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1. 发明申请

WO2009055639A4 PERSONAL HEMODIALYSIS SYSTEM 审中-公开
标题翻译：个人血液透析系统
公开(公告)号：WO2009055639A4
公开(公告)日：2009-11-26
申请号：PCT/US2008081058
申请日：2008-10-24
申请人： BAXTER INT , BAXTER HEALTHCARE SA , CHILDERS ROBERT W , KELLY THOMAS D , ROGER RODOLFO
发明人： CHILDERS ROBERT W , KELLY THOMAS D , ROGER RODOLFO
IPC分类号： A61M1/16 , A61M1/28
CPC分类号： A61M1/1621 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1649 , A61M1/166 , A61M1/168 , A61M1/1686 , A61M1/1688 , A61M1/28 , A61M1/281 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3652 , A61M2205/128 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379 , A61M2205/6036 , B01D61/243 , B01D61/30 , Y10T29/49826 , Y10T137/0396 , Y10T137/87893
摘要： A dialysis machine includes a dialysis instrument having a pump actuator and first and second valve actuators, and a disposable cassette operable with the dialysis instrument, the disposable cassette including a pump portion operable with the pump actuator, first and second valve chambers (282, 284) operable with the first and second valve actuators, the first and second valve chambers communicating fluidly with each other, at least the first valve chamber communicating fluidly with a compliance chamber (286), the compliance chamber negating a first backpressure due to a pneumatic closing pressure used to close the first valve chamber to help to ensure the pneumatic pressure applied to the first valve chamber will close the first valve chamber against a second backpressure from an existing closure of the second valve chamber.
摘要翻译：透析机包括具有泵致动器和第一和第二阀致动器的透析仪器以及可与透析仪器一起操作的一次性盒，一次性盒包括可与泵致动器一起操作的泵部分，第一和第二阀室（282,284 ），所述第一和第二阀门腔室可与所述第一和第二阀门致动器一起操作，所述第一和第二阀门腔室彼此流体连通，至少所述第一阀门腔室与顺从性腔室（286）流体连通，所述顺从性腔室由于气动关闭而抵消第一背压压力用于关闭第一阀室以帮助确保施加到第一阀室的气动压力将关闭第一阀室，抵抗来自第二阀室的现有关闭的第二背压。

2. 发明申请

WO2009055639A3 PERSONAL HEMODIALYSIS SYSTEM 审中-公开
标题翻译：个人血液透析系统
公开(公告)号：WO2009055639A3
公开(公告)日：2009-07-23
申请号：PCT/US2008081058
申请日：2008-10-24
申请人： BAXTER INT , BAXTER HEALTHCARE SA , CHILDERS ROBERT W , KELLY THOMAS D , ROGER RODOLFO
发明人： CHILDERS ROBERT W , KELLY THOMAS D , ROGER RODOLFO
IPC分类号： A61M1/16 , A61M1/28
CPC分类号： A61M1/1621 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1649 , A61M1/166 , A61M1/168 , A61M1/1686 , A61M1/1688 , A61M1/28 , A61M1/281 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3652 , A61M2205/128 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379 , A61M2205/6036 , B01D61/243 , B01D61/30 , Y10T29/49826 , Y10T137/0396 , Y10T137/87893
摘要： A dialysis machine includes a dialysis instrument having a pump actuator and first and second valve actuators, and a disposable cassette operable with the dialysis instrument, the disposable cassette including a pump portion operable with the pump actuator, first and second valve chambers (282, 284) operable with the first and second valve actuators, the first and second valve chambers communicating fluidly with each other, at least the first valve chamber communicating fluidly with a compliance chamber (286), the compliance chamber negating a first backpressure due to a pneumatic closing pressure used to close the first valve chamber to help to ensure the pneumatic pressure applied to the first valve chamber will close the first valve chamber against a second backpressure from an existing closure of the second valve chamber.
摘要翻译：透析机包括具有泵致动器和第一和第二阀致动器的透析器，以及可与透析器一起操作的一次性盒，一次性盒包括可与泵致动器一起操作的泵部分，第一和第二阀室（282,284 可操作的第一和第二阀致动器，所述第一和第二阀室彼此流动连通，至少所述第一阀室与顺应性腔室（286）流体连通，所述柔量室由于气动闭合而抵消第一背压用于关闭第一阀室的压力以帮助确保施加到第一阀室的气动压力将相对于来自第二阀室的现有封闭件的第二背压而关闭第一阀室。

