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    • 1. 发明申请
    • DEVICES FOR SELECTIVE RECRUITMENT, ISOLATION, ACTIVATION, AND/OR ELIMINATION OF VARIOUS CELL POPULATIONS
    • 选择性招募,分离,激活和/或消除各种细胞群体的设备
    • WO2007089762A3
    • 2008-02-14
    • PCT/US2007002505
    • 2007-01-31
    • BIOMED SOLUTIONS LLCGOSS KENDRICKGEBERT CAROL
    • GOSS KENDRICKGEBERT CAROL
    • A61F2/06
    • A61L27/38
    • Implantable devices comprise at least one or more targeting molecules that form a primary coating layer for selectively recruiting, isolating, activating, and/or eliminating any cells of interest, such as T cells, monocytes, and stem cells The devices can be utilized for selectively removing a particular subset of cells from a patient Various non-selective pharmaceutical and biological agents can be incorporated into the devices so that cells can be isolated for elimination or for activation/differentiation Cell-type selectivity is conferred by the presence of cell-specific targeting molecules incorporated into the device, preferably at the surface level to permit interaction between the cells of interest and the targeting molecules Related therapeutic methods for utilizing the devices are also provided These devices can be manufactured as stents, catheters, a holding chamber, or any other device, and can be manufactured into any shape, including a conduit, a vessel, and a tubing
    • 可植入装置包含至少一种或多种靶向分子,其形成用于选择性募集,分离,活化和/或消除任何目标细胞的初级包被层,例如T细胞,单核细胞和干细胞。该装置可用于选择性地 从患者去除特定的细胞亚群可以将多种非选择性药物和生物制剂并入装置中,以便分离细胞用于消除或激活/分化细胞型选择性由细胞特异性靶向的存在赋予 分子结合到装置中,优选在表面水平以允许感兴趣的细胞和靶向分子之间的相互作用。还提供了用于利用装置的相关治疗方法。这些装置可以制造成支架,导管,保持室或任何其他 装置,并且可以制造成任何形状,包括导管,容器和管道