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1. 发明申请

WO2010071894A2 TFPI INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： TFPI抑制剂及其使用方法
公开(公告)号：WO2010071894A2
公开(公告)日：2010-06-24
申请号：PCT/US2009069060
申请日：2009-12-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA , 3B PHARMACEUTICALS GMBH , COSMIX MOLECULAR BIOLOG GMBH , DOCKAL MICHAEL , EHRLICH HARTMUT , SCHEIFLINGER FRIEDRICH , REIMER ULF , REINEKE ULRICH , POLAKOWSKI THOMAS , SCHNEIDER EBERHARD
发明人： DOCKAL MICHAEL , EHRLICH HARTMUT , SCHEIFLINGER FRIEDRICH , REIMER ULF , REINEKE ULRICH , POLAKOWSKI THOMAS , SCHNEIDER EBERHARD
IPC分类号： A61K38/10 , A61P7/02 , C07K7/08
CPC分类号： C07K14/4703 , A61K38/00 , A61K47/551 , A61K47/557 , A61K47/60 , C07K7/08 , C07K14/001
摘要： The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject.
摘要翻译：本发明提供了结合组织因子途径抑制剂（TFPI）（包括TFPI抑制肽）及其组合物的肽。肽可以用于抑制TFPI，增强凝血因子缺陷受试者中的凝血酶形成，增加受试者中的血块形成和/或治疗受试者的血液凝固障碍。

2. 发明申请

WO2011115712A8 TFPI INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： TFPI抑制剂及其使用方法
公开(公告)号：WO2011115712A8
公开(公告)日：2013-10-10
申请号：PCT/US2011024604
申请日：2011-02-11
申请人： BAXTER INT , BAXTER HEALTHCARE SA , DOCKAL MICHAEL , HARTMANN RUDOLF , FRIES MARKUS , SCHEIFLINGER FRIEDRICH , EHRLICH HARTMUT , REINEKE ULRICH , OSTERKAMP FRANK , POLAKOWSKI THOMAS
发明人： DOCKAL MICHAEL , HARTMANN RUDOLF , FRIES MARKUS , SCHEIFLINGER FRIEDRICH , EHRLICH HARTMUT , REINEKE ULRICH , OSTERKAMP FRANK , POLAKOWSKI THOMAS
IPC分类号： A61K38/18 , A61K38/16 , C40B40/10
CPC分类号： A61K38/10 , A61K38/00 , A61K2121/00 , C07K1/14 , C07K7/08 , C07K14/00 , C07K14/8114 , G01N33/68 , G01N2333/745 , G01N2333/8114 , G01N2333/96444 , G01N2333/96447 , G01N2500/02 , G01N2500/04 , G01N2500/20 , G06F19/16 , G06F19/18
摘要： The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
摘要翻译：本发明提供了结合组织因子途径抑制剂（TFPI）（包括TFPI抑制肽）及其组合物的肽。肽可以用于抑制TFPI，增强凝血因子缺陷的受试者中的凝血酶形成，增加受试者的血块形成，治疗受试者的血液凝固障碍，纯化TFPI和鉴定TFPI结合化合物。

3. 发明申请

WO2011115712A3 TFPI INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： TFPI抑制剂和使用方法
公开(公告)号：WO2011115712A3
公开(公告)日：2011-11-24
申请号：PCT/US2011024604
申请日：2011-02-11
申请人： BAXTER INT , BAXTER HEAL THCARE S A , DOCKAL MICHAEL , HARTMANN RUDOLF , FRIES MARKUS , SCHEIFLINGER FRIEDRICH , EHRLICH HARTMUT , REINEKE ULRICH , OSTERKAMP FRANK , POLAKOWSKI THOMAS
发明人： DOCKAL MICHAEL , HARTMANN RUDOLF , FRIES MARKUS , SCHEIFLINGER FRIEDRICH , EHRLICH HARTMUT , REINEKE ULRICH , OSTERKAMP FRANK , POLAKOWSKI THOMAS
IPC分类号： A61K38/18 , A61K38/16 , C40B40/10
CPC分类号： A61K38/10 , A61K38/00 , A61K2121/00 , C07K1/14 , C07K7/08 , C07K14/00 , C07K14/8114 , G01N33/68 , G01N2333/745 , G01N2333/8114 , G01N2333/96444 , G01N2333/96447 , G01N2500/02 , G01N2500/04 , G01N2500/20 , G06F19/16 , G06F19/18
摘要： The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
摘要翻译：本发明提供了结合组织因子途径抑制剂（TFPI）的肽，包括TFPI抑制肽及其组合物。所述肽可用于抑制TFPI，增强凝血因子缺陷受试者中的凝血酶形成，增加受试者的血块形成，治疗受试者中的凝血障碍，纯化TFPI并鉴定TFPI结合化合物。

