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1. 发明申请

WO2011011105A3 TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY 审中-公开
标题翻译：用于成像，疾病预防和治疗的可追踪的抗感染药
公开(公告)号：WO2011011105A3
公开(公告)日：2011-03-17
申请号：PCT/US2010033918
申请日：2010-05-06
申请人： BAYLOR COLLEGE MEDICINE , KE SHI , WANG WEI , MAWAD MICHEL
发明人： KE SHI , WANG WEI , MAWAD MICHEL
IPC分类号： A61K49/00 , C07D403/06
CPC分类号： A61K49/0052 , A61K49/0032 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/574 , G01N33/582 , G01N2800/56
摘要： The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.
摘要翻译：本发明提供了基于类视黄酸衍生物的结构的非放射性近红外光学成像剂。已经通过共焦显微镜在细胞水平上评估了非放射性近红外光学成像剂，并且在使用各种异种移植模型的整个动物体内进行了体内评估。该药物在人类癌细胞和多种异种移植物模型中的特异性摄取表明，非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于早期癌症研究和诊断。此外，本发明提供了非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于体内药物再分布的可视化，其可用于确定最佳生物剂量。最终，可视化数据可用作分析工具，以减少任何全身毒性。

2. 发明申请

WO2008025000A3 IMAGING AGENTS FOR FUNCTIONAL IMAGING OF LYMPHATIC STRUCTURES 审中-公开
标题翻译： LYMPHAIS结构功能成像成像剂
公开(公告)号：WO2008025000A3
公开(公告)日：2008-11-20
申请号：PCT/US2007076801
申请日：2007-08-24
申请人： BAYLOR COLLEGE MEDICINE , SHARMA RUCHI , WANG WEI , SEVICK-MURACA EVA
发明人： SHARMA RUCHI , WANG WEI , SEVICK-MURACA EVA
IPC分类号： A61K49/00
CPC分类号： A61B5/0071 , A61B5/0059 , A61B5/0064 , A61B5/41 , A61B5/415 , A61B5/418 , A61K47/61 , A61K49/0032 , A61K49/0034 , A61K49/0041 , A61K49/0054 , A61M5/007
摘要： Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid which bind to the receptors. Lymph vascular cell receptor expression may be related to the beginnings of tumor formation. As such, embodiments of the imaging agents may be used to stain lymph structures for detailed imaging of lymph architecture as well as serving as potential markers for tumor angiogenesis, tumor metastases, etc.
摘要翻译：公开了靶向淋巴管细胞受体和透明质酸细胞受体的新型成像剂。所公开的成像剂掺入结合受体的生物分子例如透明质酸。淋巴管细胞受体的表达可能与肿瘤形成的开始有关。因此，成像剂的实施方案可以用于染色淋巴结构以用于淋巴结构的详细成像，以及用作肿瘤血管生成，肿瘤转移等的潜在标记。

3. 发明申请

WO2005019247A3 CYCLIC PEPTIDE AND IMAGING COMPOUND COMPOSITIONS AND USES FOR TARGETED IMAGING AND THERAPY 审中-公开
标题翻译：循环肽和成像化合物组合物和用于靶向成像和治疗的用途
公开(公告)号：WO2005019247A3
公开(公告)日：2005-05-19
申请号：PCT/US2004026220
申请日：2004-08-13
申请人： UNIV TEXAS , LI CHUN , KE SHI , WANG WEI
发明人： LI CHUN , KE SHI , WANG WEI
IPC分类号： A61K49/00 , A61K51/08 , C07K7/56 , C07K14/81 , C07K7/64
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K51/08 , A61K51/082 , A61K51/088 , C07K7/56 , C07K14/8146
摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf) NIR imaging compositions and novel cyclic HWGFTL polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
摘要翻译：本发明涉及可与成像剂缀合的新型环肽，包括新型成像剂。具体地说，它包括c（KRGDf）NIR成像组合物和可以特别用于NIR，MRI和核成像以及治疗的新型循环HWGFTL多肽。此外，本发明包括新型成像剂，例如TS-ICG衍生物。本发明还涉及制备和使用这些化合物的方法。这些用途包括手术前和术中检测肿瘤细胞和治疗监测。

