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1. 发明申请

WO2006110479A1 TANDEM HIGH FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY (FAIMS) / ION MOBILITY SPECTROMETRY 审中-公开
标题翻译： TANDEM高场非对称波形离子移动光谱（FAIMS）/离子移动光谱
公开(公告)号：WO2006110479A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/012879
申请日：2006-04-06
申请人： BATTELLE MEMORIAL INSTITUTE , TANG, Keqi , SHVARTSBURG, Alexandre, A. , SMITH, Richard
发明人： TANG, Keqi , SHVARTSBURG, Alexandre, A. , SMITH, Richard
IPC分类号： G01N27/64
CPC分类号： G01N27/624 , H01J49/004
摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamics ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.
摘要翻译：本发明涉及气相离子的分离和表征装置。该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。另一方面，使用电动离子漏斗实施FAIMS / IMS接口，特别是包括沙漏离子漏斗。本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。

2. 发明申请

WO2006105464A1 METHOD AND APPARATUS FOR ION MOBILITY SPECTROMETRY WITH ALIGNMENT OF DIPOLE DIRECTION (IMS-ADD) 审中-公开
标题翻译：用于离子交换光谱的方法和装置（IMS-ADD）
公开(公告)号：WO2006105464A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/012149
申请日：2006-03-30
申请人： BATTELLE MEMORIAL INSTITUTE , SHVARTSBURG, Alexandre, A. , TANG, Keqi , SMITH, Richard, D.
发明人： SHVARTSBURG, Alexandre, A. , TANG, Keqi , SMITH, Richard, D.
IPC分类号： G01N27/64 , H01J49/40
CPC分类号： G01N27/624 , H01J49/004 , H01J49/40
摘要： Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that "locks" the ion dipoles with moments exceeding a certain value^ That value depends on the buffer gas composition, pressure, and temperature, but may be as low as ~ 3 Debye under certain conditions. The presently disclosed method measures the direction- specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.
摘要翻译：描述了用于分析物质的技术和仪器，包括在表征单个组分之前需要分离的复杂样品/混合物。公开了用于分离离子混合物和鉴定离子的方法，包括蛋白质和其它大分子离子及其不同的结构异构体。分离离子在分离期间不能自由旋转，而是基本上相对于漂移方向取向。通过以特定的角度对漂移场施加更强的交变电场来实现对准，该交变电场以超过一定值的力“锁定”离子偶极子。该值取决于缓冲气体组成，压力和温度，但是在某些条件下可能低至〜3德拜。目前公开的方法测量提供与已知方法获得的结构信息互补的方向特异性横截面，并且当与这些方法耦合时，增加气相分离的总峰容量和特异性。沿垂直于离子偶极方向的方向特定横截面同时进行2-D分离也是可能的。

