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1. 发明申请

WO2007038127A1 METHOD AND APPARATUS FOR HIGH-ORDER DIFFERENTIAL ION MOBILITY SEPARATIONS 审中-公开
标题翻译：用于高阶差分离子移动分离的方法和装置
公开(公告)号：WO2007038127A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/036633
申请日：2006-09-20
申请人： BATTELLE MEMORIAL INSTITUTE , SHVARTSBURG, Alexandre, A. , SMITH, Richard, D. , ANDERSON, Gordon, A.
发明人： SHVARTSBURG, Alexandre, A. , SMITH, Richard, D. , ANDERSON, Gordon, A.
IPC分类号： G01N27/64
CPC分类号： G01N27/624
摘要： The present invention relates generally to separation of ions based on their transport properties. More particularly, the invention relates to separation of ionic mixtures and characterization of ions in gases using higher-order differential ion mobility spectrometry (HODIMS) enabled by asymmetric waveforms of fundamentally new types. The invention discloses a method and apparatus for separation of ionic mixtures and characterization, identification, or quantification of ions in a gas based substantially on the terms of third or higher order in a series expansion of ion mobility as a function of electric field intensity. This is achieved using a periodic, time-dependent electric field with novel waveform profiles that cancel or substantially reduce the contributions to time-averaged ion motion of the leading n (where n ≥ 2) terms of that expansion, thereby achieving ion separations based substantially on the ( n + 1 )th term. Separations using HODIMS with different n are expected to be highly orthogonal, enabling multidimensional separations employing HODIMS analyzers of different orders. The expected high orthogonality between HODIMS and mass spectrometry or ion mobility spectrometry would make HODIMS/MS and HODIMS/IMS combinations powerful analytical tools of broad utility.
摘要翻译：本发明一般涉及基于它们的运输特性分离离子。更具体地，本发明涉及离子混合物的分离和使用通过基本上新型的不对称波形实现的高阶差分离子迁移谱（HODIMS）的气体中的离子表征。本发明公开了一种用于分离离子混合物的方法和装置，并且基于离子迁移率的串联扩展作为电场强度的函数，基本上以三阶或更高阶的项为基础来表征，鉴定或定量气体中的离子。这是使用具有新颖波形分布的周期性，时间依赖性电场来实现的，其消除或基本上减少对该扩展的前导n（其中n = 2）项的时间平均离子运动的贡献，从而实现基本上基于离子分离在第（n + 1）项。使用具有不同n的HODIMS的分离预计将具有高度正交性，可以使用具有不同阶数的HODIMS分析仪进行多维分离。 HODIMS和质谱法或离子迁移光谱法之间预期的高正交性将使HODIMS / MS和HODIMS / IMS组合成为强大的广泛应用的分析工具。

2. 发明申请

WO2006105464A1 METHOD AND APPARATUS FOR ION MOBILITY SPECTROMETRY WITH ALIGNMENT OF DIPOLE DIRECTION (IMS-ADD) 审中-公开
标题翻译：用于离子交换光谱的方法和装置（IMS-ADD）
公开(公告)号：WO2006105464A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/012149
申请日：2006-03-30
申请人： BATTELLE MEMORIAL INSTITUTE , SHVARTSBURG, Alexandre, A. , TANG, Keqi , SMITH, Richard, D.
发明人： SHVARTSBURG, Alexandre, A. , TANG, Keqi , SMITH, Richard, D.
IPC分类号： G01N27/64 , H01J49/40
CPC分类号： G01N27/624 , H01J49/004 , H01J49/40
摘要： Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that "locks" the ion dipoles with moments exceeding a certain value^ That value depends on the buffer gas composition, pressure, and temperature, but may be as low as ~ 3 Debye under certain conditions. The presently disclosed method measures the direction- specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.
摘要翻译：描述了用于分析物质的技术和仪器，包括在表征单个组分之前需要分离的复杂样品/混合物。公开了用于分离离子混合物和鉴定离子的方法，包括蛋白质和其它大分子离子及其不同的结构异构体。分离离子在分离期间不能自由旋转，而是基本上相对于漂移方向取向。通过以特定的角度对漂移场施加更强的交变电场来实现对准，该交变电场以超过一定值的力“锁定”离子偶极子。该值取决于缓冲气体组成，压力和温度，但是在某些条件下可能低至〜3德拜。目前公开的方法测量提供与已知方法获得的结构信息互补的方向特异性横截面，并且当与这些方法耦合时，增加气相分离的总峰容量和特异性。沿垂直于离子偶极方向的方向特定横截面同时进行2-D分离也是可能的。