4. 发明申请

WO2013052433A3 METHODS AND COMPOSITIONS FOR REDUCING FOOD INTAKE AND BODY WEIGHT GAIN IN ANIMALS 审中-公开
标题翻译：用于减少食物摄取和体重增加动物体内的方法和组合物
公开(公告)号：WO2013052433A3
公开(公告)日：2014-05-08
申请号：PCT/US2012058386
申请日：2012-10-02
申请人： NESTEC SA , PAN YUANLONG , WANG WEI , SHERRILL SCOTT
发明人： PAN YUANLONG , WANG WEI , SHERRILL SCOTT
IPC分类号： A01N43/04
CPC分类号： A61K31/202 , A23L33/105 , A23L33/12 , A23V2002/00 , A61K31/05 , A61K2300/00 , A23V2200/08 , A23V2200/332 , A23V2250/0616 , A23V2250/1868 , A23V2250/187 , A23V2250/1882 , A23V2250/211 , A23V2250/304 , A23V2250/70
摘要： Methods and compositions for reducing food intake and body weight gain and particularly to the use of carotenoids and unsaturated fatty acids (UFA) for reducing food intake and body weight gain in animals. The methods comprise administering in conjunction to the animal one or more carotenoids and one or more UFA in an amount effective for reducing food intake and body weight gain in the animal.
摘要翻译：用于减少食物摄入和体重增加的方法和组合物，特别是使用类胡萝卜素和不饱和脂肪酸（UFA）来减少动物的摄食量和体重增加。所述方法包括联合给予动物一种或多种类胡萝卜素和一种或多种UFA，其量可有效减少动物体内的食物摄入和体重增加。

5. 发明申请

WO2011127862A3 METHOD AND DEVICE FOR MULTITHREAD TO ACCESS MULTIPLE COPIES 审中-公开
标题翻译：用于多媒体访问多个复制的方法和设备
公开(公告)号：WO2011127862A3
公开(公告)日：2012-04-26
申请号：PCT/CN2011074384
申请日：2011-05-20
申请人： HUAWEI TECH CO LTD , WANG WEI , LIU YIYANG , ZHANG XIAOFENG
发明人： WANG WEI , LIU YIYANG , ZHANG XIAOFENG
IPC分类号： G06F9/46
CPC分类号： G06F12/1009 , G06F2212/2542
摘要： A method and a device for multithread to access multiple copies are provided. The method comprises: when multiple threads of a process are distributed to different nodes, a thread page directory table whose content is the same as that of a process page directory table of processes is created, and each thread page directory table comprises special entries for pointing to specific data and common entries except the special entries, in which each thread corresponds to a thread page directory table, the execution of each thread is based on the corresponding thread page directory table, and the specific data is the data with multiple copies at different nodes; for each thread, when each thread is dispatched and the special entries in the thread page directory table of the thread does not point to the specific data stored in the node where the thread exists, the special entries are modified to point to the specific data based on the physical addresses of the specific data. Based on the solution mentioned above, the threads distributed to different nodes can be enabled to access the data copy stored in the node where the thread exists, thus the system performance is improved.
摘要翻译：提供了一种用于多线程访问多个副本的方法和设备。该方法包括：当进程的多个线程被分发到不同的节点时，创建其内容与进程的页面目录表的内容相同的线程页目录表，并且每个线程页目录表包括用于指向的特殊条目特定数据和常用条目除特殊条目外，其中每个线程对应于一个线程页目录表，每个线程的执行基于相应的线程页目录表，具体数据是具有不同副本的数据节点; 对于每个线程，当每个线程被分派并且线程的线程页目录表中的特殊条目不指向存储在线程存在的节点中的特定数据时，特殊条目被修改以指向特定的数据关于具体数据的物理地址。基于上述解决方案，可以使分配给不同节点的线程能够访问存在于存在线程的节点中的数据副本，从而提高系统性能。

