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1. 发明申请

WO2006049812A3 PROCESS FOR TREATING A BIOLOGICAL ORGANISM 审中-公开
标题翻译：处理生物有机体的过程
公开(公告)号：WO2006049812A3
公开(公告)日：2009-04-09
申请号：PCT/US2005036376
申请日：2005-10-07
申请人： TECHNOLOGY INNOVATIONS LLC , TUSZYNSKI JACK A , GREENWALD HOWARD J , CURRY STEPHEN H , GOSS KENDRICK
发明人： TUSZYNSKI JACK A , GREENWALD HOWARD J , CURRY STEPHEN H , GOSS KENDRICK
IPC分类号： C12N5/00 , C12N13/00
CPC分类号： A61N7/00 , A61K31/195 , A61K31/282 , A61K31/337 , A61K31/35 , A61K31/4985 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/706 , A61K31/7072 , A61K41/0004 , A61K45/06 , A61N1/326 , A61N2/002 , A61K2300/00
摘要： A process for treating a biological organism, comprising the steps in which a cell cycle arresting drug is administered to the organism to produce synchronized cells, the microtubules within the synchronized cells are stabilized by means of a microtubule stabilizing agent, and the synchronized cells with the stabilized microtubules are then contacted with mechanical vibration energy.
摘要翻译：一种用于治疗生物体的方法，包括将细胞周期阻滞药物施用于生物体以产生同步细胞的步骤，同步细胞内的微管通过微管稳定剂稳定，并且与然后将稳定的微管与机械振动能接触。

2. 发明申请

WO2007089762A2 DEVICES FOR SELECTIVE RECRUITMENT, ISOLATION, ACTIVATION, AND/OR ELIMINATION OF VARIOUS CELL POPULATIONS 审中-公开
标题翻译：选择性招募，分离，激活和/或消除各种细胞群体的设备
公开(公告)号：WO2007089762A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002505
申请日：2007-01-31
申请人： BIOMED SOLUTIONS, LLC , GOSS, Kendrick , GEBERT, Carol
发明人： GOSS, Kendrick , GEBERT, Carol
IPC分类号： A61K48/00
CPC分类号： A61L27/38
摘要： Implantable devices comprise at least one or more targeting molecules that form a primary coating layer for selectively recruiting, isolating, activating, and/or eliminating any cells of interest, such as T cells, monocytes, and stem cells. The implantable devices can be utilized for selectively removing a particular subset of cells from bodily fluids of a patient. Various non-selective pharmaceutical agents and biological agents can be incorporated into the implantable devices so that cells of interest can be isolated for elimination or for activation/differentiation. Cell-type selectivity is conferred by the presence of cell-type-specific targeting molecules incorporated into the implantable device, preferably at the surface level to permit direct or indirect interaction between the cells of interest and targeting molecules of the implantable device. Related therapeutic methods for utilizing the implantable devices are also provided. These implantable devices can be manufactured as a stent, a catheter, a holding chamber, or any other device, and can be manufactured into any shape, including a conduit, a vessel, and a tubing.
摘要翻译：可植入装置包含至少一种或多种靶向分子，其形成用于选择性募集，分离，活化和/或消除任何目标细胞如T细胞，单核细胞和干细胞的初级包被层。可植入装置可用于从患者的体液中选择性地去除细胞的特定子集。可以将各种非选择性药剂和生物制剂掺入到可植入装置中，使得可以分离感兴趣的细胞用于消除或激活/分化。细胞型选择性由掺入到可植入装置中的细胞型特异性靶向分子的存在赋予，优选在表面水平，以允许感兴趣的细胞和可植入装置的靶向分子之间的直接或间接相互作用。还提供了用于利用可植入装置的相关治疗方法。这些可植入装置可以被制造成支架，导管，保持室或任何其它装置，并且可以制造成任何形状，包括导管，容器和管。

3. 发明申请

WO2007086882A3 BIOLOGICAL POLYMER WITH DIFFERENTLY CHARGED PORTIONS 审中-公开
公开(公告)号：WO2007086882A3
公开(公告)日：2007-08-02
申请号：PCT/US2006/005264
申请日：2006-02-15
申请人： TECHNOLOGY INNOVATIONS, LLC , GOSS, Kendrick , TUSZYNSKI, Jack, A. , GREENWALD, Howard, J.
发明人： TUSZYNSKI, Jack, A. , GREENWALD, Howard, J.
IPC分类号： C07K14/00
摘要： A biological polymer assembly with a biological polymer that contains at least 90 percent of tubulin and a positively charged segment. The positively charged segment has a molecular weight of at least about 5,000 Daltons, a bulk electrical conductivity of at least about 10 -7 ohm -1 meter -1 Siemens, a concentration of elemental charges per cubic centimeter of from about 10 12 to about 10 25 , and a length of at least about 2 nanometer.