3. 发明申请

WO2005045876A2 IMPROVED HIGH PERFORMANCE ION MOBILITY SPECTROMETRY USING HOURGLASS ELECTRODYNAMIC FUNNEL AND INTERNAL ION FUNNEL 审中-公开
标题翻译：使用HOURGLASS电动飞行器和内部飞机的改进的高性能离子运动光谱
公开(公告)号：WO2005045876A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/029181
申请日：2004-09-07
申请人： BATTELLE MEMORIAL INSTITUTE , SMITH, Richard, D. , TANG, Keqi , SHVARTSBURG, Alexandre, A.
发明人： SMITH, Richard, D. , TANG, Keqi , SHVARTSBURG, Alexandre, A.
IPC分类号： H01J49/04
CPC分类号： H01J49/066 , G01N27/622 , H01J49/40
摘要： A method and apparatus enabling increased sensitivity in ion mobility spectrometry/mass spectrometry instruments which substantially reduces or eliminates the loss of ions in ion mobility spectrometer drift tubes utilizing a device for transmitting ions from an ion source which allows the transmission of ions without significant delay to an hourglass electrodynamic ion funnel at the entrance to the drift tube and/or an internal ion funnel at the exit of the drift tube. An hourglass electrodynamic funnel is formed of at least an entry element, a center element, and an exit element, wherein the aperture of the center element is smaller than the aperture of the entry element and the aperture of the exit elements. Ions generated in a relatively high pressure region by an ion source at the exterior of the hourglass electrodynamic funnel are transmitted to a relatively low pressure region at the entrance of the hourglass funnel through a conductance limiting orifice. Alternating and direct electrical potentials are applied to the elements of the hourglass electrodynamic funnel thereby drawing ions into and through the hourglass electrodynamic funnel thereby introducing relatively large quantities of ions into the drift tube while maintaining the gas pressure and composition at the interior of the drift tube as distinct from those at the entrance of the electrodynamic funnel and allowing a positive gas pressure to be maintained within the drift tube, if desired. An internal ion funnel is provided within the drift tube and is positioned at the exit of said drift tube. The advantage of the internal ion funnel is that ions that are dispersed away from the exit aperture within the drift tube, such as those that are typically lost in conventional drift tubes to any subsequent analysis or measurement, are instead directed through the exit of the drift tube, vastly increasing the amount of ions exiting the drift tube.
摘要翻译：一种能够提高离子迁移光谱/质谱仪器灵敏度的方法和装置，其基本上减少或消除了离子迁移谱仪漂移管中的离子损失，其利用离子源传输离子的装置，离子源允许离子传输而不会显着延迟漂移管入口处的沙漏电动力离子漏斗和/或漂移管出口处的内部离子漏斗。沙漏电动漏斗由至少一个入口元件，中心元件和出口元件形成，其中中心元件的孔径小于入口元件的孔径和出口元件的孔径。在沙漏电动漏斗的外部由离子源在较高压力区域产生的离子通过电导限制孔传输到沙漏漏斗入口处的相对低压区域。将交替和直接的电势施加到沙漏电动力学漏斗的元件，从而将离子吸入和穿过沙漏电动力学漏斗，从而将相对大量的离子引入漂移管中，同时保持气体压力和组成在漂移管的内部与电动漏斗的入口处的那些不同，并且如果需要，允许在漂移管内保持正的气体压力。内部离子漏斗设置在漂移管内并且位于所述漂移管的出口处。内部离子漏斗的优点是离散在漂移管内的出口孔的离子，例如通常在常规漂移管中丢失到任何后续分析或测量中的离子，而是通过漂移出口管，大大增加离开漂移管的离子的量。

4. 发明申请

WO2006110479A1 TANDEM HIGH FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY (FAIMS) / ION MOBILITY SPECTROMETRY 审中-公开
标题翻译： TANDEM高场非对称波形离子移动光谱（FAIMS）/离子移动光谱
公开(公告)号：WO2006110479A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/012879
申请日：2006-04-06
申请人： BATTELLE MEMORIAL INSTITUTE , TANG, Keqi , SHVARTSBURG, Alexandre, A. , SMITH, Richard
发明人： TANG, Keqi , SHVARTSBURG, Alexandre, A. , SMITH, Richard
IPC分类号： G01N27/64
CPC分类号： G01N27/624 , H01J49/004
摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamics ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.
摘要翻译：本发明涉及气相离子的分离和表征装置。该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。另一方面，使用电动离子漏斗实施FAIMS / IMS接口，特别是包括沙漏离子漏斗。本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。

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