4. 发明申请

WO0125449A2 NOVEL IMMOBILIZABLE AMYLOSUCRASE, THE USE THEREOF AND METHOD FOR PRODUCING POLY(1,4-ALPHA-GLUCAN) 审中-公开
标题翻译：新的可固定的淀粉蔗糖及其保利生产用途和方法（1,4-α-葡聚糖）
公开(公告)号：WO0125449A2
公开(公告)日：2001-04-12
申请号：PCT/EP0009695
申请日：2000-10-04
申请人： AXIVA GMBH , BENGS HOLGER , POLAKOWSKI THOMAS , HELD ANJA , GALLERT KARL CHRISTIAN
发明人： BENGS HOLGER , POLAKOWSKI THOMAS , HELD ANJA , GALLERT KARL-CHRISTIAN
IPC分类号： C12N9/10 , C12N11/06 , C12N15/54 , C12P19/18 , C12N15/62 , C12P19/04
CPC分类号： C12N9/1051 , C07K2319/00 , C12N11/06 , C12P19/18 , C12Y204/01004
摘要： The invention relates to a novel biotechnical continuous method for producing linear poly(1,4-alpha-glucan), whereby the poly(1,4-glucan) is produced as a solid in a modified biotransformation by using immobilized fusion proteins which have an amylosucrase activity.
摘要翻译：本发明涉及一种新的生物技术连续方法通过包括Amylosucrasektivität保持聚固定化的融合蛋白的手段制备线性聚（1,4-α-D-葡聚糖）的，在改进的生物转化（1,4-葡聚糖）被回收，为固体。

5. 发明申请

WO0125449A9 NOVEL IMMOBILIZABLE AMYLOSUCRASE, THE USE THEREOF AND METHOD FOR PRODUCING POLY(1,4-ALPHA-GLUCAN) 审中-公开
标题翻译：新的可固定的淀粉蔗糖及其保利生产用途和方法（1,4-α-葡聚糖）
公开(公告)号：WO0125449A9
公开(公告)日：2002-09-06
申请号：PCT/EP0009695
申请日：2000-10-04
申请人： CELANESE VENTURES GMBH , BENGS HOLGER , POLAKOWSKI THOMAS , HELD ANJA , GALLERT KARL-CHRISTIAN
发明人： BENGS HOLGER , POLAKOWSKI THOMAS , HELD ANJA , GALLERT KARL-CHRISTIAN
IPC分类号： C12N9/10 , C12N11/06 , C12N15/54 , C12P19/18 , C12N15/62 , C12P19/04
CPC分类号： C12N9/1051 , C07K2319/00 , C12N11/06 , C12P19/18 , C12Y204/01004
摘要： The invention relates to a novel biotechnical continuous method for producing linear poly(1,4-alpha-glucan), whereby the poly(1,4-glucan) is produced as a solid in a modified biotransformation by using immobilized fusion proteins which have an amylosucrase activity.
摘要翻译：本发明涉及一种新的生物技术连续方法通过包括Amylosucrasektivität保持聚固定化的融合蛋白的手段制备线性聚（1,4-α-D-葡聚糖）的，在改进的生物转化（1,4-葡聚糖）被回收，为固体。

6. 发明申请

WO2005010030A2 C5A RECEPTOR ANTAGONISTS 审中-公开
标题翻译： C5a受体拮抗剂
公开(公告)号：WO2005010030A2
公开(公告)日：2005-02-03
申请号：PCT/EP2004008057
申请日：2004-07-19
申请人： JERINI AG , HUMMEL GERD , LOCARDI ELSA , POLAKOWSKI THOMAS , SCHARN DIRK , SCHNATBAUM KARSTEN
发明人： HUMMEL GERD , LOCARDI ELSA , POLAKOWSKI THOMAS , SCHARN DIRK , SCHNATBAUM KARSTEN
IPC分类号： A61K38/00 , C07K7/06 , C07K7/50 , C07K7/56 , C07K14/47 , C07K14/705 , C07K7/00
CPC分类号： C07K7/56 , C07K14/705
摘要： The invention relates to a C5a receptor antagonist of structure (I), wherein X1 is a radical having a mass of about 1-300 and stands for R5-, R5-CO-, R5-N(R6)-CO-, R5-O-CO-, R5-SO2-, R5-N(R6)-SO2-, R5-N(R6)-, R5-N(R6)-CS-, R5-N(R6)-C(NH)-, R5-CS-, R5-P(O)OH-, R5-B(OH)- or R5-CH=N-O-CH2-CO-, wherein R5/R6 represent H, F, hydroxy, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, acyl, substituted acyl, alkoxy, alkoxyalkyl, substituted alkoxyalkyl, aryloxyalkyl or substituted aryloxyalkyl; X2 = radical (biological bonding properties of a mimicrying phenylalanine unit); X3/X4 = spacer (amino acids, amino-acid analogs and amino-acid derivatives); X5 = radical (biological bonding properties of a mimicrying cyclohexylalanine or homoleucine unit); X6 = radical (biological bonding properties of a mimicrying tryptophan unit); X7 = radical (biological bonding properties of a mimicrying norleucine or phenylalanine unit), a chemical bond being formed between X3 and X7.
摘要翻译： C5a受体拮抗剂，其具有结构（I），其中X为基团具有约1-300的质量，并且其中X 1是R 5 - ，R 5 -CO-，R 5-N（R6）-CO-，R5-O -CO-，R 5 -SO 2 - ，R 5-N（R 6）-SO 2 - ，R 5-N（R6） - ，R 5-N（R6） - CS-，R5-N（R 6）-C（NH） - ， - R5-CS-，R5-P（O）OH-，R 5-B（OH） - ，或R 5-CH = NO-CH 2 CO-，其中R 5 / R 6是H，F，羟基，烷基，取代的烷基，环烷基，取代环烷基，杂环基，取代的杂环基，芳基烷基，取代芳烷基，芳基，取代芳基，杂芳基，取代的杂芳基，酰基，取代酰基，烷氧基，烷氧基烷基，取代的烷氧基烷基，芳氧基烷基或取代的芳氧基，X2 =自由基（生物结合苯丙氨酸的特征部分mimikrierend），X3 / X4 =间隔（氨基酸，氨基酸类似物和氨基酸衍生物），X5 =自由基（生物结合的Cyclohexylalanin-或高亮氨酸单元mimikrierend的特性），X6 =自由基（生物结合色氨酸Einhe的特征它mimikrierend），X7 =正亮氨酸或苯丙氨酸单元mimikrierend的自由基（生物结合特征，一个化学键X3和X7）之间形成。