3. 发明申请

WO2009061608A4 BALANCED FLOW DIALYSIS MACHINE 审中-公开
标题翻译：平衡流量分析机
公开(公告)号：WO2009061608A4
公开(公告)日：2009-07-09
申请号：PCT/US2008080673
申请日：2008-10-22
申请人： BAXTER INT , BAXTER HEALTHCARE SA , HOGARD MICHAEL E , BUSBY DONALD D , CHILDERS ROBERT W , DING YUANPANG S , HOLIAN KATHERINE M , JABLONSKI MARK E , KELLY THOMAS D , LO YING-CHENG , MALIEKKAL SHINCY J , ROGER RODOLFO G , SMITH DONALD A , YARDIMCI ATIF M
发明人： HOGARD MICHAEL E , BUSBY DONALD D , CHILDERS ROBERT W , DING YUANPANG S , HOLIAN KATHERINE M , JABLONSKI MARK E , KELLY THOMAS D , LO YING-CHENG , MALIEKKAL SHINCY J , ROGER RODOLFO G , SMITH DONALD A , YARDIMCI ATIF M
IPC分类号： A61M1/16 , A61M1/28 , A61M1/34
CPC分类号： A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1635 , A61M1/166 , A61M1/1696 , A61M1/28 , A61M1/284 , A61M1/288 , A61M1/341 , A61M1/3413 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3444 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M2205/12 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3393
摘要： A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.
摘要翻译：公开了一种用于平衡肾替代液体流动的系统和方法。该方法使用压力控制和压力感测装置来更精确地计量和平衡新鲜透析液和用过的透析液的流动。平衡系统可以使用一个或两个平衡装置，例如平衡管，曲折路径或平衡室。

4. 发明申请

WO2005044339A3 HIGH CONVECTION HOME HEMODIALYSIS/HEMOFILTRATION AND SORBENT SYSTEM 审中-公开
标题翻译：高对流主页肝细胞分析/ HEMOFILTRATION和SORBENT系统
公开(公告)号：WO2005044339A3
公开(公告)日：2005-08-11
申请号：PCT/US2004037053
申请日：2004-11-05
申请人： BAXTER INT , BAXTER HEALTHCARE SA , KELLY THOMAS D , CHILDERS ROBERT W , BUSBY DON , ROGER RODOLFO , EL SAYYID WALEED MUTASEM , DIN SHAHID Q
发明人： KELLY THOMAS D , CHILDERS ROBERT W , BUSBY DON , ROGER RODOLFO , EL SAYYID WALEED MUTASEM , DIN SHAHID Q
IPC分类号： A61M1/16 , A61M1/34 , B01D61/58
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers (20, 30) are connected in series. A restriction (40) is placed between the two dialyzers in the dialysate flow path (962). The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.
摘要翻译：提供了一种用于进行肾脏替代疗法的系统，方法和装置。在一个实施例中，两个小型高通量透析器（20,30）串联连接。在透析液流路（962）中的两个透析器之间设置限制（40）。在一个优选实施例中，限制是可变的和可调节的。限制在静脉透析器中产生正压，导致高度有意的反渗透。该回流导致透析液通过高通量静脉膜直接流入患者血液中。随后从动脉透析器将患者的过滤后的溶液进行超滤。透析液扩散到静脉过滤器中，从动脉透析器中除去透析液会导致患者的毒素对流运输。另外，透析液不直接扩散到患者体内，而是穿过两个透析器的膜，从而提供废物的扩散清除。