6. 发明申请

WO2011110135A3 MASTER-STANDBY SWITCHING METHOD, SYSTEM CONTROL UNIT AND COMMUNICATION SYSTEM 审中-公开
标题翻译：主站待机方式，系统控制单元和通信系统
公开(公告)号：WO2011110135A3
公开(公告)日：2012-03-22
申请号：PCT/CN2011073277
申请日：2011-04-25
申请人： HUAWEI TECH CO LTD , ZHAO HU , LIU YONGHE , SUN YUAN , WANG WEI
发明人： ZHAO HU , LIU YONGHE , SUN YUAN , WANG WEI
IPC分类号： H04B1/74 , H04L12/24
CPC分类号： H04B1/74
摘要： The present invention discloses a master-standby switching method, system control unit and communication system. The method includes: a first system control unit transmits detection messages to an opposite network element according to a set detection period; when receiving a master-standby switching command, the first system control unit stops transmitting the detection messages, which makes a transmission link switching triggered because the first system control unit does not transmit the detection messages during a set timeout period; and at the same time, the first system control unit initiates a switching timer; and when detecting that the value of the switching timer reaches the switching timing value, the first system control unit performs a reset operation to implement the master-standby switching, wherein the switching timing value is greater than the timeout period. Before performing the reset operation for the master-standby switching, the system control unit in the present invention firstly stops, on its own initiative, transmitting the detection messages, delays stopping working for a period of time, until the transmission link switching is finished. Thus under the circumstance of the master-standby switching being performed, the packet loss of the service data messages can be reduced and the continuity and reliability of the service can be ensured.
摘要翻译：本发明公开了一种主备切换方法，系统控制单元和通信系统。该方法包括：第一系统控制单元根据设定的检测周期将检测消息发送给相对的网元; 当接收到主备切换命令时，第一系统控制单元停止发送检测消息，这使得由于第一系统控制单元在设置的超时期间不发送检测消息而触发传输链路切换; 并且同时第一系统控制单元启动切换定时器; 并且当检测到切换定时器的值达到切换定时值时，第一系统控制单元执行复位操作以实现主 - 备用切换，其中切换定时值大于超时周期。在执行主备切换的复位操作之前，本发明的系统控制单元首先首先停止发送检测消息，延迟停止工作一段时间，直到传输链路切换完成。因此，在进行主备切换的情况下，可以减少业务数据报文的丢包，保证业务的连续性和可靠性。

7. 发明申请

WO2010141113A3 NANO-MATERIAL AND METHOD OF FABRICATION 审中-公开
标题翻译：纳米材料和制造方法
公开(公告)号：WO2010141113A3
公开(公告)日：2011-02-24
申请号：PCT/US2010024121
申请日：2010-02-12
申请人： BABCOCK & WILCOX TECH SERV Y12 , UT BATTELLE LLC , MENCHHOFER PAUL A , SEALS ROLAND D , HOWE JANE Y , WANG WEI
发明人： MENCHHOFER PAUL A , SEALS ROLAND D , HOWE JANE Y , WANG WEI
IPC分类号： B82B1/00 , B82B3/00
CPC分类号： B01J23/755 , B01J23/745 , B01J23/75 , B82Y30/00 , C01B31/022 , C01B32/158 , Y10T428/298 , Y10T428/2991
摘要： A fluffy nano-material and method of manufacture are described. At 2000X magnification the fluffy nanomaterial has the appearance of raw, uncarded wool, with individual fiber lengths ranging from approximately four microns to twenty microns. Powder-based nanocatalysts are dispersed in the fluffy nanomaterial. The production of fluffy nanomaterial typically involves flowing about 125 cc/min of organic vapor at a pressure of about 400 torr over powder-based nano-catalysts for a period of time that may range from approximately thirty minutes to twenty-four hours.
摘要翻译：描述了蓬松的纳米材料和制造方法。在2000X放大倍数下，蓬松的纳米材料具有原始的未梳理羊毛的外观，单个纤维长度范围为约4微米至20微米。粉末状纳米催化剂分散在蓬松的纳米材料中。蓬松的纳米材料的生产通常涉及在大约400托的压力下将大约125cc /分钟的有机蒸气在粉末状纳米催化剂上流动约30分钟至24小时的时间。