3. 发明申请

WO2005045876A2 IMPROVED HIGH PERFORMANCE ION MOBILITY SPECTROMETRY USING HOURGLASS ELECTRODYNAMIC FUNNEL AND INTERNAL ION FUNNEL 审中-公开
标题翻译：使用HOURGLASS电动飞行器和内部飞机的改进的高性能离子运动光谱
公开(公告)号：WO2005045876A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/029181
申请日：2004-09-07
申请人： BATTELLE MEMORIAL INSTITUTE , SMITH, Richard, D. , TANG, Keqi , SHVARTSBURG, Alexandre, A.
发明人： SMITH, Richard, D. , TANG, Keqi , SHVARTSBURG, Alexandre, A.
IPC分类号： H01J49/04
CPC分类号： H01J49/066 , G01N27/622 , H01J49/40
摘要： A method and apparatus enabling increased sensitivity in ion mobility spectrometry/mass spectrometry instruments which substantially reduces or eliminates the loss of ions in ion mobility spectrometer drift tubes utilizing a device for transmitting ions from an ion source which allows the transmission of ions without significant delay to an hourglass electrodynamic ion funnel at the entrance to the drift tube and/or an internal ion funnel at the exit of the drift tube. An hourglass electrodynamic funnel is formed of at least an entry element, a center element, and an exit element, wherein the aperture of the center element is smaller than the aperture of the entry element and the aperture of the exit elements. Ions generated in a relatively high pressure region by an ion source at the exterior of the hourglass electrodynamic funnel are transmitted to a relatively low pressure region at the entrance of the hourglass funnel through a conductance limiting orifice. Alternating and direct electrical potentials are applied to the elements of the hourglass electrodynamic funnel thereby drawing ions into and through the hourglass electrodynamic funnel thereby introducing relatively large quantities of ions into the drift tube while maintaining the gas pressure and composition at the interior of the drift tube as distinct from those at the entrance of the electrodynamic funnel and allowing a positive gas pressure to be maintained within the drift tube, if desired. An internal ion funnel is provided within the drift tube and is positioned at the exit of said drift tube. The advantage of the internal ion funnel is that ions that are dispersed away from the exit aperture within the drift tube, such as those that are typically lost in conventional drift tubes to any subsequent analysis or measurement, are instead directed through the exit of the drift tube, vastly increasing the amount of ions exiting the drift tube.
摘要翻译：一种能够提高离子迁移光谱/质谱仪器灵敏度的方法和装置，其基本上减少或消除了离子迁移谱仪漂移管中的离子损失，其利用离子源传输离子的装置，离子源允许离子传输而不会显着延迟漂移管入口处的沙漏电动力离子漏斗和/或漂移管出口处的内部离子漏斗。沙漏电动漏斗由至少一个入口元件，中心元件和出口元件形成，其中中心元件的孔径小于入口元件的孔径和出口元件的孔径。在沙漏电动漏斗的外部由离子源在较高压力区域产生的离子通过电导限制孔传输到沙漏漏斗入口处的相对低压区域。将交替和直接的电势施加到沙漏电动力学漏斗的元件，从而将离子吸入和穿过沙漏电动力学漏斗，从而将相对大量的离子引入漂移管中，同时保持气体压力和组成在漂移管的内部与电动漏斗的入口处的那些不同，并且如果需要，允许在漂移管内保持正的气体压力。内部离子漏斗设置在漂移管内并且位于所述漂移管的出口处。内部离子漏斗的优点是离散在漂移管内的出口孔的离子，例如通常在常规漂移管中丢失到任何后续分析或测量中的离子，而是通过漂移出口管，大大增加离开漂移管的离子的量。

4. 发明申请

WO2009042328A2 LOW PRESSURE ELECTROSPRAY IONIZATION SYSTEM AND PROCESS FOR EFFECTIVE TRANSMISSION OF IONS 审中-公开
标题翻译：低压电沉积离子系统和有效传输离子的方法
公开(公告)号：WO2009042328A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/074238
申请日：2008-08-25
申请人： BATTELLE MEMORIAL INSTITUTE , TANG, Keqi , PAGE, Jason, S. , KELLY, Ryan, T. , SMITH, Richard, D.
发明人： TANG, Keqi , PAGE, Jason, S. , KELLY, Ryan, T. , SMITH, Richard, D.
IPC分类号： H01J49/16 , H01J49/06
CPC分类号： H01J49/165 , H01J49/066
摘要： A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel "interfaceless" electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.
摘要翻译：公开了一种系统和方法，其提供在具有低有效离子损耗的耦合级之间的离子的完全传输。进一步描述了一种新颖的“无接触”电喷雾离子化系统，其在减压下操作电喷雾，使得标准电喷雾样品溶液可以直接喷射到提供离子聚焦并将离子传输到质量分析器中的电动离子漏斗中。