5. 发明申请

WO2008033788A2 MEDICAL FLUID SYSTEM WITH FLEXIBLE SHEETING DISPOSABLE UNIT 审中-公开
标题翻译：医疗流体系统灵活的一次性使用一次性单元
公开(公告)号：WO2008033788A2
公开(公告)日：2008-03-20
申请号：PCT/US2007078089
申请日：2007-09-11
申请人： BAXTER INT , BAXTER HEALTHCARE SA , YING-CHENG LO , CHILDERS ROBERT W , KELLY THOMAS D , ROHDE JUSTIN
发明人： YING-CHENG LO , CHILDERS ROBERT W , KELLY THOMAS D , ROHDE JUSTIN
IPC分类号： A61M1/28 , A61M1/16 , A61M1/34
CPC分类号： A61M1/1639 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1635 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/34 , A61M1/3627 , A61M2205/127 , A61M2205/3331 , A61M2205/3368 , A61M2205/502 , Y10T29/49826
摘要： A kidney failure therapy system includes: (a) a dialysate supply; (b) at least one valve actuator; (c) at least one pump actuator; and (d) a disposable unit including first and second flexible sheets sealed together for form: (i) at least one flow path configured to be placed in fluid communication with the dialysate supply; and operable with the at least one valve actuator; and (ii) a least one pumping portion configured to operate with the at least one pump actuator.
摘要翻译：肾衰竭治疗系统包括：（a）透析液供应; （b）至少一个阀致动器; （c）至少一个泵致动器; （d）一次性单元，所述一次性单元包括密封在一起以形成以下形式的第一和第二柔性片材：（i）至少一个流动路径，所述至少一个流动路径被配置为与透析液供应源流体连通; 并且与所述至少一个阀致动器一起操作; 和（ii）至少一个泵送部分，其构造成与所述至少一个泵致动器一起操作。

6. 发明申请

WO2007143497A2 DYNAMIC WEIGHT BALANCING OF FLOW IN KIDNEY FAILURE TREATMENT SYSTEMS 审中-公开
标题翻译： KIDNEY失败治疗系统动态平衡动态平衡
公开(公告)号：WO2007143497A2
公开(公告)日：2007-12-13
申请号：PCT/US2007070074
申请日：2007-05-31
申请人： BAXTER INT , BAXTER HEALTHCARE SA , ROGER RODOLFO G , HOGARD MICHAEL E , KELLY THOMAS D
发明人： ROGER RODOLFO G , HOGARD MICHAEL E , KELLY THOMAS D
IPC分类号： A61M1/14 , A61M1/16
CPC分类号： A61M1/16 , A61M1/14 , A61M1/1605 , A61M1/1613 , A61M1/28 , A61M1/284 , A61M1/341 , A61M2205/3334 , A61M2205/3393
摘要： A kidney failure treatment system includes: (i) a dialysate supply; (ii) a weighing device; a control container coupled operably to the weighing device; (iii) a diffusion membrane; (iv) a drain; first and second pumps; (v) a first fluid conduit coupled fluidly to the dialysate supply and the diffusion membrane, the first fluid conduit coupled operably to the first pump; (vi) a second fluid conduit coupled fluidly to the control container and the drain, the second fluid conduit coupled operably to the first pump; and (vii) a third fluid conduit coupled fluidly to the diffusion membrane and the control conduit, the third fluid conduit coupled operably to the second pump.
摘要翻译：肾衰竭治疗系统包括：（i）透析液供应; （ii）称重装置; 可操作地连接到称重装置的控制容器; （iii）扩散膜; （iv）排水; 第一和第二泵; （v）流体地连接到透析液供应源和扩散膜的第一流体导管，第一流体导管可操作地连接到第一泵; （vi）流体地连接到所述控制容器和所述排水口的第二流体管道，所述第二流体管道可操作地连接到所述第一泵; 和（vii）与所述扩散膜和所述控制管道流体连接的第三流体管道，所述第三流体管道可操作地连接到所述第二泵。

7. 发明申请

WO2005061026A3 MEDICAL FLUID THERAPY FLOW CONTROL SYSTEMS AND METHODS 审中-公开
标题翻译：医用流体治疗流量控制系统及方法
公开(公告)号：WO2005061026A3
公开(公告)日：2005-12-15
申请号：PCT/US2004040145
申请日：2004-12-01
申请人： BAXTER INT , BAXTER HEALTHCARE SA , KELLY THOMAS D , EL SAYYID WALEED M
发明人： KELLY THOMAS D , EL SAYYID WALEED M
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36
CPC分类号： A61M1/3462 , A61M1/1601 , A61M1/1635 , A61M1/1672 , A61M1/30 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3434 , A61M1/3437 , A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649 , A61M2205/3303 , A61M2205/3306 , A61M2205/50 , A61M2205/7518
摘要： Systems and methods for improving medical fluid delivery systems, such as hemofiltration ("HF") and hemodiafiltration ("HDF") are provided. In first embodiments, systems and methods for selectively performing pre-and postdilution HF and HDF clearance modes is provided. In other embodiments, systems and methods for providing prime bolus and rinseback fluid volumes before, during and/or after HF and HDF therapies are provided. In further embodiments, improved systems and methods for removing ultrafiltrate from the patient are provided. Still further, improved filtration configurations and methods are provided.
摘要翻译：提供了用于改善医疗流体递送系统的系统和方法，例如血液滤过（“HF”）和血液透析滤过（“HDF”）。在第一实施例中，提供用于选择性地执行前后稀释HF和HDF清除模式的系统和方法。在其它实施方案中，提供在HF和HDF治疗之前，期间和/或之后提供初次推注和冲洗液体体积的系统和方法。在另外的实施例中，提供了用于从患者去除超滤液的改进的系统和方法。此外，提供了改进的过滤构造和方法。

