/76 , A61K2300/00
摘要： Methods of promoting or inhibiting weight loss by modulating activity levels of γδ T cells.

9. 发明申请

WO2009110962A3 TIME MANAGEMENT FOR OUTGOING ELECTRONIC MAIL 审中-公开
标题翻译：电子邮件的时间管理
公开(公告)号：WO2009110962A3
公开(公告)日：2010-11-25
申请号：PCT/US2009001048
申请日：2009-02-19
申请人： ALCATEL LUCENT USA INC , BRENNER MICHAEL RALF
发明人： BRENNER MICHAEL RALF
IPC分类号： G06Q50/00
CPC分类号： G06Q10/107 , H04L51/34
摘要： Apparatus and methods of delivering electronic messages, such as e-mail, which provide e-mail users with additional control over the delivery process. A sending delay timer is incorporated into e-mail products, such as e-mail client and server software. Instead of trying to catch a message after it has been sent, the present invention controls the time an outgoing message is to leave the sending e-mail client and/or server, thereby allowing the message to be retrieved for modification or deletion without relying on ineffective recall features of conventional products. A single timer may be implemented, in which case all messages would be subjected to the same delay. Alternatively, multiple timers can also be implemented, wherein the timers can be individually set to delay messages meeting certain criteria, such as the intended recipient. During the effective delayed transmission time interval, since the message is still under the control of the e-mail software client, all local operations on the message can still be performed: i.e. the message can be viewed, edited, or deleted altogether. At the expiration of the time delay interval, the last rendition of the message (if one still exists in the sender's outbound e-mailbox) would be finally sent to the target recipient's e-mail address indicated. This feature does not interfere with any other pre-existing 'recall' mechanisms, which can still be exercised as desired.
摘要翻译：传送诸如电子邮件的电子消息的装置和方法，其向电子邮件用户提供对传送过程的额外控制。发送延迟定时器被并入电子邮件产品，如电子邮件客户端和服务器软件。本发明不是在发送消息之后尝试捕获消息，而是控制传出消息离开发送电子邮件客户端和/或服务器的时间，从而允许检索消息以进行修改或删除，而不依赖于传统产品无效召回功能。可以实现单个定时器，在这种情况下，所有消息将遭受相同的延迟。或者，也可以实现多个定时器，其中定时器可以被单独设置为延迟满足某些标准的消息，诸如预期的接收者。在有效的延迟发送时间间隔期间，由于消息仍然在电子邮件软件客户端的控制下，所以仍然可以执行消息上的所有本地操作：即可以完全查看，编辑或删除消息。在延时间隔到期时，消息的最后再现（如果仍然存在于发件人的出站电子邮箱中）将最终发送到指定的目标收件人的电子邮件地址。此功能不会干扰任何其他预先存在的“召回”机制，这些机制仍然可以根据需要进行。

10. 发明申请

WO2008007942A1 MEANS AND METHODS FOR MANIPULATING SEQUENTIAL PHAGOLYSOMAL-CYTOSOLIC TRANSLOCATION OF MYCOBACTERIA, AND USES THEREOF 审中-公开
标题翻译：用于操纵MYCOBACTERIA的顺序化学 - 细胞转移转移的手段和方法及其用途
公开(公告)号：WO2008007942A1
公开(公告)日：2008-01-17
申请号：PCT/NL2006/000349
申请日：2006-07-10
申请人： HET NEDERLANDS KANKER INSTITUUT , SPEELMAN-VAN DER WEL, Nicole, Neeltje , BRENNER, Michael, Barry , PETERS, Jacobus, Peter, Johannes
发明人： SPEELMAN-VAN DER WEL, Nicole, Neeltje , BRENNER, Michael, Barry , PETERS, Jacobus, Peter, Johannes
IPC分类号： C12N15/09 , C12N1/20 , C12R1/32
CPC分类号： C12N1/36 , A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/35
摘要： Mycobacteria such as M. tuberculosis and M. leprae are considered to be prototypical intracellular bacilli that have evolved strategies to enable growth in the intracellular phagosomes of the host cell. By contrast, we show that lysosomes rapidly fuse with the virulent M. tuberculosis and M. leprae-containing phagosomes of human monocyte-derived dendritic cells and macrophages. After 2 days, M. tuberculosis progressively translocate from phagolysosomes into the cytosol where they replicate. Cytosolic entry is also observed for M. leprae but not for the vaccine strain, M. bovis BCG, or killed mycobacteria, and is dependent upon secretion of the mycobacterial gene products CFP-10 and ESAT-6 of the RD1 region. The present invention further provides means and methods for using these findings in therapeutic and immunogenic compositions.
摘要翻译：分枝杆菌如结核分枝杆菌和麻疯病被认为是原型细胞内杆菌，其具有促进宿主细胞的细胞内吞噬体生长的策略。相比之下，我们显示溶酶体与人单核细胞衍生的树突状细胞和巨噬细胞的毒性结核分枝杆菌和含有leprae的吞噬体快速融合。 2天后，结核分枝杆菌从吞噬体逐渐转移到细胞质中，在那里它们复制。也观察到麻疯树进入细胞因子，但不是针对疫苗株，牛分枝杆菌BCG或杀死的分枝杆菌，并且依赖于RD1区域的分枝杆菌基因产物CFP-10和ESAT-6的分泌。本发明还提供了在治疗和免疫原性组合物中使用这些发现的方法和方法。

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