7. 发明申请

WO0204656A2 BIO-PROBES AND USE THEREOF 审中-公开
标题翻译： BIOSOND及其用途
公开(公告)号：WO0204656A2
公开(公告)日：2002-01-17
申请号：PCT/EP0107259
申请日：2001-06-26
申请人： XZILLION GMBH & CO KG , WAGNER PETER , POLAKOWSKI THOMAS
发明人： WAGNER PETER , POLAKOWSKI THOMAS
IPC分类号： G01N33/483 , B03C5/00 , C12N15/09 , C12Q1/68 , G01N27/447 , G01N33/53 , G01N33/566 , G01N37/00 , C12Q1/00
CPC分类号： G01N27/44726 , B03C5/005 , C12Q1/6806 , C12Q1/6813
摘要： The invention relates to the application of bio-probes which bind specifically to biological material and thus permit the detection and/or separation of the material so marked from an environment of similar biological material, by means of electrophoresis or dielectrophoresis. Said bio-probes are characterised in that they alter the electrical and/or dielectric properties of the biological material.
摘要翻译：本发明涉及生物传感器在生物传感器中的应用，所述生物传感器与生物材料特异性结合，从而能够通过电泳或介电电泳从类似于环境的生物材料中检测和/或分离由此标记的材料。生物传感器的特征在于它们改变生物材料的电和/或介电性质。

8. 发明申请

WO0212553A3 METHOD FOR DETECTING MUTATIONS IN NUCLEOTIDE SEQUENCES 审中-公开
标题翻译：法突变的核苷酸序列检测
公开(公告)号：WO0212553A3
公开(公告)日：2003-01-30
申请号：PCT/EP0108127
申请日：2001-07-13
申请人： NANOGEN RECOGNOMICS GMBH , KAPPEL ANDREAS , POLAKOWSKI THOMAS , PIGNOT MARC , WINDHAB NORBERT , BEHRENSDORF HEIKE , MUTH JOCHEN
发明人： KAPPEL ANDREAS , POLAKOWSKI THOMAS , PIGNOT MARC , WINDHAB NORBERT , BEHRENSDORF HEIKE , MUTH JOCHEN
IPC分类号： G01N33/53 , B01J19/00 , C07H21/00 , C07K14/195 , C07K14/245 , C12N9/00 , C12N15/09 , C12N15/52 , C12Q20060101 , C12Q1/25 , C12Q1/34 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention relates to a method for simultaneously detecting mutations in different nucleotide sequences and for determining the transcription rate of mutated and non-mutated nucleotide sequences. The inventive method comprises the following steps: hybridizing single-stranded sample nucleotide sequences to single-stranded reference nucleotide sequences, fixating, before or during hybridization, single-stranded reference nucleotide sequences or single-stranded sample nucleotide sequences, or fixating, after or during hybridization, heteroduplices from reference and sample nucleotide sequences on an electronically addressable surface, incubating them with a substrate that recognizes heteroduplex mismatches, and detecting the substrate bonds.
摘要翻译：本发明涉及一种方法，突变可以在与各种核苷酸序列并行地检测到，毗邻允许突变和未突变的核苷酸序列的转录速率的测定方法。该方法包括用固定的单参考核苷酸序列或单样本的核苷酸序列的单链参考核苷酸序列的单样品核苷酸序列的杂交的步骤之前或之后或在杂交到一个过程中的杂交或异源双链从参考和样品的核苷酸序列中电子可寻址表面，孵育异源双链体不匹配识别衬底键的底物和检测。

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