4. 发明申请

WO2007050135A2 PROCESS FOR TREATING A BIOLOGICAL ORGANISM 审中-公开
标题翻译：处理生物有机体的过程
公开(公告)号：WO2007050135A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/022048
申请日：2006-06-07
申请人： TECHNOLOGY INNOVATIONS, LLC , TUSZYNSKI, Jack, A. , GOSS, Kendrick , GREENWALD, Howard, J. , FRITZ, Garold, F.
发明人： TUSZYNSKI, Jack, A. , GOSS, Kendrick , GREENWALD, Howard, J. , FRITZ, Garold, F.
IPC分类号： A61K9/26 , A61N1/00
CPC分类号： A61N7/00 , A61B8/08
摘要： A process for treating cells within a biological organism in which sonic energy is focused on cells within a biological organism while the frequency and/or the power level of such energy is varied. In addition there is provided a process for synergistically combining sonic energy and other forms of energy, or other therapeutic agents, in the treatment of cells in living organisms. Furthermore there is provided a process for assaying the efficacy of other therapeutic agents with sonic energy.
摘要翻译：一种处理生物体内的细胞的方法，其中声能量集中在生物体内的细胞上，同时这种能量的频率和/或功率水平变化。此外，提供了一种将声能和其他形式的能量或其他治疗剂协同地组合在活细胞中的细胞的治疗中的方法。此外，提供了一种用于测定具有声能的其它治疗剂的功效的方法。

5. 发明申请

WO2006093675A2 PROCESS AND APPARATUS FOR TREATING BIOLOGICAL ORGANISMS 审中-公开
标题翻译：处理生物有机体的方法和装置
公开(公告)号：WO2006093675A2
公开(公告)日：2006-09-08
申请号：PCT/US2006005415
申请日：2006-02-16
申请人： BIOMED SOLUTIONS LLC , WEINER MICHAEL L , GRAY ROBERT W , MACDONALD STUART G , TUSZYNSKI JACK A , GOSS KENDRICK , ANGELICA AMARA D
发明人： WEINER MICHAEL L , GRAY ROBERT W , MACDONALD STUART G , TUSZYNSKI JACK A , GOSS KENDRICK , ANGELICA AMARA D
IPC分类号： A61N5/00
CPC分类号： A61N5/00
摘要： An apparatus for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.
摘要翻译：一种用于治疗生物体的装置，包括用于向生物体生物发射和输送能量的装置，用于改变发射的能量的类型和量的可编程控制器以及用于感测生物体的状况的装置。

6. 发明申请

WO2007050135A3 PROCESS FOR TREATING A BIOLOGICAL ORGANISM 审中-公开
标题翻译：处理生物有机体的过程
公开(公告)号：WO2007050135A3
公开(公告)日：2009-04-16
申请号：PCT/US2006022048
申请日：2006-06-07
申请人： TECHNOLOGY INNOVATIONS LLC , TUSZYNSKI JACK A , GOSS KENDRICK , GREENWALD HOWARD J , FRITZ GAROLD F
发明人： TUSZYNSKI JACK A , GOSS KENDRICK , GREENWALD HOWARD J , FRITZ GAROLD F
IPC分类号： A61B8/00 , A61B5/055 , A61N7/00 , H01S1/06
CPC分类号： A61N7/00 , A61B8/08
摘要： A process for treating cells within a biological organism in which sonic energy is focused on cells within a biological organism while the frequency and/or the power level of such energy is varied. In addition there is provided a process for synergistically combining sonic energy and other forms of energy, or other therapeutic agents, in the treatment of cells in living organisms. Furthermore there is provided a process for assaying the efficacy of other therapeutic agents with sonic energy.
摘要翻译：一种处理生物体内的细胞的方法，其中声能量集中在生物体内的细胞上，同时这种能量的频率和/或功率水平变化。此外，提供了一种将声能和其他形式的能量或其他治疗剂协同地组合在活细胞中的细胞的治疗中的方法。此外，提供了一种用于测定具有声能的其它治疗剂的功效的方法。

7. 发明申请

WO2007086882A2 BIOLOGICAL POLYMER WITH DIFFERENTLY CHARGED PORTIONS 审中-公开
标题翻译：具有不同充电方式的生物聚合物
公开(公告)号：WO2007086882A2
公开(公告)日：2007-08-02
申请号：PCT/US2006005264
申请日：2006-02-15
申请人： TECHNOLOGY INNOVATIONS LLC , GOSS KENDRICK , TUSZYNSKI JACK A , GREENWALD HOWARD J
发明人： TUSZYNSKI JACK A , GREENWALD HOWARD J
IPC分类号： C07K14/47 , C07K14/435 , G01N33/543
CPC分类号： C07K14/47 , C07K14/435 , G01N33/5438
摘要： A biological polymer assembly with a biological polymer that contains at least 90 percent of tubulin and a positively charged segment. The positively charged segment has a molecular weight of at least about 5,000 Daltons, a bulk electrical conductivity of at least about 10 -7 ohm -1 meter -1 Siemens, a concentration of elemental charges per cubic centimeter of from about 10 12 to about 10 25 , and a length of at least about 2 nanometer.
摘要翻译：具有生物聚合物的生物聚合物组合物，其含有至少90％的微管蛋白和带正电的部分。带正电的链段具有至少约5,000道尔顿的分子量，体电导率至少为约10 -7欧姆-1 / 西门子，每立方厘米的元素电荷浓度为约10 12至约10 25，长度为至少约2纳米。