5. 发明申请

WO2012050642A3 MICROCHIP CAPILLARY ELECTROPHORESIS ABSENT ELECTROKINETIC INJECTION 审中-公开
公开(公告)号：WO2012050642A3
公开(公告)日：2012-04-19
申请号：PCT/US2011/041032
申请日：2011-06-20
申请人： BATTELLE MEMORIAL INSTITUTE , SUN, Xuefei , KELLY, Ryan T. , TANG, Keqi , SMITH, Richard D.
发明人： SUN, Xuefei , KELLY, Ryan T. , TANG, Keqi , SMITH, Richard D.
IPC分类号： G01N27/26 , G01N27/447 , G01N35/10
摘要： Microchip capillary electrophoresis (CE) utilizing a sample injector based on a mechanical valve rather than electrokinetic injection can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. In one instance CE electrodes continuously apply an electric field for CE separation along a separation channel. A sample channel is connected to the separation channel at an intersection and has a sample pressure that is greater than that which is present in the separation channel near the intersection. The sample channel does not have electrodes that apply voltages for electrokinetic injection. A sample injector in the sample channel or at the intersection comprises a mechanical valve to control sample injection from the sample channel to the separation channel.

6. 发明申请

WO2010051051A2 RADIAL ARRAYS OF NANO-ELECTROSPRAY IONIZATION EMITTERS AND METHODS OF FORMING ELECTROSPRAYS 审中-公开
标题翻译：纳米电子辐射发射体的径向阵列和电子成形方法
公开(公告)号：WO2010051051A2
公开(公告)日：2010-05-06
申请号：PCT/US2009/035817
申请日：2009-03-03
申请人： BATTELLE MEMORIAL INSTITUTE , KELLY, Ryan , TANG, Keqi , SMITH, Richard, D.
发明人： KELLY, Ryan , TANG, Keqi , SMITH, Richard, D.
IPC分类号： H01J49/00
CPC分类号： H01J49/167
摘要： Electrospray ionization emitter arrays, as well as methods for forming electrosprays, are described. The arrays are characterized by a radial configuration of three or more nano- electrospray ionization emitters without an extractor electrode. The methods are characterized by distributing fluid flow of the liquid sample among three or more nano- electrospray ionization emitters, forming an electrospray at outlets of the emitters without utilizing an extractor electrode, and directing the electrosprays into an entrance to a mass spectrometry device. Each of the nano-electrospray ionization emitters can have a discrete channel for fluid flow. The nano-electrospray ionization emitters are circularly arranged such that each is shielded substantially equally from an electrospray-inducing electric field.
摘要翻译：描述了电喷射电离发射体阵列以及形成电喷雾的方法。阵列的特征在于具有三个或更多个不具有提取电极的纳米电喷雾电离发射体的径向配置。所述方法的特征在于，分配三种或更多种纳米电喷雾电离发射体之间的液体样品的流体流动，在不利用提取电极的情况下在发射体的出口处形成电喷雾，并且将电喷雾引导至质谱装置的入口。每个纳米电喷雾电离发射体可以具有用于流体流动的离散通道。纳米电喷雾电离发射体是圆形排列的，使得每个电子发射体与电喷雾诱导电场基本上相等地被屏蔽。

7. 发明申请

WO2007092227A3 MONOLITHIC ELECTROSPRAY IONIZATION EMITTERS AND METHODS OF MAKING SAME 审中-公开
公开(公告)号：WO2007092227A3
公开(公告)日：2007-08-16
申请号：PCT/US2007/002657
申请日：2007-01-29
申请人： BATTELLE MEMORIAL INSTITUTE , TANG, Keqi , PAGE, Jason, S. , LUO, Quanzhou , SMITH, Richard, D.
发明人： TANG, Keqi , PAGE, Jason, S. , LUO, Quanzhou , SMITH, Richard, D.
IPC分类号： H01J49/16 , G01N30/72
摘要： Electrospray ionization (ESI) apparatuses and methods of making the same are disclosed. In one embodiment, an ESI emitter comprises a capillary tube filled with a porous monolithic material, wherein the end of the emitter is tapered and the tip of the tapered end comprises a protrusion of the porous monolithic material. One embodiment of the method for making ESI emitters comprises filling a capillary tube with a porous monolithic material and tapering the end of the capillary tube, thereby exposing a portion of the porous material. The exposed portion of the porous material at the tapered end, rather than the capillary tube itself, forms the tip of the ESI emitter.