8. 发明申请

WO2010141112A2 ANCHORED NANOSTRUCTURE MATERIALS AND METHOD OF FABRICATION 审中-公开
标题翻译：锚固的纳米结构材料和制造方法
公开(公告)号：WO2010141112A2
公开(公告)日：2010-12-09
申请号：PCT/US2010024098
申请日：2010-02-12
申请人： BABCOCK & WILCOX TECH SERV Y12 , UT BATTELLE LLC , SEALS ROLAND D , MENCHHOFER PAUL A , HOWE JANE Y , WANG WEI
发明人： SEALS ROLAND D , MENCHHOFER PAUL A , HOWE JANE Y , WANG WEI
IPC分类号： B82B1/00 , B82B3/00
CPC分类号： B01J2/006 , B01J21/08 , B01J23/745 , B01J31/0274 , B01J35/0013 , B01J35/006 , B01J37/0207 , B01J37/0209 , B01J37/033 , B01J37/18 , B22F1/025 , B82Y30/00 , B82Y40/00 , C01B32/15 , Y10T428/12181 , Y10T428/25 , Y10T428/2991 , Y10T428/2993
摘要： Anchored nanostructure materials and methods for their fabrication are described. The anchored nanostructure materials may utilize nano-catalysts that include powder-based or solid-based support materials. The support material may comprise metal, such as NiAl, ceramic, a cermet, or silicon or other metalloid. Typically, nanoparticles are disposed adjacent a surface of the support material. Nanostructures may be formed as anchored to nanoparticles that are adjacent the surface of the support material by heating the nano- catalysts and then exposing the nano-catalysts to an organic vapor. The nanostructures are typically single wall or multi-wall carbon nanotubes.
摘要翻译：描述了锚定的纳米结构材料及其制造方法。锚定的纳米结构材料可以使用包括基于粉末或固体的支撑材料的纳米催化剂。载体材料可以包括金属，例如NiAl，陶瓷，金属陶瓷或硅或其它准金属。通常，纳米颗粒邻近支撑材料的表面设置。纳米结构可以通过加热纳米催化剂然后将纳米催化剂暴露于有机蒸气而锚定在邻近载体材料表面的纳米颗粒上。纳米结构通常是单壁或多壁碳纳米管。

9. 发明申请

WO2008103483A3 MARINE ALKALOID MAKALUVAMINES AND DERIVATIVES THEREOF 审中-公开
标题翻译：海洋生物碱生物胺及其衍生物
公开(公告)号：WO2008103483A3
公开(公告)日：2008-11-27
申请号：PCT/US2008002419
申请日：2008-02-25
申请人： UAB RESEARCH FOUNDATION , VELU SADANANDAN E , RAISCH KEVIN P , WANG WEI , ZHANG RUIWEN
发明人： VELU SADANANDAN E , RAISCH KEVIN P , WANG WEI , ZHANG RUIWEN
IPC分类号： A61K31/70
CPC分类号： A61K31/4745 , C07D471/06
摘要： The present disclosure provides compounds based on the marine alkaloid makaluvamine. Described are compounds of the general formula (I) and (II). Also described are pharmaceutical compositions comprising one or more of the compounds of the general formula (I) and (II). The compounds and pharmaceutical compositions described inhibit the growth of several cancer lines, induce apoptosis and cell cycle arrest, display topoisomerase II inhibitory activity and modulate the activity and/or expression of key proteins involved in the regulation of cell growth. Methods of treatment and prevention using the compounds and pharmaceutical compositions described are also provided.
摘要翻译：本公开提供基于海洋生物碱麦卡洛芬的化合物。描述了通式（I）和（II）的化合物。还描述了包含一种或多种通式（I）和（II）的化合物的药物组合物。描述的化合物和药物组合物抑制几种癌细胞系的生长，诱导细胞凋亡和细胞周期停滞，显示拓扑异构酶II抑制活性并调节参与调节细胞生长的关键蛋白的活性和/或表达。还提供了使用所述化合物和药物组合物治疗和预防的方法。

10. 发明申请

WO2008003942A3 POWDER DELIVERY APPARATUS 审中-公开
标题翻译：粉末输送装置
公开(公告)号：WO2008003942A3
公开(公告)日：2008-10-09
申请号：PCT/GB2007002465
申请日：2007-07-02
申请人： UNIV MANCHESTER , LI LIN , WANG WEI , SYED WAHEED UL HAQ
发明人： LI LIN , WANG WEI , SYED WAHEED UL HAQ
IPC分类号： B05B7/14 , B05D1/12 , B05D3/04 , B05D3/06 , C23C24/00 , C23C24/10
CPC分类号： C23C24/10 , B05D1/12 , B05D3/0493 , B05D3/068 , C23C24/00
摘要： A direct radiation deposition apparatus comprising a feed conduit and a nozzle arranged to deliver powder to a substrate, and a radiation source arranged to simultaneously direct a radiation beam onto the substrate and thereby melt the powder, wherein the apparatus further comprises an actuator arranged to apply a vibration to the nozzle which causes powder to fall from the nozzle onto the substrate.
摘要翻译：一种直接辐射沉积设备，包括供给导管和布置成将粉末输送到基底的喷嘴，以及布置成将辐射束同时引导到基底上并由此熔化粉末的辐射源，其中该装置还包括致动器，向喷嘴施加振动，导致粉末从喷嘴落到基底上。

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