8. 发明申请

WO2006104510A2 WATER-SOLUBLE COMPOUND 审中-公开
标题翻译：水溶性化合物
公开(公告)号：WO2006104510A2
公开(公告)日：2006-10-05
申请号：PCT/US2005028181
申请日：2005-08-09
申请人： TECHNOLOGY INNOVATIONS LLC , TUSZYNSKI JACK A , GREENWALD HOWARD J , CURRY STEPHEN H , GOSS KENDRICK
发明人： TUSZYNSKI JACK A , GREENWALD HOWARD J , CURRY STEPHEN H , GOSS KENDRICK
IPC分类号： C07K14/47
CPC分类号： A61K31/135
摘要： A water-soluble magnetic anti-mitotic compound with a water-solubility of at least 100 micrograms per milliliter, a molecular weight of at least 150 grams per mole, a mitotic index factor of at least 10 percent, a positive magnetic susceptibility of at least 1,000 x 10 -6 cgs, and a magnetic moment of at least 0.5 bohr magnetrons, wherein said compound is comprised of at least 7 carbon atoms and at least one inorganic atom with a positive magnetic susceptibility of at least 200 x 10 -6 .
摘要翻译：水溶性磁性抗有丝分裂化合物，其水溶解度为至少100微克/毫升，分子量至少为150克/摩尔，有丝分裂指数因子至少为10％，至少至少的磁化率为 1,000×10 -6个cgs，以及至少为0.5伏的磁控管的磁矩，其中所述化合物由至少7个碳原子组成，并且至少一个具有至少的磁化率的无机原子 200×10 -6。

9. 发明申请

WO2006093675A3 PROCESS AND APPARATUS FOR TREATING BIOLOGICAL ORGANISMS 审中-公开
公开(公告)号：WO2006093675A3
公开(公告)日：2006-09-08
申请号：PCT/US2006/005415
申请日：2006-02-16
申请人： BIOMED SOLUTIONS, LLC , WEINER, Michael, L. , GRAY, Robert, W. , MACDONALD, Stuart, G. , TUSZYNSKI, Jack, A. , GOSS, Kendrick , ANGELICA, Amara, D.
发明人： WEINER, Michael, L. , GRAY, Robert, W. , MACDONALD, Stuart, G. , TUSZYNSKI, Jack, A. , GOSS, Kendrick , ANGELICA, Amara, D.
IPC分类号： A61N5/10 , G21K5/00 , G01N23/00
摘要： An apparatus for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.

10. 发明申请

WO2007089762A3 DEVICES FOR SELECTIVE RECRUITMENT, ISOLATION, ACTIVATION, AND/OR ELIMINATION OF VARIOUS CELL POPULATIONS 审中-公开
标题翻译：选择性招募，分离，激活和/或消除各种细胞群体的设备
公开(公告)号：WO2007089762A3
公开(公告)日：2008-02-14
申请号：PCT/US2007002505
申请日：2007-01-31
申请人： BIOMED SOLUTIONS LLC , GOSS KENDRICK , GEBERT CAROL
发明人： GOSS KENDRICK , GEBERT CAROL
IPC分类号： A61F2/06
CPC分类号： A61L27/38
摘要： Implantable devices comprise at least one or more targeting molecules that form a primary coating layer for selectively recruiting, isolating, activating, and/or eliminating any cells of interest, such as T cells, monocytes, and stem cells The devices can be utilized for selectively removing a particular subset of cells from a patient Various non-selective pharmaceutical and biological agents can be incorporated into the devices so that cells can be isolated for elimination or for activation/differentiation Cell-type selectivity is conferred by the presence of cell-specific targeting molecules incorporated into the device, preferably at the surface level to permit interaction between the cells of interest and the targeting molecules Related therapeutic methods for utilizing the devices are also provided These devices can be manufactured as stents, catheters, a holding chamber, or any other device, and can be manufactured into any shape, including a conduit, a vessel, and a tubing
摘要翻译：可植入装置包含至少一种或多种靶向分子，其形成用于选择性募集，分离，活化和/或消除任何目标细胞的初级包被层，例如T细胞，单核细胞和干细胞。该装置可用于选择性地从患者去除特定的细胞亚群可以将多种非选择性药物和生物制剂并入装置中，以便分离细胞用于消除或激活/分化细胞型选择性由细胞特异性靶向的存在赋予分子结合到装置中，优选在表面水平以允许感兴趣的细胞和靶向分子之间的相互作用。还提供了用于利用装置的相关治疗方法。这些装置可以制造成支架，导管，保持室或任何其他装置，并且可以制造成任何形状，包括导管，容器和管道

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