8. 发明申请

WO2015167990A1 MICROFLUIDIC SAMPLE INJECTOR ABSENT ELECTROKINETIC INJECTION 审中-公开
标题翻译：微流体样品注射器无菌电动注射
公开(公告)号：WO2015167990A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/027728
申请日：2015-04-27
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： TANG, Keqi , KELLY, Ryan, T.
IPC分类号： G01N27/447
CPC分类号： G01N27/44743 , A61M39/22 , A61M2205/0244 , B01L3/502738 , B01L3/502753 , B01L3/502784 , B01L2400/0487 , F16K99/0015 , F16K99/0055 , G01N27/44791
摘要： Microfluidic sample injection, which is based on a mechanical valve rather than electrokinetic injection into an integrated separation channel or a discrete separation column, can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. An interface allowing the use of a discrete separation column easily allows for flexibility to utilize the microfluidic injector with existing analytical techniques. Multiple sample channels and/or sample sources can be utilized with the microfluidic sample injector.
摘要翻译：基于机械阀而不是电动注入集成分离通道或离散分离柱的微流体样品注入可以提供改进的样品注入，增强的能力，并且可以消除将分离通道中的电场改变为诱导注射样品。允许使用离散分离柱的界面容易允许利用现有分析技术利用微流体注射器的灵活性。多个样品通道和/或样品源可以与微流体样品注射器一起使用。

9. 发明申请

WO2015030885A1 APPARATUS AND METHOD OF DISSOCIATING IONS IN A MULTIPOLE ION GUIDE 审中-公开
标题翻译：多离子指南中的离子的分解方法
公开(公告)号：WO2015030885A1
公开(公告)日：2015-03-05
申请号：PCT/US2014/039212
申请日：2014-05-22
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： WEBB, Ian K. , TANG, Keqi , SMITH, Richard D. , IBRAHIM, Yehia M. , ANDERSON, Gordon A.
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/063 , H01J49/0063
摘要： A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.
摘要翻译：公开了一种在多极离子导向器中离解离子的方法。将带电离子流供给到离子导向器。将主RF场施加到离子导向器以将离子限制在离子导向器上。激发RF场被施加到离子导向器的一对杆上。当施加的激发RF场与离子的长期频率共振时，离子发生解离。多极离子导向器是但不限于四极，六极和八极。

10. 发明申请

WO2014137398A1 SHEATHLESS INTERFACE FOR COUPLING CAPILLARY ELECTROPHORESIS WITH MASS SPECTROMETRY 审中-公开
标题翻译：用于耦合毛细管电泳的无密封接口，具有质谱分析
公开(公告)号：WO2014137398A1
公开(公告)日：2014-09-12
申请号：PCT/US2013/064011
申请日：2013-10-09
申请人： BATTELLE MEMORIAL INSTITUTE , UNIVERSITY OF MARYLAND
发明人： WANG, Chenchen , TANG, Keqi , SMITH, Richard D.
IPC分类号： H01J49/16 , G01N27/447 , G01N30/72
CPC分类号： H01J49/167 , G01N27/44713 , G01N30/7266
摘要： A sheathless interface for coupling capillary electrophoresis (CE) with mass spectrometry is disclosed. The sheathless interface includes a separation capillary for performing CE separation and an emitter capillary for electrospray ionization. A portion of the emitter capillary is porous or, alternatively, is coated to form an electrically conductive surface. A section of the emitter capillary is disposed within the separation capillary, forming a joint. A metal tube, containing a conductive liquid, encloses the joint.
摘要翻译：公开了一种用于耦合毛细管电泳（CE）和质谱的无鞘界面。无鞘界面包括用于进行CE分离的分离毛细管和用于电喷雾离子化的发射体毛细管。发射管毛细管的一部分是多孔的，或者替代地，被涂覆以形成导电表面。发射管毛细管的一部分设置在分离毛细管内，形成接头。包含导电液体的金属管封闭接头。

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