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    • 2. 发明申请
    • PROBE FOR DETECTING A PARTICULAR NUCLEIC ACID SEQUENCE
    • 用于检测特定核酸序列的探针
    • WO2008142571A3
    • 2009-03-12
    • PCT/IB2008002111
    • 2008-05-21
    • UNIV BERLIN HUMBOLDTSEITZ OLIVERGROSSMANN TOM NROEGLIN LARS
    • SEITZ OLIVERGROSSMANN TOM NROEGLIN LARS
    • C12Q1/68
    • C12Q1/6818C12Q1/6832C12Q2537/119C12Q2525/301
    • The invention relates to a detection molecule (triplex Molecular Beacon, tMB) for detecting a particular nucleic acid sequence, in particular for detecting a single nucleotide mismatch in a target nucleic acid. Such a detection molecule comprises a) an oligonucleotide, and b) a probe comprising a first stem forming portion with a fluorophore for generating a detection signal, a second stem forming portion with a quencher for quenching the detection signal from the fluorophore when the quencher is in proximity to the fluorophore, and a loop forming portion located between the first and the second stem forming portion, for allowing the first stem forming portion to form a stem structure together with the second stem forming portion of the probe and with the oligonucleotide. According to the invention, the oligonucleotide comprises a portion allowing it to form a triplex structure with the first and second stem forming portions of the probe.
    • 本发明涉及用于检测特定核酸序列的特异性检测分子(三重分子信标(triplex Molecular Beacon,tMB)),特别是用于检测目标核酸中的单核苷酸错配。 这样的检测分子包含:a)寡核苷酸,和b)包含具有产生检测信号的荧光团的第一茎形成部分的探针,当猝灭剂为猝灭剂时,具有猝灭剂的第二茎形成部分用于猝灭来自荧光团的检测信号 位于第一和第二茎形成部分之间的环形部分,用于允许第一茎形成部分与探针的第二茎形成部分和寡核苷酸一起形成茎结构。 根据本发明,寡核苷酸包括允许其与探针的第一和第二茎形成部分形成三重结构的部分。
    • 5. 发明申请
    • ARRANGEMENT AND METHOD FOR DISPLAYING DATA RELATING TO A HAND-HELD APPLIANCE USING AN APPLIANCE CONSOLE
    • 装置和方法对于代表手持设备相关数据与设备CONSOLE
    • WO2009153125A3
    • 2010-04-15
    • PCT/EP2009056167
    • 2009-05-20
    • BRAUER TIMRABENSDORF JANSEITZ OLIVER
    • BRAUER TIMRABENSDORF JANSEITZ OLIVER
    • G06F9/445
    • G06F8/60
    • The invention relates to an arrangement for displaying data relating to a hand-held appliance using an appliance console and at least one hand-held appliance coupled to the appliance console by means of a holding device. The processing unit is designed to display a record of data relating to a hand-held appliance removed from the holding device. The processing unit of the appliance console is also designed to generate a protocol message by means of removal processes and to transmit said message to a central computer used to provide a new record of data relating to hand-held appliances on the appliance console, on the basis of the protocol messages. The appliance console is designed to replace the previous record contained in the memory of the appliance console with the new record of data relating to hand-held appliances.
    • 用于显示在设备的控制台相关的手持设备数据以及与耦合到装置控制台手持装置的保持装置中的至少一个,其中,所述处理单元被适配为从所述保持装置的手持设备的数据线的集合,并且进一步形成在仪表盘的处理单元数据显示布局 是通过去除操作,以产生一个日志消息,并且提供用于传输到中央计算机,其被配置成提供基于所述协议消息一组新的手持设备特定的数据到设备的控制台,并且该装置控制台被配置成与一组新的手持设备特定的数据,以在存储器中的先前的 以替换位于设备支架组。