8. 发明申请

WO2013028809A3 DUAL FLOW SORBENT CARTRIDGE 审中-公开
标题翻译：双流SORBENT CARTRIDGE
公开(公告)号：WO2013028809A3
公开(公告)日：2013-05-16
申请号：PCT/US2012051946
申请日：2012-08-22
申请人： MEDTRONIC INC , KELLY THOMAS D , LYU SUPING
发明人： KELLY THOMAS D , LYU SUPING
IPC分类号： A61M1/34 , A61J1/06 , A61M1/10 , A61M1/14
CPC分类号： A61M1/1696 , A61M1/16 , A61M1/3609 , A61M2205/15 , A61M2205/3313 , A61M2205/3317 , A61M2205/50 , A61M2205/75 , A61M2209/082 , A61M2230/65 , B01D15/00 , B01D15/02 , B01D2313/44 , B01J20/0211 , B01J20/0292 , B01J20/20 , B01J20/24 , B01J2220/62
摘要： Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制部件，具有至少两个分开的流动路径的吸附剂药筒，以及被配置为具有适于穿戴或携带的重量和尺寸的流体储存器需要治疗的个体。用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。透析电路和用于循环血液的体外循环通过透析膜流体连通。在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

9. 发明申请

WO2013040082A3 POLYSTYRENE SULFONATE RESIN FOR USE WITH A HEMODIALYSIS SYSTEM HAVING A CONTROLLED COMPLIANCE DIALYSIS CIRCUIT 审中-公开
标题翻译：聚苯乙烯磺酸盐树脂，用于具有可控顺应性分析回路的血液透析系统
公开(公告)号：WO2013040082A3
公开(公告)日：2013-05-10
申请号：PCT/US2012054930
申请日：2012-09-12
申请人： MEDTRONIC INC , KELLY THOMAS D , LYU SUPING
发明人： KELLY THOMAS D , LYU SUPING
IPC分类号： A61M1/14 , A61M1/10 , A61M1/38
CPC分类号： A61M1/3621 , A61M1/1696
摘要： Sorbent cartridges having a polystyrene sulfonate resin saturated with calcium ions for the performance of kidney replacement therapy are disclosed. Systems and methods having or using a sorbent cartridge, a dialyzer, control components, a cartridge having a polystyrene sulfonate resin, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. A system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了具有用钙离子饱和的聚苯乙烯磺酸盐树脂进行肾脏替代治疗的吸附剂药筒。公开了具有或使用吸附剂盒，透析器，控制组件，具有聚苯乙烯磺酸盐树脂的盒和配置为适于由需要治疗的个体穿戴或携带的重量和尺寸的流体储存器的系统和方法。用于进行肾脏替代治疗的系统具有受控的依从性透析回路，其中控制泵控制流体穿过透析膜的双向运动。该系统提供了对吸附剂筒的入口和出口电导率的监测，以量化或监测吸附剂筒的尿素去除。

10. 发明申请

WO2013019994A3 HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME 审中-公开
标题翻译：具有控制合格体积的流路的血液透析系统
公开(公告)号：WO2013019994A3
公开(公告)日：2013-04-25
申请号：PCT/US2012049398
申请日：2012-08-02
申请人： MEDTRONIC INC , KELLY THOMAS D , LYU SUPING , PUDIL BRYANT J , MEYER THOMAS E
发明人： KELLY THOMAS D , LYU SUPING , PUDIL BRYANT J , MEYER THOMAS E
IPC分类号： A61M1/34 , A61M1/16 , A61M1/38
CPC分类号： A61M1/3482 , A61M1/1696 , A61M2202/0021 , A61M2202/0413
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。透析电路和用于循环血液的体外循环通过透析膜流体连通。在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

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